6mck A 3.77 BS01 JDP A 1 D478 I479 C522 G523 L526 I656 A659 N660 R662 G684 A685 T688 D247 I248 C291 G292 L295 I416 A419 N420 R422 G444 A445 T448 3.6.4.6 0005524,0016887 -logKd/Ki=7.92, IC50=0.012uM IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck B 3.77 BS01 JDP B 1 D478 I479 C522 G523 L526 I656 A659 N660 G684 A685 T688 D247 I248 C291 G292 L295 I416 A419 N420 G444 A445 T448 3.6.4.6 0005524,0016887 -logKd/Ki=7.92, IC50=0.012uM IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck C 3.77 BS01 JDP C 1 V474 D478 I479 L482 G523 L526 I656 A659 G684 A685 T688 V243 D247 I248 L251 G292 L295 I416 A419 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck D 3.77 BS01 JDP D 1 D478 I479 L482 C522 G523 L526 S652 I656 A659 N660 R662 G684 A685 T688 D247 I248 L251 C291 G292 L295 S412 I416 A419 N420 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck E 3.77 BS01 JDP E 1 D478 I479 C522 G523 L526 A655 I656 A659 R662 G684 A685 T688 D247 I248 C291 G292 L295 A415 I416 A419 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck F 3.77 BS01 JDP F 1 D478 I479 L482 C522 G523 L526 S652 I656 A659 R662 G684 A685 T688 D247 I248 L251 C291 G292 L295 S412 I416 A419 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck G 3.77 BS01 JDP G 1 D478 I479 C522 G523 L526 I656 A659 N660 R662 G684 A685 T688 D247 I248 C291 G292 L295 I416 A419 N420 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck H 3.77 BS01 JDP H 1 D478 I479 L482 C522 G523 L526 I656 A659 N660 G684 A685 T688 D247 I248 L251 C291 G292 L295 I416 A419 N420 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck I 3.77 BS01 JDP I 1 D478 I479 L482 C522 G523 L526 S652 I656 A659 N660 R662 G684 A685 T688 D247 I248 L251 C291 G292 L295 S412 I416 A419 N420 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck J 3.77 BS01 JDP J 1 V474 D478 I479 L482 C522 L526 S652 I656 A659 R662 G684 A685 T688 V243 D247 I248 L251 C291 L295 S412 I416 A419 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck K 3.77 BS01 JDP K 1 D478 I479 L482 C522 G523 L526 S652 I656 A659 N660 R662 G684 A685 T688 D247 I248 L251 C291 G292 L295 S412 I416 A419 N420 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 6mck L 3.77 BS01 JDP L 1 D478 I479 C522 L526 I656 A659 R662 G684 A685 T688 D247 I248 C291 L295 I416 A419 R422 G444 A445 T448 3.6.4.6 0005524,0016887 IC50=1030nM, Ki=26nM P55072 30591537 900 RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 7rli A 3.1 BS01 JDP A 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli B 3.1 BS01 JDP B 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli C 3.1 BS01 JDP C 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli D 3.1 BS01 JDP D 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli E 3.1 BS01 JDP E 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli F 3.1 BS01 JDP F 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli G 3.1 BS01 JDP G 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli H 3.1 BS01 JDP H 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli I 3.1 BS01 JDP I 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli J 3.1 BS01 JDP J 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli K 3.1 BS01 JDP K 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rli L 3.1 BS01 JDP L 1 D478 I479 G521 C522 G523 L526 A655 I656 A659 N660 G684 A685 T688 D458 I459 G501 C502 G503 L506 A635 I636 A639 N640 G664 A665 T668 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 901 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS 7rlj A 3.8 BS02 JDP A 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj B 3.8 BS02 JDP B 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj C 3.8 BS02 JDP C 1 V474 I479 L526 A685 V454 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj D 3.8 BS02 JDP D 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj E 3.8 BS02 JDP E 1 V474 I479 G521 C522 G523 L526 G684 A685 V454 I459 G501 C502 G503 L506 G664 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj F 3.8 BS02 JDP F 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj G 3.8 BS02 JDP G 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj H 3.8 BS02 JDP H 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj I 3.8 BS02 JDP I 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj J 3.8 BS02 JDP J 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj K 3.8 BS02 JDP K 1 V474 D478 I479 G523 L526 A685 V454 D458 I459 G503 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF 7rlj L 3.8 BS02 JDP L 1 V474 D478 I479 L526 A685 V454 D458 I459 L506 A665 3.6.4.6 0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035331,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,0140455,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=1030nM, Ki=26nM P55072 34520757 803 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGF