1t1r A 2.3 BS02 IMB A 1 K124 D149 S150 E151 W211 M213 N226 P273 M275 K125 D150 S151 E152 W212 M214 N227 P274 M276 1.1.1.267 0008299,0016491,0019288,0030145,0030604,0042802,0046872,0051484,0070402,1990065 ic50=4uM IC50=4000nM P45568 15339150 3001 GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS 1t1r B 2.3 BS02 IMB B 1 K124 D149 S150 E151 W211 M213 E230 P273 M275 K125 D150 S151 E152 W212 M214 E231 P274 M276 1.1.1.267 0008299,0016491,0019288,0030145,0030604,0042802,0046872,0051484,0070402,1990065 ic50=4uM -logKd/Ki=5.40, IC50=4uM IC50=4000nM P45568 15339150 2001 GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS