1q41 A 2.1 BS01 IXM A 1 I62 A83 Y134 V135 P136 T138 R141 L188 C199 I28 A49 Y94 V95 P96 T98 R101 L148 C159 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 ic50=22nM -logKd/Ki=7.66, IC50=22nM IC50=200nM P49841 14529625 451 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQA 1q41 B 2.1 BS01 IXM B 1 A83 L132 Y134 V135 P136 R141 L188 A49 L92 Y94 V95 P96 R101 L148 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 ic50=22nM IC50=200nM P49841 14529625 452 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 1unh A 2.35 BS01 IXM A 1 I10 A31 F80 F82 C83 D84 Q85 D86 L133 I9 A24 F69 F71 C72 D73 Q74 D75 L122 D126 K128 Q130 N131 N144 C157 T164 D115 K117 Q119 N120 N133 C146 T153 2.7.11.1 0000226,0000307,0001764,0001963,0002039,0004672,0004674,0004693,0005176,0005515,0005524,0005634,0005654,0005737,0005829,0005874,0005886,0006338,0006468,0006886,0006915,0007160,0007268,0007399,0007409,0007416,0007519,0008017,0008045,0008306,0008542,0014044,0014069,0016020,0016079,0016241,0016301,0016310,0016477,0016533,0018105,0018107,0019233,0021537,0021549,0021695,0021697,0021766,0021819,0021954,0021987,0022038,0030027,0030036,0030054,0030175,0030182,0030334,0030424,0030425,0030426,0030517,0030549,0030900,0031175,0031397,0031594,0031914,0032801,0035249,0035418,0042220,0042981,0042995,0043005,0043025,0043113,0043125,0043204,0043525,0044024,0045202,0045786,0045861,0045892,0045956,0046826,0048148,0048156,0048167,0048488,0048489,0048511,0048675,0048709,0048813,0050321,0051301,0051402,0051649,0051726,0051879,0051966,0060078,0060079,0061001,0070509,0090314,0098793,0106310,1903076,1903421,1904646 ic50=0.1uM -logKd/Ki=7.00, IC50=0.10uM Q00535 15689152 1288 QKYEKLEKIYGTVFKAKNRHEIVALKRVRLDGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 1unh B 2.35 BS01 IXM B 1 I10 A31 F80 F82 C83 D84 Q85 L133 I9 A24 F69 F71 C72 D73 Q74 L122 D126 K128 Q130 N131 N144 C157 T164 D115 K117 Q119 N120 N133 C146 T153 2.7.11.1 0000226,0000307,0001764,0001963,0002039,0004672,0004674,0004693,0005176,0005515,0005524,0005634,0005654,0005737,0005829,0005874,0005886,0006338,0006468,0006886,0006915,0007160,0007268,0007399,0007409,0007416,0007519,0008017,0008045,0008306,0008542,0014044,0014069,0016020,0016079,0016241,0016301,0016310,0016477,0016533,0018105,0018107,0019233,0021537,0021549,0021695,0021697,0021766,0021819,0021954,0021987,0022038,0030027,0030036,0030054,0030175,0030182,0030334,0030424,0030425,0030426,0030517,0030549,0030900,0031175,0031397,0031594,0031914,0032801,0035249,0035418,0042220,0042981,0042995,0043005,0043025,0043113,0043125,0043204,0043525,0044024,0045202,0045786,0045861,0045892,0045956,0046826,0048148,0048156,0048167,0048488,0048489,0048511,0048675,0048709,0048813,0050321,0051301,0051402,0051649,0051726,0051879,0051966,0060078,0060079,0061001,0070509,0090314,0098793,0106310,1903076,1903421,1904646 ic50=0.1uM Q00535 15689152 1288 QKYEKLEKIYGTVFKAKNRHEIVALKRVRLDGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 2qkr A 2.6 BS01 IXM A 1 V29 V37 A49 F98 F100 M101 L151 V13 V18 A29 F67 F69 M70 L120 D144 K146 Q148 N149 D162 T182 D113 K115 Q117 N118 D130 T145 2.7.11.22,2.7.11.23 0004672,0004674,0004693,0005524,0005634,0005737,0006468,0016310,0046872,0051301,0051726 Q5CRJ8 401 YFQGLMEKYLEKVGEGVVYKAKDSQRIVALKRISTAIREISLLKELHHPNIVSLIDVIHSECLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDALKLADFGLARAFGIPVRVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQ