3k84 A 2.25 BS01 K84 A 1 M191 F192 S193 S217 T236 I238 G239 S241 T377 T488 W531 M159 F160 S161 S185 T204 I206 G207 S209 T345 T456 W499 K142 S217 S218 T236 I238 G239 G240 S241 F244 K110 S185 S186 T204 I206 G207 G208 S209 F212 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 -logKd/Ki=8.52, Ki=0.003uM Ki=3nM P97612 19924997 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQP 3k84 B 2.25 BS01 K84 B 1 K142 M191 F192 S193 S217 T236 D237 I238 G239 S241 K111 M160 F161 S162 S186 T205 D206 I207 G208 S210 K142 S217 S218 T236 I238 G239 G240 S241 F244 K111 S186 S187 T205 I207 G208 G209 S210 F213 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 Ki=3nM P97612 19924997 1 TGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP