3fc2 A 2.45 BS01 IBI A 1 L59 C67 V114 E131 C133 R134 R136 F183 L23 C31 V78 E95 C97 R98 R100 F147 D176 K178 G180 N181 D194 T214 D140 K142 G144 N145 D158 T178 2.7.11.21 0004672,0005524,0006468 ic50=0.87nM -logKd/Ki=9.06, IC50=0.87nM IC50=0.870000nM P53350 19383823 10 AKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAP 5v67 A 1.78 BS01 IBI A 1 W81 P82 L92 Y97 Y139 N140 W40 P41 L51 Y56 Y98 N99 ? IC50=1070nM, Kd=255nM O60885 34710325 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5vbr A 1.9 BS01 IBI A 1 P51 V56 L61 L63 Y66 Y108 N109 I115 P27 V32 L37 L39 Y42 Y84 N85 I91 ? Q58F21 34710325 201 GAASTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQE 5vbr B 1.9 BS01 IBI B 1 P51 V56 L61 L63 Y66 Y108 N109 P24 V29 L34 L36 Y39 Y81 N82 ? Q58F21 34710325 201 STNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQE 7lak A 1.831 BS01 IBI A 1 W97 P98 Q101 V103 Y155 N156 I162 W25 P26 Q29 V31 Y83 N84 I90 ? P25440 34710325 201 GRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIP 7lej A 1.73 BS01 IBI A 1 P294 V299 L304 L306 Y351 N352 H356 P38 V43 L48 L50 Y95 N96 H100 ? Q58F21 34710325 401 AAYFQGAASTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIP 7n7n A 2.3 BS01 IBI A 1 F134 I143 K145 N198 V199 F200 L230 I358 D359 F95 I104 K106 N159 V160 F161 L191 I276 D277 2.7.1.149 0001750,0001917,0005515,0005524,0005634,0005654,0005737,0005764,0005776,0005829,0005886,0006629,0010506,0016301,0016308,0016309,0016310,0035855,0042803,0042995,0046488,0046627,0046854,0052742,0061909,0090119,1902635,2000786 P48426 34001596 501 SDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKVNPEQYSKRFLDFIGHIL