5tca A 3.15 BS01 J55 A 1 L40 C41 R152 C194 K195 G196 S198 T213 S214 S216 R217 L25 C26 R137 C179 K180 G181 S183 T198 S199 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 -logKd/Ki=7.72, Kd=18.85nM Kd=19nM, IC50=19nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca B 3.15 BS01 J55 B 1 L40 C41 H56 C57 R152 C194 K195 G196 S198 T213 S214 G215 S216 R217 L25 C26 H41 C42 R137 C179 K180 G181 S183 T198 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca C 3.15 BS01 J55 A 1 H148 A149 H133 A134 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca C 3.15 BS02 J55 C 1 L40 C41 H56 C57 C194 K195 G196 S198 T213 S214 S216 R217 L25 C26 H41 C42 C179 K180 G181 S183 T198 S199 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 301 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca C 3.15 BS03 J55 C 2 R20 G135 L137 H158 V159 L160 R191 R5 G120 L122 H143 V144 L145 R176 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 302 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca D 3.15 BS01 J55 D 1 L40 C41 C57 R152 C194 K195 G196 S198 T213 S214 G215 S216 R217 L25 C26 C42 R137 C179 K180 G181 S183 T198 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 301 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca D 3.15 BS02 J55 D 2 L137 L160 P162 R191 L122 L145 P147 R176 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 302 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca E 3.15 BS01 J55 D 2 A62 D63 G64 V66 A90 A47 D48 G49 V51 A75 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 302 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca E 3.15 BS02 J55 E 1 L40 C41 H56 R152 C194 K195 G196 S198 T213 S214 G215 S216 R217 L25 C26 H41 R137 C179 K180 G181 S183 T198 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca F 3.15 BS01 J55 F 1 L40 C41 H56 C57 C194 K195 G196 S198 T213 S214 G215 S216 R217 L25 C26 H41 C42 C179 K180 G181 S183 T198 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tca G 3.15 BS01 J55 G 1 L40 C41 C57 C194 K195 G196 S198 T213 S214 G215 S216 R217 L25 C26 C42 C179 K180 G181 S183 T198 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 Kd=19nM, IC50=19nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA