1e9h A 2.5 BS01 INR A 1 I10 A31 K33 F80 F82 L83 H84 Q85 K89 L134 D145 I10 A31 K33 F80 F82 L83 H84 Q85 K89 L134 D145 D127 K129 Q131 N132 D145 T158 T165 D127 K129 Q131 N132 D145 T158 T165 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=35nM -logKd/Ki=7.46, IC50=35nM IC50=3e+2nM P24941 11377199 1298 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 1e9h C 2.5 BS01 INR C 1 A31 K33 F80 E81 F82 L83 H84 Q85 L134 D145 A32 K34 F81 E82 F83 L84 H85 Q86 L135 D146 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=35nM IC50=3e+2nM P24941 11377199 1298 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 1uzu A 2.3 BS02 INR A 1 N282 F285 A610 G612 Y613 N263 F266 A582 G584 Y585 H377 K568 R569 K574 T676 K680 H349 K540 R541 K546 T648 K652 2.4.1.1 0000166,0004645,0005737,0005975,0005977,0005980,0008184,0016757,0030170,0098723,0102250,0102499 Ki=13.8uM P00489 15153119 1000 QISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAP 1v0o A 1.9 BS01 INR A 1 I10 A30 K32 F79 H81 L82 D83 L132 D143 I8 A28 K30 F69 H71 L72 D73 L122 D133 D125 K127 Q129 N130 D143 K156 T163 D115 K117 Q119 N120 D133 K146 T153 2.7.11.22,2.7.11.23 0004672,0004674,0004693,0005524,0005634,0005737,0006357,0006468,0008353,0016310,0046872,0051301,0051726,0106310 ic50=5.5uM -logKd/Ki=5.26, IC50=5.50uM Q07785 14604523 2638 KYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLSTTIREISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 1v0o B 1.9 BS01 INR B 1 I10 A30 K32 F79 H81 L82 D83 Q84 D85 L132 D143 I8 A28 K30 F67 H69 L70 D71 Q72 D73 L120 D131 D125 K127 Q129 N130 D143 K156 T163 D113 K115 Q117 N118 D131 K144 T151 2.7.11.22,2.7.11.23 0004672,0004674,0004693,0005524,0005634,0005737,0006357,0006468,0008353,0016310,0046872,0051301,0051726,0106310 ic50=5.5uM Q07785 14604523 2638 KYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLTIREISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE