1aod A 2.6 BS01 INS A 1 H45 R84 R124 K126 D204 Y206 H25 R64 R104 K106 D184 Y186 H45 D46 R84 H93 D278 H25 D26 R64 H73 D258 4.6.1.13 0004436,0005576,0005737,0006629,0008081,0016042,0016829 P34024 9367761 296 VTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDITWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLNIYHGPIFLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKF 1g0i A 2.4 BS05 INS A 1 R168 R170 R168 R170 E65 D81 I83 D84 D201 E65 D81 I83 D84 D201 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 Q57573 11170378 594 MKWDEIGKNIAKEIEKEILPYFGRKDKSYVVGTSPSGDETEIFDKISEDIALKYLKSLNVNIVSEELGVIDNSSEWTVVIDPIDGSFNFINGIPFFAFCFGVFKNNEPYYGLTYEFLTKSFYEAYKGKGAYLNGRKIKVKDFNPNNIVISYYPSKKIDLEKLRNKVKRVRIFGAFGLEMCYVAKGTLDAVFDVRPKVRAVDIASSYIICKEAGALITDENGDELKFDLNATDRLNIIVANSKEMLDIILDLL 1g0i B 2.4 BS05 INS B 1 R468 R470 R168 R170 E365 D381 I383 D384 S386 D501 E65 D81 I83 D84 S86 D201 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 Q57573 11170378 294 MKWDEIGKNIAKEIEKEILPYFGRKDKSYVVGTSPSGDETEIFDKISEDIALKYLKSLNVNIVSEELGVIDNSSEWTVVIDPIDGSFNFINGIPFFAFCFGVFKNNEPYYGLTYEFLTKSFYEAYKGKGAYLNGRKIKVKDFNPNNIVISYYPSKKIDLEKLRNKVKRVRIFGAFGLEMCYVAKGTLDAVFDVRPKVRAVDIASSYIICKEAGALITDENGDELKFDLNATDRLNIIVANSKEMLDIILDLL 1iev A 2.8 BS01 INS A 1 D95 R158 K206 H207 M250 Y253 D285 W286 M316 D95 R158 K206 H207 M250 Y253 D285 W286 M316 D285 E491 D285 E491 3.2.1.21 0004553,0005576,0005975,0016798 Q9XEI3 11709165 617 DYVLYKDATKPVEDRVADLLGRMTLAEKIGQMTQIERLVATPDVLRDNFIGSLLSGGGSVPRKGATAKEWQDMVDGFQKACMSTRLGIPMIYGIDAVHGQNNVYGATIFPHNVGLGATRDPYLVKRIGEATALEVRATGIQYAFAPCIAVCRDPRWGRCYESYSEDRRIVQSMTELIPGLQGDVPKDFTSGMPFVAGKNKVAACAKHFVGDGGTVDGINENNTIINREGLMNIHMPAYKNAMDKGVSTVMISYSSWNGVKMHANQDLVTGYLKDTLKFKGFVISDWEGIDRITTPAGSDYSYSVKASILAGLDMIMVPNKYQQFISILTGHVNGGVIPMSRIDDAVTRILRVKFTMGLFENPYADPAMAEQLGKQEHRDLAREAARKSLVLLKNGKTSTDAPLLPLPKKAPKILVAGSHADNLGYQCGGWTIEWQGDTGRTTVGTTILEAVKAAVDPSTVVVFAENPDAEFVKSGGFSYAIVAVGEHPYTETKGDNLNLTIPEPGLSTVQAVCGGVRCATVLISGRPVVVQPLLAASDALVAAWLPGSEGQGVTDALFGDFGFTGRLPRTWFKSVDQLPMNVGDAHYDPLFRLGYGLTTNAT 1ptg A 2.6 BS01 INS A 1 R69 R163 D198 Y200 R69 R163 D198 Y200 H32 D33 R69 H82 D274 H32 D33 R69 H82 D274 4.6.1.13 0004436,0005576,0006629,0008081,0016042,0016829 P14262 7664726 801 ASSVNELENWSKWMQPIPDSIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLI 1y7v A 2.4 BS01 INS A 1 D127 F128 W179 N234 F246 Y313 E340 C342 W381 D127 F128 W179 N234 F246 Y313 E340 C342 W381 E235 E340 C342 N370 E235 E340 C342 N370 2.4.1.-,3.2.1.-,3.2.1.45,3.2.1.46 0004336,0004348,0005102,0005124,0005515,0005615,0005764,0005765,0005783,0005794,0005802,0006665,0006678,0006680,0006914,0007005,0007040,0007417,0008203,0008340,0008422,0009267,0009268,0014004,0016020,0016241,0016757,0016787,0016798,0019882,0019915,0021694,0021859,0022904,0023021,0030259,0031175,0031333,0032006,0032436,0032715,0033077,0033574,0035307,0042391,0043161,0043202,0043243,0043407,0043524,0043627,0046512,0046513,0046527,0048469,0048854,0048872,0050295,0050728,0050877,0050905,0051246,0051248,0051402,0061436,0061518,0061744,0070062,0071356,0071425,0071548,0072676,0097066,0098773,1901805,1903052,1903061,1904457,1904925,1905037,1905165 P04062 15817452 507 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 1y7v B 2.4 BS01 INS B 1 D127 F128 W179 N234 F246 Y313 E340 C342 W381 D127 F128 W179 N234 F246 Y313 E340 C342 W381 E235 E340 C342 N370 E235 E340 C342 N370 2.4.1.-,3.2.1.-,3.2.1.45,3.2.1.46 0004336,0004348,0005102,0005124,0005515,0005615,0005764,0005765,0005783,0005794,0005802,0006665,0006678,0006680,0006914,0007005,0007040,0007417,0008203,0008340,0008422,0009267,0009268,0014004,0016020,0016241,0016757,0016787,0016798,0019882,0019915,0021694,0021859,0022904,0023021,0030259,0031175,0031333,0032006,0032436,0032715,0033077,0033574,0035307,0042391,0043161,0043202,0043243,0043407,0043524,0043627,0046512,0046513,0046527,0048469,0048854,0048872,0050295,0050728,0050877,0050905,0051246,0051248,0051402,0061436,0061518,0061744,0070062,0071356,0071425,0071548,0072676,0097066,0098773,1901805,1903052,1903061,1904457,1904925,1905037,1905165 P04062 15817452 506 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 2huo A 2.0 BS04 INS A 1 D85 S87 D88 D124 K127 G141 D142 H194 H220 S221 D58 S60 D61 D97 K100 G114 D115 H167 H193 S194 1.13.99.1 0004033,0005506,0005737,0008199,0016234,0016491,0016651,0019310,0046872,0050113 Q9QXN5 17012379 303 FRNYTSGPLLDRVFTTYKLMHTHQTVDFVSRKRIQYGSFSYKKMTIMEAVGMLDDLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVGLLHDLGKIMALWGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELGMYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMIRFHSFYPWHTGGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPDVESLRPYYQGLIDKYCPGTLSW 2os9 A 1.7 BS04 INS A 1 E321 N323 E329 N341 R343 E117 N119 E125 N137 R139 ? -logKd/Ki=2.24, IC50=5.7mM P35247 17417879 631 ASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 2os9 B 1.7 BS04 INS B 1 E321 N323 E329 N341 R343 E117 N119 E125 N137 R139 ? P35247 17417879 632 ASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 2os9 C 1.7 BS04 INS C 1 E321 N323 E329 N341 R343 E116 N118 E124 N136 R138 ? P35247 17417879 633 SLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF 2r71 A 2.07 BS03 INS A 1 G653 P655 E659 G312 P314 E318 3.4.21.- 0005576 P24627 787 YTRVVWCAVGPEEQKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADALNLDGGYIYTAGKCGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKKANEGLTWNSLKDKKSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSCAPGADPKSRLCALCAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVAFVKNDTVWENTNGESTADWAKNLKREDFRLLCLDGTRKPVTEAQSCHLAVAPNHAVVSRSDRAAHVEQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLFNDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSLEACAF 2r71 A 2.07 BS04 INS A 2 D378 T401 D462 D37 T60 D121 3.4.21.- 0005576 P24627 788 YTRVVWCAVGPEEQKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADALNLDGGYIYTAGKCGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKKANEGLTWNSLKDKKSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSCAPGADPKSRLCALCAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVAFVKNDTVWENTNGESTADWAKNLKREDFRLLCLDGTRKPVTEAQSCHLAVAPNHAVVSRSDRAAHVEQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLFNDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSLEACAF 2x1i A 2.36 BS01 INS A 1 C5 R42 C2 R39 D293 E340 D395 D290 E337 D392 2.4.1.25 0004134,0005975,0016757 Q2VJA0 21117235 1503 PCAYGLLLHPTSLPGPWGVGVLGEEARGFLRFLKEAGARYWQVLPLGPTGYGDSPYQSFSAFAGNPYLIDLRPLVDRGFVRLEDPGFPEGRVDYGLLYAWKWPALRAAFQGFRQKASPEEKEDFARFQEEEAWWLRDYALFMTLKSHHGGLPWNAWPLALRTREERALKEAEASLAEEIAFHAFTQWLFFRQWGALKEEAEALGIAFIGDMPIFVAEDSAEVWAHPEWFHLDEEGRPTVVAGVPPDYFSETGQRWGNPLYRWEVLEEEGFSFWIARLRKALELFHLVRIDHFRGFEAYWEIPASCPTAVEGRWVKAPGEKLFARIQEAFGRIPILAEDLGVITPEVEALRDRFGLPGMKVLQFAFDNGMENPFLPHNYPEHGRVVVYTGTHDNDTTLGWYRTATPHERDFLKRYLADWGITFREEAEVPWALMRLGMASRARLAVYPVQDVLALGSEARMNYPGRPSGNWAWRLRPGEIKEEHGERLLSLAEATGRV 2x1i A 2.36 BS02 INS A 2 E27 R30 R34 E24 R27 R31 D293 E340 D395 D290 E337 D392 2.4.1.25 0004134,0005975,0016757 Q2VJA0 21117235 1504 PCAYGLLLHPTSLPGPWGVGVLGEEARGFLRFLKEAGARYWQVLPLGPTGYGDSPYQSFSAFAGNPYLIDLRPLVDRGFVRLEDPGFPEGRVDYGLLYAWKWPALRAAFQGFRQKASPEEKEDFARFQEEEAWWLRDYALFMTLKSHHGGLPWNAWPLALRTREERALKEAEASLAEEIAFHAFTQWLFFRQWGALKEEAEALGIAFIGDMPIFVAEDSAEVWAHPEWFHLDEEGRPTVVAGVPPDYFSETGQRWGNPLYRWEVLEEEGFSFWIARLRKALELFHLVRIDHFRGFEAYWEIPASCPTAVEGRWVKAPGEKLFARIQEAFGRIPILAEDLGVITPEVEALRDRFGLPGMKVLQFAFDNGMENPFLPHNYPEHGRVVVYTGTHDNDTTLGWYRTATPHERDFLKRYLADWGITFREEAEVPWALMRLGMASRARLAVYPVQDVLALGSEARMNYPGRPSGNWAWRLRPGEIKEEHGERLLSLAEATGRV 3bxd A 2.0 BS03 INS A 1 D85 S87 D88 D124 K127 G141 D142 H194 H220 S221 Y223 D58 S60 D61 D97 K100 G114 D115 H167 H193 S194 Y196 1.13.99.1 0004033,0005506,0005737,0008199,0016234,0016491,0016651,0019310,0046872,0050113 Ki=62uM Q9QXN5 18364358 303 FRNYTSGPLLDRVFTTYKLMHTHQTVDFVSRKRIQYGSFSYKKMTIMEAVGMLDDLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVGLLHDLGKIMALWGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELGMYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMIRFHSFYPWHTGGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPDVESLRPYYQGLIDKYCPGTLSW 3ea2 A 1.95 BS01 INS A 1 H32 R69 R163 D198 Y200 H32 R69 R163 D198 Y200 H32 D33 R69 H82 D274 H32 D33 R69 H82 D274 4.6.1.13 0004436,0005576,0006629,0008081,0016042,0016829 P08954 19369255 801 ASSVNELENWSKWMQPIPDNIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEGSFSSTFEKNYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNESGGYNNFYWPDNETFTTTVNQNVNVTVQDKYKVNYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYSYASSINPEIANDIKQKNPTRVGWVIQDYINEKWSPLLYQEVIRANKSLI 3ea2 B 1.95 BS01 INS B 1 H32 R69 R163 D198 Y200 H32 R69 R163 D198 Y200 H32 D33 R69 H82 D274 H32 D33 R69 H82 D274 4.6.1.13 0004436,0005576,0006629,0008081,0016042,0016829 P08954 19369255 802 ASSVNELENWSKWMQPIPDNIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEGSFSSTFEKNYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNESGGYNNFYWPDNETFTTTVNQNVNVTVQDKYKVNYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYSYASSINPEIANDIKQKNPTRVGWVIQDYINEKWSPLLYQEVIRANKSLI 3nt4 A 2.5001 BS02 INS A 1 H155 H176 Y235 W272 H155 H176 Y235 W272 K97 H176 K97 H176 1.1.1.18,1.1.1.369 0000166,0016491,0019310,0050112 P26935 20809899 801 MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKVVEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATTAEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTVGDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETKGGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRFVAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPEFYQ 3nt4 B 2.5001 BS02 INS B 1 H155 H176 W272 H155 H176 W272 K97 H176 K97 H176 1.1.1.18,1.1.1.369 0000166,0016491,0019310,0050112 P26935 20809899 802 MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKVVEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATTAEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTVGDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETKGGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRFVAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPEFYQ 3ntr A 2.6503 BS02 INS A 1 T173 H176 T173 H176 V97 H176 V97 H176 1.1.1.18,1.1.1.369 0000166,0016491,0019310,0050112 P26935 20809899 801 MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKVVEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEVPLATTAEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTVGDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETKGGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRFVAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPEFYQ 3ntr B 2.6503 BS02 INS B 1 N157 T173 N157 T173 V97 H176 V97 H176 1.1.1.18,1.1.1.369 0000166,0016491,0019310,0050112 P26935 20809899 802 MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKVVEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEVPLATTAEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTVGDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETKGGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRFVAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPEFYQ 3v16 A 2.05 BS01 INS A 1 R67 R166 D206 Y208 R67 R166 D206 Y208 H30 D31 R67 H80 D281 H30 D31 R67 H80 D281 4.6.1.13 0006629,0008081 P45723 22390775 401 SDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKL 3v1h A 1.9 BS01 INS A 1 H30 R67 K113 R166 D206 Y208 H28 R65 K111 R164 D204 Y206 H30 D31 R67 H80 D281 H28 D29 R65 H78 D279 4.6.1.13 0006629,0008081 P45723 22390775 401 SLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASYINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKLEHHHH 4f2b A 2.16 BS01 INS A 1 H30 R67 K113 R166 D206 Y208 F239 H29 R66 K112 R165 D205 Y207 F238 H30 D31 R67 H80 D281 H29 D30 R66 H79 D280 4.6.1.13 0006629,0008081 P45723 23038258 401 DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKLEH 4f2b B 2.16 BS01 INS B 1 H30 R67 K113 D206 H29 R66 K112 D205 H30 D31 R67 H80 D281 H29 D30 R66 H79 D280 4.6.1.13 0006629,0008081 P45723 23038258 401 DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKL 4i9t A 2.0 BS01 INS A 1 H30 R67 R166 D206 Y208 H30 R67 R166 D206 Y208 H30 D31 R67 H80 D281 H30 D31 R67 H80 D281 4.6.1.13 0006629,0008081 P45723 23576432 502 SDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASYINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKLEH 4i9t A 2.0 BS02 INS A 2 Y285 T286 Y285 T286 H30 D31 R67 H80 D281 H30 D31 R67 H80 D281 4.6.1.13 0006629,0008081 P45723 23576432 503 SDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASYINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKLEH 4irx A 1.451 BS01 INS A 1 Q49 F51 D125 R126 N168 D169 S174 R178 S203 N231 D258 Q278 Q20 F22 D96 R97 N139 D140 S145 R149 S174 N202 D229 Q249 ? Kd=0.76uM -logKd/Ki=6.12, Kd=0.76uM A0A0H3C834 23504019 401 GLVPRGSHMEVVVSFNDLSQPFFVAMRRELEDEAAKLGVKVQVLDAQNNSSKQISDLQAAAVQGAKVVIVAPTDSKALAGAADDLVEQGVAVISVDRNIAGGKTAVPHVGADNVAGGRAMADWVVKTYPAGARVVVITNDPGSSSSIERVKGVHDGLAAGGPAFKIVTEQTANSKRDQALTVTQNILTSMRDTPPDVILCLNDDMAMGALEAVRAAGLDSAKVKVIGFDAIPEALARIKAGEMVATVEQNPGLQIRTALRQAVDKIKSGAALKSVSLKPVLITSGNLTEASRIGEM 4irx B 1.451 BS01 INS B 1 Q49 F51 D125 R126 N168 D169 S174 R178 S203 N231 D258 Q278 Q20 F22 D96 R97 N139 D140 S145 R149 S174 N202 D229 Q249 ? Kd=0.76uM A0A0H3C834 23504019 401 GLVPRGSHMEVVVSFNDLSQPFFVAMRRELEDEAAKLGVKVQVLDAQNNSSKQISDLQAAAVQGAKVVIVAPTDSKALAGAADDLVEQGVAVISVDRNIAGGKTAVPHVGADNVAGGRAMADWVVKTYPAGARVVVITNDPGSSSSIERVKGVHDGLAAGGPAFKIVTEQTANSKRDQALTVTQNILTSMRDTPPDVILCLNDDMAMGALEAVRAAGLDSAKVKVIGFDAIPEALARIKAGEMVATVEQNPGLQIRTALRQAVDKIKSGAALKSVSLKPVLITSGNLTEASRIGEM 4mio D 1.5 BS02 INS D 1 K97 H155 N157 D172 T173 H176 Y236 K97 H155 N157 D172 T173 H176 Y236 K97 K97 1.1.1.18,1.1.1.369 0000166,0016491,0019310,0050112 A0A0J9X1Y2 402 MVVKVGVIGTGAMGRAHIDRLTNVLTGAEVVAVTDIDHEAAEAAVRDFHLNAKVYPDDTSLLQDPDIDAVFVVSFGGAHEATVLKALDTDKFIFTEKPLATTLEGAKRIVDKELTKSKKVIQVGFMRRYDQGIRALKEKLDTGIIGAPLVVRASHINPNVASNYSNEMAITDTLIHEIDEMHWLLDDEYTSIQITYPRQSAEVRNEGLHDPQLATLTTKKGTVIQVLVHVTAQYGYEVKLEVIGETGELQLPNYGLGPILRSNANQQTAVEMSWINRFIQAYNTEVQEFIDEVAKSEPPVGPSAWDGYIAAITAAAANRSQKDQETVLINVAGTPTFYQ 4miy D 1.42 BS02 INS D 1 K97 H155 N157 D172 T173 H176 Y236 K97 H155 N157 D172 T173 H176 Y236 K97 K97 1.1.1.18,1.1.1.369 0000166,0016491,0019310,0050112 A0A0J9X1Y2 402 MVVKVGVIGTGAMGRAHIDRLTNVLTGAEVVAVTDIDHEAAEAAVRDFHLNAKVYPDDTSLLQDPDIDAVFVVSFGGAHEATVLKALDTDKFIFTEKPLATTLEGAKRIVDKELTKSKKVIQVGFMRRYDQGIRALKEKLDTGIIGAPLVVRASHINPNVASNYSNEMAITDTLIHEIDEMHWLLDDEYTSIQITYPRQSAEVRNEGLHDPQLATLTTKKGTVIQVLVHVTAQYGYEVKLEVIGETGELQLPNYGLGPILRSNANQQTAVEMSWINRFIQAYNTEVQEFIDEVAKSEPPVGPSAWDGYIAAITAAAANRSQKDQETVLINVAGTPTFYQ 4ru1 A 1.5 BS01 INS A 1 H57 D62 W65 N137 Q180 Q186 R190 L235 D260 Q280 H12 D17 W20 N92 Q135 Q141 R145 L190 D215 Q235 ? 0030246,0030288 A0LVW8 401 NTPHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 B 1.5 BS01 INS B 1 H57 D62 W65 N137 Q180 Q186 R190 L235 D260 Q280 H12 D17 W20 N92 Q135 Q141 R145 L190 D215 Q235 ? 0030246,0030288 A0LVW8 401 NTPHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 C 1.5 BS01 INS C 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 402 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 D 1.5 BS01 INS D 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H11 D16 W19 N91 Q134 R144 L189 D214 Q234 ? 0030246,0030288 A0LVW8 401 TPHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 E 1.5 BS01 INS E 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 402 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 F 1.5 BS01 INS F 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 G 1.5 BS01 INS G 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 H 1.5 BS01 INS H 1 H57 D62 W65 N137 Q180 Q186 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 Q139 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 I 1.5 BS01 INS I 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 J 1.5 BS01 INS J 1 H57 D62 W65 N137 Q180 Q186 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 Q139 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 K 1.5 BS01 INS K 1 H57 D62 W65 N137 Q180 Q186 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 Q139 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4ru1 L 1.5 BS01 INS L 1 H57 D62 W65 N137 Q180 R190 L235 D260 Q280 H10 D15 W18 N90 Q133 R143 L188 D213 Q233 ? 0030246,0030288 A0LVW8 401 PHLTIAMITHQQPGDTFWDIIRKGALAAAAKDNVTLKYSNDPDSTKEAVLIQDAVNAKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQWKESGALMYFGQDETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQYTKLYVNGADQPSVRTTIAAKLKQDPSIDLVITLGAPIAQLAIQAVKDAGSNAKIATFDFNTQVPAEIENGQLQWAIDQQPYVEGYEAVDSLWLYITNGDTIGGGEAVKTGPFFVDKSNVAAVAKFAERGTR 4rv3 A 2.0 BS01 INS A 1 H30 R67 R166 D206 H29 R66 R165 D205 H30 D31 R67 H80 D281 H29 D30 R66 H79 D280 4.6.1.13 0006629,0008081 P45723 26092728 402 DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASFINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNKL 4rxm A 1.75 BS01 INS A 1 E39 D112 R113 S160 R164 W189 N216 D243 Q263 E19 D92 R93 S140 R144 W169 N196 D223 Q243 401 SMKDELVVFSLPNLSSPFEVQLQKVAVETSKKLEIKLQVLDGQSSSTKQASDLENAITRGAKGIIISPNDVNAISGAVEEIIKEKIPAATLDRKVESSKPVPHFGANNYTGGQEVAKAVKAKYPNGAKIILLTGQPGSTSNIERTKGIRDELAAGGDKYKIVVDQTGNWLRSEGLRIIESVLPTLKEKPEVIISANDDMALGAIEALRSQGLKAGDILVTGFDSTPEALARVKDGWLYLTADQRPSFAVSTALEQVVGNIRESKEVSGADYPPKIILKDNLQEAERFAEIS 4rxm B 1.75 BS01 INS B 1 E39 D112 R113 S160 R164 W189 N216 D243 Q263 E17 D90 R91 S138 R142 W167 N194 D221 Q241 401 KDELVVFSLPNLSSPFEVQLQKVAVETSKKLEIKLQVLDGQSSSTKQASDLENAITRGAKGIIISPNDVNAISGAVEEIIKEKIPAATLDRKVESSKPVPHFGANNYTGGQEVAKAVKAKYPNGAKIILLTGQPGSTSNIERTKGIRDELAAGGDKYKIVVDQTGNWLRSEGLRIIESVLPTLKEKPEVIISANDDMALGAIEALRSQGLKAGDILVTGFDSTPEALARVKDGWLYLTADQRPSFAVSTALEQVVGNIRESKEVSGADYPPKIILKDNLQEAERFAEI 4s3g A 2.5 BS01 INS A 1 H30 R67 R166 D206 Y208 H29 R66 R165 D205 Y207 H30 D31 R67 H80 D281 H29 D30 R66 H79 D280 4.6.1.13 0006629,0008081 P45723 26092728 401 DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNK 4wre A 1.751 BS03 INS A 1 E195 N197 E202 N214 R216 E103 N105 E110 N122 R124 ? P08427 28719181 403 QTELYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIKEMCTRAGGNIAVPRTPEENEAIASIAKKYNNYVYLGMIDDFHYLDGASVSYTNWYPGEPNGQGKEDCVEMYTDGTWNDRGCLQYRLAVCEF 4wuw A 2.398 BS01 INS A 1 E195 E202 N214 D215 E111 E118 N130 D131 ? P08427 28719181 501 EELQTELYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIKEMCTRAGGNIAVPRTPEENEAIASIAKKYNNYVYLGMIDDQTEGDFHYLDGASVSYTNWYPGEPRGQGKEDCVEMYTDGTWNDRGCLQYRLAVCEF 4xf6 A 2.08 BS03 INS A 1 D12 G25 G26 Y30 Y75 V112 Q136 R140 D219 D12 G25 G26 Y30 Y75 V112 Q136 R140 D219 2.7.1.64 0000166,0016301,0016310 Q5JDA3 25972008 303 MKCLVVGHVVRDIVKKGNKVLERLGGGAYYSALALSRFCDVEILTSFSNLPEEWIKELESMAKLQVVPSETTTTYELTYLDGNRRRLKLLERASPIEELPDGEYDVLLMNPVAREVPPALVTSALKKFPFVAVDIQGFIRSSSPGEIQYQPIDGSFLKGVKILHADLGEYQYLQGFSPEFVDVLLLSNGPEPGKAFLHGREYTFEPVHVGVDESTGAGDVFLGAFTGFYSQCPFVQALKRAAAFTALFLKNRSVDFSMDDVNELAMKVEVKRV 4xf6 B 2.08 BS03 INS B 1 D12 G26 Y75 L77 Q136 R140 T215 D219 D12 G26 Y75 L77 Q136 R140 T215 D219 2.7.1.64 0000166,0016301,0016310 Q5JDA3 25972008 303 MKCLVVGHVVRDIVKKGNKVLERLGGGAYYSALALSRFCDVEILTSFSNLPEEWIKELESMAKLQVVPSETTTTYELTYLDGNRRRLKLLERASPIEELPDGEYDVLLMNPVAREVPPALVTSALKKFPFVAVDIQGFIRSSSPGEIQYQPIDGSFLKGVKILHADLGEYQYLQGFSPEFVDVLLLSNGPEPGKAFLHGREYTFEPVHVGVDESTGAGDVFLGAFTGFYSQCPFVQALKRAAAFTALFLKNRSVDFSMDDVNELAMKVEVKRV 4xf7 A 1.93 BS01 INS A 1 D12 G25 G26 Y30 Y75 Q136 R140 D219 D12 G25 G26 Y30 Y75 Q136 R140 D219 2.7.1.64 0000166,0016301,0016310 Q5JDA3 25972008 301 MKCLVVGHVVRDIVKKGNKVLERLGGGAYYSALALSRFCDVEILTSFSNLPEEWIKELESMAKLQVVPSETTTTYELTYLDGNRRRLKLLERASPIEELPDGEYDVLLMNPVAREVPPALVTSALKKFPFVAVDIQGFIRSSSPGEIQYQPIDGSFLKGVKILHADLGEYQYLQGFSPEFVDVLLLSNGPEPGKAFLHGREYTFEPVHVGVDESTGAGDVFLGAFTGFYSQCPFVQALKRAAAFTALFLKNRSVDFSMDDVNELAMKVEVKRV 4xf7 B 1.93 BS01 INS B 1 D12 G25 G26 Y30 Y75 Q136 R140 D219 D12 G25 G26 Y30 Y75 Q136 R140 D219 2.7.1.64 0000166,0016301,0016310 Q5JDA3 25972008 301 MKCLVVGHVVRDIVKKGNKVLERLGGGAYYSALALSRFCDVEILTSFSNLPEEWIKELESMAKLQVVPSETTTTYELTYLDGNRRRLKLLERASPIEELPDGEYDVLLMNPVAREVPPALVTSALKKFPFVAVDIQGFIRSSSPGEIQYQPIDGSFLKGVKILHADLGEYQYLQGFSPEFVDVLLLSNGPEPGKAFLHGREYTFEPVHVGVDESTGAGDVFLGAFTGFYSQCPFVQALKRAAAFTALFLKNRSVDFSMDDVNELAMKVEVKRV 4yo7 A 1.7 BS02 INS A 1 D53 N130 R131 R183 N233 D259 Q279 D17 N94 R95 R147 N197 D223 Q243 ? 0030246,0046872 Q9KAG4 405 TGDSGQKVIGVSISNLDEFLTYMQDAMKEEAANYPDFEFIFSDAQNDSTQQMAQVENFISRNVDAIIVNPVDTTSAVDIVNMVNDAGIPIIIANRTFDGVDQATAFVGSESIQSGLLQMEEVAKLLNNEGNIAIMDGELGHEAQIMRTEGNKQIIEEHDGLEVVLQGTAKFDRSEGMRLMENWLNSGTEIDAVVANNDEMALGAILALEAVGKLDDVIVAGIDATPAALEAMKEGKLDVTVFQDAKGQGATSVKVAVQAANGEDVEDAMIPYELVTPENVEEYEAKY 5fyr A 1.45 BS01 INS A 1 H26 E48 D119 N189 R260 W262 H25 E47 D110 N180 R251 W253 ? 0006629,0008081,0046872 A0A1S4NYD4 28045383 301 QESPAFIDPASWNTPFNGIAQVACHNCYEKQYANTFSSVLDSVRTLELDFWDQRDAVSGGSPHHWFVRHNPGGNDNNCTGGKNDLEACLNDVKNWSDKHPGHFPITLILDKKQGWSKESSGRTPKDFDELVARVFQGKLFTPQDLATHIGSGAGALQGNLKGKSWPTANDLQGKVLLVLNHSENQKLSQYAEARTSKAKVFISPVTNGQNDISGKVSGMSSQSSGYVAMNNMGKGDKSWAKQAFAYSHIGRVWGDDEVSFAQHINQKINLSAYYRFAAQSAGGYRIRPF 5fyr B 1.45 BS01 INS B 1 H26 E48 D119 N189 R260 W262 H25 E47 D110 N180 R251 W253 ? 0006629,0008081,0046872 A0A1S4NYD4 28045383 301 QESPAFIDPASWNTPFNGIAQVACHNCYEKQYANTFSSVLDSVRTLELDFWDQRDAVSGGSPHHWFVRHNPGSGNDNNCTGKNDLEACLNDVKNWSDKHPGHFPITLILDKKQGWSKESSGRTPKDFDELVARVFQGKLFTPQDLATHIGSGAGALQGNLKGKSWPTANDLQGKVLLVLNHSENQKLSQYAEARTSKAKVFISPVTNGQNDISGKVSGMSSQSSGYVAMNNMGKGDKSWAKQAFAYSHIGRVWGDDEVSFAQHINQKINLSAYYRFAAQSAGGYRIRPF 5fyr C 1.45 BS01 INS C 1 H26 E48 D119 N189 R260 W262 H25 E47 D116 N186 R257 W259 ? 0006629,0008081,0046872 A0A1S4NYD4 28045383 301 QESPAFIDPASWNTPFNGIAQVACHNCYEKQYANTFSSVLDSVRTLELDFWDQRDAVSGGSPHHWFVRHNPGTQSGNDNNCTGDGTGKNDLEACLNDVKNWSDKHPGHFPITLILDKKQGWSKESSGRTPKDFDELVARVFQGKLFTPQDLATHIGSGAGALQGNLKGKSWPTANDLQGKVLLVLNHSENQKLSQYAEARTSKAKVFISPVTNGQNDISGKVSGMSSQSSGYVAMNNMGKGDKSWAKQAFAYSHIGRVWGDDEVSFAQHINQKINLSAYYRFAAQSAGGYRIRPF 5fyr D 1.45 BS01 INS D 1 H26 E48 D119 N189 R260 W262 H25 E47 D118 N188 R259 W261 ? 0006629,0008081,0046872 A0A1S4NYD4 28045383 301 QESPAFIDPASWNTPFNGIAQVACHNCYEKQYANTFSSVLDSVRTLELDFWDQRDAVSGGSPHHWFVRHNPGTLFQSGNDNNCTGDGTGKNDLEACLNDVKNWSDKHPGHFPITLILDKKQGWSKESSGRTPKDFDELVARVFQGKLFTPQDLATHIGSGAGALQGNLKGKSWPTANDLQGKVLLVLNHSENQKLSQYAEARTSKAKVFISPVTNGQNDISGKVSGMSSQSSGYVAMNNMGKGDKSWAKQAFAYSHIGRVWGDDEVSFAQHINQKINLSAYYRFAAQSAGGYRIRPF 5ya8 A 2.3 BS02 INS A 1 K106 Y135 Y163 E165 R178 D191 H195 K100 Y129 Y157 E159 R172 D185 H189 ? 0000166 K7ZP76 29799855 402 ALGVALIGTGFMGKCHAMAWRNVATAFGGLPPRLEVLADMPADKAHSLASSFGFARGTADWREAVSDPAVDVVSITTPNGLHREMAEAALAAGKHVWLEKPMALSVEDAQAMEAAARASDRRTIIGYNYTRSPAFRAAVDLIAEGAIGRPIHFRGMYDEDYMADPDLPWSWRLTRKDGGLGALGDLGCHLVSVMVSLMGPVARVYAQADTVITDRPHQGGTARVENEDQAQALIRFASGTSGEFSCSRVARGYRCRLAWEVQGTEGTLRFDQERMNELWLYQPGRPEIDGFRRILTGPAQPGFAAFCPGGGHNFGFNEQKVVEAEMLRQAIAGRGKAWPDFTDGLTIERVIHGMATSAQTGQPVNF 5ya8 B 2.3 BS02 INS B 1 K106 Y135 Y163 E165 R178 D191 H195 K100 Y129 Y157 E159 R172 D185 H189 ? 0000166 K7ZP76 29799855 402 ALGVALIGTGFMGKCHAMAWRNVATAFGGLPPRLEVLADMPADKAHSLASSFGFARGTADWREAVSDPAVDVVSITTPNGLHREMAEAALAAGKHVWLEKPMALSVEDAQAMEAAARASDRRTIIGYNYTRSPAFRAAVDLIAEGAIGRPIHFRGMYDEDYMADPDLPWSWRLTRKDGGLGALGDLGCHLVSVMVSLMGPVARVYAQADTVITDRPHQGGTARVENEDQAQALIRFASGTSGEFSCSRVARGYRCRLAWEVQGTEGTLRFDQERMNELWLYQPGRPEIDGFRRILTGPAQPGFAAFCPGGGHNFGFNEQKVVEAEMLRQAIAGRGKAWPDFTDGLTIERVIHGMATSAQTGQPVNF 5ya8 D 2.3 BS02 INS D 1 K106 Y135 Y163 E165 R178 D191 L192 H195 K100 Y129 Y157 E159 R171 D184 L185 H188 ? 0000166 K7ZP76 29799855 402 ALGVALIGTGFMGKCHAMAWRNVATAFGGLPPRLEVLADMPADKAHSLASSFGFARGTADWREAVSDPAVDVVSITTPNGLHREMAEAALAAGKHVWLEKPMALSVEDAQAMEAAARASDRRTIIGYNYTRSPAFRAAVDLIAEGAIGRPIHFRGMYDEDYMADPDPWSWRLTRKDGGLGALGDLGCHLVSVMVSLMGPVARVYAQADTVITDRPHQGGTARVENEDQAQALIRFASGTSGEFSCSRVARGYRCRLAWEVQGTEGTLRFDQERMNELWLYQPGRPEIDGFRRILTGPAQPGFAAFCPGGGHNFGFNEQKVVEAEMLRQAIAGRGKAWPDFTDGLTIERVIHGMATSAQTGQPVNF 5ysp A 1.7 BS01 INS A 1 D11 G25 I76 N78 Q141 R145 D11 G25 I76 N78 Q135 R139 ? Q9WYP6 29720581 301 MITFIGHVSKDVNVVDGKREIAYGGGVVMGAITSSLLGVKTKVITKCTREDVSKFSFLRDNGVEVVFLKSPRTTSIENRYRESFLISAADPFTESDLAFIEGEAVHINPLWYGEFPEDLIPVLRRKVMFLSADAQGFVRVPENEKLVYRDWEMKEKYLKYLDLFKVDSREAETLTGTNDLRESCRIIRSFGAKIILATHASGVIVFDGNFYEASFRSWSLEGRTGRGDTCTAAFLVGFVFKKMSIEKATKFAAAVTSVKMRHPGPLRREDLEAI 5ysp B 1.7 BS01 INS B 1 D11 G25 I76 N78 Q141 R145 D11 G25 I76 N78 Q136 R140 ? Q9WYP6 29720581 301 MITFIGHVSKDVNVVDGKREIAYGGGVVMGAITSSLLGVKTKVITKCTREDVSKFSFLRDNGVEVVFLKSPRTTSIENRYTRESFLISAADPFTESDLAFIEGEAVHINPLWYGEFPEDLIPVLRRKVMFLSADAQGFVRVPENEKLVYRDWEMKEKYLKYLDLFKVDSREAETLTGTNDLRESCRIIRSFGAKIILATHASGVIVFDGNFYEASFRSWSLEGRTGRGDTCTAAFLVGFVFKKMSIEKATKFAAAVTSVKMRHPGPLRREDLEAI 5ysq A 1.47 BS01 INS A 1 D11 G25 I76 N78 Q141 R145 D11 G25 I76 N78 Q135 R139 ? Q9WYP6 29720581 301 MITFIGHVSKDVNVVDGKREIAYGGGVVMGAITSSLLGVKTKVITKCTREDVSKFSFLRDNGVEVVFLKSPRTTSIENRYRESFLISAADPFTESDLAFIEGEAVHINPLWYGEFPEDLIPVLRRKVMFLSADAQGFVRVPENEKLVYRDWEMKEKYLKYLDLFKVDSREAETLTGTNDLRESCRIIRSFGAKIILATHASGVIVFDGNFYEASFRSWSLEGRTGRGDTCTAAFLVGFVFKKMSIEKATKFAAAVTSVKMRHPGPLRREDLEAISGDQY 5ysq B 1.47 BS01 INS B 1 D11 G25 G26 I76 N78 L116 Q141 R145 D11 G25 G26 I76 N78 L116 Q141 R145 ? Q9WYP6 29720581 301 MITFIGHVSKDVNVVDGKREIAYGGGVVMGAITSSLLGVKTKVITKCTREDVSKFSFLRDNGVEVVFLKSPRTTSIENRYGSDPDTRESFLISAADPFTESDLAFIEGEAVHINPLWYGEFPEDLIPVLRRKVMFLSADAQGFVRVPENEKLVYRDWEMKEKYLKYLDLFKVDSREAETLTGTNDLRESCRIIRSFGAKIILATHASGVIVFDGNFYEASFRSWSLEGRTGRGDTCTAAFLVGFVFKKMSIEKATKFAAAVTSVKMRHPGPLRREDLEAI 6b5z A 2.3 BS04 INS A 1 D85 Y155 G170 S171 A172 D200 D85 Y155 G170 S171 A172 D200 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 308 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b5z B 2.3 BS05 INS B 1 D85 Y155 G170 S171 A172 R191 D200 D85 Y155 G170 S171 A172 R191 D200 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 306 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6ktl D 1.65 BS02 INS D 1 K106 Y163 E165 D191 H195 K101 Y158 E160 D186 H190 ? 0000166 K7ZP76 31842701 402 KALGVALIGTGFMGKCHAMAWRNVATAFGGLPPRLEVLADMPADKAHSLASSFGFARGTADWREAVSDPAVDVVSITTPNGLHREMAEAALAAGKHVWLEKPMALSVEDAQAMEAAARASDRRTIIGYNYTRSPAFRAAVDLIAEGAIGRPIHFRGMYDEDYMADPDLPWSWALTRKDGGLGALGDLGCHLVSVMVSLMGPVARVYAQADTVITDRPHQGGTARVENEDQAQALIRFASGTSGEFSCSRVARGYRCRLAWEVQGTEGTLRFDQERMNELWLYQPGRPEIDGFRRILTGPAQPGFAAFCPGGGHNFGFNEQKVVEAEMLRQAIAGRGKAWPDFTDGLTIERVIHGMATSAQTGQPVNFL 6s2a A 2.7 BS01 INS A 1 R69 K115 R163 D198 Y200 R69 K115 R163 D198 Y200 H32 D33 R69 A82 D274 H32 D33 R69 A82 D274 4.6.1.13 0004436,0005576,0006629,0008081,0016042,0016829 P14262 301 TSSVNELENWSKWMQPIPDSIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHAGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLI 6s2a B 2.7 BS01 INS B 1 H32 R69 R163 D198 Y200 H32 R69 R163 D198 Y200 H32 D33 R69 A82 D274 H32 D33 R69 A82 D274 4.6.1.13 0004436,0005576,0006629,0008081,0016042,0016829 P14262 301 TSSVNELENWSKWMQPIPDSIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHAGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLI 6s2a C 2.7 BS01 INS C 1 H32 R69 R163 D198 Y200 H32 R69 R163 D198 Y200 H32 D33 R69 A82 D274 H32 D33 R69 A82 D274 4.6.1.13 0004436,0005576,0006629,0008081,0016042,0016829 P14262 301 TSSVNELENWSKWMQPIPDSIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHAGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLI 6x7z A 1.0 BS05 INS A 1 D110 D111 Q129 S130 Q156 G157 D159 D100 D101 Q119 S120 Q146 G147 D149 ? A1YIY3 33824212 1006 DSLFAGLVGEYYGTNSQLNNISDFRALVDSKEADATFEAANISYGRGSSDVAKGTHLQEFLGSDASTLSTDPGDNTDGGIYLQGYVYLEAGTYNFKVTADDGYEITINGNPVATVDNNQSVYTVTHASFTISESGYQAIDMIWWDQGGDYVFQPTLSADGGSTYFVLDSAILSSTGETPYT 7d5n B 1.8 BS02 INS B 1 K115 Y144 R191 D205 H209 K114 Y143 R190 D204 H208 ? 0000166 C1DLC3 502 INGSKRIAQPIRWAMVGGGRNSQIGYIHRSAALRDQSFALVAGAFDIDPGRGREFGVQLGVDPQRCYPDYRTLFEQEARRPDGIQAVSVATPNGTHFAITRAALEAGLHVVCEKPLCFTLEEAETLREIALANNRVVGVTYGYAGHQLIEQARAMIADGELGEIRMVHMQFAHGFHSAPVEGQNEATKWRVDPRLAGPSYVLGDVGTHPLYLSEVMLPEFRIKRLMCSRQSFVKSRAPLEDNAYTLMEYEGGAMGLVWSSAVNAGSMHGQKIRVIGSRASLEWWDEHPNQLAFEIQGQPVQVLERGMGYLHPGALLDDRIGAGHPEGLFEAWSNLYYRFAMAMDATERGDGALLAGLRYPDIHAGVEGVRWVERCVQSADRGGVWVDYL