1fdq A 2.1 BS01 HXA A 1 V40 T60 E72 T74 A75 D76 M115 R126 Y128 V40 T60 E72 T74 A75 D76 M115 R126 Y128 ? 0005504,0005515,0005634,0005737,0005829,0007399,0008285,0008289,0015908,0050673 Kd=53.4nM -logKd/Ki=7.27, Kd=53.4nM O15540 10854433 133 VEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA 1fdq B 2.1 BS01 HXA B 1 M520 T560 E572 T574 A575 D576 L617 R626 Y628 M20 T60 E72 T74 A75 D76 L117 R126 Y128 ? 0005504,0005515,0005634,0005737,0005829,0007399,0008285,0008289,0015908,0050673 Kd=53.4nM O15540 10854433 633 VEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA 1mv9 A 1.9 BS02 HXA A 1 I268 A271 A272 Q275 L309 I310 F313 R316 L326 A327 V342 I345 C432 L436 I22 A25 A26 Q29 L63 I64 F67 R70 L80 A81 V96 I99 C186 L190 ? 0003677,0003707,0005634,0006355,0008270 P19793 11981034 200 DMPVERILEAELAVEPDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQ 2byo A 2.15 BS04 HXA A 1 V121 Q123 V97 Q99 ? 0005319,0005576,0005886,0006869,0009274,0009986,0071770 P9WK65 16541102 1215 SDPALLAEIRQSLDATKGLTSVHVAVRTTGKVDSLLGITSADVDVRANPLAAKGVCTYNDEQGVPFRVQGDNISVKLFDDWSNLGSISELSTSRVGVTQLLSGVTNLQAQGTEVIDGISTTKITGTIPASSVKMLDPGAKSARPATVWIAQDGSHHLVRASIDLGSGSIQLTQSKWNEPVNVD 2g7z A 2.05 BS03 HXA A 1 T62 S63 L94 S95 R172 I262 I263 H266 A271 F272 A273 T63 S64 L95 S96 R173 I258 I259 H262 A267 F268 A269 ? 0008289 P67372 9136 AMGTIKIVTDSSITIEPELIKALDITVVPLSVMIDSKLYSDNDLKEEGHFLSLMKASKSLPKTSQPPVGLFAETYENLVKKGVTDIVAIHLSPALSGTIEASRQGAEIAEAPVTVLDSGFTDQAMKFQVVEAAKMAKAGASLNEILAAVQAIKSKTELYIGVSTLENLVKGGRIGRVTGLNVKVVMALKNDELKTLVKGRGNKTFTKWLDSYLAKNSHRPIAEIAISYAGEASLALTLKERIAAYYNHSISVLETGSIIQTHTGEGAFAVMVRYE 2g7z B 2.05 BS02 HXA B 1 T62 S63 S95 R172 T259 I262 I263 H266 F272 A273 T63 S64 S96 R173 T255 I258 I259 H262 F268 A269 ? 0008289 P67372 8136 AMGTIKIVTDSSITIEPELIKALDITVVPLSVMIDSKLYSDNDLKEEGHFLSLMKASKSLPKTSQPPVGLFAETYENLVKKGVTDIVAIHLSPALSGTIEASRQGAEIAEAPVTVLDSGFTDQAMKFQVVEAAKMAKAGASLNEILAAVQAIKSKTELYIGVSTLENLVKGGRIGRVTGVNVKVVMALKNDELKTLVKGRGNKTFTKWLDSYLAKNSHRPIAEIAISYAGEASLALTLKERIAAYYNHSISVLETGSIIQTHTGEGAFAVMVRYE 2vv0 A 2.55 BS01 HXA A 1 C285 R288 S289 H323 L340 I341 S342 M364 H449 Y473 C69 R72 S73 H107 L124 I125 S126 M148 H233 Y257 ? 0003677,0004879,0005634,0006355 P37231 19172745 1476 ALNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKD 2vv0 B 2.55 BS01 HXA B 1 C285 R288 I326 L330 I341 S342 M348 C65 R68 I106 L110 I121 S122 M128 ? 0003677,0004879,0005634,0006355 P37231 19172745 1477 SADLRALAKHLYDSYIKSFPLTKAKARAILTGKDKSPFVIYDMNSLMMGEDKIKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETHPLLQEIYKDL 3hs7 A 2.65 BS02 HXA A 1 R120 F205 F209 L352 S353 Y355 F381 Y385 W387 V523 G526 A527 S530 G533 L534 R89 F174 F178 L321 S322 Y324 F350 Y354 W356 V492 G495 A496 S499 G502 L503 Q203 H207 L384 Y385 H388 G526 S530 Q172 H176 L353 Y354 H357 G495 S499 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030216,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 Q05769 20463020 1 HHPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNV 3hs7 B 2.65 BS02 HXA B 1 R120 F205 F209 Y348 V349 S353 Y355 F381 Y385 W387 G526 A527 S530 G533 L534 R89 F174 F178 Y317 V318 S322 Y324 F350 Y354 W356 G495 A496 S499 G502 L503 Q203 H207 L384 Y385 H388 G526 S530 Q172 H176 L353 Y354 H357 G495 S499 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030216,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 Q05769 20463020 1 HHPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQ 5y5c A 2.61 BS01 HXA B 1 L46 I56 I84 V92 F105 L43 I53 I81 V89 F102 ? 0005515,0005576,0019841,0036041,0036094,0042802 P02754 201 TQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI 5y5c A 2.61 BS02 HXA B 2 A86 E89 A83 E86 ? 0005515,0005576,0019841,0036041,0036094,0042802 P02754 202 TQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI 5y5c B 2.61 BS01 HXA B 2 L46 I56 L87 N90 V92 F105 L42 I52 L83 N86 V88 F101 ? 0005515,0005576,0019841,0036041,0036094,0042802 P02754 202 QTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI 7wkb A 0.81 BS01 HXA A 1 M20 V25 P38 F57 K58 D76 R126 Y128 M21 V26 P39 F58 K59 D77 R127 Y129 ? 0005515,0005615,0005634,0005737,0005829,0008092,0008285,0008289,0015909,0032365,0036041,0042632,0046320,0050873,0055091,0070062,0070538,0071073,0140214,2001245 P05413 201 MVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA 8eit R 2.8 BS01 HXA R 1 V84 F87 Y91 L138 R183 L186 Y240 V82 F85 Y89 L136 R172 L175 Y229 3.2.1.17 0003796,0004930,0005886,0007186,0007200,0007204,0008289,0009253,0016020,0016798,0016998,0030073,0030430,0031640,0032024,0032691,0042593,0042742,0044659,0045125,0051928,0070542,0099105,1990806 O14842,P00720 37216523 401 LPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGTSLGINTPVSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYL 8h0d A 2.01 BS01 HXA A 1 D152 S153 L154 W185 G204 A205 L247 N248 M282 P285 A287 T334 F338 F388 T392 V402 D124 S125 L126 W157 G176 A177 L219 N220 M254 P257 A259 T306 F310 F360 T364 V374 ? 0006629,0016298,0016788 A0A7Y4B3E8 37558668 501 MVSAAEVVSAQENQTYTYVRCWYRTSHSKDDAATDWKWAKNQDGSDFTIDGYWWSSVSFKNMFYTNTSQNVIRQRCEETLDLANENADITFFAADNRYSYNHTIWSNDAAMQPDQINKVVALGDSLSDTGNIFNASQWRFPNPNSWFLGHFSNGFVWTEYVAKAKNLPLYNWAVGGAAGENQYIALTGVGEQVSSYLTYTKLAKNYNPANTLFTLEFGLNDFMNYNRSVPEVKADYAEALIRLTDAGAKNFMLMTLPDATKAPQFKYSTQEEIETIRAKVLKMNEFIKAQAMYYKAQGYNIALFDTHALFEKLTSAPEEHGFVNASDPCLDINRSSSVDYMYTHSLRSECAASGADKFVFWDVTHPTTATHRYVAEKMLESSNNLEEFRF 8h4i R 3.06 BS01 HXA R 1 M118 S123 I126 W198 E204 F211 N215 I284 L288 M97 S102 I105 W174 E180 F187 N191 I241 L245 ? 0001818,0004930,0005504,0005764,0005765,0005768,0005886,0005929,0006954,0007186,0007189,0007200,0007204,0008289,0008527,0010008,0010827,0016020,0030139,0030154,0032691,0032870,0036321,0042277,0042995,0043066,0045444,0045669,0046879,0050728,0050872,0050873,0050912,0060170,0070094,0070374,0090275,0090336,0120162 Q5NUL3 37286793 401 RTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLC 8h4l R 3.07 BS01 HXA R 1 F88 M118 I126 D208 F211 W277 F68 M98 I106 D188 F191 W257 ? 0001818,0004930,0005504,0005764,0005765,0005768,0005886,0005929,0006954,0007186,0007189,0007200,0007204,0008289,0008527,0010008,0010827,0016020,0030139,0030154,0032691,0032870,0036321,0042277,0042995,0043066,0045444,0045669,0046879,0050728,0050872,0050873,0050912,0060170,0070094,0070374,0090275,0090336,0120162 Q5NUL3 37286793 401 NRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYN 8t3q R 3.14 BS01 HXA R 1 T119 G122 L173 E204 D208 F211 W277 I280 I284 I287 N291 T98 G101 L149 E173 D177 F180 W246 I249 I253 I256 N260 ? 0004930,0007186,0016020 Q5NUL3 38198545 401 RTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNE 8t3v R 3.39 BS01 HXA R 1 A83 V84 F87 L135 L138 F142 R183 R258 A83 V84 F87 L135 L138 F142 R180 R255 ? 0004930,0005886,0007186,0007200,0007204,0008289,0016020,0030073,0032024,0032691,0042593,0045125,0051928,0070542,0099105,1990806 O14842 38198545 302 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYL