3nuy A 2.1 BS01 JPZ A 1 A109 S160 L212 A37 S88 L140 D205 K207 E209 N210 D223 T245 D133 K135 E137 N138 D151 T164 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=3.46, IC50=345uM O15530 24900229 370 QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKL 4lm4 A 1.48 BS01 JPZ A 1 L675 S677 I692 Q726 F729 L230 S232 I247 Q281 F284 3.1.4.17 0004114,0007165,0008081 Ki=910uM -logKd/Ki=3.04, Ki=910uM Q9Y233 24375910 900 AGTSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWI 4pnn A 1.65 BS02 JPZ A 1 H1031 G1032 Y1060 F1061 K1067 S1068 Y1071 E1138 H69 G70 Y98 F99 K105 S106 Y109 E176 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=4.52, IC50>30uM Q9H2K2 25286857 1202 KEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pnn B 1.65 BS02 JPZ B 1 H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H75 G76 Y104 F105 A106 K111 S112 Y115 E182 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 YFQGSDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pnn C 1.65 BS01 JPZ C 1 H1031 G1032 Y1060 F1061 K1067 S1068 Y1071 E1138 H79 G80 Y108 F109 K115 S116 Y119 E186 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP