1ahf A 2.3 BS02 IOP A 1 I17 L18 I37 G38 W140 R386 I13 L14 I33 G34 W130 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 P00509 7664122 411 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 2ay5 A 2.4 BS02 IOP B 1 Y70 S296 Y65 S281 W140 D222 A224 K258 W127 D208 A210 K243 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 -logKd/Ki=2.59, Kd=2.6mM P95468 9930977 414 MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV 2ay5 B 2.4 BS02 IOP B 1 G38 W140 N142 R386 G28 W121 N123 R365 W140 D222 A224 K258 W121 D202 A204 K237 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 Kd=2.6mM -logKd/Ki=2.59, Kd=2.6mM P95468 9930977 414 MLGNLKPQAPDKILALMGEFGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV 2oli A 2.21 BS01 IOP A 1 L2 F5 K69 L2 F5 K60 Y28 G30 G32 H48 D49 Y52 Y73 D99 Y27 G29 G31 H47 D48 Y51 Y64 D89 3.1.1.4 0004623,0005509,0005543,0005576,0006644,0016042,0016787,0035821,0042130,0046872,0047498,0050482,0090729 P59071 1001 SLLEFGKMILEETGKLAIPSYSSYGCYCGWGGKGTPKDATDRCCFVHDCCYGNLPDCNPKSDRYKYKRVNGAIVCEKGTSCENRICECDKAAAICFRQNLNTYSKKYMLYPDFLCKGELKC 4ejk A 1.794 BS02 IOP A 1 W42 P44 K45 K55 V56 W42 P44 K45 K55 V56 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Kd=5.3uM P12499 23540839 101 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 4ejl A 2.445 BS01 IOP A 1 P44 K45 K55 V56 P44 K45 K55 V56 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Kd=7.2uM -logKd/Ki=5.14, Kd=7.2uM P12499 23540839 106 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMNLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 5o0f B 1.704 BS01 IOP B 1 L36 G69 Q70 G71 L73 K87 L36 G67 Q68 G69 L71 K85 H17 R90 S127 H17 R88 S125 2.7.7.3 0003824,0004595,0005524,0005737,0009058,0015937,0016779 B1MDL6 28648615 201 MTGAVCPGSFDPVTLGHLDVFERAAAQFDEVIVAVLINPAGMFTVDERIEMIRESTADLPNLRVESGQGLLVDFVRERGLNAIVKGLRTGTDFEYELQMAQMNKHIAGVDTFFVATAPAYSFVSSSLAKEVATYGGDVSALLPASVHQRLLGKLR 5o0f C 1.704 BS01 IOP C 1 G8 L36 G69 G71 L73 G8 L36 G65 G67 L69 H17 R90 S127 H17 R86 S123 2.7.7.3 0003824,0004595,0005524,0005737,0009058,0015937,0016779 B1MDL6 28648615 201 MTGAVCPGSFDPVTLGHLDVFERAAAQFDEVIVAVLIAGMFTVDERIEMIRESTADLPNLRVESGQGLLVDFVRERGLNAIVKGLRTGTDFEYELQMAQMNKHIAGVDTFFVATAPAYSFVSSSLAKEVATYGGDVSALLPASVHQRLLGKLR 6f7f A 2.128 BS01 IOP A 1 R54 I57 T81 R84 G85 R50 I53 T77 R80 G81 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLK 6f7f B 2.128 BS01 IOP B 1 R54 I57 T81 R84 G85 R51 I54 T78 R81 G82 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 QSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6f7f C 2.128 BS01 IOP C 1 R54 I57 T81 R84 G85 R50 I53 T77 R80 G81 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6f7f D 2.128 BS01 IOP D 1 R54 I57 T81 R84 G85 R51 I54 T78 R81 G82 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 QSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLK 6fal A 1.2 BS01 IOP A 1 R54 T81 R84 G85 Y88 R45 T72 R75 G76 Y79 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 AMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLLK 6fal A 1.2 BS02 IOP B 1 L41 M42 L32 M33 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 AMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLLK 6fal B 1.2 BS01 IOP B 1 R54 I57 T81 R84 G85 R42 I45 T69 R72 G73 ? 0003677,0003700,0005737,0006355,0043565,0045892 P0A881 201 EQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLLKSDL 6qmg A 1.65 BS01 IOP A 1 H17 I20 G88 R90 H17 I20 G83 R85 H17 R90 S127 H17 R85 S122 2.7.7.3 0003824,0004595,0005524,0005737,0009058,0015937,0016779,0034214 P9WPA5 201 MTGAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAILVGMFDLDERIAMVKESTTHLPNLRVQVGHGLVVDFVRSCGMTAIVKGLRTGTDFEYELQMAQMNKHIAGVDTFFVATAPRYSFVSSSLAKEVAMLGGDVSELLPEPVNRRLRDRLN 7kh3 A 1.5 BS01 IOP A 1 S28 H32 R46 S50 V65 S19 H23 R37 S41 V56 ? 0003677,0003700,0006355,0006950 C5CSP2 36266335 201 RFVDDYLPALLAQASQLISSEFHEVARQHGFSVSEWRVMASLAGSEPISIGQLAQVTVTKQPTVTRLLDRMEARGQVERLPHESDRRITLVRITRKGLKAVEHLMELAREHERRVLEPFGLRRAEELKQTLRQMIDLHVH