1r0p A 1.8 BS01 KSA A 1 I1084 V1092 A1108 K1110 P1158 Y1159 M1160 M1211 R1227 M1229 Y1230 I35 V43 A55 K57 P105 Y106 M107 M158 R174 M176 Y177 D1204 A1206 R1208 N1209 D1222 A1243 D151 A153 R155 N156 D169 A190 2.7.10.1 0004672,0004713,0005524,0006468 Kd=10nM -logKd/Ki=8.00, Kd=10nM P08581 14559966 0 TVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVK 3eqf A 2.7 BS01 KSA A 1 L74 G75 G77 V82 A95 K97 M143 E144 H145 M146 G149 Q153 S194 L197 C207 L36 G37 G39 V44 A57 K59 M105 E106 H107 M108 G111 Q115 S156 L159 C169 D190 K192 S194 N195 D208 D217 T226 D152 K154 S156 N157 D170 D179 T188 2.7.12.2 0000165,0000187,0004672,0004674,0004708,0004712,0004713,0005078,0005515,0005524,0005634,0005737,0005739,0005769,0005770,0005783,0005794,0005813,0005816,0005829,0005856,0005886,0005925,0006468,0006935,0007165,0007507,0008285,0010628,0014044,0016020,0016310,0021697,0030182,0030216,0030295,0030878,0032872,0035987,0038133,0042552,0043410,0043539,0044342,0045893,0048009,0048538,0048679,0048870,0050772,0060020,0060324,0060425,0060440,0060502,0060674,0060711,0070371,0070374,0071902,0090170,0090398,0097110,0106310,1903226,2000641 Q02750 19161339 1 ELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4kik A 2.83 BS01 KSA A 1 L21 G22 V29 A42 K44 M96 Y98 G102 E149 I165 L13 G14 V18 A31 K33 M81 Y83 G87 E134 I150 D145 K147 E149 N150 D166 T185 D130 K132 E134 N135 D151 T160 2.7.11.1,2.7.11.10 0004672,0005524,0006468 O14920 23792959 800 TQTCGAWEMKERLGTGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISLNEGHTLDMDLVFLFDNSKITYETQRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACS 4kik B 2.83 BS01 KSA B 1 L21 G22 V29 A42 K44 M96 E97 Y98 C99 G102 E149 V152 I165 D166 L21 G22 V29 A42 K44 M96 E97 Y98 C99 G102 E149 V152 I165 D166 D145 K147 E149 N150 D166 T185 D145 K147 E149 N150 D166 T182 2.7.11.1,2.7.11.10 0004672,0005524,0006468 O14920 23792959 700 HSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACS 4wsq A 1.95 BS04 KSA A 1 A53 V60 A72 K74 M126 D127 F128 C129 G132 Q133 E180 L183 C193 D194 A25 V32 A44 K46 M98 D99 F100 C101 G104 Q105 E152 L155 C165 D166 D176 K178 N181 D194 T222 D148 K150 N153 D166 T194 2.7.11.1 0004672,0005524,0006468 Q2M2I8 26853940 405 GLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAK 4wsq B 1.95 BS02 KSA B 1 A53 V60 A72 K74 D127 F128 Q133 E180 L183 C193 D194 A21 V28 A40 K42 D95 F96 Q101 E148 L151 C161 D162 D176 K178 N181 D194 T222 D144 K146 N149 D162 T190 2.7.11.1 0004672,0005524,0006468 Q2M2I8 26853940 404 GYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEA 5m5a A 1.9 BS01 KSA A 1 I17 T19 G20 V25 A38 K40 C70 Y88 C89 E93 E136 L139 I149 D150 I16 T18 G19 V24 A37 K39 C69 Y87 C88 E92 E135 L138 I148 D149 D132 K134 E136 N137 D150 S171 D131 K133 E135 N136 D149 S155 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 29191878 404 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCASLAYAAPELIQGKLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR