1nf8 A 1.6 BS01 ISC A 1 F43 Q78 R87 W94 K122 V150 Y151 G155 F43 Q78 R87 W94 K122 V150 Y151 G155 H37 A38 K122 H37 A38 K122 3.3.2.15 0002047,0008908,0016787,0017000 Kd=0.015uM -logKd/Ki=7.82, Kd=0.015uM P0DPB9 12741825 220 MSGIPEITAYPLPTAQQLPANLARWSLEPRRAVLLVHAMQRYFLRPLPESLRAGLVANAARLRRWCVEQGVQIAYTAQPGSMTEEQRGLLKDFWGPGMRASPADREVVEELAPGPDDWLLTKWRYSAFFHSDLLQRMRAAGRDQLVLCGVYAHVGVLISTVDAYSNDIQPFLVADAIADFSEAHHRMALEYAASRCAMVVTTDEVLE 3hwo A 2.3 BS03 ISC A 1 G214 S215 E241 H276 I346 R347 A360 G361 E376 K380 G202 S203 E229 H264 I334 R335 A348 G349 E364 K368 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K135 E185 A201 E229 H264 A291 F315 R335 G351 E364 K368 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ2 20079748 1900 MATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 3hwo B 2.3 BS03 ISC B 1 G214 S215 E241 H276 I346 R347 A360 G361 A362 E376 K380 G201 S202 E228 H263 I333 R334 A347 G348 A349 E363 K367 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K134 E184 A200 E228 H263 A290 F314 R334 G350 E363 K367 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ2 20079748 1800 ATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 3tg2 A 1.101 BS01 ISC A 1 I3 H34 N35 F40 Q77 R86 W93 Y121 V146 Y147 I150 G151 I2 H33 N34 F39 Q76 R85 W92 Y120 V145 Y146 I149 G150 H34 N35 K118 H33 N34 K117 3.3.2.1 0008908 P0C6D3 22993087 501 AIPKIASYPLPVSLPTNKVDWRIDASRAVLLIHNMQEYFVHYFDSQAEPIPSLIKHIQQLKAHAKQAGIPVVYTAQPANQDPAERALLSDFWGPGLSEETAIIAPLAPESGDVQLTKWRYSAFKKSPLLDWLRETGRDQLIITGVYAHIGILSTALDAFMFDIQPFVIGDGVADFSLSDHEFSLRYISGRTGAVKSTQQACLEIA 5eso A 2.05 BS01 ISC A 1 S29 R30 T78 R107 Q118 S29 R30 T78 R107 Q118 C26 E55 C26 E55 2.2.1.9 0000287,0005886,0009234,0016740,0030145,0030976,0046872,0070204 P9WK11 27291649 602 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNDVSSRIFHDVDVGALCRAYHVESRQIEVDELGPTLDQPAGMRVLEVKADRSSLRQLHAAIKAAL 5eso B 2.05 BS02 ISC B 1 S29 R30 T78 R107 Q118 S29 R30 T78 R107 Q118 C26 E55 C26 E55 2.2.1.9 0000287,0005886,0009234,0016740,0030145,0030976,0046872,0070204 P9WK11 27291649 602 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQAGMRVLEVKADRSSLRQLHAAIKAAL 5eso C 2.05 BS01 ISC B 1 R282 L478 R271 L467 C26 E55 C25 E54 2.2.1.9 0000287,0005886,0009234,0016740,0030145,0030976,0046872,0070204 P9WK11 27291649 602 NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL 5eso D 2.05 BS01 ISC A 1 R282 L478 R271 L467 C26 E55 C26 E55 2.2.1.9 0000287,0005886,0009234,0016740,0030145,0030976,0046872,0070204 P9WK11 27291649 602 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL 5jxz A 1.88 BS02 ISC A 1 L212 G214 S215 E241 A303 I346 R347 A360 G361 E376 K380 L195 G197 S198 E224 A286 I329 R330 A343 G344 E359 K363 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K130 E180 A196 E224 H259 A286 F310 R330 G346 E359 K363 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ3 27373320 402 TLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASATRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGL 5jxz B 1.88 BS02 ISC B 1 L212 G214 S215 E241 A303 I346 R347 A360 G361 E376 K380 L195 G197 S198 E224 A282 I325 R326 A339 G340 E355 K359 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K130 E180 A196 E224 H257 A282 F306 R326 G342 E355 K359 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ3 27373320 402 ATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRSSELHVPSSPQLITTPTLWHLATPFEGKAQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGL 5jy4 A 2.11 BS02 ISC A 1 L212 G214 S215 E241 A303 I346 R347 A360 G361 A362 E376 K380 L198 G200 S201 E227 A289 I332 R333 A346 G347 A348 E362 K366 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K133 E183 A199 E227 H262 A289 F313 R333 G349 E362 K366 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ3 27373320 402 TLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFG 5jy4 B 2.11 BS02 ISC B 1 G214 S215 E241 H276 A303 I346 R347 A360 G361 E376 K380 G197 S198 E224 H259 A286 I329 R330 A343 G344 E359 K363 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K130 E180 A196 E224 H259 A286 F310 R330 G346 E359 K363 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ3 27373320 402 TLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 5jzd A 2.303 BS01 ISC A 1 G214 S215 E241 H276 A303 I346 R347 A360 G361 E376 K380 G201 S202 E228 H263 A290 I333 R334 A347 G348 E363 K367 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K134 E184 A200 E228 H263 A290 F314 R334 G350 E363 K367 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ2 27373320 401 ATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 5jzd B 2.303 BS01 ISC B 1 L212 G214 S215 E241 H276 A303 I346 R347 A360 G361 E376 K380 L198 G200 S201 E227 H262 A289 I332 R333 A346 G347 E362 K366 K147 E197 A213 E241 H276 A303 F327 R347 G363 E376 K380 K133 E183 A199 E227 H262 A289 F313 R333 G349 E362 K366 5.4.4.2 0000287,0008909,0009058,0009239,0016853,0046872 P0AEJ2 27373320 401 TLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH