6o94 A 1.98 BS01 LRS A 1 I185 M192 G193 E194 V200 A211 Y262 Y264 M265 P266 G268 L318 I23 M30 G31 E32 V38 A49 Y100 Y102 M103 P104 G106 L156 D311 K313 A315 N316 D329 T351 D149 K151 A153 N154 D167 T185 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Ki=7.4nM -logKd/Ki=8.74, Ki=1.8nM IC50=97nM, Ki=1.8nM Q9NWZ3 31082230 502 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 6o94 B 1.98 BS01 LRS B 1 M192 G193 V200 A211 Y262 Y264 M265 P266 G268 L318 M31 G32 V39 A50 Y101 Y103 M104 P105 G107 L157 D311 K313 A315 N316 D329 T351 D150 K152 A154 N155 D168 T186 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Ki=7.4nM IC50=97nM, Ki=1.8nM Q9NWZ3 31082230 502 DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 6o94 C 1.98 BS01 LRS C 1 M192 G193 V200 A211 Y262 Y264 M265 P266 G268 L318 M30 G31 V38 A49 Y94 Y96 M97 P98 G100 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T179 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Ki=7.4nM IC50=97nM, Ki=1.8nM Q9NWZ3 31082230 501 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 6o94 D 1.98 BS01 LRS D 1 M192 V200 A211 Y262 Y264 M265 P266 N267 G268 L318 M30 V38 A49 Y94 Y96 M97 P98 N99 G100 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T178 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Ki=7.4nM IC50=97nM, Ki=1.8nM Q9NWZ3 31082230 501 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT