1d7u A 1.95 BS02 LCS A 1 G111 A112 W138 H139 E210 D243 A245 Q246 K272 R406 G109 A110 W136 H137 E208 D241 A243 Q244 K270 R404 G21 W138 E210 D243 Q246 K272 T303 R406 G19 W136 E208 D241 Q244 K270 T301 R404 4.1.1.64 0008453,0008483,0009436,0016831,0019481,0030170,0047432 P16932 10556038 500 LNDDATFWRNARQHLVRYGGTFEPMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHCHPEIVSVIGEYAGKLDHLFSGMLSRPVVDLATRLANITPPGLDRALLLSTGAESNEAAIRMAKLVTGKYEIVGFAQSWHGMTGAAASATYSAGRKGVGPAAVGSFAIPAPFTYRPRFERNGAYDYLAELDYAFDLIDRQSSGNLAAFIAEPILSSGGIIELPDGYMAALKRKCEARGMLLILDEAQTGVGRTGTMFACQRDGVTPDILTLSKTLGAGLPLAAIVTSAAIEERAHELGYLFYTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERFDCIGDVRGRGLLLGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRIAPPLTVSEDEIDLGLSLLGQAIERAL 4d9e A 2.47 BS01 LCS A 1 N50 K51 N79 G194 S195 A196 T198 Y287 T315 G316 G317 N50 K51 N79 G194 S195 A196 T198 Y287 T315 G316 G317 K51 Y261 Y287 K51 Y261 Y287 4.4.1.15 0003824,0016829,0019148,0046416 Q8ZNT7 22574144 402 MPLHHLTRFPRLEFIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAGTHAGLAVGLEHLMPDVELIGVTVSRSVAEQKPKVIALQQAIAGQLALTATADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQKRFNDDGPILFIHTGGAPALFAYHPHV 4d9e B 2.47 BS01 LCS B 1 N50 K51 N79 S195 A196 T198 Y287 T315 G316 G317 N47 K48 N76 S192 A193 T195 Y284 T312 G313 G314 K51 Y261 Y287 K48 Y258 Y284 4.4.1.15 0003824,0016829,0019148,0046416 Q8ZNT7 22574144 402 HHLTRFPRLEFIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAGTHAGLAVGLEHLMPDVELIGVTVSRSVAEQKPKVIALQQAIAGQLALTATADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQKRFNDDGPILFIHTGGAPALFAYHPHV 4d9e C 2.47 BS01 LCS C 1 N50 K51 N79 G194 S195 A196 T198 Y287 T315 G316 G317 N45 K46 N74 G189 S190 A191 T193 Y282 T310 G311 G312 K51 Y261 Y287 K46 Y256 Y282 4.4.1.15 0003824,0016829,0019148,0046416 Q8ZNT7 22574144 401 LTRFPRLEFIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAGTHAGLAVGLEHLMPDVELIGVTVSRSVAEQKPKVIALQQAIAGQLALTATADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQKRFNDDGPILFIHTGGAPALFAYHPHV 4d9e D 2.47 BS01 LCS D 1 N50 K51 S78 N79 H80 G194 S195 A196 T198 Y287 T315 G316 G317 N50 K51 S78 N79 H80 G194 S195 A196 T198 Y287 T315 G316 G317 K51 Y261 Y287 K51 Y261 Y287 4.4.1.15 0003824,0016829,0019148,0046416 Q8ZNT7 22574144 402 MPLHHLTRFPRLEFIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAGTHAGLAVGLEHLMPDVELIGVTVSRSVAEQKPKVIALQQAIAGQLALTATADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQKRFNDDGPILFIHTGGAPALFAYHPHV 4oma A 1.6 BS01 LCS A 1 G88 I89 Y113 D185 S207 T209 K210 V338 S339 R374 G87 I88 Y112 D184 S206 T208 K209 V337 S338 R373 R60 Y113 D185 K210 R59 Y112 D184 K209 4.4.1.11 0005737,0016829,0016846,0018826,0019346,0030170 -logKd/Ki=4.17, Ki=68uM Q84AR1 25398880 401 SDCRTYGFNTQIVHAGQQPDPSTGALSTPIFQTSTFVFDSAEQGAARFALEESGYIYTRLGNPTTDALEKKLAVLERGEAGLATASGISAITTTLLTLCQQGDHIVSASAIYGCTHAFLSHSMPKFGINVSFVDAAKPEEIRAAMRPETKVVYIETPANPTLSLVDIETVAGIAHQQGALLVVDNTFMSPYCQQPLQLGADIVVHSVTKYINGHGDVIGGIIVGKQEFIDQARFVGLKDITGGCMSPFNAWLTLRGVKTLGIRMERHCENALKIARFLEGHPSITRVYYPGLSSHPQYELGQRQMSLPGGIISFEIAGGLEAGRRMINSVELCLLAVSLGDTETLIQHPASMTHSPVAPEERLKAGITDGLIRLSVGLEDPEDIINDLEHAIRKAT 6qp1 A 1.42 BS01 LCS A 1 A47 G106 I107 Y132 N184 D212 I214 H215 S245 K246 R376 A31 G90 I91 Y116 N168 D196 I198 H199 S229 K230 R360 0009058,0030170 32719469 501 YNFDEIIDRRYTNAMNVEGYKGYLLIRMWVADMDFGTPEVVLNAIRERLNKKILGYTNVFGSEYYEAFVSWTKKRYGFTFSQEHLVFSHGIVAGLIELVGYICDKDDKALIVTPSYGPFKMACDKNHISTVYSPLINHHGYYEIDFDDVRKKVETENIKLCIFANPHNPTGRVWSEEELATLGQIMKENDVWLISDEIHCDIKRSGQSHIPFAKAVPDYDKIITTMSQSKAFNIAGLMFSNIIIQNESLLKTWNTHHFGTENPLSVVATQAAYEKGEGWLQAMNHYLDDNFNYLADFLEKELPHAEFKIPEATYLAWVDLSYYIKEKDIDESMAKFFIKNAGVIIEGAEQFVHNAEGHIRINIAVPREVMKKGLQKIKAALVENLY 6qp1 B 1.42 BS01 LCS B 1 A47 G106 I107 Y132 N184 D212 I214 H215 S245 K246 R376 A52 G111 I112 Y137 N189 D217 I219 H220 S250 K251 R376 0009058,0030170 32719469 501 GGGFAVNYNFDEIIDRRYTNAMNVEGYKGYLFGDADTSDLKDNDELIRMWVADMDFGTPEVVLNAIRERLNKKILGYTNVFGSEYYEAFVSWTKKRYGFTFSQEHLVFSHGIVAGLIELVGYICDKDDKALIVTPSYGPFKMACDKNHISTVYSPLINHHGYYEIDFDDVRKKVETENIKLCIFANPHNPTGRVWSEEELATLGQIMKENDVWLISDEIHCDIKRSGQSHIPFAKAVPDYDKIITTMSQSKAFNIAGLMFSNIIIQNESLLKTWNTHHFGTENPLSVVATQAAYEKGEGWLQAMNHYLDDNFNYLADFLEKELPHAEFKIPEATYLAWVDLSYYIKESMAKFFIKNAGVIIEGAEQFVHNAEGHIRINIAVPREVMKKGLQKIKAALV 8ahu A 1.41 BS01 LCS A 1 F33 R52 R137 K143 Y147 E176 A178 R179 S180 L199 G201 I202 T203 S238 T239 F35 R54 R139 K145 Y149 E178 A180 R181 S182 L201 G203 I204 T205 S240 T241 ? 0003824,0008483,0019752,0046394,0046872 F4KWH0 37331714 302 GHMIKYYNINGQQVPVENATLHVSDLSILRGYGIFDYFLAREGHPLFLDDYLNRFYRSAAELYLEIPFDKAELRRQIYALLQANEVREAGIRLVLTGGYSPDGYTPVNPNLLIMMYDLPASAWEFSAQGIKIITHPFQRELPEVKTINYSTGIRMLKTIKERGATDLIYVDQGEWIRESARSNFFLVMPDNTIVTADEKILWGITRRQVIDAAREAGYAVEERRIHITELDQAREAFFTSTIKGVMAIGQIDDRVFGDGTIGKVTQELQDLFVGKVKAYLETC 8aie A 1.9 BS01 LCS A 1 T34 R51 K142 Y146 S174 H175 S176 T198 T199 G234 T235 V236 K237 T35 R52 K143 Y147 S175 H176 S177 T199 T200 G235 T236 V237 K238 ? 0003824,0008483,0019752,0046394 D5EHC5 301 HMNLCYIDGKFLPLEEAKLPVTDLIIQRGVGVFETISTHSRRPLMLTPHLKRLEGSATASSIVMPATLDEMARIIREGIKKMGCETMVRPYITGGDSFGKDHLFSSSRYFVIFEEIRKPDPILYEKGVALHPINAERYLPSTKSINYMLSFTGQRDSKGAYEILYCPEGEIVEGSHSTFFLIKNGHLITAPTSRALSGTTRQIVLELARRGNIQVEERCPLLTELPEAEEAFITGTVKELLPVVRIGDQIIGNGVPGKLTKHLHQVYLSSIVEWLE