6r7d A 2.35 BS01 JUQ A 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM -logKd/Ki=8.62, IC50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLR 6r7d B 2.35 BS01 JUQ B 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLR 6r7d B 2.35 BS02 JUQ C 1 Q19 A20 Q24 A25 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLR 6r7d C 2.35 BS01 JUQ C 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM -logKd/Ki=8.62, IC50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRL 6r7d D 2.35 BS01 JUQ D 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRT 6r7d E 2.35 BS01 JUQ E 1 N55 Y59 R90 Y93 R104 L108 L115 W116 N60 Y64 R95 Y98 R109 L113 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLR 6r7d F 2.35 BS01 JUQ D 1 Q19 A20 Q24 A25 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRT 6r7d F 2.35 BS02 JUQ F 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRT 6r7d G 2.35 BS01 JUQ G 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLR 6r7d H 2.35 BS01 JUQ H 1 N55 Y59 R90 Y93 R104 L108 S111 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 S116 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTL 6r7d I 2.35 BS01 JUQ I 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRL 6r7d J 2.35 BS01 JUQ J 1 N55 Y59 R90 Y93 R104 L108 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLR 6r7d K 2.35 BS01 JUQ K 1 N55 Y59 R90 Y93 R104 L108 L115 W116 N60 Y64 R95 Y98 R109 L113 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRT 6r7d L 2.35 BS01 JUQ L 1 N55 Y59 R90 Y93 R104 L108 S111 A112 L115 W116 N60 Y64 R95 Y98 R109 L113 S116 A117 L120 W121 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 ic50=2.4nM IC50=50.0nM Q16873 31415176 201 HHHHHHKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRL