1b8o A 1.5 BS02 IMH A 1 H86 Y88 A116 G118 F200 E201 M219 N243 H257 V260 H84 Y86 A114 G116 F198 E199 M217 N241 H255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Ki=23pM -logKd/Ki=10.64, Ki=23pM P55859 11170405 600 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1g2o A 1.75 BS02 IMH A 1 Y92 A120 G122 Y188 E189 V205 G206 M207 N231 H243 Y86 A114 G116 Y182 E183 V199 G200 M201 N225 H237 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Ki=28pM -logKd/Ki=10.55, Ki=28pM P9WP01 11444966 351 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o B 1.75 BS02 IMH B 1 Y92 A120 G122 Y188 E189 G206 M207 N231 H243 Y86 A114 G116 Y182 E183 G200 M201 N225 H237 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Ki=28pM -logKd/Ki=10.55, Ki=28pM P9WP01 11444966 352 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o C 1.75 BS02 IMH C 1 H90 Y92 A120 G122 Y188 E189 G206 M207 N231 H243 H84 Y86 A114 G116 Y182 E183 G200 M201 N225 H237 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Ki=28pM P9WP01 11444966 353 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1nw4 A 2.2 BS01 IMH A 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM -logKd/Ki=9.07, Kd=860pM Q8I3X4 14982926 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 B 2.2 BS01 IMH B 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM -logKd/Ki=9.07, Kd=860pM Q8I3X4 14982926 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 C 2.2 BS01 IMH C 1 S91 C92 Y160 E182 M183 E184 D206 W212 S89 C90 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 D 2.2 BS01 IMH D 1 S91 C92 G93 Y160 V181 E182 M183 E184 D206 W212 S89 C90 G91 Y158 V179 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 304 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 E 2.2 BS01 IMH E 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 305 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 F 2.2 BS01 IMH F 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 306 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1pf7 E 2.6 BS01 IMH E 1 Y88 A116 E201 M219 T242 N243 H257 Y87 A115 E200 M218 T241 N242 H256 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=10.14, Ki=72pM P00491 13679061 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1rr6 A 2.5 BS01 IMH A 1 A116 A117 G118 F200 E201 V217 M219 N243 H257 A114 A115 G116 F198 E199 V215 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=10.25, Kd=56pM P00491 14982926 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 1rt9 A 2.3 BS01 IMH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y86 A114 A115 G116 F198 E199 V215 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=10.25, Ki=56pM P00491 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 2ff1 A 2.07 BS02 IMH A 1 N12 D14 D40 W83 M164 E184 N186 W260 D261 N12 D14 D40 W83 M164 E184 N186 W247 D248 D10 D15 D40 W83 T137 W185 N186 W260 D261 D10 D15 D40 W83 T137 W185 N186 W247 D248 3.2.2.1 0006139,0016798,0016799,0046872 Ki=6.2nM -logKd/Ki=8.21, Ki=6.2nM Q9GPQ4 16630632 401 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 2ff1 B 2.07 BS02 IMH B 1 N12 D40 W83 M164 N173 E184 N186 Y257 W260 D261 N12 D40 W83 M164 N173 E184 N186 Y246 W249 D250 D10 D15 D40 W83 T137 W185 N186 W260 D261 D10 D15 D40 W83 T137 W185 N186 W249 D250 3.2.2.1 0006139,0016798,0016799,0046872 Ki=6.2nM Q9GPQ4 16630632 402 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 2ff2 A 2.2 BS02 IMH A 1 N12 D14 D40 W83 M164 E184 N186 R252 Y257 W260 D261 N11 D13 D39 W82 M163 E183 N185 R251 Y256 W259 D260 D10 D15 D40 W83 T137 W185 N186 W260 D261 D9 D14 D39 W82 T136 W184 N185 W259 D260 3.2.2.1 0006139,0016798,0016799,0046872 Ki=6.2nM -logKd/Ki=8.21, Ki=6.2nM Q9GPQ4 16630632 501 AKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCELLRDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 2ff2 B 2.2 BS02 IMH B 1 N12 D14 D40 W83 M164 N173 E184 N186 R252 Y257 W260 D261 N12 D14 D40 W83 M164 N173 E184 N186 R252 Y257 W260 D261 D10 D15 D40 W83 T137 W185 N186 W260 D261 D10 D15 D40 W83 T137 W185 N186 W260 D261 3.2.2.1 0006139,0016798,0016799,0046872 Ki=6.2nM Q9GPQ4 16630632 502 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCELLRDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 2oc4 A 2.592 BS01 IMH A 1 A116 A117 G118 F200 E201 V217 M219 N243 D257 A116 A117 G118 F200 E201 V217 M219 N243 D257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 D257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 D257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=7.07, Ki=86nM P00491 17407325 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANDEEVLAAGKQAAQKLEQFVSILMASIPLPD 2oc9 A 2.59 BS01 IMH A 1 A116 G118 F200 E201 V217 M219 N243 V260 A110 G112 F194 E195 V211 M213 N237 V254 S33 H86 Y88 E89 A116 M219 S220 N243 V245 G257 S33 H80 Y82 E83 A110 M213 S214 N237 V239 G251 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=7.96, Ki=11nM P00491 17407325 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANGEEVLAAGKQAAQKLEQFVSILMASIPL 2on6 A 2.503 BS01 IMH A 1 A116 A117 G118 F200 E201 V217 G218 M219 S220 N243 A112 A113 G114 F196 E197 V213 G214 M215 S216 N239 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 F257 S33 H60 H82 Y84 E85 A112 M215 S216 N239 V241 F253 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=172nM -logKd/Ki=6.76, Ki=172nM P00491 17407325 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANFEEVLAAGKQAAQKLEQFVSILMASIPLPD 2q7o E 2.9 BS01 IMH E 1 A116 A117 G118 F200 E201 V217 M219 T242 N243 A116 A117 G118 F200 E201 V217 M219 T242 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=7.92, Ki=12nM P00491 18154341 291 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 3b9g A 1.4 BS02 IMH A 1 N12 D14 D40 M164 E184 N186 W250 D251 N12 D14 D40 M164 E184 N186 W250 D251 D10 D15 D40 W83 T137 W185 N186 W250 D251 D10 D15 D40 W83 T137 W185 N186 W250 D251 3.2.2.1 0006139,0016798,0016799,0046872 Ki=19uM -logKd/Ki=4.72, Ki=19uM Q9GPQ4 18519562 501 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMGGGYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 3b9g B 1.4 BS02 IMH B 1 N12 D14 D40 W83 M164 E184 N186 W250 D251 N11 D13 D39 W82 M163 E183 N185 W249 D250 D10 D15 D40 W83 T137 W185 N186 W250 D251 D9 D14 D39 W82 T136 W184 N185 W249 D250 3.2.2.1 0006139,0016798,0016799,0046872 Ki=19uM Q9GPQ4 18519562 502 AKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMGGGYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 3fow A 2.8 BS01 IMH A 1 S91 C92 G93 F160 E182 M183 E184 D206 S89 C90 G91 F158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V211 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 24416224 278 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGIGSAGCAICFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMFYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKLVPHQLENMIKIALGACAKLATKYA 3fow B 2.8 BS01 IMH B 1 I66 S91 C92 G93 F160 E182 M183 E184 D206 I64 S89 C90 G91 F158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V210 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 24416224 276 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGIGSAGCAICFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMFYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFLVPHQLENMIKIALGACAKLATKYA 3mb8 A 1.9 BS01 IMH A 1 T96 C97 G98 F165 D186 M187 E188 D210 P213 T94 C95 G96 F163 D184 M185 E186 D208 P211 H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226 H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224 2.4.2.1 0003824,0004731,0004850,0005829,0006218,0009116,0016757 Q2HXR2 24585883 280 LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREYRSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKPKTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGIEAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIATCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY 3mb8 B 1.9 BS01 IMH B 1 T96 C97 G98 F165 D186 M187 E188 D210 T94 C95 G96 F163 D184 M185 E186 D208 H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226 H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224 2.4.2.1 0003824,0004731,0004850,0005829,0006218,0009116,0016757 Q2HXR2 24585883 280 LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREYRSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKPKTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGIEAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIATCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY 6zk2 A 2.2 BS02 IMH A 1 D22 N47 V90 H91 L159 N168 E174 A175 Y233 D250 D13 N38 V81 H82 L150 N159 E165 A166 Y224 D241 ? 0006139,0016798,0016799,0046872 B6THD4 38044809 402 RDKLIIDTDPGIDDSMTILMAFRAPSVEIIGLTTIFGNVDTKGATRNALLLCERAGCPEVPVAEGSHEPLKGGKPRVADFVHGSDGIGNLFLPAPSAKKVEESAADFLINKVSEFPGEVSVLALGPLTNVALAIKRDPSFASKVKKIVVLGGAFFAAGNVNPAAEANIHGDPEAADIVFTSGADIVVVGINITTQVCLTDEDLLELRNSKGKHAAFLYEMCKFYRDWHAKSDGFHGIFLHDPVSFTAVLHPEYFTFKKGVVRVETQGICTGHTLMDQGLKKWNSENPWSGYKPISVAWTVDVPKVISFIKKLLMAP 6zk2 B 2.2 BS02 IMH B 1 D22 N47 V90 H91 L159 N168 E174 A175 Y233 D250 D13 N38 V81 H82 L150 N159 E165 A166 Y224 D241 ? 0006139,0016798,0016799,0046872 B6THD4 38044809 402 RDKLIIDTDPGIDDSMTILMAFRAPSVEIIGLTTIFGNVDTKGATRNALLLCERAGCPEVPVAEGSHEPLKGGKPRVADFVHGSDGIGNLFLPAPSAKKVEESAADFLINKVSEFPGEVSVLALGPLTNVALAIKRDPSFASKVKKIVVLGGAFFAAGNVNPAAEANIHGDPEAADIVFTSGADIVVVGINITTQVCLTDEDLLELRNSKGKHAAFLYEMCKFYRDWHAKSDGFHGIFLHDPVSFTAVLHPEYFTFKKGVVRVETQGICTGHTLMDQGLKKWNSENPWSGYKPISVAWTVDVPKVISFIKKLLMAP 6zk2 C 2.2 BS02 IMH C 1 D22 N47 V90 H91 L159 N168 E174 A175 D250 D13 N38 V81 H82 L150 N159 E165 A166 D241 ? 0006139,0016798,0016799,0046872 B6THD4 38044809 402 RDKLIIDTDPGIDDSMTILMAFRAPSVEIIGLTTIFGNVDTKGATRNALLLCERAGCPEVPVAEGSHEPLKGGKPRVADFVHGSDGIGNLFLPAPSAKKVEESAADFLINKVSEFPGEVSVLALGPLTNVALAIKRDPSFASKVKKIVVLGGAFFAAGNVNPAAEANIHGDPEAADIVFTSGADIVVVGINITTQVCLTDEDLLELRNSKGKHAAFLYEMCKFYRDWHAKSDGFHGIFLHDPVSFTAVLHPEYFTFKKGVVRVETQGICTGHTLMDQGLKKWNSENPWSGYKPISVAWTVDVPKVISFIKKLLMAP 6zk2 D 2.2 BS02 IMH D 1 D22 N47 V90 H91 L159 N168 E174 A175 D250 D13 N38 V81 H82 L150 N159 E165 A166 D241 ? 0006139,0016798,0016799,0046872 B6THD4 38044809 402 RDKLIIDTDPGIDDSMTILMAFRAPSVEIIGLTTIFGNVDTKGATRNALLLCERAGCPEVPVAEGSHEPLKGGKPRVADFVHGSDGIGNLFLPAPSAKKVEESAADFLINKVSEFPGEVSVLALGPLTNVALAIKRDPSFASKVKKIVVLGGAFFAAGNVNPAAEANIHGDPEAADIVFTSGADIVVVGINITTQVCLTDEDLLELRNSKGKHAAFLYEMCKFYRDWHAKSDGFHGIFLHDPVSFTAVLHPEYFTFKKGVVRVETQGICTGHTLMDQGLKKWNSENPWSGYKPISVAWTVDVPKVISFIKKLLMAP 6zk5 A 1.9 BS02 IMH A 1 D12 N37 H81 L149 N158 E164 A165 W226 H239 D240 D13 N38 H82 L150 N159 E165 A166 W227 H240 D241 3.2.2.- 0006139,0016798,0016799,0046872 B6T563 38044809 402 NSKIIIDTDPGIDDSVAILMAFQMPGVQVLGLTTIFGNCTTEHATRNALILCEKASHLEVPVAEGSHEPLKGGKPHVADFVHGPDGLGNVDLPDPTIKKVEESATDFLVDKVSRFPGEVSVLALGPLTNIALAIKKDPSFVKNVKKIVVLGGAFFAAGNATPSAEANIHSDPEAADMVFTSGADIYVVGLNITTQVSFTDKDLLELRNSQGKYAQFLCDVCKFYLDWHTESYGAPVIFLHDPVSFAALVRPELFTFKKGVVRVETQGICVGHTSMDMLLKKWNSENPWTGYSPISVAWTVDVPKVVAFVKELVTKP 6zk5 B 1.9 BS01 IMH B 1 D12 N37 H81 L149 N158 E164 A165 W226 H239 D240 D13 N38 H82 L150 N159 E165 A166 W227 H240 D241 3.2.2.- 0006139,0016798,0016799,0046872 B6T563 38044809 401 NSKIIIDTDPGIDDSVAILMAFQMPGVQVLGLTTIFGNCTTEHATRNALILCEKASHLEVPVAEGSHEPLKGGKPHVADFVHGPDGLGNVDLPDPTIKKVEESATDFLVDKVSRFPGEVSVLALGPLTNIALAIKKDPSFVKNVKKIVVLGGAFFAAGNATPSAEANIHSDPEAADMVFTSGADIYVVGLNITTQVSFTDKDLLELRNSQGKYAQFLCDVCKFYLDWHTESYGAPVIFLHDPVSFAALVRPELFTFKKGVVRVETQGICVGHTSMDMLLKKWNSENPWTGYSPISVAWTVDVPKVVAFVKELVTKP 8db8 B 2.21 BS01 IMH B 1 D12 N37 I76 I79 H80 M151 N160 E166 F167 D239 D12 N37 I76 I79 H80 M151 N160 E166 F167 D239 ? 0005829,0006139,0006152,0008477,0016787,0016799,0046872 A2EYV3 35994320 401 MKLWIDTDCGIDDATAILICLANPSIEIVGISCIGGNASLQNVIRNVNRTLKVWGKTDIPIFGGCQAPLVQPKMEIPHIHGGDGLGDINDNDFGTNTPNKLEKEHAVNALIHAANTIEDLNILCLAPLTNIAIALSMAPEAILKIKHFYIMGGAENGKGNITPYGEFNWRADPEAAQIVLQTYPQYQTTIASWTLAVFNSFNANDYDFFNLDGNLVRRFIRETWKPIIAFDGGRICPADPLAAFIAVYGDRAIKRAERLHLSMVLEGEKLGMSLAEPDEKGCLVVKECDAELFVKILRELQDHQ 8db8 D 2.21 BS01 IMH D 1 D12 N37 H80 M151 N160 E166 F167 N168 D239 D12 N37 H80 M151 N160 E166 F167 N168 D239 ? 0005829,0006139,0006152,0008477,0016787,0016799,0046872 A2EYV3 35994320 401 MKLWIDTDCGIDDATAILICLANPSIEIVGISCIGGNASLQNVIRNVNRTLKVWGKTDIPIFGGCQAPLVQPKMEIPHIHGGDGLGDINDNDFGTNTPNKLEKEHAVNALIHAANTIEDLNILCLAPLTNIAIALSMAPEAILKIKHFYIMGGAENGKGNITPYGEFNWRADPEAAQIVLQTYPQYQTTIASWTLAVFNSFNANDYDFFNLDGNLVRRFIRETWKPIIAFDGGRICPADPLAAFIAVYGDRAIKRAERLHLSMVLEGEKLGMSLAEPDEKGCLVVKECDAELFVKILRELQDH 8pqp A 1.709 BS01 IMH A 1 Y7 S10 F14 P40 N44 N62 D82 E88 Y6 S9 F13 P39 N43 N61 D81 E87 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQANLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8swt A 1.66 BS01 IMH A 1 H84 Y86 A114 S115 G116 F192 E193 Y198 G210 M211 D235 H247 H90 Y92 A120 S121 G122 F198 E199 Y204 G216 M217 D241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q5LAA3 37812583 300 NLYFQSMMAMLEKIQETAAFLKGKMHTSPETAIILGTGLGSLANEITEKYEIKYEDIPNFPVSTVEGHSGKLIFGKLGNKEIMAMQGRFHYYEGYSMKEVTFPVRVMRELGIKTLFVSNASGGTNPEFEIGDLMIITDHINYFPEHPLRGKNIPYGPRFPDMSEAYDKELIRKADAIAAEKGIKVQHGIYIGTQGPTFETPAEYKLFHILGADAVGMSTVPEVIVANHCGIKVFGISVVTDLGVEGKIVEVSHEEVQKAADAAQPKMTTIMRELINRA 8swt B 1.66 BS01 IMH B 1 H84 Y86 A114 S115 G116 F192 E193 G210 M211 D235 H247 H85 Y87 A115 S116 G117 F193 E194 G211 M212 D236 H248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q5LAA3 37812583 300 SMMAMLEKIQETAAFLKGKMHTSPETAIILGTGLGSLANEITEKYEIKYEDIPNFPVSTVEGHSGKLIFGKLGNKEIMAMQGRFHYYEGYSMKEVTFPVRVMRELGIKTLFVSNASGGTNPEFEIGDLMIITDHINYFPEHPLRGKNIPYGPRFPDMSEAYDKELIRKADAIAAEKGIKVQHGIYIGTQGPTFETPAEYKLFHILGADAVGMSTVPEVIVANHCGIKVFGISVVTDLGVEGKIVEVSHEEVQKAADAAQPKMTTIMRELINRA 8swu A 2.34 BS01 IMH A 1 Y85 A113 A114 G115 Y192 E193 M211 N235 H247 V250 Y82 A110 A111 G112 Y189 E190 M208 N232 H244 V247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 A0A0H2YR30 37812583 301 SMDLSNKIKAAAEYIKGKSKYNPTIGLILGSGLGAIADQIEDAEYFPYNEIPNFPVSTAGRLVIGKFQGKEVVAMQGRFHYYEGYSMQEVTCPVRVMRLLGVETLVVTNAAGAVNKDYTPGDLMIISDHLNLSGSNPLIGKNLNEFGTRFPDMSNAYDKDLRAQVKDIAKNLGIEVREGVYAMFSGPTYETPAEVRMARILGADAVGMSTVPEVIIANHSGMKVIGVSCMTNMAAGILEQPLNHEEVMETSAKVRKTFIELMTNIIKEI 8swu B 2.34 BS01 IMH B 1 A113 G115 Y192 E193 G210 M211 N235 H247 V250 A108 G110 Y187 E188 G205 M206 N230 H242 V245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 A0A0H2YR30 37812583 301 MDLSNKIKAAAEYIKGKSKYNPTIGLILGSGLGAIADQIEDAEYFPYNEIPNFPVSAGRLVIGKFQGKEVVAMQGRFHYYEGYSMQEVTCPVRVMRLLGVETLVVTNAAGAVNKDYTPGDLMIISDHLNLSGSNPLIGKNLNEFGTRFPDMSNAYDKDLRAQVKDIAKNLGIEVREGVYAMFSGPTYETPAEVRMARILGADAVGMSTVPEVIIANHSGMKVIGVSCMTNMAAGILEQPLNHEEVMETSAKVRKTFIELMTNIIKEI 8swu C 2.34 BS01 IMH C 1 A113 G115 Y192 E193 M211 N235 H247 V250 A109 G111 Y188 E189 M207 N231 H243 V246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 A0A0H2YR30 37812583 301 SMDLSNKIKAAAEYIKGKSKYNPTIGLILGSGLGAIADQIEDAEYFPYNEIPNFPVSTGRLVIGKFQGKEVVAMQGRFHYYEGYSMQEVTCPVRVMRLLGVETLVVTNAAGAVNKDYTPGDLMIISDHLNLSGSNPLIGKNLNEFGTRFPDMSNAYDKDLRAQVKDIAKNLGIEVREGVYAMFSGPTYETPAEVRMARILGADAVGMSTVPEVIIANHSGMKVIGVSCMTNMAAGILEQPLNHEEVMETSAKVRKTFIELMTNIIKEI