2ito A 3.25 BS01 IRE A 1 S719 A743 K745 M766 L788 T790 M793 G796 S24 A48 K50 M71 L93 T95 M98 G101 D837 A839 R841 N842 D855 D142 A144 R146 N147 D160 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=6.91, Kd=123.6nM P00533 17349580 2020 GEAPNQALLRILKETEFKKIKVLSSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLMDEEDMDDVVDADEYLIP 2ity A 3.42 BS01 IRE A 1 L718 A743 L788 T790 L792 M793 G796 L844 L22 A47 L92 T94 L96 M97 G100 L148 D837 A839 R841 N842 D855 D141 A143 R145 N146 D159 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.27, Kd=53.5nM P00533 17349580 2020 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLDEEDMDDVVDADEYLIP 2itz A 2.8 BS01 IRE A 1 A743 K745 L788 T790 L792 M793 D800 L844 D855 A47 K49 L92 T94 L96 M97 D104 L148 D159 D837 A839 R841 N842 D855 D141 A143 R145 N146 D159 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=8.59, Kd=2.6nM P00533 17349580 2021 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPMDEEDMDDVVDADEYLIP 3ug2 A 2.5 BS01 IRE A 1 S719 A743 K745 L788 M790 M793 D800 S23 A44 K46 L84 M86 M89 D96 D837 A839 R841 N842 D855 G874 D133 A135 R137 N138 D151 G170 2.7.10.1 0004672,0004713,0005524,0006468 Kd=5.6nM -logKd/Ki=8.25, Kd=5.6nM P00533 22349823 1 EAPNQALLRILKETEFKKIKVLSSGTVYKGLWIPEGEKVKIPVAIKESPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLEDMDDVVDADEYLI 4i22 A 1.71 BS01 IRE A 1 L718 A743 K745 L788 M790 L792 M793 G796 D800 L844 L19 A44 K46 L84 M86 L88 M89 G92 D96 L140 D837 A839 R841 N842 D855 D133 A135 R137 N138 D151 2.7.10.1 0004672,0004713,0005524,0006468 P00533 23273428 9001 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 4wkq A 1.85 BS01 IRE A 1 L718 A743 K745 L788 T790 M793 G796 D800 L844 T854 L25 A47 K49 L87 T89 M92 G95 D99 L143 T153 D837 A839 R841 N842 D855 G874 D136 A138 R140 N141 D154 G173 2.7.10.1 0004672,0004713,0005524,0006468 P00533 1101 AMGEAPNQALLRILKETEFKKIKVLGSGTVYKGLWIPEGEKVKIPVAIKESPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDMDDVVDADEYLIPQ 5y7z A 2.804 BS01 IRE A 1 L46 K69 C126 K127 G128 E132 L180 C190 L23 K46 C103 K104 G105 E109 L157 C167 D173 K175 N178 D191 T223 D150 K152 N155 D168 T200 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.81, Kd=15.4nM O14976 30214852 401 SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQN 5y7z B 2.804 BS01 IRE B 1 K69 E124 L125 C126 G128 E132 L180 C190 D191 K46 E101 L102 C103 G105 E109 L157 C167 D168 D173 K175 N178 D191 T223 D150 K152 N155 D168 T200 2.7.11.1 0004672,0005524,0006468 O14976 30214852 401 SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQN 5y80 A 2.5 BS01 IRE A 1 L46 K69 C126 G128 Q129 L180 L23 K46 C103 G105 Q106 L154 D173 K175 N178 D191 T223 D147 K149 N152 D165 T197 2.7.11.1 0004672,0005524,0006468 Kd=1.62nM -logKd/Ki=8.79, Kd=1.62nM O14976 30214852 401 SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELL 5y80 A 2.5 BS02 IRE A 2 A81 R172 G193 S194 H200 V214 I218 N221 Q244 A58 R146 G167 S168 H174 V188 I192 N195 Q218 D173 K175 N178 D191 T223 D147 K149 N152 D165 T197 2.7.11.1 0004672,0005524,0006468 Kd=1.62nM -logKd/Ki=8.79, Kd=1.62nM O14976 30214852 402 SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELL