1a9q A 2.0 BS01 HPA A 1 A117 G118 F200 E201 M219 N243 A117 G118 F200 E201 M219 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 -logKd/Ki=6.17, Kd=0.68uM Kd=680nM P55859 9585525 290 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1a9r A 2.0 BS01 HPA A 1 A117 G118 F200 E201 V217 N243 A117 G118 F200 E201 V217 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=680nM P55859 9585525 290 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1a9t A 2.0 BS02 HPA A 1 A116 A117 G118 F200 E201 V217 N243 A116 A117 G118 F200 E201 V217 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=680nM P55859 9585525 290 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 1bdh A 2.7 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLAVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1bdi A 3.0 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1jfs A 2.9 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y72 F73 R189 T191 R195 F220 D274 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 11781089 599 ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDFGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1jft A 2.5 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y72 F73 R189 T191 R195 F220 D274 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 11781089 599 ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDAGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR 1jh9 A 2.55 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y72 F73 R189 T191 R195 F220 D274 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 11781089 599 ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDRGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1pnr A 2.7 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 7973627 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1qp0 A 2.9 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 10438625 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1qp4 A 3.0 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 10438625 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1qp7 A 2.9 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 Y71 F72 R188 T190 R194 F219 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 10438625 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLAVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1qpz A 2.5 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y72 F73 R189 T191 R195 F220 D274 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 10438625 599 ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1qqa A 3.0 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 10438625 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLAVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1qqb A 2.7 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 10438625 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLAVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1vfn A 2.15 BS01 HPA A 1 A117 G118 F200 E201 V217 N243 A107 G108 F190 E191 V207 N233 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S30 H76 Y78 E79 A106 M209 S210 N233 V235 H245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Ki=2.5uM -logKd/Ki=5.60, Ki=2.5uM Kd=680nM P55859 9020983 300 GYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDSQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1vpw A 2.7 BS02 HPA A 1 Y73 F74 R190 T192 R196 F221 D275 Y71 F72 R188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 9628480 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSMKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 1zay A 2.7 BS02 HPA A 1 Y73 F74 T192 R196 F221 D275 Y71 F72 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 2pud A 2.6 BS02 HPA A 1 Y73 F74 T192 R196 F221 D275 Y71 F72 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 7973627 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLEANTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 2pug A 2.7 BS02 HPA A 1 Y73 F74 Q190 T192 R196 F221 D275 Y71 F72 Q188 T190 R194 F219 D273 ? 0000976,0001217,0002057,0003677,0003700,0005515,0005829,0006164,0006355,0042803,0045892,1900372 P0ACP7 9454587 599 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLEQNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR 2w3r B 2.9 BS02 HPA B 1 E232 R310 F344 F459 T460 L461 A529 E231 R309 F343 F442 T443 L444 A512 Q197 E232 R310 H314 R342 G729 E730 Q196 E231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKESQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w3r D 2.9 BS02 HPA D 1 R310 F344 F459 T460 R309 F343 F442 T443 Q197 E232 R310 H314 R342 G729 E730 Q196 E231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKESQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w3r F 2.9 BS02 HPA F 1 E232 R310 F344 F459 T460 L461 E231 R309 F343 F442 T443 L444 Q197 E232 R310 H314 R342 G729 E730 Q196 E231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKESQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w3r H 2.9 BS02 HPA H 1 E232 R310 F344 F459 T460 A529 E231 R309 F343 F442 T443 A512 Q197 E232 R310 H314 R342 G729 E730 Q196 E231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKESQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w55 B 3.4 BS02 HPA B 1 Q232 R310 F344 F459 T460 A529 Q231 R309 F343 F442 T443 A512 Q197 Q232 R310 H314 R342 G729 E730 Q196 Q231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKQSQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w55 D 3.4 BS02 HPA D 1 Q232 R310 F344 F459 T460 A529 Q231 R309 F343 F442 T443 A512 Q197 Q232 R310 H314 R342 G729 E730 Q196 Q231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKQSQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w55 F 3.4 BS02 HPA F 1 Q232 R310 F344 T460 A528 A529 Q231 R309 F343 T443 A511 A512 Q197 Q232 R310 H314 R342 G729 E730 Q196 Q231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKQSQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 2w55 H 3.4 BS02 HPA H 1 Q232 R310 F344 F459 T460 L461 A529 Q231 R309 F343 F442 T443 L444 A512 Q197 Q232 R310 H314 R342 G729 E730 Q196 Q231 R309 H313 R341 G712 E713 1.1.1.204 0005506,0016491,0030151,0046872 O54051 19109249 1780 SVGKPLPHDSARAHVTGQARYLDDLPCPANTLHLAFGLSTEASAAITGLDLEPVRESPGVIAVFTAADLPHDNDASPAPSPEPVLATGEVHFVGQPIFLVAATSHRAARIAARKARITYAPRPAILTLDQALAADSRFEGGPVIWARGDVETALAGAAHLAEGCFEIGGQEHFYLEGQAALALPAEGGVVIHCSSQHPSEIQHKVAHALGLAFHDVRVEMRRMGGGFGGKQSQGNHLAIACAVAARATGRPCKMRYDRDDDMVITGKRHDFRIRYRIGADASGKLLGADFVHLARCGWSADLSLPVCDRAMLHADGSYFVPALRIESHRLRTNTQSNTAFRGFGGPQGALGMERAIEHLARGMGRDPAELRALNFYDPPEKKTQTTHYGQEVADCVLGELVTRLQKSANFTTRRAEIAAWNSTNRTLARGIALSPVKFGISFTLTHLNQAGALVQIYTDGSVALNHGGTEMGQGLHAKMVQVAAAVLGIDPVQVRITATDTSKVPNTSATAASSGADMNGMAVKDACETLRGRLAGFVAAREGCAARDVIFDAGQVQASGKSWRFAEIVAAAYMARISLSATGFYATPKLSWDRLRGQGRPFLYFAYGAAITEVVIDRLTGENRILRTDILHDAGASLNPALDIGQIEGAYVQGAGWLTTEELVWDHCGRLMTHAPSTYKIPAFSDRPRIFNVALWDQPNREETIFRSKAVGEPPFLLGISAFLALHDACAACGPHWPDLQAPATPEAVLAAVRRAEGRA 3enz A 2.03 BS01 HPA A 1 S91 C92 G93 E182 D206 S89 C90 G91 E180 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz B 2.03 BS01 HPA B 1 S91 C92 G93 Y160 D206 W212 S89 C90 G91 Y158 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALE 3enz C 2.03 BS01 HPA C 1 S91 C92 G93 Y160 D206 W212 S89 C90 G91 Y158 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALEH 3enz D 2.03 BS01 HPA D 1 S91 C92 G93 Y160 D206 S89 C90 G91 Y158 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz E 2.03 BS01 HPA E 1 S91 C92 G93 Y160 D206 S89 C90 G91 Y158 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3enz F 2.03 BS01 HPA F 1 S91 C92 G93 Y160 D206 S89 C90 G91 Y158 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3fnq A 1.85 BS01 HPA A 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 A112 A113 G114 Y196 E197 V213 G214 M215 T238 N239 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 981 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPK 3fnq B 1.85 BS01 HPA B 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 A105 A106 G107 Y189 E190 V206 G207 M208 T231 N232 S35 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H75 Y77 E78 A105 M208 S209 N232 S234 H243 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 991 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSLADGVKDKITIPYTKIPNFPQTGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLHEEVLATGAQRAELMQSWFEKIIEKLPKD 3fnq C 1.85 BS01 HPA C 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 A115 A116 G117 Y199 E200 V216 G217 M218 T241 N242 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H63 H85 Y87 E88 A115 M218 S219 N242 S244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 975 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLP 3lba A 2.24 BS01 HPA A 1 A113 A114 G115 Y190 E191 V207 G208 N233 A107 A108 G109 Y184 E185 V201 G202 N227 S30 H83 Y85 E86 A113 M209 S210 N233 A235 S30 H77 Y79 E80 A107 M203 S204 N227 A229 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q8DTU4 290 MSLLKKIYETRDFLTAKGVQKPEFGLILGSGLGELAEEIENALVLNYADIPNWGRSGKLIYGELAGRKVLALQGRFHYYEGNSMELVTFPIRIMKALGCQGLIVTNAAGGIGFGPGTLMAISDHINLTGANPLMGENLDDFGFRFPDMSNAYTADYREVAHQVADKIGIKLDEGVYIGVSGPSYETPAEIRAFKTLGADAVGMSTVPEVIVAVHSGLKVLGISAITNYAAGFQSELNVVAVTQQIKEDFKGLVKAILVEL 3nrz C 1.8 BS01 HPA C 1 E802 R880 F914 F1009 T1010 A1079 E232 R310 F344 F439 T440 A509 Q767 E802 R880 H884 R912 G1260 E1261 Q197 E232 R310 H314 R342 G690 E691 1.17.1.4,1.17.3.2 0005506,0016491,0043546 -logKd/Ki=5.34, Kd=4.6uM P80457 20615869 1 DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCK 3nrz L 1.8 BS01 HPA L 1 E802 R880 F914 F1009 T1010 A1079 E232 R310 F344 F439 T440 A509 H884 R912 E1261 H314 R342 E691 1.17.1.4,1.17.3.2 0005506,0016491,0043546 P80457 20615869 1 DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTT 3ozb A 2.8 BS01 HPA A 1 A100 V101 G102 L180 E181 V197 G198 M199 N223 A83 V84 G85 L163 E164 V180 G181 M182 N206 T24 P47 F73 P74 A100 M199 T200 N223 A225 M235 T10 P33 F56 P57 A83 M182 T183 N206 A208 M218 2.4.2.44 0003824,0005829,0006166,0009116,0016757,0016763,0017061,0019509 Q9HZK1 21197954 260 MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLA 3ozb B 2.8 BS01 HPA B 1 V101 G102 L180 E181 V197 M199 N223 V81 G82 L160 E161 V177 M179 N203 T24 P47 P74 A100 M199 T200 N223 A225 M235 T9 P32 P54 A80 M179 T180 N203 A205 M215 2.4.2.44 0003824,0005829,0006166,0009116,0016757,0016763,0017061,0019509 Q9HZK1 21197954 260 SVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLA 3ozb C 2.8 BS01 HPA C 1 V101 G102 E181 V197 M199 N223 V83 G84 E163 V179 M181 N205 T24 P47 F73 P74 A100 M199 T200 N223 A225 M235 T9 P32 F55 P56 A82 M181 T182 N205 A207 M217 2.4.2.44 0003824,0005829,0006166,0009116,0016757,0016763,0017061,0019509 Q9HZK1 21197954 260 SVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGRFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVL 3ozb D 2.8 BS01 HPA D 1 A100 V101 G102 E181 V197 G198 M199 N223 A81 V82 G83 E162 V178 G179 M180 N204 T24 P47 F73 P74 A100 M199 T200 N223 A225 M235 T9 P32 F54 P55 A81 M180 T181 N204 A206 M216 2.4.2.44 0003824,0005829,0006166,0009116,0016757,0016763,0017061,0019509 Q9HZK1 21197954 260 SVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLA 3ozb E 2.8 BS01 HPA E 1 V101 G102 E181 V197 N223 V79 G80 E159 V175 N201 T24 P47 P74 A100 M199 T200 N223 A225 M235 T8 P31 P52 A78 M177 T178 N201 A203 M213 2.4.2.44 0003824,0005829,0006166,0009116,0016757,0016763,0017061,0019509 Q9HZK1 21197954 260 VYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLA 3ozb F 2.8 BS01 HPA F 1 A100 V101 G102 E181 V197 M199 N223 A81 V82 G83 E162 V178 M180 N204 T24 P47 F73 P74 A100 M199 T200 N223 A225 M235 T9 P32 F54 P55 A81 M180 T181 N204 A206 M216 2.4.2.44 0003824,0005829,0006166,0009116,0016757,0016763,0017061,0019509 Q9HZK1 21197954 260 SVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLA 3ozf A 1.944 BS01 HPA A 1 Y116 I146 D148 K176 F197 V198 Y121 I151 D153 K181 F202 V203 E144 D145 D148 F197 R210 E149 D150 D153 F202 R215 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 232 PRGSHMPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozf B 1.944 BS01 HPA B 1 Y116 I146 D148 K176 F197 V198 Y122 I152 D154 K182 F203 V204 E144 D145 D148 F197 R210 E150 D151 D154 F203 R216 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 232 VPRGSHMPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozf C 1.944 BS01 HPA C 1 Y116 I146 D148 K176 F197 V198 Y115 I145 D147 K175 F196 V197 E144 D145 D148 F197 R210 E143 D144 D147 F196 R209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 232 PIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKAT 3ozf D 1.944 BS02 HPA D 1 Y116 I146 D148 K176 F197 V198 Y115 I145 D147 K175 F196 V197 E144 D145 D148 F197 R210 E143 D144 D147 F196 R209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 235 PIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKAT 3pan A 2.627 BS02 HPA A 1 H18 L60 Y63 S169 H196 E199 H220 D277 D278 H15 L57 Y60 S166 H193 E196 H217 D274 D275 H16 H18 H196 E199 H220 D277 H13 H15 H193 E196 H217 D274 3.5.4.2 0000034,0006146,0008270,0009117,0016787,0019239,0043103,0046872 Q9I6Y4 328 YEWLNALPKAELHLHLEGTLEPELLFALAERNRIALPWNDVETLRKAYAFNNLQEFLDLYYAGADVLRTEQDFYDLTWAYLQKCKAQNVVHVEPFFDPQTHTDRGIPFEVVLAGIRAALRDGEKLLGIRHGLILSFLRHLSEEQAQKTLDQALPFRDAFIAVGLDSSEVGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKVERIDHGVRAFEDERLMRRLIDEQIPLTVCPLSNTKLCVFDDMSQHTILDMLERGVKVTVNSDDPAYFGGYVTENFHALQQSLGMTEEQARRLAQNSLDARL 3pan B 2.627 BS02 HPA B 1 H18 L56 L60 Y63 S169 H196 E199 D277 D278 H15 L53 L57 Y60 S166 H193 E196 D274 D275 H16 H18 H196 E199 H220 D277 H13 H15 H193 E196 H217 D274 3.5.4.2 0000034,0006146,0008270,0009117,0016787,0019239,0043103,0046872 Q9I6Y4 328 YEWLNALPKAELHLHLEGTLEPELLFALAERNRIALPWNDVETLRKAYAFNNLQEFLDLYYAGADVLRTEQDFYDLTWAYLQKCKAQNVVHVEPFFDPQTHTDRGIPFEVVLAGIRAALRDGEKLLGIRHGLILSFLRHLSEEQAQKTLDQALPFRDAFIAVGLDSSEVGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKVERIDHGVRAFEDERLMRRLIDEQIPLTVCPLSNTKLCVFDDMSQHTILDMLERGVKVTVNSDDPAYFGGYVTENFHALQQSLGMTEEQARRLAQNSLDARLV 3scz A 1.95 BS01 HPA A 1 G122 Y188 E189 G206 M207 N231 G117 Y183 E184 G201 M202 N226 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S31 H63 H85 Y87 E88 A115 M202 S203 N226 A228 H238 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 269 PDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3scz B 1.95 BS01 HPA B 1 A120 A121 G122 Y188 E189 V205 G206 M207 T230 N231 A114 A115 G116 Y182 E183 V199 G200 M201 T224 N225 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 269 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 4dab A 1.85 BS01 HPA A 1 G92 F159 V177 M179 G91 F158 V176 M178 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4uc0 A 2.4 BS01 HPA A 1 A109 G110 F184 E185 G202 M203 T226 N227 A99 G100 F174 E175 G192 M193 T216 N217 S25 H78 Y80 E81 A108 M203 S204 N227 G229 S23 H68 Y70 E71 A98 M193 S194 N217 G219 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 B9JYS2 301 PAVDLLIDRLNGLLPRIAIVLGSGLGGLVDEVENAVRIPFADIPGFPKELVAGLFAGQPIIMLAGRVHYYEEGDAAAMRLPIETLASLGVTTLILTNAAGSLRADMPPGSVMQLIDHINFSGHNPLIGETGDGRFVGMTQAYDGELAEAMRRAADAEDISLSSGVYMWFSGPSFETPAEIRMARTLGADAVGMSTVPEVILARFFGLKVAAASVITNYGAGMTDMAPIGGRRLVAILKRMIVDGGAD 5ifk A 1.967 BS01 HPA A 1 A130 G131 E214 M232 T255 N256 A119 G120 E203 M221 T244 N245 S42 H98 Y100 E101 A129 M232 S233 N256 C258 H281 S38 H87 Y89 E90 A118 M221 S222 N245 C247 H270 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 27768715 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 5ifk B 1.967 BS01 HPA B 1 A130 G131 F213 E214 M232 N256 A117 G118 F200 E201 M219 N243 S42 H98 Y100 E101 A129 M232 S233 N256 C258 H281 S38 H85 Y87 E88 A116 M219 S220 N243 C245 H268 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 27768715 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 5ifk C 1.967 BS01 HPA C 1 A130 G131 F213 E214 V230 M232 T255 N256 A116 G117 F199 E200 V216 M218 T241 N242 S42 H98 Y100 E101 A129 M232 S233 N256 C258 H281 S37 H84 Y86 E87 A115 M218 S219 N242 C244 H267 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 27768715 401 INEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 5mx4 C 2.31 BS01 HPA C 1 T90 C91 G92 F159 I178 E179 M180 D204 L206 T90 C91 G92 F159 I178 E179 M180 D204 L206 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.3 0003824,0004731,0004850,0005829,0006139,0006152,0009116,0009164,0016757,0016763 K2JXG0 28336275 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 A 2.41 BS01 HPA A 1 T90 C91 F159 I178 D204 T90 C91 F159 I178 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 B 2.41 BS01 HPA B 1 G92 F159 G92 F159 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 C 2.41 BS01 HPA C 1 T90 C91 G92 F159 I178 D204 T90 C91 G92 F159 I178 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 D 2.41 BS01 HPA D 1 T90 G92 F159 T90 G92 F159 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 F 2.41 BS01 HPA F 1 T90 C91 F159 T90 C91 F159 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx8 A 2.4 BS01 HPA A 1 T90 C91 G92 F159 M180 S203 D204 T90 C91 G92 F159 M180 S203 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5tbu A 2.1 BS01 HPA A 1 A119 G120 Y202 E203 N245 A115 G116 Y198 E199 N241 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 301 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 6hgq A 1.9 BS02 HPA A 1 F26 R27 R67 E104 Y105 L129 F25 R26 R66 E103 Y104 L128 2.4.2.7 0002055,0003999,0005515,0005576,0005654,0005737,0005829,0006166,0006168,0007625,0016208,0016757,0032263,0032264,0034774,0044209,0046083,0070062 P07741 31160323 204 ADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE 6hgq B 1.9 BS02 HPA B 1 F26 R27 R67 E104 Y105 L129 F20 R21 R61 E98 Y99 L123 2.4.2.7 0002055,0003999,0005515,0005576,0005654,0005737,0005829,0006166,0006168,0007625,0016208,0016757,0032263,0032264,0034774,0044209,0046083,0070062 P07741 31160323 202 SELQLVEQRIRSFPDFPVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE 6hgq C 1.9 BS02 HPA C 1 F26 R27 R67 E104 Y105 L129 F25 R26 R66 E103 Y104 L128 2.4.2.7 0002055,0003999,0005515,0005576,0005654,0005737,0005829,0006166,0006168,0007625,0016208,0016757,0032263,0032264,0034774,0044209,0046083,0070062 P07741 31160323 202 ADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE 6hgq D 1.9 BS03 HPA D 1 F26 R27 R67 E104 Y105 L129 F23 R24 R64 E101 Y102 L126 2.4.2.7 0002055,0003999,0005515,0005576,0005654,0005737,0005829,0006166,0006168,0007625,0016208,0016757,0032263,0032264,0034774,0044209,0046083,0070062 P07741 31160323 202 SELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE 6ii7 A 2.48 BS02 HPA A 1 H48 G205 D314 D315 H36 G193 D302 D303 3.5.4.31,3.5.4.4 0004000,0005829,0006154,0006166,0009168,0009897,0016787,0019239,0043103,0046103,0046872,0046936,0060169,0090614 Q8IJA9 31002765 402 INYLTKDELDIDLSQMDKKERYKIWKRLPKCELHCHLDVCFSVDFFLNVIRKYNIQPNMSDEEIIDYYLFSKPGKSLDEFVEKALRLTDIYIDYTVVEDLAKHAVFNKYKEGVVLMEFRYSPSFMSFKHNLDKDLIHEAIVKGLNEAVALLEYKIQVGLLCTGDGGLSHERMKEAAEFCIKHKKDFVGYDHAGHEVDLKPFKDIFDNIREEGISISVHAGEDVSIPNLNSLYTAINLLHVKRIGHGIRVSESQELIDLVKEKDILLEVCPISNVLLNNVKSMDTHPIRMLYDAGVKVSVNSDDPGMFLTNITDNYEELYTHLNFTLADFMKMNLWAVQKSFVDPDIKNKIISKYF 8q6y A 1.81 BS03 HPA A 1 I277 D279 L281 M382 K383 I270 D272 L274 M375 K376 0004497,0006707,0008395,0036199,0046872 A0A0F4JF04 503 ILDFPFTWDGTHLPAQIGELAPVVKVRTIAGAEAWLVSSYELVKQVLEDDRFSLKNTSDPGVPRQYALTIPPEVVNNMGNITGAGLRKAVMKAINPKAPGLQEWMEEHAAELVERMLKHGAPVDIRSMFTDPFSEAMHCQILGIPHEAAPLLSESLPIAFMNSPREIPAARLNWDRDIAYMTARLDDTEQGLIGDLAKLRGTEGYEHVSDEMFATVGVTLFGAGVISTAGFLAMALVTLLTHPEEADHLADHPELMPQAVDELLRINLSIGDGLPRLAMEDMTLGEVEVKKGELVLVLPEGANFDPSVFPDPHRLDFTRANSSAHFSFGGGSHYCPATALGKKHAEIGLRAVLAAMPRLRLAVPVEQLVWRTGFMKRLPERLPVMWGSG 8q6y B 1.81 BS02 HPA B 1 I277 D279 L281 M382 K383 I270 D272 L274 M375 K376 0004497,0006707,0008395,0036199,0046872 A0A0F4JF04 504 ILDFPFTWDGTHLPAQIGELAPVVKVRTIAGAEAWLVSSYELVKQVLEDDRFSLKNTSDPGVPRQYALTIPPEVVNNMGNITGAGLRKAVMKAINPKAPGLQEWMEEHAAELVERMLKHGAPVDIRSMFTDPFSEAMHCQILGIPHEAAPLLSESLPIAFMNSPREIPAARLNWDRDIAYMTARLDDTEQGLIGDLAKLRGTEGYEHVSDEMFATVGVTLFGAGVISTAGFLAMALVTLLTHPEEADHLADHPELMPQAVDELLRINLSIGDGLPRLAMEDMTLGEVEVKKGELVLVLPEGANFDPSVFPDPHRLDFTRANSSAHFSFGGGSHYCPATALGKKHAEIGLRAVLAAMPRLRLAVPVEQLVWRTGFMKRLPERLPVMWGS 8q6y B 1.81 BS03 HPA B 2 T76 I77 F167 V225 T69 I70 F160 V218 0004497,0006707,0008395,0036199,0046872 A0A0F4JF04 505 ILDFPFTWDGTHLPAQIGELAPVVKVRTIAGAEAWLVSSYELVKQVLEDDRFSLKNTSDPGVPRQYALTIPPEVVNNMGNITGAGLRKAVMKAINPKAPGLQEWMEEHAAELVERMLKHGAPVDIRSMFTDPFSEAMHCQILGIPHEAAPLLSESLPIAFMNSPREIPAARLNWDRDIAYMTARLDDTEQGLIGDLAKLRGTEGYEHVSDEMFATVGVTLFGAGVISTAGFLAMALVTLLTHPEEADHLADHPELMPQAVDELLRINLSIGDGLPRLAMEDMTLGEVEVKKGELVLVLPEGANFDPSVFPDPHRLDFTRANSSAHFSFGGGSHYCPATALGKKHAEIGLRAVLAAMPRLRLAVPVEQLVWRTGFMKRLPERLPVMWGS 8swp A 2.1 BS01 HPA A 1 A129 A130 G131 F213 E214 V230 T255 N256 A118 A119 G120 F202 E203 V219 T244 N245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swp B 2.1 BS01 HPA B 1 A129 A130 G131 E214 M232 N256 A119 A120 G121 E184 M202 N226 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swp D 2.1 BS01 HPA D 1 A129 A130 G131 F213 E214 V230 M232 T255 N256 A120 A121 G122 F204 E205 V221 M223 T246 N247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swp E 2.1 BS01 HPA E 1 A130 G131 F213 E214 M232 N256 A123 G124 F188 E189 M207 N231 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 EQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSTVPGHSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI