1oja A 1.7 BS02 ISN A 1 Y60 L171 Q206 F343 Y58 L169 Q204 F341 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 Ki=3uM IC50=18750nM, Ki=3000nM P27338 12913124 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTI 1oja B 1.7 BS02 ISN B 1 Y60 L171 Q206 F343 Y58 L169 Q204 F341 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 Ki=3uM IC50=18750nM, Ki=3000nM P27338 12913124 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLI 2bk5 A 1.83 BS02 ISN A 1 Y60 L171 I198 Q206 F343 Y58 L169 I196 Q204 F341 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 Ki=3uM IC50=18750nM, Ki=3000nM P27338 15710600 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTI 2bk5 B 1.83 BS02 ISN B 1 Y60 L171 I198 Q206 F343 Y58 L169 I196 Q204 F341 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 Ki=3uM IC50=18750nM, Ki=3000nM P27338 15710600 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLI 2xfp A 1.66 BS02 ISN A 1 Y60 L171 Q206 F343 Y435 Y58 L169 Q204 F341 Y433 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 IC50=18750nM, Ki=3000nM P27338 20855894 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTI 2xfp B 1.66 BS02 ISN B 1 Y60 L171 Q206 F343 Y58 L169 Q204 F341 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 IC50=18750nM, Ki=3000nM P27338 20855894 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLI 5oji A 1.6 BS02 ISN A 1 S148 S150 Y161 V193 S199 L202 S148 S150 Y161 V193 S199 L202 G21 S148 Y161 K165 G21 S148 Y161 K165 1.1.1.184 0003824,0004090,0016491 G5EGA6 29151266 302 MPSNCRRFEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGHIASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMTKLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYITGEMIIIAGGVQARL 5oji B 1.6 BS02 ISN B 1 S148 Y149 I158 Y161 G192 M198 S199 S148 Y149 I158 Y161 G192 M198 S199 G21 S148 Y161 K165 G21 S148 Y161 K165 1.1.1.184 0003824,0004090,0016491 G5EGA6 29151266 302 MPSNCRRFEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGHIASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMTKLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYITGEMIIIAGGVQARL 5ph6 A 1.742 BS02 ISN A 1 Q309 C310 S311 L335 W336 G339 Q299 C300 S301 L325 W326 G329 G174 Y181 H192 E194 H280 A292 G164 Y171 H182 E184 H270 A282 1.14.11.66 Q6B0I6 28436492 415 AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQD 5ph6 A 1.742 BS03 ISN A 2 C168 I301 K305 C158 I291 K295 G174 Y181 H192 E194 H280 A292 G164 Y171 H182 E184 H270 A282 1.14.11.66 Q6B0I6 28436492 416 AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQD 5rtf B 1.0 BS01 ISN B 1 M2 S5 M2 S5 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33853786 201 SMVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFL 6af5 A 1.65 BS01 ISN A 1 L101 K148 A171 L100 K147 A170 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 Q99497 30063823 201 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 6af9 A 1.39 BS01 ISN A 1 E18 G74 G75 C106 A107 H126 E17 G73 G74 C105 A106 H125 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 -logKd/Ki=5.49, Kd=3.2uM Q99497 30063823 201 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 6af9 A 1.39 BS02 ISN A 2 L101 K148 A171 L100 K147 A170 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 -logKd/Ki=5.49, Kd=3.2uM Q99497 30063823 202 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 6af9 A 1.39 BS03 ISN A 3 L166 E170 K175 A178 K182 L165 E169 K174 A177 K181 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 -logKd/Ki=5.49, Kd=3.2uM Q99497 30063823 203 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 6afa A 1.65 BS01 ISN A 1 E15 E18 G75 C106 A107 H126 E14 E17 G74 C105 A106 H125 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 -logKd/Ki=5.49, Kd=3.2uM Q99497 30063823 201 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 6afb A 1.6 BS01 ISN A 1 L101 K148 A171 L100 K147 A170 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 Q99497 30063823 201 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAISAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 6afb A 1.6 BS02 ISN A 2 L166 E170 K175 A178 K182 L165 E169 K174 A177 K181 3.1.2.-,3.5.1.-,3.5.1.124 0000785,0001046,0001933,0001963,0002866,0003690,0003697,0003713,0003723,0003729,0005102,0005507,0005515,0005634,0005654,0005737,0005739,0005758,0005759,0005783,0005829,0005886,0005912,0006281,0006508,0006914,0006954,0006979,0007005,0007265,0007338,0008021,0008047,0008233,0008344,0009438,0010273,0010628,0010629,0016532,0016605,0016684,0019249,0019430,0019826,0019899,0019900,0019955,0030073,0030091,0030414,0030424,0030521,0030546,0031334,0031397,0032435,0032679,0032757,0033138,0033234,0033864,0034599,0034614,0036470,0036471,0036478,0036524,0042177,0042542,0042593,0042743,0042802,0042803,0043005,0043523,0043524,0044297,0044388,0044390,0045121,0045296,0045340,0045944,0046295,0046826,0048471,0050681,0050727,0050787,0050821,0051583,0051881,0051897,0051899,0051920,0055105,0060081,0060765,0061691,0061727,0070062,0070301,0070994,0097110,0106044,0106045,0106046,0110095,0140041,0140297,1900182,1900242,1901984,1902176,1902177,1902236,1902903,1902958,1903073,1903094,1903122,1903135,1903136,1903181,1903189,1903190,1903197,1903376,1903377,1903384,1903427,1903428,1903599,1903751,1905259,1990381,1990422,2000277,2000379,2001237 Q99497 30063823 202 ASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAISAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLK 7h8y A 1.91 BS01 ISN A 1 T111 C143 R144 D145 W148 T114 C146 R147 D148 W151 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 206 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h8y B 1.91 BS01 ISN B 1 K40 W41 C60 K39 W40 C59 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 201 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h8y B 1.91 BS02 ISN B 2 T111 C143 R144 D145 W148 T110 C142 R143 D144 W147 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 205 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h8y C 1.91 BS01 ISN C 1 T111 C143 W148 T114 C146 W151 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 203 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h8y D 1.91 BS01 ISN D 1 T111 C143 D145 W148 T110 C142 D144 W147 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 205 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 8ak9 A 1.95 BS03 ISN A 1 I8 F64 F82 I2 F58 F76 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 409 GIDPFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 8ak9 B 1.95 BS03 ISN B 1 F82 F86 M157 F68 F72 M143 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 411 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE