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BioLiP
Download all results in tab-seperated text for 14664 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    9601 5unx:B (2.03) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9602 5uny:A (1.82) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9603 5uny:B (1.82) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9604 5unz:A (1.95) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9605 5unz:B (1.95) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9606 5uo0:A (1.97) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9607 5uo0:B (1.97) BS02 HEM 1.14.13.39 GO:0004517 ... P29476 28422508
    9608 5uo1:A (1.9) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9609 5uo1:B (1.9) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9610 5uo2:A (1.947) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9611 5uo2:B (1.947) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9612 5uo3:A (2.2) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9613 5uo3:B (2.2) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9614 5uo4:A (2.0) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9615 5uo4:B (2.0) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9616 5uo5:A (2.0) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9617 5uo5:B (2.0) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9618 5uo6:A (1.96) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9619 5uo6:B (1.96) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9620 5uo7:A (2.06) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9621 5uo7:B (2.06) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28422508
    9622 5uo8:A (2.18) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9623 5uo8:B (2.18) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9624 5uo8:C (2.18) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9625 5uo8:D (2.18) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9626 5uo9:A (2.19) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9627 5uo9:B (2.19) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9628 5uo9:C (2.19) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9629 5uo9:D (2.19) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9630 5uoa:A (2.2) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9631 5uoa:B (2.2) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9632 5uob:A (2.292) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9633 5uob:B (2.292) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9634 5uob:C (2.292) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9635 5uob:D (2.292) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9636 5uoc:A (2.2) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9637 5uoc:B (2.2) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9638 5uoc:C (2.2) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9639 5uoc:D (2.2) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28422508
    9640 5uod:A (2.01) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28422508
    9641 5uod:B (2.01) BS03 HEM 1.14.13.39 GO:0004517 ... P29473 28422508
    9642 5urc:A (1.85) BS01 HEM ? GO:0004601 ... P69905 28858508
    9643 5urc:B (1.85) BS01 HEM ? GO:0004601 ... P68871 28858508
    9644 5urc:C (1.85) BS01 HEM ? GO:0004601 ... P69905 28858508
    9645 5urc:D (1.85) BS01 HEM ? GO:0004601 ... P68871 28858508
    9646 5ut7:A (1.85) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9647 5ut8:A (1.78) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9648 5ut9:A (1.85) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9649 5uta:A (1.81) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9650 5utb:A (1.78) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9651 5utc:A (1.8) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9652 5utd:A (1.78) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9653 5uvb:A (1.54) BS01 HEM ? GO:0004497 ... Q2IU02 N/A
    9654 5uys:A (2.392) BS01 HEM 1.14.14.19
    1.14.14.32
    GO:0004497 ... P05093 36773804
    9655 5uys:B (2.392) BS01 HEM 1.14.14.19
    1.14.14.32
    GO:0004497 ... P05093 36773804
    9656 5uys:C (2.392) BS01 HEM 1.14.14.19
    1.14.14.32
    GO:0004497 ... P05093 36773804
    9657 5uys:D (2.392) BS01 HEM 1.14.14.19
    1.14.14.32
    GO:0004497 ... P05093 36773804
    9658 5v2c:E (1.9) BS01 HEM ? GO:0005506 ... P12238 28741056
    9659 5v2c:F (1.9) BS01 HEM ? GO:0005506 ... P12239 28741056
    9660 5v2c:e (1.9) BS01 HEM ? GO:0005506 ... P12238 28741056
    9661 5v2c:f (1.9) BS01 HEM ? GO:0005506 ... P12239 28741056
    9662 5v3t:A (1.899) BS01 HEM ? GO:0005344 ... A0A6L7H965 N/A
    9663 5v3t:B (1.899) BS01 HEM ? GO:0005344 ... A0A6L7H965 N/A
    9664 5v3u:A (2.5) BS01 HEM ? GO:0005344 ... A0A6L7H965 N/A
    9665 5v3u:B (2.5) BS01 HEM ? GO:0005344 ... A0A6L7H965 N/A
    9666 5v3v:A (2.14) BS01 HEM ? GO:0005344 ... A0A6L7H965 N/A
    9667 5v3v:B (2.14) BS01 HEM ? GO:0005344 ... A0A6L7H965 N/A
    9668 5v4o:A (1.95) BS01 HEM 1.11.1.21 GO:0004096 ... Q3JNW6 28409923
    9669 5v4o:B (1.95) BS01 HEM 1.11.1.21 GO:0004096 ... Q3JNW6 28409923
    9670 5v53:A (1.7) BS01 HEM 1.11.1.21 GO:0004096 ... Q3JNW6 28409923
    9671 5v53:B (1.7) BS01 HEM 1.11.1.21 GO:0004096 ... Q3JNW6 28409923
    9672 5v5j:A (1.814) BS01 HEM ? GO:0004601 ... Q9NAV7 29128676
    9673 5v5j:B (1.814) BS01 HEM ? GO:0004601 ... Q9NAV7 29128676
    9674 5v5q:A (1.961) BS01 HEM ? GO:0004601 ... Q9NAV7 29128676
    9675 5v5q:B (1.961) BS01 HEM ? GO:0004601 ... Q9NAV7 29128676
    9676 5v5r:A (1.2) BS01 HEM ? GO:0004601 ... Q9NAV8 29128676
    9677 5v5r:B (1.2) BS01 HEM ? GO:0004601 ... Q9NAV8 29128676
    9678 5v5z:A (2.9) BS01 HEM 1.14.14.154 GO:0001766 ... P10613 30126961
    9679 5vbu:A (3.31) BS01 HEM 1.14.14.16 GO:0004497 ... P08686 28539365
    9680 5vbu:B (3.31) BS01 HEM 1.14.14.16 GO:0004497 ... P08686 28539365
    9681 5vbu:C (3.31) BS01 HEM 1.14.14.16 GO:0004497 ... P08686 28539365
    9682 5vc0:A (2.7) BS01 HEM 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73
    GO:0002933 ... P08684 28590129
    9683 5vcc:A (1.7) BS01 HEM 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73
    GO:0002933 ... P08684 28590129
    9684 5vcd:A (1.95) BS01 HEM 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73
    GO:0002933 ... P08684 28590129
    9685 5vce:A (2.2) BS01 HEM 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73
    GO:0002933 ... P08684 28590129
    9686 5vcg:A (2.2) BS01 HEM 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73
    GO:0002933 ... P08684 28590129
    9687 5veu:A (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9688 5veu:B (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9689 5veu:C (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9690 5veu:D (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9691 5veu:E (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9692 5veu:F (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9693 5veu:G (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9694 5veu:H (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9695 5veu:I (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9696 5veu:J (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9697 5veu:K (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9698 5veu:L (2.91) BS01 HEM 1.14.14.1 GO:0002933 ... P20815 29093019
    9699 5via:A (1.764) BS01 HEM ? GO:0004601 ... Q4QC30 28584975
    9700 5vj0:A (1.93) BS01 HEM ? GO:0004601 ... E3G9I4 29308295
    9701 5vj0:B (1.93) BS01 HEM ? GO:0004601 ... E3G9I4 29308295
    9702 5vj0:C (1.93) BS01 HEM ? GO:0004601 ... E3G9I4 29308295
    9703 5vj0:D (1.93) BS01 HEM ? GO:0004601 ... E3G9I4 29308295
    9704 5vjs:A (2.0) BS01 HEM N/A N/A N/A 35999239
    9705 5vjt:A (1.45) BS03 HEM N/A N/A N/A 35999239
    9706 5vju:A (2.08) BS01 HEM N/A N/A N/A 35999239
    9707 5vlx:A (1.8) BS01 HEM ? GO:0004601 ... Q9NAV7 29170897
    9708 5vlx:B (1.8) BS01 HEM ? GO:0004601 ... Q9NAV7 29170897
    9709 5vmm:A (3.6) BS01 HEM ? GO:0004601 ... P69905 29109153
    9710 5vmm:C (3.6) BS01 HEM ? GO:0004601 ... P69905 29109153
    9711 5vmm:E (3.6) BS01 HEM ? N/A Q7A656 29109153
    9712 5vmm:F (3.6) BS01 HEM ? N/A Q7A656 29109153
    9713 5vnu:A (1.584) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 28768416
    9714 5vrt:A (1.995) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 28768416
    9715 5vts:A (1.571) BS01 HEM ? GO:0004601 ... Q9NAV7 N/A
    9716 5vts:B (1.571) BS01 HEM ? GO:0004601 ... Q9NAV7 N/A
    9717 5vtt:A (1.903) BS01 HEM ? GO:0004601 ... Q9NAV7 N/A
    9718 5vtt:B (1.903) BS01 HEM ? GO:0004601 ... Q9NAV7 N/A
    9719 5vui:A (2.06) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9720 5vui:B (2.06) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9721 5vuj:A (1.952) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9722 5vuj:B (1.952) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9723 5vuk:A (1.95) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9724 5vuk:B (1.95) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9725 5vul:A (2.0) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9726 5vul:B (2.0) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9727 5vum:A (2.1) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9728 5vum:B (2.1) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9729 5vun:A (1.745) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9730 5vun:B (1.745) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9731 5vuo:A (1.8) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9732 5vuo:B (1.8) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9733 5vup:A (1.94) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9734 5vup:B (1.94) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9735 5vuq:A (2.002) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9736 5vuq:B (2.002) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9737 5vur:A (1.97) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9738 5vur:B (1.97) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9739 5vus:A (1.95) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9740 5vus:B (1.95) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9741 5vut:A (2.0) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9742 5vut:B (2.0) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9743 5vuu:A (1.96) BS01 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9744 5vuu:B (1.96) BS03 HEM 1.14.13.39 GO:0004517 ... P29476 28776992
    9745 5vuv:A (1.983) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9746 5vuv:B (1.983) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9747 5vuw:A (2.03) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9748 5vuw:B (2.03) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9749 5vux:A (2.3) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9750 5vux:B (2.3) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9751 5vuy:A (2.154) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9752 5vuy:B (2.154) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9753 5vuz:A (1.97) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9754 5vuz:B (1.97) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9755 5vv0:A (1.8) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9756 5vv0:B (1.8) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9757 5vv1:A (1.95) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9758 5vv1:B (1.95) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9759 5vv2:A (2.0) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9760 5vv2:B (2.0) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9761 5vv3:A (2.18) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9762 5vv3:B (2.18) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9763 5vv4:A (2.1) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9764 5vv4:B (2.1) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9765 5vv5:A (2.15) BS01 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9766 5vv5:B (2.15) BS03 HEM 1.14.13.39 GO:0004517 ... P29475 28776992
    9767 5vv6:A (2.0) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9768 5vv6:B (2.0) BS03 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9769 5vv7:A (2.2) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9770 5vv7:B (2.2) BS03 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9771 5vv8:A (2.15) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9772 5vv8:B (2.15) BS03 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9773 5vv9:A (2.5) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9774 5vv9:B (2.5) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9775 5vva:A (2.55) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9776 5vva:B (2.55) BS03 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9777 5vvb:A (2.15) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9778 5vvb:B (2.15) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9779 5vvb:C (2.15) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9780 5vvb:D (2.15) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9781 5vvc:A (2.4) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9782 5vvc:B (2.4) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9783 5vvc:C (2.4) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9784 5vvc:D (2.4) BS02 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9785 5vvd:A (2.25) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9786 5vvd:B (2.25) BS02 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9787 5vvd:C (2.25) BS01 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9788 5vvd:D (2.25) BS03 HEM 1.14.13.39 GO:0004517 ... P29474 28776992
    9789 5vvg:A (2.3) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9790 5vvg:B (2.3) BS02 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9791 5vvn:A (2.4) BS01 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9792 5vvn:B (2.4) BS03 HEM 1.14.13.39 GO:0004517 ... P29473 28776992
    9793 5vws:A (2.411) BS01 HEM ? GO:0004497 ... D6Y4Z8 28535034
    9794 5vzn:A (1.7) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9795 5vzo:A (1.78) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9796 5vzp:A (1.78) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9797 5vzq:A (1.79) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 29999305
    9798 5w0c:A (2.001) BS01 HEM 1.14.14.1
    1.14.14.51
    1.14.14.52
    1.14.14.53
    GO:0004497 ... P11712 28815830
    9799 5w58:A (2.267) BS01 HEM 1.14.99.1 GO:0001516 ... Q05769 29326169
    9800 5wbe:A (2.75) BS01 HEM 1.14.99.1 GO:0004601 ... P05979 28710965

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218