1fjw A 1.9 BS06 IPH A 1 L133 V139 H142 E143 L202 L133 V139 H142 E143 L202 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 11287678 507 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGDGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSEMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 1fjw A 1.9 BS07 IPH A 2 Y84 S92 Y93 I100 L144 V148 Y84 S92 Y93 I100 L144 V148 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 11287678 508 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGDGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSEMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 1foh A 2.4 BS02 IPH A 1 D54 Q112 R265 I279 Y289 A366 G367 D54 Q112 R265 I279 Y289 A353 G354 D54 R281 Y289 P364 D54 R281 Y289 P351 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 9634698 802 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERHILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSDHESTPLQFGHKTENSLFHSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERHAFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFSAYLDSENSVISLYTPKVSDRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKS 1foh B 2.4 BS02 IPH B 1 D54 Q112 R265 I279 Y289 A366 G367 D54 Q112 R265 I279 Y289 A353 G354 D54 R281 Y289 P364 D54 R281 Y289 P351 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 9634698 802 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERHILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSDHESTPLQFGHKTENSLFHSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERHAFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFSAYLDSENSVISLYTPKVSDRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKSTA 1foh C 2.4 BS02 IPH C 1 D54 G55 Q112 V114 I279 Y289 G367 D54 G55 Q112 V114 I279 Y289 G359 D54 R281 Y289 P364 D54 R281 Y289 P356 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 9634698 802 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERHILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSDHESTPLQFGHKTENSLFHSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLRVDRTKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERHAFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFSAYLDSENSVISLYTPKVSDRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKSTA 1foh D 2.4 BS02 IPH D 1 D54 G55 Q112 V114 I279 Y289 G367 D54 G55 Q112 V114 I279 Y289 G359 D54 R281 Y289 P364 D54 R281 Y289 P356 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 9634698 802 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERHILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSDHESTPLQFGHKTENSLFHSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQVDRTKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERHAFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFSAYLDSENSVISLYTPKVSDRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKS 1jhx A 2.0 BS01 IPH A 1 V84 Q88 V81 Q85 E174 E317 E171 E314 2.4.2.21 0000166,0008939,0009236,0016757 Q05603 11441022 990 LHALLRDIPAPDAEAMARTQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLP 1jhy A 2.0 BS01 IPH A 1 S80 V84 S77 V81 E174 E317 E171 E314 2.4.2.21 0000166,0008939,0009236,0016757 Q05603 11441022 990 LHALLRDIPAPDAEAMARTQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLP 1pn0 A 1.7 BS02 IPH A 1 D54 R265 M277 I279 Y289 P364 A366 G367 D54 R265 M277 I279 Y289 P354 A356 G357 D54 R281 Y289 P364 D54 R281 Y289 P354 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 12925790 6012 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERRILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSEDESTPLQFGHKTENGLFRSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQATKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERQPFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFAAYLDSENSVISRYTPKGADRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKS 1pn0 B 1.7 BS02 IPH B 1 D54 Q112 V114 M277 I279 Y289 P364 A366 G367 D54 Q112 V114 M277 I279 Y289 P354 A356 G357 D54 R281 Y289 P364 D54 R281 Y289 P354 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 12925790 6022 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERRILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSEDESTPLQFGHKTENGLFRSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQATKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERQPFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFAAYLDSENSVISRYTPKGADRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKS 1pn0 C 1.7 BS02 IPH C 1 D54 Q112 M277 I279 Y289 P364 A366 G367 D54 Q112 M277 I279 Y289 P358 A360 G361 D54 R281 Y289 P364 D54 R281 Y289 P358 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 12925790 6032 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERRILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSEDESTPLQFGHKTENGLFRSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQARVDRTKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERQPFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFAAYLDSENSVISRYTPKGADRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKS 1pn0 D 1.7 BS02 IPH D 1 D54 Q112 M277 I279 Y289 P364 A366 G367 D54 Q112 M277 I279 Y289 P358 A360 G361 D54 R281 Y289 P364 D54 R281 Y289 P358 1.14.13.7 0004497,0009056,0016491,0016709,0018662,0019336,0071949 P15245 12925790 6042 TKYSESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRSTKVYNGQADGLQCRTLESLKNLGLADKILSEANDMSTIALYNPDENGHIRRTDRIPDTLPGISRYHQVVLHQGRIERRILDSIAEISDTRIKVERPLIPEKMEIDSSKAEDPEAYPVTMTLRYMSEDESTPLQFGHKTENGLFRSNLQTQEEEDANYRLPEGKEAGEIETVHCKYVIGCDGGHSWVRRTLGFEMIGEQTDYIWGVLDAVPASNFPDIRSRCAIHSAESGSIMIIPRENNLVRFYVQLQARVDRTKFTPEVVIANAKKIFHPYTFDVQQLDWFTAYHIGQRVTEKFSKDERVFIAGDACHTHSPKAGQGMNTSMMDTYNLGWKLGLVLTGRAKRDILKTYEEERQPFAQALIDFDHQFSRLFSGRPAKDVADEMGVSMDVFKEAFVKGNEFASGTAINYDENLVTDKKSSKQELAKNCVVGTRFKSQPVVRHSEGLWMHFGDRLVTDGRFRIIVFAGKATDATQMSRIKKFAAYLDSENSVISRYTPKGADRNSRIDVITIHSCHRDDIEMHDFPAPALHPKWQYDFIYADCDSWHHPHPKSYQAWGVDETKGAVVVVRPDGYTSLVTDLEGTAEIDRYFSGILVEPKEKSGAQTEADWTKS 1qiy F 2.3 BS03 IPH E 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10508408 22 FVNQYLCGSHLVEALYLVCGERGFFYTPKT 1wav B 2.5 BS03 IPH A 1 H10 L11 A14 H10 L11 A14 ? 0005179,0005576 P01315 8760462 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKA 1wav J 2.5 BS03 IPH J 1 H10 L11 A14 H10 L11 A14 ? 0005179,0005576 P01315 8760462 31 FVNQHLCGSHLVEALYLVCGERGFFYTPKA 1wav L 2.5 BS03 IPH H 1 H10 A14 H10 A14 ? 0005179,0005576 P01315 8760462 31 FVNQHLCGSHLVEALYLVCGERGFFYTPKA 1zeg B 1.6 BS02 IPH B 1 E13 L17 E13 L17 ? 0005179,0005576 P01308 9708987 33 FVNQHLCGSHLVEALYLVCGERGFFYTDKT 2as3 A 1.4 BS02 IPH A 1 H175 G178 K179 T180 G191 M230 L232 D235 H172 G175 K176 T177 G188 M227 L229 D232 R48 H52 H175 G191 D235 R45 H49 H172 G188 D232 1.11.1.5 0004601,0006979,0020037,0034599 Kd=4.1mM P00431 16490206 500 LVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHISGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPGGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL 2old B 2.6 BS03 IPH B 1 Y38 P46 Y38 P46 17582169 2001 QSALPQPASVSGSPGQSITISCTGTSSDVGGYDLVSWYQHHPGGAPKLIIYEVTNRPSGVSDRFSGSKSGNTASLTISGLQAEDEADYYCSSYASGSTPRIFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 2omb D 2.9 BS02 IPH D 1 Y38 Y89 Y38 Y89 17582169 2002 QSALPQPASVSGSPGQSITISCTGTSSDVGGYDLVSWYQHHPGGAPKLIIYEVTNRPSGVSDRFSGSKSGNTASLTISGLQAEDEADYYCSSYASGSTPRIFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 2pzv A 1.25 BS01 IPH A 1 Y16 N40 F86 V88 D103 Y15 N39 F82 V84 D99 Y16 N40 D100 D103 Y15 N39 D96 D99 5.3.3.1 0004769,0008202,0016853 Kd=135uM P07445 16602823 401 NLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVENPFGQPPIHGREQIAAFYRQGLKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSV 2pzv B 1.25 BS01 IPH B 1 Y16 N40 F86 V101 D103 Y15 N39 F82 V97 D99 Y16 N40 D100 D103 Y15 N39 D96 D99 5.3.3.1 0004769,0008202,0016853 Kd=135uM P07445 16602823 402 NLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVENPFGQPPIHGREQIAAFYRQGLKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSV 2pzv C 1.25 BS01 IPH C 1 Y16 N40 F86 D103 Y15 N39 F82 D99 Y16 N40 D100 D103 Y15 N39 D96 D99 5.3.3.1 0004769,0008202,0016853 Kd=135uM P07445 16602823 403 NLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVENPFGQPPIHGREQIAAFYRQGLKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSV 2pzv D 1.25 BS01 IPH D 1 Y16 N40 F86 V101 D103 Y15 N39 F82 V97 D99 Y16 N40 D100 D103 Y15 N39 D96 D99 5.3.3.1 0004769,0008202,0016853 Kd=135uM P07445 16602823 404 NLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVENPFGQPPIHGREQIAAFYRQGLKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSV 3aiy B -1.00 BS03 IPH A 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 3aiy D -1.00 BS03 IPH C 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 3aiy F -1.00 BS03 IPH E 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 3aiy H -1.00 BS03 IPH G 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 3aiy J -1.00 BS03 IPH I 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 3aiy L -1.00 BS03 IPH K 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 3guo A 2.16 BS01 IPH A 1 I78 A99 E102 I78 A99 E102 E11 D20 E11 D20 3.2.1.17 0003796,0009253,0016798,0016998,0030430,0031640,0042742,0044659 Ka=9150M^-1 Kd=103000nM P00720 19663503 501 MNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINEVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYNQCPDRAKRVITTFRTGTWDAYK 3guo B 2.16 BS01 IPH B 1 A99 E102 A99 E102 E11 D20 E11 D20 3.2.1.17 0003796,0009253,0016798,0016998,0030430,0031640,0042742,0044659 Ka=9150M^-1 Kd=103000nM P00720 19663503 501 MNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINEVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYNQCPDRAKRVITTFRTGTWDAYK 3nx8 A 2.0 BS02 IPH A 1 A70 M120 Y122 L173 T183 A56 M106 Y108 L159 T169 D166 K168 E170 N171 D184 T201 D152 K154 E156 N157 D170 T187 2.7.11.11 0000287,0001669,0001707,0001843,0002027,0003091,0004672,0004674,0004679,0004691,0004712,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0010881,0016241,0016310,0016607,0018105,0019221,0019901,0019904,0030145,0031410,0031514,0031594,0031625,0032024,0032703,0034237,0034380,0034605,0034704,0035694,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0050850,0051726,0055117,0061136,0070062,0070417,0070613,0071333,0071374,0071377,0071872,0086064,0097546,0098794,0098978,0099103,0099170,0106310,1903779,1904262,1904539,1990044,2000810 P17612 22213702 351 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3nx8 A 2.0 BS03 IPH A 2 G50 T51 G52 E127 E170 G36 T37 G38 E113 E156 D166 K168 E170 N171 D184 T201 D152 K154 E156 N157 D170 T187 2.7.11.11 0000287,0001669,0001707,0001843,0002027,0003091,0004672,0004674,0004679,0004691,0004712,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0010881,0016241,0016310,0016607,0018105,0019221,0019901,0019904,0030145,0031410,0031514,0031594,0031625,0032024,0032703,0034237,0034380,0034605,0034704,0035694,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0050850,0051726,0055117,0061136,0070062,0070417,0070613,0071333,0071374,0071377,0071872,0086064,0097546,0098794,0098978,0099103,0099170,0106310,1903779,1904262,1904539,1990044,2000810 P17612 22213702 352 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3nx8 A 2.0 BS04 IPH A 3 L40 F43 R45 I335 L26 F29 R31 I321 D166 K168 E170 N171 D184 T201 D152 K154 E156 N157 D170 T187 2.7.11.11 0000287,0001669,0001707,0001843,0002027,0003091,0004672,0004674,0004679,0004691,0004712,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0010881,0016241,0016310,0016607,0018105,0019221,0019901,0019904,0030145,0031410,0031514,0031594,0031625,0032024,0032703,0034237,0034380,0034605,0034704,0035694,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0050850,0051726,0055117,0061136,0070062,0070417,0070613,0071333,0071374,0071377,0071872,0086064,0097546,0098794,0098978,0099103,0099170,0106310,1903779,1904262,1904539,1990044,2000810 P17612 22213702 353 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3q3o A 1.95 BS03 IPH A 1 E104 E134 F176 E197 E103 E133 F175 E196 E104 E134 H137 E197 E231 H234 E103 E133 H136 E196 E230 H233 1.14.13.236 0004497,0009056,0016491,0018638,0042203,0046872 Q00456 22264099 503 AMHPRKDWYELTRATNWTPSYVTEEQLFPERMSGHMGIPLEKWESYDEPYKTSYPEYVSIQREKDAGAYSVKAALERAKIYENSDPGWISTLKSHYGAIAVGEYAAVTGEGRMARFSKAPGNRNMATFGMMDELRHGQLQLFFPHEYCKKDRQFDWAWRAYHSNEWAAIAAKHFFDDIITGRDAISVAIMLTFSFETGFTNMQFLGLAADAAEAGDYTFANLISSIQTDESRHAQQGGPALQLLIENGKREEAQKKVDMAIWRAWRLFAVLTGPVMDYYTPLEDRSQSFKEFMYEWIIGQFERSLIDLGLDKPWYWDLFLKDIDELHHSYHMGVWYWRTTAWWNPAAGVTPEERDWLEEKYPGWNKRWGRCWDVITENVLNDRMDLVSPETLPSVCNMSQIPLVGVPGDDWNIEVFSLEHNGRLYHFGSEVDRWVFQQDPVQYQNHMNIVDRFLAGQIQPMTLEGALKYMGFQSIEEMGKDAHDFAWADKC 3q3o A 1.95 BS04 IPH A 2 W167 W338 P394 V396 P403 W166 W337 P393 V395 P402 E104 E134 H137 E197 E231 H234 E103 E133 H136 E196 E230 H233 1.14.13.236 0004497,0009056,0016491,0018638,0042203,0046872 Q00456 22264099 504 AMHPRKDWYELTRATNWTPSYVTEEQLFPERMSGHMGIPLEKWESYDEPYKTSYPEYVSIQREKDAGAYSVKAALERAKIYENSDPGWISTLKSHYGAIAVGEYAAVTGEGRMARFSKAPGNRNMATFGMMDELRHGQLQLFFPHEYCKKDRQFDWAWRAYHSNEWAAIAAKHFFDDIITGRDAISVAIMLTFSFETGFTNMQFLGLAADAAEAGDYTFANLISSIQTDESRHAQQGGPALQLLIENGKREEAQKKVDMAIWRAWRLFAVLTGPVMDYYTPLEDRSQSFKEFMYEWIIGQFERSLIDLGLDKPWYWDLFLKDIDELHHSYHMGVWYWRTTAWWNPAAGVTPEERDWLEEKYPGWNKRWGRCWDVITENVLNDRMDLVSPETLPSVCNMSQIPLVGVPGDDWNIEVFSLEHNGRLYHFGSEVDRWVFQQDPVQYQNHMNIVDRFLAGQIQPMTLEGALKYMGFQSIEEMGKDAHDFAWADKC 3q3o A 1.95 BS05 IPH A 3 W167 G334 V335 W338 P403 W166 G333 V334 W337 P402 E104 E134 H137 E197 E231 H234 E103 E133 H136 E196 E230 H233 1.14.13.236 0004497,0009056,0016491,0018638,0042203,0046872 Q00456 22264099 505 AMHPRKDWYELTRATNWTPSYVTEEQLFPERMSGHMGIPLEKWESYDEPYKTSYPEYVSIQREKDAGAYSVKAALERAKIYENSDPGWISTLKSHYGAIAVGEYAAVTGEGRMARFSKAPGNRNMATFGMMDELRHGQLQLFFPHEYCKKDRQFDWAWRAYHSNEWAAIAAKHFFDDIITGRDAISVAIMLTFSFETGFTNMQFLGLAADAAEAGDYTFANLISSIQTDESRHAQQGGPALQLLIENGKREEAQKKVDMAIWRAWRLFAVLTGPVMDYYTPLEDRSQSFKEFMYEWIIGQFERSLIDLGLDKPWYWDLFLKDIDELHHSYHMGVWYWRTTAWWNPAAGVTPEERDWLEEKYPGWNKRWGRCWDVITENVLNDRMDLVSPETLPSVCNMSQIPLVGVPGDDWNIEVFSLEHNGRLYHFGSEVDRWVFQQDPVQYQNHMNIVDRFLAGQIQPMTLEGALKYMGFQSIEEMGKDAHDFAWADKC 3q3o A 1.95 BS06 IPH A 4 I100 F176 Q204 L268 F269 L272 T273 I99 F175 Q203 L267 F268 L271 T272 E104 E134 H137 E197 E231 H234 E103 E133 H136 E196 E230 H233 1.14.13.236 0004497,0009056,0016491,0018638,0042203,0046872 Q00456 22264099 507 AMHPRKDWYELTRATNWTPSYVTEEQLFPERMSGHMGIPLEKWESYDEPYKTSYPEYVSIQREKDAGAYSVKAALERAKIYENSDPGWISTLKSHYGAIAVGEYAAVTGEGRMARFSKAPGNRNMATFGMMDELRHGQLQLFFPHEYCKKDRQFDWAWRAYHSNEWAAIAAKHFFDDIITGRDAISVAIMLTFSFETGFTNMQFLGLAADAAEAGDYTFANLISSIQTDESRHAQQGGPALQLLIENGKREEAQKKVDMAIWRAWRLFAVLTGPVMDYYTPLEDRSQSFKEFMYEWIIGQFERSLIDLGLDKPWYWDLFLKDIDELHHSYHMGVWYWRTTAWWNPAAGVTPEERDWLEEKYPGWNKRWGRCWDVITENVLNDRMDLVSPETLPSVCNMSQIPLVGVPGDDWNIEVFSLEHNGRLYHFGSEVDRWVFQQDPVQYQNHMNIVDRFLAGQIQPMTLEGALKYMGFQSIEEMGKDAHDFAWADKC 3q3o B 1.95 BS01 IPH B 1 Q95 T164 H165 Y168 Q94 T163 H164 Y167 1.14.13.236 0004497,0009056,0016491,0016709,0018638,0042203 Q00460 22264099 308 SFESKKPMRTWSHLAEMRKKPSEYDIVSRKLHYSTNNPDSPWELSPDSPMNLWYKQYRNASPLKHDNWDAFTDPDQLVYRTYNLMQDGQESYVQSLFDQFNEREHDQMVREGWEHTMARCYSPLRYLFHCLQMSSAYVQQMAPASTISNCCILQTADSLRWLTHTAYRTHELSLTYPDAGLGEHERELWEKEPGWQGLRELMEKQLTAFDWGEAFVSLNLVVKPMIVESIFKPLQQQAWENNDTLLPLLIDSQLKDAERHSRWSKALVKHALENPDNHAVIEGWIEKWRPLADRAAEAYLSMLSS 3u3e A 1.21 BS02 IPH A 1 L89 A90 H93 L104 F138 I142 L89 A90 H93 L104 F138 I142 1.11.1.-,1.7.-.- 0004601,0005344,0005737,0015671,0016491,0016528,0019430,0019825,0020037,0046872,0070062,0098809 P02185 23192025 202 VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG 4a71 A 1.61 BS02 IPH A 1 F89 E93 H96 S104 L107 F108 F88 E92 H95 S103 L106 F107 R48 H52 H175 W191 D235 R47 H51 H174 W190 D234 1.11.1.5 0004601,0006979,0020037,0034599 P00431 22093282 1296 TPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNAIGYGPVLVRLAWHTSGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDADYVRTFFQRLNMNDREVVALMGAHALGKTHLKRSGYEGPWGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL 4a71 A 1.61 BS03 IPH A 2 L30 I40 G41 G43 M119 L29 I39 G40 G42 M118 R48 H52 H175 W191 D235 R47 H51 H174 W190 D234 1.11.1.5 0004601,0006979,0020037,0034599 P00431 22093282 1297 TPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNAIGYGPVLVRLAWHTSGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDADYVRTFFQRLNMNDREVVALMGAHALGKTHLKRSGYEGPWGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL 4aiy B -1.00 BS03 IPH A 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 4aiy D -1.00 BS03 IPH C 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 4aiy F -1.00 BS03 IPH E 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 4aiy H -1.00 BS03 IPH G 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 4aiy J -1.00 BS03 IPH I 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 4aiy L -1.00 BS03 IPH K 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 4h07 A 1.14 BS02 IPH A 1 L89 A90 H93 L104 F138 I142 Y146 L90 A91 H94 L105 F139 I143 Y147 1.11.1.-,1.7.-.- 0004601,0005344,0005737,0015671,0016491,0016528,0019430,0019825,0020037,0046872,0070062,0098809 P02185 23192025 202 MVLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHTVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG 4hds A 2.4 BS01 IPH A 1 M87 M177 L317 E319 M86 M176 L311 E313 E176 E319 E175 E313 2.4.2.21 0008939,0009236,0016757 F6MZ55 23039029 801 SLLQATVAKIMRPDTVIKDQVKTKLAGVLQSAGSLGRLEDMVEQYAGITGELNPALPKPCMVVASADHGVARRVVSAYPIETTIHMTANYLISQGASANAFANFCGADMVVVDMGVAGDLSYVPGLWHRKIAYGTQDFTEGPAMTREQAIQAVETGIDIVNDRVKHGNRCFCLGEMGIGNTTSSATIVGAFTGLAPEKVTGRGSRLKTKMEIVGRALAVNKPNPQDGLDVLAKVGGFELGALAGVILGSAANRCAVVIDGLNTTAAALIANVIHPLSKEYMFASHLSGEPAHSIALRQLQLEACLELGVRLGEGIGASMVVDMLYVAIKLLNN 5aiy B -1.00 BS03 IPH A 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 5aiy D -1.00 BS03 IPH C 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 5aiy F -1.00 BS03 IPH E 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 5aiy H -1.00 BS03 IPH G 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 5aiy J -1.00 BS03 IPH I 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 5aiy L -1.00 BS03 IPH K 1 L11 A14 L11 A14 ? 0005179,0005576 P01308 10723989 22 FVNQHLCGSHLVEALYLVCGERGFFYTPKT 5frw A 2.1 BS01 IPH A 1 G98 P99 H102 V110 F128 Y157 G91 P92 H95 V103 F121 Y150 ? O84957 27050690 1209 FSATMRDGLSNLARRLRFAMKEGSIWLGEQRMILLHTAALGALRKELVDTLGMERARGLFMRMGFHSGVRDAELAKTMRSGHSDFGMLEMGPCLHTIEGVVRVTPLTVDINIAAGVYHGEFLWEDSFEGDVHRQMFGVAQAPVCWMQIGYATGYTSALMGKTILYRELECVGCGHPHCRILGKPLEQWEDGEAELALYQPD 5frw B 2.1 BS01 IPH B 1 G98 P99 H102 F128 W130 Y157 G88 P89 H92 F118 W120 Y147 ? O84957 27050690 1209 TMRDGLSNLARRLRFAMKEGSIWLGEQRMILLHTAALGALRKELVDTLGMERARGLFMRMGFHSGVRDAELAKTMRSGHSDFGMLEMGPCLHTIEGVVRVTPLTVDINIAAGVYHGEFLWEDSFEGDVHRQMFGVAQAPVCWMQIGYATGYTSALMGKTILYRELECVGCGHPHCRILGKPLEQWEDGEAELALYQPD 5kbe A 2.5 BS02 IPH A 1 G102 P103 H106 F132 Y161 Y165 G88 P89 H92 F118 Y147 Y151 ? Kd=0.46uM -logKd/Ki=6.34, Kd=0.46uM Q43965 27362503 602 EQNKDIQDLLDKIVFDAQHGQIWFDENRMLLMHTSILGFLRKDLYQMLGLERTKRFFIRCGYQAGMRDAEVTSKLRPNLNEAEAFMAGPQMHGIRGMVQVEVNELHLSHDLKQFYADFNWLNSFEAEVHLSEFGASDQPACWMLLGYACGYSSFVMGQTIIYQETHCVAQGDEHCRIIGKPLSEWDAVSDEIIALQAEL 5kbe B 2.5 BS02 IPH B 1 G102 P103 H106 F132 Y161 A162 Y176 G89 P90 H93 F119 Y148 A149 Y163 ? Kd=0.46uM Q43965 27362503 302 LEQNKDIQDLLDKIVFDAQHGQIWFDENRMLLMHTSILGFLRKDLYQMLGLERTKRFFIRCGYQAGMRDAEVTSKLRPNLNEAEAFMAGPQMHGIRGMVQVEVNELHLSHDLKQFYADFNWLNSFEAEVHLSEFGASDQPACWMLLGYACGYSSFVMGQTIIYQETHCVAQGDEHCRIIGKPLSEWENALIRFMSPDAVSDEIIAL 6iy8 A 3.42 BS01 IPH A 1 P97 H100 M126 A156 P85 H88 M114 A144 ? 0005524,0006355,0008134,0016887 Q7WSM9 32483114 600 MDPEFTNLIHFQSTEGKIWLGEQRMLLLQVSAMASFRREMVNTLGIERAKGFFLRQGYQSGLKDAELARKLRPNASEYDMFLAGPQLHSLKGLVKVRPTEVDIDKESGRFYAEMEWIDSFEVEISQTDLGQMQDPVCWTLLGYACAYSSAFMGREIIFKEVSCRGCGGDKCRVIGKPAEEWDDVASFKQYFKNDPIIEELYELQSQLVSLRTNLDKQEGQYYGIGQTPAYQTVRNMMDKAAQGKVSVLLLGETGVGKEVIARSVHLRSKRAAEPFVAVNCAAIPPDLIESELFGVEKGAFTGATQSRMGRFERADKGTIFLDEVIELSPRAQASLLRVLQEGELERVGDNRTRKIDVRVIAATHEDLAEAVKAGRFRADLYYRLNVFPVAIPALRERREDIPLLVEHFLQRFHQEYGKRTLGLSDKALEACLHYSWPGNIRELENVIERGIILTDPNESISVQALFPRA 6iy8 B 3.42 BS02 IPH B 1 P97 H100 A156 Y159 F170 P81 H84 A140 Y143 F154 ? 0005524,0006355,0008134,0016887 Q7WSM9 32483114 602 FTNLIHFQSTEGKIWLGEQRMLLLQVSAMASFRREMVNTLGIERAKGFFLRQGYQSGLKDAELARKLRPNASEYDMFLAGPQLHSLKGLVKVRPTEVDIDKESGRFYAEMEWIDSFEVEISQTDLGQMQDPVCWTLLGYACAYSSAFMGREIIFKEVSCRGCGGDKCRVIGKPAEEWDDVASFKQYFKNDPIIEELYELQSQLVSLRTNLDKQEGQYYGIGQTPAYQTVRNMMDKAAQGKVSVLLLGETGVGKEVIARSVHLRSKRAAEPFVAVNCAAIPPDLIESELFGVEKGAFTGATQSRMGRFERADKGTIFLDEVIELSPRAQASLLRVLQEGELERVGDNRTRKIDVRVIAATHEDLAEAVKAGRFRADLYYRLNVFPVAIPALRERREDIPLLVEHFLQRFHQEYGKRTLGLSDKALEACLHYSWPGNIRELENVIERGIILTDPNESISVQALFPRA 6iy8 C 3.42 BS01 IPH C 1 P97 H100 M126 A156 P84 H87 M113 A143 ? 0005524,0006355,0008134,0016887 Q7WSM9 32483114 600 DPEFTNLIHFQSTEGKIWLGEQRMLLLQVSAMASFRREMVNTLGIERAKGFFLRQGYQSGLKDAELARKLRPNASEYDMFLAGPQLHSLKGLVKVRPTEVDIDKESGRFYAEMEWIDSFEVEISQTDLGQMQDPVCWTLLGYACAYSSAFMGREIIFKEVSCRGCGGDKCRVIGKPAEEWDDVASFKQYFKNDPIIEELYELQSQLVSLRTNLDKQEGQYYGIGQTPAYQTVRNMMDKAAQGKVSVLLLGETGVGKEVIARSVHLRSKRAAEPFVAVNCAAIPPDLIESELFGVEKGAFTGATQSRMGRFERADKGTIFLDEVIELSPRAQASLLRVLQEGELERVGDNRTRKIDVRVIAATHEDLAEAVKAGRFRADLYYRLNVFPVAIPALRERREDIPLLVEHFLQRFHQEYGKRTLGLSDKALEACLHYSWPGNIRELENVIERGIILTDPNESISVQALFPRA 6iy8 D 3.42 BS01 IPH D 1 H100 M126 W128 A156 H88 M114 W116 A144 ? 0005524,0006355,0008134,0016887 Q7WSM9 32483114 600 MDPEFTNLIHFQSTEGKIWLGEQRMLLLQVSAMASFRREMVNTLGIERAKGFFLRQGYQSGLKDAELARKLRPNASEYDMFLAGPQLHSLKGLVKVRPTEVDIDKESGRFYAEMEWIDSFEVEISQTDLGQMQDPVCWTLLGYACAYSSAFMGREIIFKEVSCRGCGGDKCRVIGKPAEEWDDVASFKQYFKNDPIIEELYELQSQLVSLRTNLDKQEGQYYGIGQTPAYQTVRNMMDKAAQGKVSVLLLGETGVGKEVIARSVHLRSKRAAEPFVAVNCAAIPPDLIESELFGVEKGAFTGATQSRMGRFERADKGTIFLDEVIELSPRAQASLLRVLQEGELERVGDNRTRKIDVRVIAATHEDLAEAVKAGRFRADLYYRLNVFPVAIPALRERREDIPLLVEHFLQRFHQEYGKRTLGLSDKALEACLHYSWPGNIRELENVIERGIILTDPNESISVQALFPRA 6z44 A 1.38 BS01 IPH A 1 A70 E121 Y122 V123 L173 A58 E109 Y110 V111 L161 D166 K168 N171 D184 T201 D154 K156 N159 D172 T189 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 33021032 401 ESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 7vqf A 2.3 BS01 IPH A 1 H106 W134 Y161 A162 Y165 H91 W119 Y146 A147 Y150 ? Q43965 35988639 301 DQNKDIQDLLDKIVFDAQHGQIWFDENRMLLMHTSILGFLRKDLYQMLGLERTKRFFIRCGYQAGMRDAEVTSKLRPNNEAEAFMAGPQMHGIRGMVQVEVNELHLSHDLKQFYADFNWLNSFEAEVHLSEFPASDQPACWMLLGYACGYSSFVMGQTIIYQETHCVAQGDEHCRIIGKPLSEWENADELI 7wdg A 2.07 BS03 IPH A 1 I263 E267 I256 E260 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 503 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdg A 2.07 BS06 IPH A 2 R147 S164 Q169 P170 H171 R146 S163 Q168 P169 H170 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 506 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdg A 2.07 BS07 IPH A 3 K309 G315 T411 K302 G308 T404 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 507 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdg B 2.07 BS03 IPH B 1 I263 E267 L437 I256 E260 L430 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 503 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdg B 2.07 BS06 IPH B 2 R147 S164 Q169 P170 H171 R146 S163 Q168 P169 H170 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 506 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdg B 2.07 BS07 IPH B 3 V308 K309 L311 G315 T411 V301 K302 L304 G308 T404 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 507 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh A 1.68 BS04 IPH A 1 R147 S164 Q169 P170 H171 R145 S162 Q167 P168 H169 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 505 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh A 1.68 BS05 IPH A 2 Q73 A74 A184 M185 L188 Q71 A72 A182 M183 L186 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 506 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh A 1.68 BS06 IPH A 3 I263 A264 E267 I255 A256 E259 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 507 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh A 1.68 BS07 IPH A 4 I366 W367 R378 A384 I358 W359 R370 A376 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 508 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh B 1.68 BS04 IPH B 1 I385 F390 I375 F380 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 505 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPNKRQFQEDIKVMNDLVDKIIADRQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh B 1.68 BS05 IPH B 2 I263 A264 E267 I253 A254 E257 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 506 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPNKRQFQEDIKVMNDLVDKIIADRQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 7wdh B 1.68 BS06 IPH B 3 R147 S164 Q169 P170 R146 S163 Q168 P169 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 P14779 36660956 507 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPNKRQFQEDIKVMNDLVDKIIADRQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL