3v9b A 2.1 BS01 IHM A 1 S208 T271 M273 N321 Y329 W332 T333 F340 Q343 M357 S368 Q369 F372 S127 T190 M192 N240 Y248 W251 T252 F259 Q262 M276 S287 Q288 F291 3.1.4.53 0004114,0007165,0008081 -logKd/Ki=9.30, IC50=0.5nM IC50=500nM Q08499 22371117 1 FGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 3v9b B 2.1 BS01 IHM B 1 T271 M273 N321 Y329 W332 T333 F340 Q369 F372 T186 M188 N236 Y244 W247 T248 F255 Q284 F287 3.1.4.53 0004114,0007165,0008081 IC50=500nM Q08499 22371117 1 TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 3v9b C 2.1 BS01 IHM C 1 T271 M273 N321 Y329 W332 T333 I336 F340 Q343 M357 Q369 F372 T184 M186 N234 Y242 W245 T246 I249 F253 Q256 M270 Q282 F285 3.1.4.53 0004114,0007165,0008081 IC50=500nM Q08499 22371117 1 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 3v9b D 2.1 BS01 IHM D 1 T271 M273 N321 P322 Y329 W332 T333 I336 F340 Q343 M357 S368 Q369 F372 T185 M187 N235 P236 Y243 W246 T247 I250 F254 Q257 M271 S282 Q283 F286 3.1.4.53 0004114,0007165,0008081 IC50=500nM Q08499 22371117 1 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ