1kf6 B 2.7 BS04 HQO C 1 T205 F206 Q225 K228 T205 F206 Q225 K228 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 -logKd/Ki=6.70, Ki=0.2uM P0AC47 11850430 700 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 1kf6 C 2.7 BS01 HQO C 1 R28 E29 R28 E29 ? 0000104,0005886,0006113,0009061,0016020,0019645,0044780,0045283 -logKd/Ki=6.70, Ki=0.2uM P0A8Q0 11850430 700 TTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVATIVILFVALYW 1kf6 D 2.7 BS01 HQO C 1 W14 F17 W15 F18 ? 0000104,0005886,0006106,0006113,0009061,0016020,0019645,0044780,0045283 -logKd/Ki=6.70, Ki=0.2uM P0A8Q3 11850430 700 MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI 1kf6 N 2.7 BS04 HQO N 1 T205 F206 Q225 T205 F206 Q225 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 11850430 800 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 1kf6 O 2.7 BS01 HQO N 1 R28 E29 R28 E29 ? 0000104,0005886,0006113,0009061,0016020,0019645,0044780,0045283 P0A8Q0 11850430 800 TTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVATIVILFVALYW 1kf6 P 2.7 BS01 HQO N 1 W14 F17 W15 F18 ? 0000104,0005886,0006106,0006113,0009061,0016020,0019645,0044780,0045283 P0A8Q3 11850430 800 MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI 1kqg C 2.8 BS03 HQO C 1 G112 Q113 H169 M172 G111 Q112 H168 M171 H169 H168 1.2.1.2 0005515,0005886,0006788,0008863,0009055,0009061,0009326,0015944,0016020,0019645,0020037,0022904,0036397,0045333,0046872 P0AEK7 11884747 811 SKSKMIVRTKFIDRACHWTVVICFFLVALSGISFFFPTLQWLTQTFGTPQMGRILHPFFGIAIFVALMFMFVRFVHHNIPDKKDIPWLLNIVEVLKGNEHKVADVGKYNAGQKMMFWSIMSMIFVLLVTGVIIWRPYFAQYFPMQVVRYSLLIHAAAGIILIHAILIHMYMAFWVKGSIKGMIEGKVSRRWAKKHHPRWYREIEKAEAKKESEEGI 2vr0 C 2.8 BS05 HQO C 1 F42 N67 K82 A85 G86 D89 F28 N53 K68 A71 G72 D75 1.10.2.- 0005886,0009055,0009061,0016020,0019333,0020037,0046872 -logKd/Ki=4.42, Ki=38uM Q72EF4 18597779 1005 LVLGGATLGVVALATVAFGMKYTDQRPFCTSCHIMNPVGVTHKLSGHANISCNDCHAPHNLLAKLPFKAIAGARDVYMNTLGHPGDLILAGMETKEVVNANCKACHTMTNVEVASMEAKKYCTDCHRNVQHMRMKPISTREVAD 2vr0 F 2.8 BS06 HQO F 1 T37 F42 N67 K82 A85 G86 D89 T24 F29 N54 K69 A72 G73 D76 1.10.2.- 0005886,0009055,0009061,0016020,0019333,0020037,0046872 Q72EF4 18597779 1005 KLVLGGATLGVVALATVAFGMKYTDQRPFCTSCHIMNPVGVTHKLSGHANISCNDCHAPHNLLAKLPFKAIAGARDVYMNTLGHPGDLILAGMETKEVVNANCKACHTMTNVEVASMEAKKYCTDCHRNVQHMRMKPISTREVADE 3ayg A 2.7 BS07 HQO A 1 A327 H328 F336 F337 A743 D746 A304 H305 F313 F314 A720 D723 ? 0004129,0009060,0015990,0016020,0020037,0022904,0046872 B3Y963 22266822 811 TTNSFLKSILIFTILISSTVLLVGGYWIFKEMAPRPKEVRSESGEVLMTKETIIGGQAVFQKYGLMDYGTVLGHGSYMGPDYTAEALKVYTEGMQDYKAKADLTDDEKSIIREQVIKEMRKNRYNPVTDVLVLTDAQVYGLEKVRDYYRDVFTNGDGWGLKKGLIKESDMPKANRAWVADSDQIQQIADFFFWTAWLSSTLRIGDEITYTNNWPYYEDAGNTMSFSAVWWSGASVTILILFIGIILYVFYRYQLSMQEAYAEGKFPVIDLRRQPLTPSQVKAGKYFVVVSALFFVQTMFGALLAHYYTEPDSFFGINWIYDILPFNIAKGYHLQLAIFWIATAWLGMGIFIAPLVGGQEPKKQGLLVDLLFWALVVLVGGSMIGQWLGVNGYLGNEWFLLGHQGWEYIELGRIWQIILVVGMLLWLFIVFRGVKRGLKRESDKGGLIHLLFYSAIAVPFFYIFAFFIQPDTNFTMADFWRWWIIHLWVEGIFEVFAVVVIGFLLVQLRLVTKKSTVRALYFQFTILLGSGVIGIGHHYYYNGSPEVWIALGAVFSALEVIPLTLLILEAYEQYKMMRDGGANFPYKATFWFLISTAIWNLVGAGVFGFLINLPAVSYFEHGQFLTPAHGHAAMMGVYGMFAIAVLLYSLRNIVKPEAWNDKWLKFSCWMLNIGLAGMVVITLLPVGILQMKEAFIHGYWASRSPSFLQQDVVQNLLLVRAVPDTIFLIGVVALLVFAIKALFHLRKPTHGEGEE 6bdo B 2.8 BS02 HQO B 1 Q317 I320 G348 I379 Q315 I318 G346 I377 N127 F170 G206 V350 L353 K377 N125 F168 G204 V348 L351 K375 ? 0000166,0003955,0016491,0019646 F5L3B8 29621505 602 KPSIVILGAGYGGIVAALGLQKRLNYNEADITLVNKNDYHYITTELHQPAAGTMHHDQARVGIKELIDEKKIKFVKDTVVAIDREQQKVTLQNGELHYDYLVVGLGSEPETFGIEGLREHAFSINSINSVRIIRQHIEYQFAKFAAEPERTDYLTIVVGGAGFTGIEFVGELADRMPELCAEYDVDPKLVRIINVEAAPTVLPGFDPALVNYAMDVLGGKGVEFKIGTPIKRCTPEGVVIEVDGEEEEIKAATVVWTGGVRGNSIVEKSGFETMRGRIKVDPYLRAPGHENIFIVGDCALIINEENNRPYPPTAQIAIQHGENVAANLAALIRGGSMTPFKPHIRGTVASLGRNDAIGIVGGRKVYGHAASWLKKLIDMRYLYLIGGLSLVLKK 6bdo C 2.8 BS02 HQO C 1 Q317 I320 G348 T349 I379 Q315 I318 G346 T347 I377 N127 F170 G206 V350 L353 K377 N125 F168 G204 V348 L351 K375 ? 0000166,0003955,0016491,0019646 F5L3B8 29621505 602 KPSIVILGAGYGGIVAALGLQKRLNYNEADITLVNKNDYHYITTELHQPAAGTMHHDQARVGIKELIDEKKIKFVKDTVVAIDREQQKVTLQNGELHYDYLVVGLGSEPETFGIEGLREHAFSINSINSVRIIRQHIEYQFAKFAAEPERTDYLTIVVGGAGFTGIEFVGELADRMPELCAEYDVDPKLVRIINVEAAPTVLPGFDPALVNYAMDVLGGKGVEFKIGTPIKRCTPEGVVIEVDGEEEEIKAATVVWTGGVRGNSIVEKSGFETMRGRIKVDPYLRAPGHENIFIVGDCALIINEENNRPYPPTAQIAIQHGENVAANLAALIRGGSMTPFKPHIRGTVASLGRNDAIGIVGGRKVYGHAASWLKKLIDMRYLYLIGGLSLVLKK 6koe A 3.75 BS04 HQO A 1 R70 D74 H94 E97 I98 T101 F156 S161 R57 D61 H81 E84 I85 T88 F143 S148 H102 D131 W166 G196 T197 H280 E282 Y284 S295 H329 H330 T355 K358 R477 H89 D118 W153 G183 T184 H267 E269 Y271 S282 H316 H317 T342 K345 R464 1.10.3.- 0004129,0005507,0005886,0006119,0009060,0015990,0016020,0016491,0016682,0020037,0022904,0042773,0046872,1902600 P34956 31888984 1004 PLILGAQVSIALSTIAIIFVLTYFKKWKWLWSEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTHGTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGGSPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTLMRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFWIWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTMGNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGVTGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGKWFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLILCYNIYYSGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKEEKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVLRSFEYDNGY 6koe E 3.75 BS04 HQO E 1 D74 H94 E97 I98 F156 S161 D61 H81 E84 I85 F143 S148 H102 D131 W166 G196 T197 H280 E282 Y284 S295 H329 H330 T355 K358 R477 H89 D118 W153 G183 T184 H267 E269 Y271 S282 H316 H317 T342 K345 R464 1.10.3.- 0004129,0005507,0005886,0006119,0009060,0015990,0016020,0016491,0016682,0020037,0022904,0042773,0046872,1902600 P34956 31888984 1004 PLILGAQVSIALSTIAIIFVLTYFKKWKWLWSEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTHGTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGGSPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTLMRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFWIWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTMGNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGVTGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGKWFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLILCYNIYYSGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKEEKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVLRSFEYDNGY 7t5k A 2.25 BS02 HQO A 1 Y3 F11 H19 T22 L100 R102 F321 I322 Y2 F10 H18 T21 L99 R101 F320 I321 1.3.5.2 0004152,0005737,0005829,0005886,0006207,0006221,0009220,0010181,0016020,0016491,0016627,0044205,0106430 P0A7E1 35441142 402 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 7t5k B 2.25 BS01 HQO B 1 H19 T22 L100 R102 L109 F321 I322 H18 T21 L99 R101 L108 F320 I321 1.3.5.2 0004152,0005737,0005829,0005886,0006207,0006221,0009220,0010181,0016020,0016491,0016627,0044205,0106430 P0A7E1 35441142 501 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 8a1y B 3.3 BS03 HQO B 1 L33 K54 M57 V145 E157 F160 L31 K52 M55 V143 E155 F158 7.2.1.1 0005886,0006814,0010181,0016020,0016655,0022904,0055085,1902444 A5F5X0 37710014 607 LKKFLEDIEHHFEPGGKHEKWFALYEAAATLFYTPGLVTKRSSHVRDSVDLKRIMIMVWLAVFPAMFWGMYNAGGQAIAALNHLYSGDQLAAIVAGNWHYWLTEMLGGTMSSDAGWGSKMLLGATYFLPIYATVFIVGGFWEVLFCMVRKHEVNEGFFVTSILFALIVPPTLPLWQAALGITFGVVVAKEVFGGTGRNFLNPALAGRAFLFFAYPAQISGDLVWTAADGYSGATALSQWAQGGAGALINNATGQTITWMDAFIGNIPGSIGEVSTLALMIGAAFIVYMGIASWRIIGGVMIGMILLSTLFNVIGSDTNAMFNMPWHWHLVLGGFAFGMFFMATDPVSASFTNSGKWAYGILIGVMCVLIRVVNPAYPEGMMLAILFANLFAPLFDHVVVERNIKRRLARYGK 8x2j C 2.7 BS03 HQO C 1 W84 F91 P138 H141 L168 D171 V172 I175 S176 D252 W69 F76 P123 H126 L153 D156 V157 I160 S161 D237 ? 0005886,0016020 A9WEV4 38299372 502 EAYLLPGETYTSISAKIGDVPLTPPLKTPKGWLAGFSVAFFMLMIFFVSVTWLFIRGVGIWGINIPVGWGMDIINFVWWIGIGHAGTLISAILLLLNQGWRNSINRFAEAMTLFAVACAGLYPILHLGRPWLFYWLIPYPNTHGMWPQFRSALAWDVFAISTYATVSLVFWLVGLIPDFATLRDRAKNIWVKRLYGIAALGWRGSARHWHRYEMASILLAGLSTPLVVSVHSIISLDFAISQVPGWQVTVFPPYFVAGAVFAGFAMVLLLMIPVRTFYGFENYITLHHLDVMAKVMLTTGMIVVYGYFMEVFASLYSGNEFEEYLLYNRLFGPSSWAYWGLLFCNAVAIQPLWFKKVRQNIPALLIISLIVSVGMWLERYVIIVISLERDFLPSSWDIYIPTIWDWSLYIGTFGLFFTLLFLFIRVLPMINIFEMRLFLYQETEKAKQR