3kmm A 2.8 BS01 LHL A 1 V259 A271 V272 K273 E288 T316 Y318 M319 G322 L371 D382 V29 A41 V42 K43 E58 T86 Y88 M89 G92 L141 D152 D364 R366 A368 N369 D382 A400 F402 D134 R136 A138 N139 D152 A170 F172 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=9.70, Kd=0.2nM Kd=0.2nM P06239 1 KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTAT 3pj1 A 2.0 BS01 LHL A 1 L408 V416 A428 I429 K430 E445 I472 T474 M477 G480 L528 L18 V23 A35 I36 K37 E47 I72 T74 M77 G80 L126 D521 A523 R525 N526 D539 F559 D119 A121 R123 N124 D137 F141 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.048uM -logKd/Ki=7.32, IC50=48nM Q06187 21280133 1 GYGSWEIDPKDLTFLKELGTGVVKYGKWRGQYDVAIKMISEDEFIEEAKVMMNLSHEKLVQLYGVCTKQIFIITEYMANGCLLNYLREMRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 3pj1 A 2.0 BS02 LHL A 2 Y425 Q459 Y461 Y32 Q61 Y63 D521 A523 R525 N526 D539 F559 D119 A121 R123 N124 D137 F141 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.048uM -logKd/Ki=7.32, IC50=48nM Q06187 21280133 2 GYGSWEIDPKDLTFLKELGTGVVKYGKWRGQYDVAIKMISEDEFIEEAKVMMNLSHEKLVQLYGVCTKQIFIITEYMANGCLLNYLREMRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES