6q8p A 3.0 BS01 HQB A 1 L167 V175 K191 F241 E242 L243 L244 L295 V324 L22 V30 K46 F96 E97 L98 L99 L150 V179 D288 K290 N293 D325 T342 D143 K145 N148 D180 T196 2.7.12.1 0004672,0005524,0006468 -logKd/Ki=7.74, IC50=18nM P49759 30731399 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 6q8p B 3.0 BS01 HQB B 1 F172 V175 A189 F241 E242 L244 L295 D325 F27 V30 A44 F96 E97 L99 L150 D177 D288 K290 N293 D325 D143 K145 N148 D177 2.7.12.1 0004672,0005524,0006468 P49759 30731399 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPRDERTLINPDIKVVDFGSATYDDEHHSTLVRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKS 6q8p C 3.0 BS01 HQB C 1 V175 A189 F241 E242 L244 L295 V29 A43 F95 E96 L98 L149 D288 K290 N293 D325 T342 D142 K144 N147 D177 T193 2.7.12.1 0004672,0005524,0006468 P49759 30731399 501 MHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKRDERTLINPDIKVVDFGSATYDDEHHSTLVTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKS