2xn3 A 2.09 BS01 ID8 A 1 L246 L269 K270 N273 L228 L251 K252 N255 ? 0004867,0005615 Kd=89nM -logKd/Ki=5.92, Kd=1198nM P05543 21325280 1356 LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR 2xn3 B 2.09 BS01 ID8 A 1 R378 R381 R18 R21 ? -logKd/Ki=5.92, Kd=1198nM P05543 21325280 1356 LHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA 3r43 A 2.0 BS02 ID8 A 1 Y24 Y55 W86 H117 W227 F306 F311 Y19 Y50 W81 H112 W216 F295 F300 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 Ki=300nM, IC50=560nM P42330 22937138 332 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSD 4jqa A 1.45 BS01 ID8 A 1 V54 Y55 W86 H117 W227 L308 V51 Y52 W83 H114 W224 L305 D50 Y55 K84 H117 D47 Y52 K81 H114 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 Ki=220nM, IC50=6970nM P52895 401 KYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPF 4jqa B 1.45 BS01 ID8 B 1 Y24 V54 Y55 W86 H117 V128 I129 W227 L308 Y22 V52 Y53 W84 H115 V126 I127 W225 L306 D50 Y55 K84 H117 D48 Y53 K82 H115 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 Ki=220nM, IC50=6970nM P52895 401 SKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPF 5ikr A 2.342 BS01 ID8 A 1 V349 S353 Y385 W387 G526 A527 S530 L531 V317 S321 Y353 W355 G494 A495 S498 L499 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005788,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050727,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 Ki=2900nM, IC50=2900nM P35354 27226593 601 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVP 5ikr B 2.342 BS01 ID8 B 1 V349 Y385 W387 V523 G526 A527 S530 L531 V317 Y353 W355 V491 G494 A495 S498 L499 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005788,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050727,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 Ki=2900nM, IC50=2900nM P35354 27226593 602 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVP