6o9d A 2.51 BS01 LTY A 1 M192 V200 A211 Y262 Y264 M265 P266 G268 A315 L318 M31 V39 A50 Y94 Y96 M97 P98 G100 A147 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T179 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 -logKd/Ki=8.70, Ki=2nM IC50=41nM, Ki=2.0nM Q9NWZ3 31082230 501 DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 6o9d B 2.51 BS01 LTY B 1 M192 V200 A211 Y262 Y264 M265 P266 G268 L318 M30 V38 A49 Y93 Y95 M96 P97 G99 L149 D311 K313 A315 N316 D329 T351 D142 K144 A146 N147 D160 T177 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=41nM, Ki=2.0nM Q9NWZ3 31082230 501 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 6o9d C 2.51 BS01 LTY C 1 M192 V200 A211 Y262 Y264 M265 P266 G268 L318 M30 V38 A49 Y92 Y94 M95 P96 G98 L148 D311 K313 A315 N316 D329 T351 D141 K143 A145 N146 D159 T176 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=41nM, Ki=2.0nM Q9NWZ3 31082230 501 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 6o9d D 2.51 BS01 LTY D 1 M192 V200 A211 Y262 Y264 M265 G268 S269 A315 L318 M29 V37 A48 Y91 Y93 M94 G97 S98 A144 L147 D311 K313 A315 N316 D329 T351 D140 K142 A144 N145 D158 T177 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=41nM, Ki=2.0nM Q9NWZ3 31082230 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT