1hpc B 2.0 BS01 LPA B 1 H34 K63 H34 K63 1.4.4.2 0005960,0019464 P16048 15299773 132 SNVLDGLKYAPSHEWVKHEGSVATIGITDHAQDHLGEVVFVELPEPGVSVTKGKGFGAVESVKATSDVNSPISGEVIEVNTGLTGKPGLINSSPYEDGWMIKIKPTSPDELESLLGAKEYTKFCEEEDAAH 1x2h A 2.91 BS01 LPA A 1 E21 F24 S72 F147 H149 E21 F24 S72 F147 H149 6.3.1.20 0005524,0005737,0005829,0009249,0016874,0016979,0017118,0036211 P32099 16043486 338 STLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTVEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKRVTNLTELLPGITHEQVCEAITEAFFAHYGERVEAEIISPNKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGHITRAQVFTDSLNPAPLEALAGRLQGCLYRADMLQQECEALLVDFPEQEKELRELSAWMAGAVR 1x2h B 2.91 BS01 LPA B 1 E21 F24 A138 R140 H149 E21 F24 A138 R140 H149 6.3.1.20 0005524,0005737,0005829,0009249,0016874,0016979,0017118,0036211 P32099 16043486 338 STLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTVEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKRVTNLTELLPGITHEQVCEAITEAFFAHYGERVEAEIISPNKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGHITRAQVFTDSLNPAPLEALAGRLQGCLYRADMLQQECEALLVDFPEQEKELRELSAWMAGAVR 2art A 2.4 BS02 LPA A 1 I46 G77 V79 H81 G148 A149 H161 A162 A163 I46 G77 V79 H81 G148 A149 H161 A162 A163 6.3.1.20 0005515,0005524,0005737,0009249,0016874,0016979,0017118,0031405,0032991,0036211,0046872 Q9HKT1 16141198 301 MEGRLLLLETPGNTRMSLAYDEAIYRSFQYGDKPILRFYRHDRSVIIGYFQVAEEEVDLDYMKKNGIMLARRYTGGGAVYHDLGDLNFSVVRSSDDMDITSMFRTMNEAVVNSLRILGLDARPGELNDVSIPVNKKTDIMAGEKKIMGAAGAMRKGAKLWHAAMLVHTDLDMLSAVLKVPSTRERVANVTDFVDVSIDEVRNALIRGFSETLHIDFREDTITEKEESLARELFDKKYSTEEWNMGLL 2c8m A 1.89 BS01 LPA A 1 R72 V79 H81 K145 G148 A149 H161 R72 V79 H81 K145 G148 A149 H161 6.3.1.20 0005515,0005524,0005737,0009249,0016874,0016979,0017118,0031405,0032991,0036211,0046872 Q9HKT1 16384580 900 MEGRLLLLETPGNTRMSLAYDEAIYRSFQYGDKPILRFYRHDRSVIIGYFQVAEEEVDLDYMKKNGIMLARRYTGGGAVYHDLGDLNFSVVRSSDDMDITSMFRTMNEAVVNSLRILGLDARPGELNDVSIPVNKKTDIMAGEKKIMGAAGAMRKGAKLWHAAMLVHTDLDMLSAVLKERVANVTDFVDVSIDEVRNALIRGFSETLHIDFREDTITEKEESLARELFDKKYSTEEWNMGL 2c8m B 1.89 BS01 LPA B 1 Y39 R72 V79 H81 K145 G148 A149 H161 Y39 R72 V79 H81 K145 G148 A149 H161 6.3.1.20 0005515,0005524,0005737,0009249,0016874,0016979,0017118,0031405,0032991,0036211,0046872 Q9HKT1 16384580 900 MEGRLLLLETPGNTRMSLAYDEAIYRSFQYGDKPILRFYRHDRSVIIGYFQVAEEEVDLDYMKKNGIMLARRYTGGGAVYHDLGDLNFSVVRSSDDMDITSMFRTMNEAVVNSLRILGLDARPGELNDVSIPVNKKTDIMAGEKKIMGAAGAMRKGAKLWHAAMLVHTDLDMLSAVLKSTRERVANVTDFVDVSIDEVRNALIRGFSETLHIDFREDTITEKEESLARELFDKKYSTEEWNMGLL 2c8m C 1.89 BS01 LPA C 1 R72 V79 H81 K145 G148 A149 H161 A162 R72 V79 H81 K145 G148 A149 H161 A162 6.3.1.20 0005515,0005524,0005737,0009249,0016874,0016979,0017118,0031405,0032991,0036211,0046872 Q9HKT1 16384580 900 MEGRLLLLETPGNTRMSLAYDEAIYRSFQYGDKPILRFYRHDRSVIIGYFQVAEEEVDLDYMKKNGIMLARRYTGGGAVYHDLGDLNFSVVRSSDDMDITSMFRTMNEAVVNSLRILGLDARPGELNDVSIPVNKKTDIMAGEKKIMGAAGAMRKGAKLWHAAMLVHTDLDMLSAVLKSTRERVANVTDFVDVSIDEVRNALIRGFSETLHIDFREDTITEKEESLARELFDKKYSTEEWNMGLL 2c8m D 1.89 BS01 LPA D 1 R72 V79 H81 K145 G148 A149 H161 A162 R72 V79 H81 K145 G148 A149 H161 A162 6.3.1.20 0005515,0005524,0005737,0009249,0016874,0016979,0017118,0031405,0032991,0036211,0046872 Q9HKT1 16384580 900 MEGRLLLLETPGNTRMSLAYDEAIYRSFQYGDKPILRFYRHDRSVIIGYFQVAEEEVDLDYMKKNGIMLARRYTGGGAVYHDLGDLNFSVVRSSDDMDITSMFRTMNEAVVNSLRILGLDARPGELNDVSIPVNKKTDIMAGEKKIMGAAGAMRKGAKLWHAAMLVHTDLDMLSAVLKRERVANVTDFVDVSIDEVRNALIRGFSETLHIDFREDTITEKEESLARELFDKKYSTEEWNMG 2iqd A 2.0 BS02 LPA A 1 W20 Y48 H110 W20 Y48 H110 D43 Y48 K77 H110 D43 Y48 K77 H110 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 Ki=25.5uM Ki=25500nM P15121 17083960 351 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF 5iby A 1.85 BS01 LPA A 1 Y35 I42 R68 G72 G73 H77 G134 H147 G148 Y39 I46 R72 G76 G77 H81 G138 H151 G152 6.3.1.20 0005524,0005737,0009249,0016874,0016979,0017118,0036211 Q830N7 401 YFQGMIFVPNENNDPRVNLAIETYLLTEMPLDEPILLFYINEPSIIIGRNQNTIEEINKEYVDEHGIHVVRRLSGGGAVYHDHGNLNFSFIMPDDGNSFRDFAKVTQPIIQALHDLGVEGAELKGRNDLVINDMKFSGNAMYATNGRMFAHGTLMFDSDIDEVVNTLRVTNIKPFLSEDKQEMTTEEFRQEILLKIFGVDSIDQVKTYELTDQDWAAINKISEQYYRNWDWNYGKSPAFNLERRHRFPIGSIEMKMNVADGAIQEIKIFGDFFGLGEIKDVEDILTGVKYDKASLEEAIDQIDVKKYFGNIEKEDLLGLIY 5ij6 A 2.0 BS01 LPA A 1 Y35 R68 G72 G73 V75 N123 G134 N135 H147 Y36 R69 G73 G74 V76 N124 G135 N136 H148 6.3.1.20 0005524,0005737,0009249,0016874,0016979,0017118,0036211 Q838C1 401 GMRYVIMQSRDIRENLATEDYLLNTLSFEEPLVLFYIQEPCVILGRNQNAYEEIDLAYAREKGIVITRRLSGGGAVYDDLGNVSFSFVVQEGHQAFGDFKAFTKPIIEALHKMGATGAEISGRNDLLIDGKKFSGNAMYTKKGKMYTHGTLMYDVDLAEVQRVLTRVTNLRPYLDEKYQQLTIEEFRNRLLMELFDVESLTEIAEKEYVLTKADQQEIRKLVAEVYGNEAWIFGEAPKFTIKKEEKFKGGIVDARLTVEKGKIIELTIYGDYFAKKETTEIVAALLGVDYQYSSIWQALAAFNFEDYFVNITKEEFVHLLVD 5t8u A 2.324 BS01 LPA A 1 R102 V109 H111 G163 S164 H176 G177 R82 V89 H91 G143 S144 H156 G157 6.3.1.20 0009249,0036211 Q8IEG9 28543853 401 GPLVLVSNNQNIHFNLSLENFLLNNYNDLLKYLNINTIEKFNEPILFLWRNNRSIIIGKNQNIWSECNLKNIKEDGVLVARRFTGGGAVYHDLGNVCFTFLNNNINTSSNFLIILNTLKNHFNIEAKTQGRNDITVNDQKCSGSAFKKIKDVFLHHGTILINLEKNILNKYLTTINLSEINNNITCENLCIALIKEFTKFYEQNYNTNIIPNDITVHYIDQNNNITKNPEFLKYYNLLKDWDWCYGKTPKFQNHIWKQFTFGKLELFFNVSNGFIKDGNIFSDCLDINLIDHLKSIFNNDIKYSKEDISIFFKKLNVENKNYLDEVRSWILQE 5t8u B 2.324 BS01 LPA B 1 W69 R102 V109 H111 H176 G177 W49 R82 V89 H91 H156 G157 6.3.1.20 0009249,0036211 Q8IEG9 28543853 401 GPLVLVSNNQNIHFNLSLENFLLNNYNDLLKYLNINTIEKFNEPILFLWRNNRSIIIGKNQNIWSECNLKNIKEDGVLVARRFTGGGAVYHDLGNVCFTFLNNNINTSSNFLIILNTLKNHFNIEAKTQGRNDITVNDQKCSGSAFKKIKDVFLHHGTILINLEKNILNKYLTPDKIKYIARTINLSEINNNITCENLCIALIKEFTKFYEQNPNDITVHYIDQNNNITKNPEFLKYYNLLKDWDWCYGKTPKFQNHIWKQFTFGKLELFFNVSNGFIKDGNIFSDCLDINLIDHLKSIFNNDIKYSKEDISIFFKKLNVENKNYLDEVRSWILQE 7yva B 2.93 BS02 LPA B 1 G266 S267 F274 L287 D288 T289 D290 R344 I351 G244 S245 F252 L265 D266 T267 D268 R322 I329 4.1.2.13 0004332,0005515,0005737,0005829,0005886,0005975,0006094,0006096,0008270,0009277,0009986,0016829,0016832,0030446,0046872,0051701,0052553 Q9URB4 402 PPAVLSKSGVIYGKDVKDLFDYAQEKGFAIPAINVTSSSTVVAALEAARDNKAPIILQTSQGGAAYFAGKGVDNKDQAASIAGSIAAAHYIRAIAPTYGIPVVLHTDHCAKKLLPWFDGMLKADEEFFAKTGTPLFSSHMLDLSEETDDENIATCAKYFERMAKMGQWLEMEIGITGGLYTSPETVFAVYESLHKISPNFSIAAAFGNVHVQLRPEILGDHQVYAKKQIGTDAKHPLYLVFHGGSGSTQEEFNTAIKNGVVKVNLDTDCQYAYLTGIRDYVTNKIEYLKAPVGNPEGADKPNKKYFDPRVWVREGEKTMSKRIAEALDIFHTKGQL 8cri A 2.1 BS01 LPA A 1 Y36 I43 R69 H78 G134 H147 Y38 I45 R71 H80 G136 H149 6.3.1.20 0005524,0005737,0009249,0016874,0016979,0017118,0036211,0046872 A0A1D2IX29 37249408 901 HMMYFIDNNNEKDPRINLAVEEFILTELNLDEPVLLFYINKPSIIIGRNQNTVEEIDTEYVEKNDVIVVRRLSGGGAVYHDEGNLNFSFITEDDGESFHNFAKFTQPIVEALKRLGVNAELKGRNDLLIDGFKVSGNAQFATKGKMFSHGTLMYDLNLDNVAASLKRVANISDFMDQEMTTEEFRDLLLLYIFGVEKVEDVKEYKLTAADWEKIHEISAKRYGNWDWNYGKSPKFDLTRTKRFPVGAVDVRLNVQKGVITDIKIFGDFFGVKNVADIEEKLVNTTYKREVLAEALVDIDVKEYFGNITKDEFLDLLY