1ftk A 1.6 BS01 KAI A 1 Y73 P101 T103 R108 L154 S158 T159 E209 M212 Y55 P83 T85 R90 L127 S131 T132 E182 M185 ? 0015276,0016020 ic50=14.5uM -logKd/Ki=4.84, IC50=14.5uM EC50=380000nM, Ki=3690nM P19491 11086992 999 KTVVVTTILESPYVMMKKMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 1fw0 A 1.9 BS01 KAI A 1 E13 Y61 P89 T91 R96 L138 G141 S142 T143 E193 M196 E10 Y58 P86 T88 R93 L135 G138 S139 T140 E190 M193 ? 0015276,0016020 -logKd/Ki=5.43, Ki=3690nM EC50=380000nM, Ki=3690nM P19491 11086992 999 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 1gr2 A 1.9 BS01 KAI A 1 E25 Y73 P101 T103 R108 L154 S158 T159 E209 M212 E10 Y55 P83 T85 R90 L127 S131 T132 E182 M185 ? 0015276,0016020 EC50=380000nM, Ki=3690nM P19491 9804426 999 KTVVVTTILESPYVMMKKMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 1p1n A 1.6 BS01 KAI A 1 Y61 P89 T91 R96 G141 S142 T143 E193 Y58 P86 T88 R93 G138 S139 T140 E190 ? 0015276,0016020 Kd=0.16uM -logKd/Ki=6.80, Kd=0.16uM EC50=380000nM, Ki=3690nM P19491 12730367 999 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTTDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 1tt1 A 1.93 BS01 KAI A 1 Y61 P89 A91 R96 G141 A142 T143 E191 Y59 P87 A89 R94 G139 A140 T141 E189 ? 0015276,0016020 Ki=64.6nM -logKd/Ki=8.15, IC50=0.007uM Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 15721240 998 NRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 1tt1 B 1.93 BS01 KAI B 1 Y61 P89 A91 R96 G141 A142 T143 E191 Y59 P87 A89 R94 G139 A140 T141 E189 ? 0015276,0016020 Ki=64.6nM Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 15721240 999 NRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 1xhy A 1.85 BS01 KAI A 1 Y58 P86 T88 R93 G138 S139 T140 E190 Y58 P86 T88 R93 G138 S139 T140 E190 ? 0015276,0016020 Ki=624nM -logKd/Ki=6.18, Ki=662nM EC50=380000nM, Ki=3690nM P19491 15591246 1001 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 2anj A 2.1 BS01 KAI A 1 W61 P89 T91 R96 L138 S142 T143 E193 W61 P89 T91 R96 L138 S142 T143 E193 ? 0015276,0016020 EC50=380000nM, Ki=3690nM P19491 16103115 999 GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKWGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 2xxt A 1.9 BS01 KAI A 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 -logKd/Ki=8.05, Kd=9.0nM Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 2xxt B 1.9 BS01 KAI B 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 2xxv A 1.7 BS01 KAI A 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPKGSPYRDKITIAILQLQEEGKLHMMKEKWW 2xxv B 1.7 BS01 KAI B 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E10 Y58 P86 A88 R93 G138 A139 T140 E188 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 RSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPKGSPYRDKITIAILQLQEEGKLHMMKEKWW 2xxy A 3.0 BS01 KAI A 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 -logKd/Ki=7.89, Kd=12.9nM Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRKKITIAILQLQEEGKLHMMKEKWW 2xxy B 3.0 BS01 KAI B 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRKKITIAILQLQEEGKLHMMKEKWW 2xxy C 3.0 BS01 KAI C 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRKKITIAILQLQEEGKLHMMKEKWW 2xxy D 3.0 BS01 KAI D 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E10 Y58 P83 A85 R90 G135 A136 T137 E185 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 21414913 900 RSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRKKITIAILQLQEEGKLHMMKEKWW 3c31 A 1.49 BS01 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c31 B 1.49 BS01 KAI B 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c32 A 1.72 BS02 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c32 B 1.72 BS02 KAI B 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c33 A 1.72 BS02 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c33 B 1.72 BS02 KAI B 1 Y61 P88 T90 R95 G140 S141 T142 E190 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c34 A 1.82 BS01 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c34 B 1.82 BS01 KAI B 1 Y61 P88 T90 R95 G140 S141 T142 E190 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c35 A 1.97 BS01 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c35 B 1.97 BS01 KAI B 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c36 A 1.68 BS01 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3c36 B 1.68 BS01 KAI B 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 18549784 401 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 3en3 A 2.43 BS01 KAI A 1 E9 Y57 P85 T87 R92 G137 S138 T139 E189 E9 Y57 P85 T87 R92 G137 S138 T139 E189 ? 0015276,0016020 EC50=47000nM, Ki=3570nM P19493 19102704 999 TVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGEC 3kfm A 2.2 BS01 KAI A 1 E9 Y57 P85 T87 R92 V134 G137 S138 T139 E189 E9 Y57 P85 T87 R92 V134 G137 S138 T139 E189 ? 0015276,0016020 EC50=47000nM, Ki=3570nM P19493 20107073 258 TVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTVDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGEC 3u92 A 1.9 BS01 KAI A 1 E13 Y61 P88 T90 R95 G140 A141 T142 E189 E11 Y59 P86 T88 R93 G138 A139 T140 E187 ? 0015276,0016020 -logKd/Ki=7.48, Ki=32.8nM Ki=32.8nM P42264 23141068 258 NRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 3u92 B 1.9 BS01 KAI B 1 E13 Y61 P88 T90 R95 G140 A141 T142 E189 E11 Y59 P86 T88 R93 G138 A139 T140 E187 ? 0015276,0016020 Ki=32.8nM P42264 23141068 258 NRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 4bdm A 3.4 BS01 KAI A 1 Y488 P516 A518 R523 V685 G688 A689 T690 E738 Y57 P83 A85 R90 V132 G135 A136 T137 E185 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 4bdm B 3.4 BS01 KAI B 1 E440 Y488 P516 A518 R523 V685 G688 A689 T690 E738 E9 Y57 P85 A87 R92 V134 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 4bdm C 3.4 BS01 KAI C 1 E440 Y488 P516 L517 A518 R523 G688 A689 T690 E738 E9 Y57 P85 L86 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 4bdm D 3.4 BS01 KAI D 1 Y488 P516 A518 R523 G688 A689 T690 E738 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 4bdo A 2.55 BS01 KAI A 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E10 Y54 P78 A80 R85 G130 A131 T132 E180 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 RSLIVTTILEEPYVLFKKLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKIGIAILQLQEEGKLHMMKEKWWR 4bdo B 2.55 BS01 KAI B 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y52 P80 A82 R87 G132 A133 T134 E182 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKIGIAILQLQEEGKLHMMKEKWWRC 4bdo C 2.55 BS01 KAI C 1 E440 Y488 P516 L517 A518 R523 G688 A689 T690 E738 E9 Y54 P82 L83 A84 R89 G134 A135 T136 E184 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKIGIAILQLQEEGKLHMMKEKWWR 4bdo D 2.55 BS01 KAI D 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y52 P75 A77 R82 G127 A128 T129 E177 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKIGIAILQLQEEGKLHMMKEKWWRC 4bdr A 1.65 BS01 KAI A 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYADKITIAILQLQEEGKLHMMKEKWWRGNGC 4bdr B 1.65 BS01 KAI B 1 E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 ? 0015276,0016020 Ki=12.7nM, Kd=39nM, EC50=1800nM P42260 23720540 900 SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYADKITIAILQLQEEGKLHMMKEKWWC 4e0w A 2.3501 BS01 KAI A 1 E15 Y63 P90 T92 R97 G142 A143 T144 E191 E11 Y59 P86 T88 R93 G138 A139 T140 E187 ? 0015276,0016020 -logKd/Ki=7.48, Ki=33nM Ki=32.8nM P42264 22425692 301 NRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 4e0x A 2.0 BS01 KAI A 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 -logKd/Ki=7.12, Ki=76nM IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 22425692 301 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 4e0x B 2.0 BS01 KAI B 1 E13 Y61 P88 T90 R95 G140 S141 T142 E190 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 22425692 301 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 4f22 A 2.06 BS01 KAI A 1 Y61 P89 T91 R96 G141 S142 T143 E193 Y58 P86 T88 R93 G138 S139 T140 E190 ? 0015276,0016020 Ki=30.26uM EC50=40000nM, Ki=5780nM P19492 22512472 301 RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTAEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 4f31 B 2.286 BS01 KAI B 1 Y61 P89 T91 R96 L138 G141 S142 T143 E193 Y58 P86 T88 R93 L135 G138 S139 T140 E190 ? 0015276,0016020 Ki=2.08uM EC50=40000nM, Ki=5780nM P19492 22512472 301 RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLASGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 4f31 D 2.286 BS01 KAI D 1 Y61 P89 L90 T91 R96 G141 S142 T143 E193 M196 Y58 P86 L87 T88 R93 G138 S139 T140 E190 M193 ? 0015276,0016020 Ki=2.08uM EC50=40000nM, Ki=5780nM P19492 22512472 301 RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLASGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 4f39 A 1.834 BS01 KAI A 1 Y61 P89 T91 R96 L138 G141 S142 T143 E193 Y58 P86 T88 R93 L135 G138 S139 T140 E190 ? 0015276,0016020 Ki=3.44uM -logKd/Ki=5.70, Ki=1980nM EC50=40000nM, Ki=5780nM P19492 22512472 301 RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 4f3g A 2.064 BS01 KAI A 1 Y61 P89 T91 R96 G141 S142 T143 E193 Y58 P86 T88 R93 G138 S139 T140 E190 ? 0015276,0016020 Ki=3.44uM EC50=40000nM, Ki=5780nM P19492 22512472 301 RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 5ikb A 2.05 BS01 KAI A 1 Y61 G88 T90 R95 I137 G140 S141 S142 E190 Y57 G84 T86 R91 I133 G136 S137 S138 E186 ? 0015276,0016020 Kd=1.9nM -logKd/Ki=8.72, Kd=1.9nM Ki=4.7nM Q01812 27524200 301 TLVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRKGTPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEG 5mfq A 1.9 BS03 KAI A 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 28360094 903 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGC 5mfq B 1.9 BS03 KAI B 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 28360094 901 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 5mfv A 2.181 BS03 KAI A 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E10 Y58 P85 T87 R92 G137 S138 T139 E187 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 28360094 903 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG 5mfv B 2.181 BS03 KAI B 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E9 Y57 P82 T84 R89 G134 S135 T136 E184 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 28360094 901 TLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 5mfw A 2.1 BS02 KAI A 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E11 Y59 P86 T88 R93 G138 S139 T140 E188 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 28360094 903 NRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW 5mfw B 2.1 BS03 KAI B 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E9 Y57 P84 T86 R91 G136 S137 T138 E186 ? 0015276,0016020 IC50=77nM, Ki=75.9nM, EC50=37000nM P22756 28360094 902 TLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 8bst A 2.7 BS02 KAI A 1 E443 Y491 P518 T520 R525 G690 A691 T692 N722 E739 E10 Y58 P85 T87 R92 G137 A138 T139 N169 E186 ? 0015276,0016020 P42264 38145505 914 RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGC 8bst B 2.7 BS03 KAI B 1 E443 Y491 P518 T520 R525 G690 A691 T692 N722 E739 E10 Y58 P85 T87 R92 G137 A138 T139 N169 E186 ? 0015276,0016020 P42264 38145505 912 RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 8bst C 2.7 BS02 KAI C 1 Y491 P518 T520 R525 A691 T692 N722 E739 Y58 P85 T87 R92 A133 T134 N164 E181 ? 0015276,0016020 P42264 38145505 908 RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW 8bst D 2.7 BS03 KAI D 1 E443 Y491 P518 T520 R525 G690 A691 T692 N722 E739 E9 Y57 P84 T86 R91 G136 A137 T138 N168 E185 ? 0015276,0016020 P42264 38145505 907 SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWR 8bsu A 2.9 BS03 KAI A 1 E15 Y63 P90 T92 R97 G142 A143 T144 E191 E9 Y57 P84 T86 R91 G136 A137 T138 E185 ? 0015276,0016020 P42264 38145505 310 SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 8bsu B 2.9 BS03 KAI B 1 E15 Y63 P90 T92 R97 G142 A143 T144 E191 E9 Y57 P84 T86 R91 G136 A137 T138 E185 ? 0015276,0016020 P42264 38145505 310 SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWR 8bsu C 2.9 BS04 KAI C 1 E15 Y63 P90 T92 R97 G142 A143 T144 N174 E191 E9 Y57 P84 T86 R91 G136 A137 T138 N168 E185 ? 0015276,0016020 P42264 38145505 310 SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 8bsu D 2.9 BS04 KAI D 1 E15 Y63 P90 T92 R97 G142 A143 T144 E191 E10 Y58 P85 T87 R92 G137 A138 T139 E186 ? 0015276,0016020 P42264 38145505 308 RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 8bsu E 2.9 BS05 KAI E 1 E15 Y63 P90 T92 R97 G142 A143 T144 N174 E191 E9 Y57 P84 T86 R91 G136 A137 T138 N168 E185 ? 0015276,0016020 P42264 38145505 317 SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWR 8bsu F 2.9 BS04 KAI F 1 E15 Y63 P90 T92 R97 A143 T144 E191 E9 Y57 P84 T86 R91 A137 T138 E185 ? 0015276,0016020 P42264 38145505 308 SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRG 8bsu G 2.9 BS05 KAI G 1 E15 Y63 P90 T92 R97 A143 T144 E191 E10 Y58 P85 T87 R92 A138 T139 E186 ? 0015276,0016020 P42264 38145505 308 RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP 8bsu H 2.9 BS05 KAI H 1 E15 Y63 P90 T92 R97 G142 A143 T144 E191 E10 Y58 P85 T87 R92 G137 A138 T139 E186 ? 0015276,0016020 P42264 38145505 308 RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWR 8r36 A 1.9 BS01 KAI A 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E11 Y59 P86 T88 R93 G138 S139 T140 E188 P22756 39079583 901 NRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGC 8r36 B 1.9 BS02 KAI B 1 E441 Y489 P516 T518 R523 G688 S689 T690 E738 E10 Y58 P85 T87 R92 G137 S138 T139 E187 P22756 39079583 902 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP