1dm7 A 2.1 BS02 HRG A 1 W358 Y359 E363 N368 W292 Y293 E297 N302 C186 R189 W358 E363 C120 R123 W292 E297 1.14.13.39 0004517,0006809 P29473 1740 GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPW 1dm7 B 2.1 BS03 HRG B 1 Q249 W358 Y359 E363 N368 Q181 W290 Y291 E295 N300 C186 R189 W358 E363 C118 R121 W290 E295 1.14.13.39 0004517,0006809 P29473 2740 KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPW 4m2e C 2.06 BS02 HRG C 1 Q123 L143 G144 H154 E156 S210 D255 F258 R321 Q115 L135 G136 H146 E148 S202 D247 F250 R313 1.14.11.41 0005506,0016491,0046872,0102525 G9MBV2 24505011 402 TPSYSLTPAEASAVAELTLELAAAYGSFGDPVLLRDLPRLAARLPEGVQDFLREFKLADRHGHTVIRGHDFDQRRIGPTPDHWRGRVRPGPEFPEELLLMLYSALLGEPFGWATQQDGHLVHDIFPIRSHENDQLGMGSKQLLTWHTEDAFHPYRSDYLILGALRNPDHVPTTVGELDLSSLSAEDIDVLFEPRYHIAPDESHLPKNNTIATEEEAARFATIQRMIDERPLGPLLYGSRLDPYMRLDPYFTSVPQDDTDARRAYDALFKVVDSGMREVVADQGDVLFIDNHRAVHGRLPFQARYDGTDRWLKRVCVTSDLRRSREMRATSATRLLG 4m2e D 2.06 BS02 HRG D 1 Q123 G144 H154 E156 D208 S210 D255 F258 R321 Q115 G136 H146 E148 D200 S202 D247 F250 R313 1.14.11.41 0005506,0016491,0046872,0102525 G9MBV2 24505011 402 TPSYSLTPAEASAVAELTLELAAAYGSFGDPVLLRDLPRLAARLPEGVQDFLREFKLADRHGHTVIRGHDFDQRRIGPTPDHWRGRVRPGPEFPEELLLMLYSALLGEPFGWATQQDGHLVHDIFPIRSHENDQLGMGSKQLLTWHTEDAFHPYRSDYLILGALRNPDHVPTTVGELDLSSLSAEDIDVLFEPRYHIAPDESHLPKNNTIATEEEAARFATIQRMIDERPLGPLLYGSRLDPYMRLDPYFTSVPQDDTDARRAYDALFKVVDSGMREVVADQGDVLFIDNHRAVHGRLPFQARYDGTDRWLKRVCVTSDLRRSREMRATSATRLLG 5ijr A 1.52 BS01 HRG A 1 W301 T316 D320 S346 E348 Y353 G414 I415 W28 T43 D47 S73 E75 Y80 G141 I142 ? -logKd/Ki=3.20, Kd=637uM O14786 29430837 501 KCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKIT 6dax A 1.7 BS02 HRG A 1 L156 V157 S158 H168 E170 D222 S224 D268 D270 L136 V137 S138 H148 E150 D202 S204 D248 D250 1.14.11.41 0005506,0016020,0016491,0016706,0017000,0046872,0102525 Q6WZB0 29708749 402 VRPWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRRLRTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFLLMLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTEDAFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIRPDDSHLQVNNSTAQQGRVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGDFSAPAEGDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRAFQPRYDGRDRWLKRINITRDLHRSRKAWAGDSRVLGQR 6db2 A 1.7 BS01 HRG A 1 Q137 L156 V157 S158 H168 D222 S224 D268 D270 R334 Q115 L134 V135 S136 H146 D200 S202 D246 D248 R312 1.14.11.41 0005506,0016020,0016491,0016706,0017000,0046872,0102525 Q6WZB0 29708749 402 PWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRRLRTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFLLMLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTEDAFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIRPDDSHLQVNNSTAQQGRVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGDFSAPAEGDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRAFQPRYDGRDRWLKRINITRDLHRSRKAWAGDSRVLGQR 7y5f A 1.52 BS02 HRG A 1 L136 V137 S138 G146 H148 D202 S204 D247 D249 R313 L137 V138 S139 G147 H149 D203 S205 D248 D250 R314 ? 0005506,0016491,0046872 A6YEH4 36176888 402 HMTAIREIRLSEPESAQAALLALECAQRYAEPDSADFLADAAVLAHDLPRAVRREVERARLDDRLHALVVRGNDVDQDALGPTPPHWRQARTAASRRYGFLLVLYASLLGDVVGWATQQDGRVVTDVLPIEGQEDSLVSSSSSVELGWHTEDAFSPYRADYVGLFSLRNPDSVATTVAGLDPDLVGPAVVDVLFGERFHIRPDNSHLPTHNSGGRLSDYFAGIVEAVENPRAVSILRGHRDAPQLCVDSDFTTAVDGDAEAAGALDTLIKHLGGALYEVVLGPGDVAFLDNRNVVHGRRPFRARFDGTDRWLKRINVTADLRKSRAARRDAQARVLGEA 7y5f B 1.52 BS02 HRG B 1 L136 V137 S138 H148 E150 D249 R313 L149 V150 S151 H161 E163 D252 R316 ? 0005506,0016491,0046872 A6YEH4 36176888 403 HHHSSGLVPRGSHMTAIREIRLSEPESAQAALLALECAQRYAEPDSADFLADAAVLAHDLPRAVRREVERARLDDRLHALVVRGNDVDQDALGPTPPHWRQARTAASRRYGFLLVLYASLLGDVVGWATQQDGRVVTDVLPIEGQEDSLVSSSSSVELGWHTEDAFSPYRADYVGLFSLRNPDSVATTVAGLDPDLVGPAVVDVLFGERFHIRPDNSHSDYFAGIVEAVENPRAVSILRGHRDAPQLCVDSDFTTAVDGDAEAAGALDTLIKHLGGALYEVVLGPGDVAFLDNRNVVHGRRPFRARFDGTDRWLKRINVTADLRKSRAARRDAQARVLGEA