2i0g A 2.5 BS01 I0G A 1 M295 E305 L339 H475 L476 M29 E39 L73 H202 L203 ? 0003677,0004879,0006355 Ki=0.19nM -logKd/Ki=9.72, Ki=0.19nM Ki=0.19nM, EC50=0.66nM Q92731 17034120 1 DALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKVPVYDLLLEMLNAH 2i0g B 2.5 BS01 I0G B 1 M295 E305 M336 I376 H475 L476 M30 E40 M71 I111 H203 L204 ? 0003677,0004879,0006355 Ki=0.19nM Ki=0.19nM, EC50=0.66nM Q92731 17034120 1 LDALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKVPVYDLLLEMLNAH 2i0j A 2.9 BS01 I0G A 1 E353 L384 R394 F404 M421 I424 H524 E48 L79 R89 F99 M116 I119 H217 ? -logKd/Ki=8.57, Ki=2.68nM Ki=2.7nM, EC50=19.4nM P03372 17034120 1 LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSM 2i0j B 2.9 BS01 I0G B 1 L349 E353 L387 R394 M421 I424 H524 L525 L37 E41 L75 R82 M109 I112 H210 L211 ? Ki=2.7nM, EC50=19.4nM P03372 17034120 1 LALSLTADQMVSALLDAEPPILYSEYDASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMPLYDLLLEMLDAH 2i0j C 2.9 BS01 I0G C 1 E353 L384 R394 F404 M421 I424 E48 L79 R89 F99 M116 I119 ? Ki=2.7nM, EC50=19.4nM P03372 17034120 1 LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSM 2i0j D 2.9 BS01 I0G D 1 L349 E353 L384 L387 R394 M421 I424 H524 L525 L36 E40 L71 L74 R81 M108 I111 H209 L210 ? Ki=2.7nM, EC50=19.4nM P03372 17034120 1 LALSLTADQMVSALLDAEPPILYSEYDSMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMLYDLLLEMLDAH