1awb A 2.5 BS03 IPD A 1 D90 D93 G94 E162 G194 T195 A196 E213 D86 D89 G90 E158 G190 T191 A192 E209 D47 E70 D90 I92 D93 T95 D220 D43 E66 D86 I88 D89 T91 D216 3.1.3.25,3.1.3.94 0000287,0005515,0005737,0005829,0006020,0006021,0006661,0006796,0007165,0008934,0016787,0030145,0031403,0042802,0042803,0046854,0046872,0052832,0052833,0052834 P29218 281 WQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDE 1awb B 2.5 BS03 IPD B 1 D93 G94 E162 G194 T195 A196 E213 D220 D89 G90 E158 G190 T191 A192 E209 D216 D47 E70 D90 I92 D93 T95 D220 D43 E66 D86 I88 D89 T91 D216 3.1.3.25,3.1.3.94 0000287,0005515,0005737,0005829,0006020,0006021,0006661,0006796,0007165,0008934,0016787,0030145,0031403,0042802,0042803,0046854,0046872,0052832,0052833,0052834 P29218 1 WQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDE 1g0h A 2.3 BS03 IPD A 1 E65 D84 G85 S86 A174 F175 R194 D201 E65 D84 G85 S86 A174 F175 R194 D201 E65 D81 I83 D84 D201 E65 D81 I83 D84 D201 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 Q57573 11170378 292 MKWDEIGKNIAKEIEKEILPYFGRKDKSYVVGTSPSGDETEIFDKISEDIALKYLKSLNVNIVSEELGVIDNSSEWTVVIDPIDGSFNFINGIPFFAFCFGVFKNNEPYYGLTYEFLTKSFYEAYKGKGAYLNGRKIKVKDFNPNNIVISYYPSKKIDLEKLRNKVKRVRIFGAFGLEMCYVAKGTLDAVFDVRPKVRAVDIASSYIICKEAGALITDENGDELKFDLNATDRLNIIVANSKEMLDIILDLL 1g0h B 2.3 BS03 IPD B 1 E365 D384 G385 S386 F475 R494 D501 E65 D84 G85 S86 F175 R194 D201 E365 D381 I383 D384 S386 D501 E65 D81 I83 D84 S86 D201 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 Q57573 11170378 592 MKWDEIGKNIAKEIEKEILPYFGRKDKSYVVGTSPSGDETEIFDKISEDIALKYLKSLNVNIVSEELGVIDNSSEWTVVIDPIDGSFNFINGIPFFAFCFGVFKNNEPYYGLTYEFLTKSFYEAYKGKGAYLNGRKIKVKDFNPNNIVISYYPSKKIDLEKLRNKVKRVRIFGAFGLEMCYVAKGTLDAVFDVRPKVRAVDIASSYIICKEAGALITDENGDELKFDLNATDRLNIIVANSKEMLDIILDLL 1ima A 2.3 BS01 IPD A 1 D93 G94 E162 G194 T195 A196 E213 I216 D220 D89 G90 E158 G190 T191 A192 E209 I212 D216 D47 E70 D90 I92 D93 T95 D220 D43 E66 D86 I88 D89 T91 D216 3.1.3.25,3.1.3.94 0000287,0005515,0005737,0005829,0006020,0006021,0006661,0006796,0007165,0008934,0016787,0030145,0031403,0042802,0042803,0046854,0046872,0052832,0052833,0052834 P29218 8068620 279 WQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDE 1ima B 2.3 BS01 IPD B 1 D93 G94 E162 G194 T195 A196 E213 I216 D220 D89 G90 E158 G190 T191 A192 E209 I212 D216 D47 E70 D90 I92 D93 T95 D220 D43 E66 D86 I88 D89 T91 D216 3.1.3.25,3.1.3.94 0000287,0005515,0005737,0005829,0006020,0006021,0006661,0006796,0007165,0008934,0016787,0030145,0031403,0042802,0042803,0046854,0046872,0052832,0052833,0052834 P29218 8068620 279 WQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDE 1lbx A 2.4 BS03 IPD A 1 D82 D85 G86 Y155 G170 S171 A172 D82 D85 G86 Y155 G170 S171 A172 E67 D82 L84 D85 D200 E67 D82 L84 D85 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 11940584 295 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 1lbx B 2.4 BS03 IPD B 1 D385 G386 Y455 S471 A472 R491 D85 G86 Y155 S171 A172 R191 E367 D382 L384 D385 T387 D500 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 11940584 595 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 2ork B 1.89 BS04 IPD B 1 E321 N323 E329 N341 R343 E117 N119 E125 N137 R139 ? ic50=1.4mM -logKd/Ki=2.85, IC50=1.4mM P35247 17417879 995 ASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 2ork C 1.89 BS04 IPD C 1 E321 N323 E329 N341 R343 E116 N118 E124 N136 R138 ? ic50=1.4mM P35247 17417879 995 SLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 3ikp B 1.75 BS04 IPD B 1 E321 N323 E329 N341 R343 E118 N120 E126 N138 R140 ? P35247 19799916 405 VASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 3ikp C 1.75 BS04 IPD C 1 E321 N323 E329 N341 R343 E116 N118 E124 N136 R138 ? P35247 19799916 405 SLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 4rw3 A 1.72 BS02 IPD A 1 H12 E32 H48 D92 K94 Y223 W225 H11 E31 H47 D91 K93 Y222 W224 H12 E32 D34 H48 G49 D53 D92 K94 W225 D228 N247 H11 E31 D33 H47 G48 D52 D91 K93 W224 D227 N246 4.6.1.- 0005576,0006629,0008081,0016042,0016829,0031640,0035821,0046872,0090729 P0CE82 25961401 304 GNRRPIWIMGHMVNAIGQIDEFVNLGANSIETDVSFDDNANPEYTYHGIPCDCGRNCKKYENFNDFLKGLRSATTPGNSKYQEKLVLVVFDLKTGSLYDNQANDAGKKLAKNLLQHYWNNGNNGGRAYIVLSIPDLNHYPLIKGFKDQLTKDGHPELMDKVGHDFSGNDDIGDVGKAYKKAGITGHIWQSDGITNCLPRGLSRVNAAVANRDSANGFINKVYYWTVDKRSTTRDALDAGVDGIMTNYPDVITDVLNEAAYKKKFRVATYDDNPWVTFKK 5f24 A 2.5 BS03 IPD A 1 D91 G92 G183 C185 N202 D86 G87 G178 C180 N197 E70 D88 I90 D91 T93 D209 E68 D83 I85 D86 T88 D204 3.1.3.25 0000166,0006020,0007165,0008934,0046872 Q2FVV7 26894675 306 TDKTLQQIDKLICSWLKQIDNVIPQLIMEMTETKRHRFDLVTNVDKQIQQQFQQFLATYFPEHQLLAEEKMITNEINHLWIMDPIDGTANLVKQQEDYCIILAYFYEGKPMLSYVYDYPHKKLYKAIRGEGAFCNGFKMEEPPSLKLEDAIISFNAQVMNLDTVQDLFDASFSYRLVGACGLDSMRVAKGQFGAHINTNPKPWDIAAQFLFAELLNLKMTTLDGKAIDHLKGAPFIISNKACHETVLKILNANGGYQKYR 5f24 B 2.5 BS03 IPD B 1 D91 G92 G183 C185 N202 D82 G83 G174 C176 N193 E70 D88 I90 D91 T93 D209 E61 D79 I81 D82 T84 D200 3.1.3.25 0000166,0006020,0007165,0008934,0046872 Q2FVV7 26894675 308 KTLQQIDKLICSWLKQIDNVIPQLIMEMTTEDLVTNVDKQIQQQFQQFLATYFPEHQLLAEEKSNAMITNEINHLWIMDPIDGTANLVKQQEDYCIILAYFYEGKPMLSYVYDYPHKKLYKAIRGEGAFCNGFKMEEPPSLKLEDAIISFNAQVMNLDTVQDLFDASFSYRLVGACGLDSMRVAKGQFGAHINTNPKPWDIAAQFLFAELLNLKMTTLDGKAIDHLKGAPFIISNKACHETVLKILNANGGYQKY 5j16 A 2.4 BS03 IPD A 1 D86 G87 T88 G182 S183 A184 D73 G74 T75 G169 S170 A171 D42 E65 D83 I85 D86 T88 D208 D29 E52 D70 I72 D73 T75 D195 ? 0006020,0007165,0008934,0046872 A0A1I9GET0 303 MALYGFAQGLIQEAGIRIKQLMEQNTNVDKATEDFIFDTILETYPNHQVLGEEGHGHDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRFK 5j16 B 2.4 BS03 IPD B 1 D86 G87 T88 G182 S183 A184 D74 G75 T76 G170 S171 A172 D42 E65 D83 I85 D86 T88 D208 D33 E56 D71 I73 D74 T76 D196 ? 0006020,0007165,0008934,0046872 A0A1I9GET0 303 GSMALYGFAQGLIQEAGIRIKQLMEQNLVTNVDKATEDFIFDTILETYPNHQVLGEEGHIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLH 5j16 C 2.4 BS03 IPD C 1 D83 D86 G87 G182 S183 A184 D66 D69 G70 G165 S166 A167 D42 E65 D83 I85 D86 T88 D208 D28 E51 D66 I68 D69 T71 D191 ? 0006020,0007165,0008934,0046872 A0A1I9GET0 303 LYGFAQGLIQEAGIRIKQLMEQNLTNVDKATEDFIFDTILETYPNHQVLGEEGDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRF 7js5 A 2.5 BS01 IPD A 1 L88 K170 Q337 H442 K444 N459 Y461 L85 K167 Q334 H432 K434 N449 Y451 3.1.4.4 0003824,0004630,0005576,0016042,0016787,0030572,0032049 Q53728 33843991 601 PPTPHLDAIERSLRDTSPGLEGSVWQRTDGNRLDAPDGDPAGWLLQTPGCWGDAGCKDRAGTRRLLDKMTRNIADARHTVDISSLAPFPNGGFEDAVVDGLKASVAAGHSPRVRILVGAAPIYHLNVVPSRYRDELIGKLGAAAGKVTLNVASMTTSKTSLSWNASKLLVVDGKTAITGGINTNKDDYLDTAHPVSDVDMALSGPAARSAGKYLDTLWDWTCRNASDPAKVWLATSNGASCMPSMEQDEAGSAPAEPTGDVPVIAVGGLGVGIKESDPSSGYHPDLPTAPDTKCTVGLHDNTNADRDYDTVNPEENALRSLIASARSHVEISQQDLNATCPPLPRYDIRTYDTLAGKLAAGVKVRIVVSDPANARSQIKSLDEISDTLRTRLVALTGDNEKASRALCGNLQLASFRSSDAAKWADGKPYALHHKLVSVDDSAFYIGSKNLYPAWLQDFGYIVESPAAAQQLKTELLDPEWKYSQQAAATPAGCP 7js7 A 2.3 BS01 IPD A 1 H168 H442 H165 H432 3.1.4.4 0003824,0004630,0005576,0016042,0016787,0030572,0032049 Q53728 33843991 603 PPTPHLDAIERSLRDTSPGLEGSVWQRTDGNRLDAPDGDPAGWLLQTPGCWGDAGCKDRAGTRRLLDKMTRNIADARHTVDISSLAPFPNGGFEDAVVDGLKASVAAGHSPRVRILVGAAPIYHLNVVPSRYRDELIGKLGAAAGKVTLNVASMTTSKTSLSWNHSKLLVVDGKTAITGGINTNKDDYLDTAHPVSDVDMALSGPAARSAGKYLDTLWDWTCRNASDPAKVWLATSNGASCMPSMEQDEAGSAPAEPTGDVPVIAVGGLGVGIKESDPSSGYHPDLPTAPDTKCTVGLHDNTNADRDYDTVNPEENALRSLIASARSHVEISQQDLNATCPPLPRYDIRTYDTLAGKLAAGVKVRIVVSDPANARSQIKSLDEISDTLRTRLVALTGDNEKASRALCGNLQLASFRSSDAAKWADGKPYALHHKLVSVDDSAFYIGSKNLYPAWLQDFGYIVESPAAAQQLKTELLDPEWKYSQQAAATPAGCP 7js7 B 2.3 BS01 IPD B 1 L88 H168 K170 H442 K444 L85 H165 K167 H429 K431 3.1.4.4 0003824,0004630,0005576,0016042,0016787,0030572,0032049 Q53728 33843991 603 PPTPHLDAIERSLRDTSPGLEGSVWQRTDGNRLDAPDGDPAGWLLQTPGCWGDAGCKDRAGTRRLLDKMTRNIADARHTVDISSLAPFPNGGFEDAVVDGLKASVAAGHSPRVRILVGAAPIYHLNVVPSRYRDELIGKLGAAAGKVTLNVASMTTSKTSLSWNHSKLLVVDGKTAITGGINTNKDDYLDTAHPVSDVDMALSGPAARSAGKYLDTLWDWTCRNASDPAKVWLATSNGASCMPSMEQDEAGSAPAEPTGDVPVIAVGGLGVGIKESDPSSGYHPDLPTAPDTKCTVGLHDNTNADRDYDTVNPEENALRSLIASARSHVEISQQDLNATCPPLPRYDIRTYDTLAGKLAAGVKVRIVVSDPANQIKSLDEISDTLRTRLVALTGDNEKASRALCGNLQLASFRSSDAAKWADGKPYALHHKLVSVDDSAFYIGSKNLYPAWLQDFGYIVESPAAAQQLKTELLDPEWKYSQQAAATPAGCP 8wdq A 2.2 BS01 IPD A 1 D89 G90 F161 R162 R188 G190 A191 A192 E209 D216 D91 G92 F163 R164 R190 G192 A193 A194 E211 D218 Q9HXI4 301 GSMQPMLNIALRAARSAGELIFRSIERLDVISVNEKDAKDYVTEVDRAAEQTIVAALRKAYPTHAIMGEEGGLIEGSGEGADYLWVIDPLDGTTNFIHGVPHFAVSIACKYKGRLEHAVVLDPVRQEEFTASRGRGAALNGRRLRVSGRKSLEGALLGTGFPFRDNQIDNLDNYLNMFRSLVGQTAGIRRAGAASLDLAYVAAGRYDAFWEFGLSEWDMAAGALLVQEAGGLVSDFTGSHEFLEKGHIVAGNTKCFKALLTTIQPHLPPSLKR 8wdq B 2.2 BS01 IPD B 1 D89 G90 T91 R162 R188 G190 A191 A192 E209 D91 G92 T93 R164 R190 G192 A193 A194 E211 Q9HXI4 302 GSMQPMLNIALRAARSAGELIFRSIERLDVISVNEKDAKDYVTEVDRAAEQTIVAALRKAYPTHAIMGEEGGLIEGSGEGADYLWVIDPLDGTTNFIHGVPHFAVSIACKYKGRLEHAVVLDPVRQEEFTASRGRGAALNGRRLRVSGRKSLEGALLGTGFPFRDNQIDNLDNYLNMFRSLVGQTAGIRRAGAASLDLAYVAAGRYDAFWEFGLSEWDMAAGALLVQEAGGLVSDFTGSHEFLEKGHIVAGNTKCFKALLTTIQPHLPPSLKR