1a05 A 2.0 BS01 IPM A 1 R95 R105 R133 Y140 D246 R95 R105 R133 Y140 D246 Y140 K190 D222 D246 D250 Y140 K190 D222 D246 D250 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q56268 9739088 401 MKKIAIFAGDGIGPEIVAAARQVLDAVDQAAHLGLRCTEGLVGGAALDASDDPLPAASLQLAMAADAVILGAVGGPRWDAYPPAKRPEQGLLRLRKGLDLYANLRPAQIFPQLLDASPLRPELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIRRIAHVAFRAAQGRRKQLCSVDKANVLETTRLWREVVTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQDKANPLATILSVAMMLRHSLNAEPWAQRVEAAVQRVLDQGLRTADIAAPGTPVIGTKAMGAAVVNALNLK 1a05 B 2.0 BS01 IPM B 1 R95 R105 R133 Y140 D246 R95 R105 R133 Y140 D246 Y140 K190 D222 D246 D250 Y140 K190 D222 D246 D250 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q56268 9739088 402 MKKIAIFAGDGIGPEIVAAARQVLDAVDQAAHLGLRCTEGLVGGAALDASDDPLPAASLQLAMAADAVILGAVGGPRWDAYPPAKRPEQGLLRLRKGLDLYANLRPAQIFPQLLDASPLRPELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIRRIAHVAFRAAQGRRKQLCSVDKANVLETTRLWREVVTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQDKANPLATILSVAMMLRHSLNAEPWAQRVEAAVQRVLDQGLRTADIAAPGTPVIGTKAMGAAVVNALNLK 1hj6 A 2.0 BS01 IPM A 1 E113 R119 R129 R153 Y160 D307 E111 R117 R127 R151 Y158 D305 Y160 K230 D283 D307 D311 Y158 K228 D281 D305 D309 1.1.1.42 0000287,0004450,0005515,0005737,0005829,0006097,0006099,0006979,0016491,0016616,0022900,0046872,0051287,0097216 P08200 11284679 1419 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 2y41 A 2.2 BS01 IPM A 1 R94 R104 R132 Y139 D241 R95 R105 R133 Y140 D242 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 21387033 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA 2y41 B 2.2 BS01 IPM A 1 K185 A345 K186 A346 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 21387033 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA 2y41 B 2.2 BS02 IPM B 1 R94 R104 R132 Y139 D241 R95 R105 R133 Y140 D242 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 21387033 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA 3vkz A 1.84 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22349232 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vl2 A 2.06 BS01 IPM A 1 E89 R97 R136 Y143 D249 E89 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22349232 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vl3 A 1.8 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22349232 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vl4 A 1.88 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22349232 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vl6 A 2.07 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22349232 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vl7 A 2.2 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22349232 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vmj A 1.56 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 22442218 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3vmk A 1.48 BS01 IPM A 1 R97 R136 Y143 D249 R103 R142 Y149 D255 Y143 K193 D225 D249 D253 Y149 K199 D231 D255 D259 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 D2YZL2 22442218 401 HHHHHGSSYQIAVLAGDGIGPEVMAEARKVLAAVEKRFDLSIEYSEYDVGGAAIDNHGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQGRRKKVTSVDKANVLACSVLWREVVEEVAKDYPDVELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAPDIAGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALSDGYLTCELLPASERSQAKSTSQMGDYIAQAIAEG 3vmk A 1.48 BS02 IPM B 1 K193 N195 K199 N201 Y143 K193 D225 D249 D253 Y149 K199 D231 D255 D259 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 D2YZL2 22442218 401 HHHHHGSSYQIAVLAGDGIGPEVMAEARKVLAAVEKRFDLSIEYSEYDVGGAAIDNHGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQGRRKKVTSVDKANVLACSVLWREVVEEVAKDYPDVELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAPDIAGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALSDGYLTCELLPASERSQAKSTSQMGDYIAQAIAEG 3vmk B 1.48 BS01 IPM A 1 K193 N195 K198 N200 Y143 K193 D225 D249 D253 Y148 K198 D230 D254 D258 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 D2YZL2 22442218 401 HHHHGSSYQIAVLAGDGIGPEVMAEARKVLAAVEKRFDLSIEYSEYDVGGAAIDNHGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQGRRKKVTSVDKANVLACSVLWREVVEEVAKDYPDVELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAPDIAGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALSDGYLTCELLPASERSQAKSTSQMGDYIAQAIAEG 3vmk B 1.48 BS02 IPM B 1 R97 R136 Y143 D249 R102 R141 Y148 D254 Y143 K193 D225 D249 D253 Y148 K198 D230 D254 D258 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 D2YZL2 22442218 401 HHHHGSSYQIAVLAGDGIGPEVMAEARKVLAAVEKRFDLSIEYSEYDVGGAAIDNHGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQGRRKKVTSVDKANVLACSVLWREVVEEVAKDYPDVELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAPDIAGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALSDGYLTCELLPASERSQAKSTSQMGDYIAQAIAEG 3vml A 1.56 BS01 IPM A 1 R97 R136 Y143 D249 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0009098,0016616,0051287 D2YZL2,Q8E9N3 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQGRRKKVTSVDKANVLACSVLWREVVEEVAKDYPDVELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAPDIAGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAG 3wzv A 1.9 BS01 IPM A 1 E89 R97 R107 R136 Y143 D249 E89 R97 R107 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3wzw A 1.8 BS01 IPM A 1 E89 R97 R136 Y143 D249 E89 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3wzx A 1.9 BS01 IPM A 1 E89 R97 R107 R136 Y143 D249 E89 R97 R107 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLASASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 3wzy A 1.55 BS01 IPM A 1 E89 R97 R136 Y143 D249 E89 R97 R136 Y143 D249 Y143 K193 D225 D249 D253 Y143 K193 D225 D249 D253 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0046872,0051287 Q8E9N3 401 SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLASASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV 4f7i A 2.0 BS01 IPM A 1 R94 R104 R132 Y139 D241 R95 R105 R133 Y140 D242 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 25211160 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLAAAAL 4f7i B 2.0 BS02 IPM B 1 R94 R104 R132 Y139 D241 R95 R105 R133 Y140 D242 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 25211160 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLAAAAL 4f7i C 2.0 BS01 IPM C 1 R94 R104 R132 Y139 D241 R95 R105 R133 Y140 D242 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 25211160 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLAAA 4f7i D 2.0 BS02 IPM D 1 R94 R104 R132 Y139 D241 R95 R105 R133 Y140 D242 Y139 K185 D217 D241 D245 Y140 K186 D218 D242 D246 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 25211160 800 SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLAAAA 4wuo A 2.05 BS01 IPM A 1 R94 R104 R132 Y139 D241 R96 R106 R134 Y141 D243 Y139 K185 D217 D241 D245 Y141 K187 D219 D243 D247 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 25497013 401 ASMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFAPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLAAA 4wuo B 2.05 BS01 IPM A 2 R94 R104 R132 Y139 D241 R94 R104 R132 Y139 D241 Y139 K185 D217 D241 D245 Y139 K185 D217 D241 D245 1.1.1.85 0000287,0003862,0005737,0005829,0009098,0016491,0016616,0042802,0046872,0051287 Q5SIY4 25497013 415 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFAPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA 4y1p A 2.2 BS01 IPM A 1 R86 R96 R117 Y124 D225 R85 R95 R115 Y122 D223 Y124 K170 D201 D225 D229 Y122 K168 D199 D223 D227 1.1.1.85 0000287,0003862,0004449,0006099,0006102,0009098,0016491,0016616,0046872,0051287 Q4JB37 27590116 402 GFVVALIQGDGIGPEVVSKSKTILARLNEKFSLPIEYIEVEAGDTTKNKFGDALPKDSLRVIEKADMILKGPVGETAADVVVKLRLMYDLYANLRPAKSLPGLNKFGDVDILVVRENTEDLYKGLEHVISDGVTVGIKVITRAASTRIAQVALNQALRRKKKVVCVHKSNVMRITDGLFAESCRNVLKGKVEYSEMYVDAAAANLVRNPQAFDVIVTENTYGDILSDEAGQIAGSLGISPSANIGDRKSLFEPVHGAAFDIAGKNIANPTAFLLSVGMMLDRMQELSGDIRYNNAAKSLRDAIYSVYSEGKYLTPDVGGSSTTDEMISAIRSKIG 4y1p B 2.2 BS01 IPM B 1 A79 R86 R96 R117 Y124 D225 A78 R85 R95 R116 Y123 D224 Y124 K170 D201 D225 D229 Y123 K169 D200 D224 D228 1.1.1.85 0000287,0003862,0004449,0006099,0006102,0009098,0016491,0016616,0046872,0051287 Q4JB37 27590116 402 GFVVALIQGDGIGPEVVSKSKTILARLNEKFSLPIEYIEVEAGDTTKNKFGDALPKDSLRVIEKADMILKGPVGETAADVVVKLRLMYDLYANLRPAKSLPGLENKFGDVDILVVRENTEDLYKGLEHVISDGVTVGIKVITRAASTRIAQVALNQALRRKKKVVCVHKSNVMRITDGLFAESCRNVLKGKVEYSEMYVDAAAANLVRNPQAFDVIVTENTYGDILSDEAGQIAGSLGISPSANIGDRKSLFEPVHGAAFDIAGKNIANPTAFLLSVGMMLDRMQELSGDIRYNNAAKSLRDAIYSVYSEGKYLTPDVGGSSTTDEMISAIRSKIG 5hn6 A 2.5 BS01 IPM A 1 L83 R86 R96 R111 Y118 D218 L83 R86 R96 R111 Y118 D218 Y118 K163 D194 D218 D222 Y118 K163 D194 D218 D222 ? 0000287,0003862,0004449,0006099,0006102,0009098,0016616,0046872,0051287 Q5JFV8 27831491 401 MYRVAVIPGDGIGPEVIDGAVRVLKAVTGRVRFEYYEGGVDVFQECGSPIREEDLEEIRRSDAVLFGATTTPFDLPGYRSLILTLRKELGLYANLRIIPDLRTGREIVIVRENSEGLYFGIGAVVNGRAVDVRLITREGAERIARFAVEQAKARGSFITFVHKANVLTGDKFFRRIVREVAGEEGVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGSIGIVPSGNYGDGIALFEPVHGSAPDIAGKGIANPIGAILSGAMLLDYLGLDGSLIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIEDLLSMDEVW 5j32 A 1.933 BS02 IPM A 1 R136 R174 Y181 D288 R106 R144 Y151 D258 L48 Y181 K232 D264 D288 D292 L18 Y151 K202 D234 D258 D262 1.1.1.85 0000287,0003862,0005829,0009098,0009507,0009536,0009553,0009555,0009570,0009941,0016491,0016616,0042803,0046872,0051287,0070403 Kd=8.3uM -logKd/Ki=5.08, Kd=8.3uM P93832 27137927 502 QMGRGSEFGKKRYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARKRRGKLCSVDKANVLEASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRTGDIYSAGTKLVGCKEMGEEVLKSVDS 5j32 B 1.933 BS02 IPM A 2 R136 R146 R174 Y181 D288 R101 R111 R139 Y146 D253 L48 Y181 K232 D264 D288 D292 L13 Y146 K197 D229 D253 D257 1.1.1.85 0000287,0003862,0005829,0009098,0009507,0009536,0009553,0009555,0009570,0009941,0016491,0016616,0042803,0046872,0051287,0070403 -logKd/Ki=5.08, Kd=8.3uM P93832 27137927 504 SEFGKKRYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARKRRGKLCSVDKANVLEASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRTGDIYSAGTKLVGCKEMGEEVLKSVDSQ 5j32 C 1.933 BS02 IPM C 1 R136 R174 Y181 D288 R96 R134 Y141 D248 L48 Y181 K232 D264 D288 D292 L8 Y141 K192 D224 D248 D252 1.1.1.85 0000287,0003862,0005829,0009098,0009507,0009536,0009553,0009555,0009570,0009941,0016491,0016616,0042803,0046872,0051287,0070403 Kd=8.3uM P93832 27137927 502 KRYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARKRRGKLCSVDKANVLEASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRTGDIYSAGTKLVGCKEMGEEVLKS 5j32 D 1.933 BS02 IPM C 2 R136 R146 R174 Y181 D288 R99 R109 R137 Y144 D251 L48 Y181 K232 D264 D288 D292 L11 Y144 K195 D227 D251 D255 1.1.1.85 0000287,0003862,0005829,0009098,0009507,0009536,0009553,0009555,0009570,0009941,0016491,0016616,0042803,0046872,0051287,0070403 P93832 27137927 504 FGKKRYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARKRRGKLCSVDKANVLEASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRTGDIYSAGTKLVGCKEMGEEVLKSV