6s77 A 2.12 BS01 KXW A 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 G194 L198 E214 A215 K241 E243 E257 M259 G260 Y261 M268 H414 W415 Y15 F16 Y19 Q25 M28 R34 G58 C59 G60 L64 E80 A81 K107 E109 E123 M125 G126 Y127 M134 H280 W281 2.1.1.319 0016274,0018216 Kd=143uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFYERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s77 B 2.12 BS01 KXW B 1 Y149 F150 Y153 Q159 R168 G192 C193 E214 A215 K241 E243 E257 M259 Y261 M268 S271 H414 W415 Y15 F16 Y19 Q25 R34 G58 C59 E80 A81 K107 E109 E123 M125 Y127 M134 S137 H280 W281 2.1.1.319 0016274,0018216 Kd=143uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFYERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s77 C 2.12 BS01 KXW C 1 Y149 F150 Y153 M162 G192 C193 E214 A215 K241 E243 E257 M259 M268 S271 H414 W415 Y15 F16 Y19 M28 G58 C59 E80 A81 K107 E109 E123 M125 M134 S137 H280 W281 2.1.1.319 0016274,0018216 Kd=143uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFYERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s77 D 2.12 BS01 KXW D 1 Y149 F150 Y153 Q159 R168 G192 C193 E214 A215 E257 M259 Y261 M268 S271 H414 W415 Y15 F16 Y19 Q25 R34 G58 C59 E80 A81 E123 M125 Y127 M134 S137 H280 W281 2.1.1.319 0016274,0018216 Kd=143uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFYERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s79 A 2.1 BS01 KXW A 1 Y149 F150 Y153 Q159 R168 G192 C193 L198 E214 A215 E257 M259 Y261 E266 M268 H414 W415 Y15 F16 Y19 Q25 R34 G58 C59 L64 E80 A81 E123 M125 Y127 E132 M134 H280 W281 2.1.1.319 0016274,0018216 Kd=1.11uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s79 B 2.1 BS01 KXW B 1 Y149 F150 Y153 Q159 R168 G192 C193 S195 E214 A215 K241 E257 Y261 E266 M268 W415 Y15 F16 Y19 Q25 R34 G58 C59 S61 E80 A81 K107 E123 Y127 E132 M134 W281 2.1.1.319 0016274,0018216 Kd=1.11uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s79 C 2.1 BS01 KXW C 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 L198 E214 A215 E257 M259 Y261 M268 S271 H414 W415 Y15 F16 Y19 Q25 M28 R34 G58 C59 L64 E80 A81 E123 M125 Y127 M134 S137 H280 W281 2.1.1.319 0016274,0018216 Kd=1.11uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 6s79 D 2.1 BS01 KXW D 1 Y149 F150 Y153 Q159 M162 G192 C193 L198 E214 A215 K241 E243 E257 Y261 E266 M268 H414 W415 Y15 F16 Y19 Q25 M28 G58 C59 L64 E80 A81 K107 E109 E123 Y127 E132 M134 H280 W281 2.1.1.319 0016274,0018216 Kd=1.11uM Q86X55 32011657 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY