1ahx A 2.0 BS02 HCI A 1 I17 L18 G38 W140 K258 R386 I13 L14 G34 W130 K246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=120uM -logKd/Ki=3.92, Kd=120uM P00509 7664122 411 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1ahx B 2.0 BS02 HCI B 1 I17 L18 I37 G38 W140 K258 R386 I13 L14 I33 G34 W130 K246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=120uM -logKd/Ki=3.92, Kd=120uM P00509 7664122 411 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1ay8 B 2.3 BS02 HCI B 1 V37 G38 W140 N142 R386 V27 G28 W121 N123 R365 W140 D222 A224 K258 W121 D202 A204 K237 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 P95468 9665848 414 MLGNLKPQAPDKILALMGEFGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV 1bxg A 2.3 BS02 HCI A 1 G39 G40 K66 G39 G40 K66 1.4.1.20 0000166,0006520,0006559,0009094,0016491,0016639,0050175 Q59771 10029526 361 SIDSALNWDGEMTVTRFDSKTGAHFVIRLDSTQLGPAAGGTRAAQYSQLADALTDAGKLAGAMTLKMAVSNLPMGGGKSVIALPAPRHSIDPSTWARILRIHAENIDKLSGNYWTGPDVNTNSADMDTLNDTTEFVFGRSLERGGAGSSAFTTAVGVFEAMKATVAHRGLGSLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERVAHAVALGHTAVALEDVLSTPCDVFAPCAMGGVITTEVARTLDCSVVAGAANNVIADEAASDILHARGILYAPDFVANAGGAIHLVGREVLGWSESVVHERAVAIGDTLNQVFEISDNDGVTPDEAARTLAGRRAREAS 1bxg B 2.3 BS02 HCI B 1 G439 G440 K466 G516 N662 G39 G40 K66 G116 N262 1.4.1.20 0000166,0006520,0006559,0009094,0016491,0016639,0050175 Q59771 10029526 761 SIDSALNWDGEMTVTRFDRMTGAHFVIRLDSTQLGPAAGGTRAAQYSQLADALTDAGKLAGAMTLKMAVSNLPMGGGKSVIALPAPRHSIDPSTWARILRIHAENIDKLSGNYWTGPDVNTNSADMDTLNDTTEFVFGRSLERGGAGSSAFTTAVGVFEAMKATVAHRGLGSLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERVAHAVALGHTAVALEDVLSTPCDVFAPCAMGGVITTEVARTLDCSVVAGAANNVIADEAASDILHARGILYAPDFVANAGGAIHLVGREVLGWSESVVHERAVAIGDTLNQVFEISDNDGVTPDEAARTLAGRRARE 1tog A 2.31 BS01 HCI A 1 L18 I37 W140 X258 R386 L14 I33 W130 X246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=0.6mM -logKd/Ki=3.22, Kd=0.6mM P00509 15461450 410 MFENITATTADPILGLADLFRADERPGKIDLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFALYNERVGACTLVAADSETVDRAFGQMKAAIRDNYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1tog B 2.31 BS01 HCI A 1 Y70 S296 Y65 S284 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=0.6mM -logKd/Ki=3.22, Kd=0.6mM P00509 15461450 410 MFENITATTADPILGLADLFRADERPGKIDLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFALYNERVGACTLVAADSETVDRAFGQMKAAIRDNYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1tog B 2.31 BS02 HCI B 1 L18 I37 G38 W140 X258 R386 L14 I33 G34 W130 X246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=0.6mM -logKd/Ki=3.22, Kd=0.6mM P00509 15461450 410 MFENITATTADPILGLADLFRADERPGKIDLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFALYNERVGACTLVAADSETVDRAFGQMKAAIRDNYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1toi A 1.9 BS01 HCI A 1 G38 W140 X258 R386 G34 W130 X246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=0.09mM -logKd/Ki=4.05, Kd=0.090mM P00509 15461450 410 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRDNYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1toj A 1.9 BS01 HCI A 1 I17 L18 I37 G38 W140 X258 R386 I13 L14 I33 G34 W130 X246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=0.41mM -logKd/Ki=3.39, Kd=0.41mM P00509 15461450 410 MFENITATTADPILGLADLFRADERPGKIDLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFALYNERVGACTLVAADSETVDRAFGQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1v2f A 2.35 BS02 HCI A 1 F15 Q32 G33 F112 R347 F15 Q32 G33 F112 R347 F112 A181 A183 K222 F112 A181 A183 K222 2.6.1.15 0005737,0008483,0009058,0016212,0030170 Q75WK2 14761974 520 MRLHPRTEAAKESIFPRMSGLAQRLGAVNLGQGFPSNPPPPFLLEAVRRALGRQDQYAPPAGLPALREALAEEFAVEPESVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFAFCKTEEELHLALERLGRVV 1v2f A 2.35 BS03 HCI B 1 Y57 F253 Y57 F253 F112 A181 A183 K222 F112 A181 A183 K222 2.6.1.15 0005737,0008483,0009058,0016212,0030170 Q75WK2 14761974 1520 MRLHPRTEAAKESIFPRMSGLAQRLGAVNLGQGFPSNPPPPFLLEAVRRALGRQDQYAPPAGLPALREALAEEFAVEPESVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFAFCKTEEELHLALERLGRVV 1v2f B 2.35 BS01 HCI A 1 Y57 F253 Y57 F253 F112 A181 A183 K222 F112 A181 A183 K222 2.6.1.15 0005737,0008483,0009058,0016212,0030170 Q75WK2 14761974 520 MRLHPRTEAAKESIFPRMSGLAQRLGAVNLGQGFPSNPPPPFLLEAVRRALGRQDQYAPPAGLPALREALAEEFAVEPESVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFAFCKTEEELHLALERLGRV 1v2f B 2.35 BS03 HCI B 1 Q32 G33 F112 F309 R347 Q32 G33 F112 F309 R347 F112 A181 A183 K222 F112 A181 A183 K222 2.6.1.15 0005737,0008483,0009058,0016212,0030170 Q75WK2 14761974 1520 MRLHPRTEAAKESIFPRMSGLAQRLGAVNLGQGFPSNPPPPFLLEAVRRALGRQDQYAPPAGLPALREALAEEFAVEPESVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFAFCKTEEELHLALERLGRV 3ayi A 1.25 BS02 HCI A 1 R143 L319 Y536 W538 F617 G659 W660 R124 L300 Y513 W515 F594 G636 W637 1.13.12.9 0000166,0004497,0050172 Ki=13.9uM Q5W9R9 21841183 907 KIATTVGEARLSGINYRHPDSALVSYPVAAAAPLGRLPAGNYRIAIVGGGAGGIAALYELGRLAATLPAGSGIDVQIYEADPDSFLHDRAIKVRGLKAGRVSAALVHNGDPASGDTIYEVGAMRFPEIAGLTWHYASAAFGDAAPIKVFPNPGKVPTEFVFGNRVDRYVGSDPKDWEDPDSPTLKVLGVVAGGLVGNPQGENVAMYPIANVDPAKIAAILNAATPPADALERIQTKYWPEFIAQYDGLTLGAAVREIVTVAFEKGTLPPVDGVLDVDESISYYVELFGRFGFGTGGFKPLYNISLVEMMRLILWDYSNEYTLPVTENVEFIRNLFLKAQNVGAGKLVVQVRQERVANACHSGTASARAQLLSYDSHNAVHSEAYDFVILAVPHDQLTPIVSRSGFEHAASQNLGDAGLGLETHTYNQVYPPLLLSDSSPAANARIVTAIGQLHMARSSKVFATVKTAALDQPWVPQWRGEPIKAVVSDSGLAASYVVPSPIVAPEYSSLLASYTWEDDSTRLRHDFGLYPQNPATETGTADGMYRTMVNRAYRYVKYAGASNAQPWWFYQLLAEARTADRFVFDWTTNKTAGGFKLDMTGDHHQSNLCFRYHTHALAASLDNRFFIASDSYSHLGGWLEGAFMSALNAVAGLIVRANRGDVSALSTEARPLVIGLRPVVKVPAA 3ayi B 1.25 BS02 HCI B 1 R143 L319 Y536 W538 F617 G659 W660 R124 L300 Y513 W515 F594 G636 W637 1.13.12.9 0000166,0004497,0050172 Ki=13.9uM Q5W9R9 21841183 1907 KIATTVGEARLSGINYRHPDSALVSYPVAAAAPLGRLPAGNYRIAIVGGGAGGIAALYELGRLAATLPAGSGIDVQIYEADPDSFLHDRAIKVRGLKAGRVSAALVHNGDPASGDTIYEVGAMRFPEIAGLTWHYASAAFGDAAPIKVFPNPGKVPTEFVFGNRVDRYVGSDPKDWEDPDSPTLKVLGVVAGGLVGNPQGENVAMYPIANVDPAKIAAILNAATPPADALERIQTKYWPEFIAQYDGLTLGAAVREIVTVAFEKGTLPPVDGVLDVDESISYYVELFGRFGFGTGGFKPLYNISLVEMMRLILWDYSNEYTLPVTENVEFIRNLFLKAQNVGAGKLVVQVRQERVANACHSGTASARAQLLSYDSHNAVHSEAYDFVILAVPHDQLTPIVSRSGFEHAASQNLGDAGLGLETHTYNQVYPPLLLSDSSPAANARIVTAIGQLHMARSSKVFATVKTAALDQPWVPQWRGEPIKAVVSDSGLAASYVVPSPIVAPEYSSLLASYTWEDDSTRLRHDFGLYPQNPATETGTADGMYRTMVNRAYRYVKYAGASNAQPWWFYQLLAEARTADRFVFDWTTNKTAGGFKLDMTGDHHQSNLCFRYHTHALAASLDNRFFIASDSYSHLGGWLEGAFMSALNAVAGLIVRANRGDVSALSTEARPLVIGLRPVVKVPAA 4gm7 A 2.6 BS03 HCI A 1 H109 F254 R255 E258 F381 H109 F254 R255 E258 F381 Q105 D108 H109 D110 T184 F186 D188 S190 R255 E258 H351 Q105 D108 H109 D110 T184 F186 D188 S190 R255 E258 H351 1.11.1.7 0004601,0006979,0020037 P80025 622 SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN 4usa A 1.13 BS06 HCI A 1 I255 F425 F494 L497 Y535 L626 I255 F425 F494 L497 Y535 L626 I390 F425 R501 F505 R533 E869 L870 I390 F425 R501 F505 R533 E869 L870 1.2.99.7 0005506,0016491,0033727,0046872,0051536,0051537 Q46509 25261288 922 MIQKVITVNGIEQNLFVDAEALLSDVLRQQLGLTGVKVGCEQGQCGACSVILDGKVVRACVTKMKRVADGAQITTIEGVGQPENLHPLQKAWVLHGGAQCGFCSPGFIVSAKGLLDTNADPSREDVRDWFQKHRNACRCTGYKPLVDAVMDAAAVINGKKPETDLEFKMPADGRIWGSKYPRPTAVAKVTGTLDYGADLGLKMPAGTLHLAMVQAKVSHANIKGIDTSEALTMPGVHSVITHKDVKGKNRITGLITFPTNKGDGWDRPILCDEKVFQYGDCIALVCADSEANARAAAEKVKVDLEELPAYMSGPAAAAEDAIEIHPGTPNVYFEQPIVKGEDTGPIFASADVTVEGDFYVGRQPHMPIEPDVAFAYMGDDGKCYIHSKSIGVHLHLYMIAPGVGLEPDQLVLVANPMGGTFGYKFSPTSEALVAVAAMATGRPVHLRYNYQQQQQYTGKRSPWEMNVKFAAKKDGTLLAMESDWLVDHGPYSEFGDLLTLRGAQFIGAGYNIPNIRGLGRTVATNHVWGSAFRGYGAPQSMFASECLMDMLAEKLGMDPLELRYKNAYRPGDTNPTGQEPEVFSLPDMIDQLRPKYQAALEKAQKESTATHKKGVGISIGVYGSGLDGPDASEAWAELNADGTITVHTAWEDHGQGADIGCVGTAHEALRPMGVAPEKIKFTWPNTATTPNSGPSGGSRQQVMTGNAIRVACENLLKACEKPGGGYYTYDELKAADKPTKITGNWTASGATHCDAVTGLGKPFVVYMYGVFMAEVTVDVATGQTTVDGMTLMADLGSLCNQLATDGQIYGGLAQGIGLALSEDFEDIKKHATLVGAGFPFIKQIPDKLDIVYVNHPRPDGPFGASGVGELPLTSPHAAIINAIKSATGVRIYRLPAYPEKVLEALKA 5ltm A 2.413 BS01 HCI B 1 F84 G85 L104 F60 G61 L80 F78 G85 L108 N223 Y314 R317 F363 Q452 F54 G61 L84 N197 Y288 R291 F337 Q426 4.3.1.24 0003824,0004397,0005737,0006559,0009072,0009698,0009699,0009800,0016829,0016841,0044550,0045548,0051289 Q3M5Z3 29057979 601 NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIFGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGADLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL 5ltm A 2.413 BS02 HCI A 1 Y314 R317 Y288 R291 F78 G85 L108 N223 Y314 R317 F363 Q452 F54 G61 L84 N197 Y288 R291 F337 Q426 4.3.1.24 0003824,0004397,0005737,0006559,0009072,0009698,0009699,0009800,0016829,0016841,0044550,0045548,0051289 Q3M5Z3 29057979 601 NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIFGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGADLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL 5ltm B 2.413 BS01 HCI B 1 Y314 R317 Y288 R291 F78 G85 L108 N223 Y314 R317 F363 Q452 F54 G61 L84 N197 Y288 R291 F337 Q426 4.3.1.24 0003824,0004397,0005737,0006559,0009072,0009698,0009699,0009800,0016829,0016841,0044550,0045548,0051289 Q3M5Z3 29057979 601 NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIFGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGADLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL 5ltm B 2.413 BS02 HCI A 1 F84 X168 L171 F60 X143 L145 F78 G85 L108 N223 Y314 R317 F363 Q452 F54 G61 L84 N197 Y288 R291 F337 Q426 4.3.1.24 0003824,0004397,0005737,0006559,0009072,0009698,0009699,0009800,0016829,0016841,0044550,0045548,0051289 Q3M5Z3 29057979 601 NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIFGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGADLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL 5vfn A 2.389 BS01 HCI A 1 K16 K20 K115 R118 K15 K19 K105 R108 N28 G30 L32 H48 K49 Y52 Y73 D99 N27 G29 L31 H47 K48 Y51 Y64 D89 ? 0004623,0005509,0005543,0005576,0006644,0016042,0035821,0042130,0042742,0047498,0050482,0090729 -logKd/Ki=3.52, Kd=300uM Q9IAT9 28751219 201 SLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGQPKDATDRCCYVHKCCYKKLTGCDPKKDRYSYSWKDKTIVCGENNPCLKELCECDKAVAICLRENLGTYNKKYRYHLKPFCKKADPC 6zgs A 2.151 BS01 HCI A 1 F60 Y119 L145 R280 F335 C362 F54 Y113 L139 R264 F319 C346 ? 0005886,0015293,0022857,0055085 A0LNN5 501 TMPRWVPLLLGLLGSTTCGMLLYAWSVFIKPLNAEFGWSRAEIAMAFAICCLIFGLMTFPAGRLSDKMGPRKVVMTGGVLLAIGFILSGFIQSKYQLYITYGVIAGFGGGMIYLPPIATAPKWWPDRRALATGFAVVGLGLGSFLMGPLATYIIEKPGMGWRYVFWYCGVAMGIMALIAGAFLEPPPAGWKPAGYTPKVTRDWTYEEAKGDTKFWLLYLAYFCGSFAGLMVIGHLAGFGRDAGLTAMAAAGAVSSLAFSNAATRILSGWFVDKIGIRVYFAALFALQTAAMIAIFQLGGSVVGLSIVAIVIGWNYGAMFTLFPATCLQFYGPTAQGSNYGLLFTACGLAGFAGPWVGGWLKDTTGTYYLPFLCAAALCALGTAIVFMTKPPEKKHALELEVLFQ 6zgs B 2.151 BS01 HCI B 1 F60 Y119 L145 R280 F335 F359 C362 F48 Y107 L133 R238 F293 F317 C320 ? 0005886,0015293,0022857,0055085 A0LNN5 501 PLLLGLLGSTTCGMLLYAWSVFIKPLNAEFGWSRAEIAMAFAICCLIFGLMTFPAGRLSDKMGPRKVVMTGGVLLAIGFILSGFIQSKYQLYITYGVIAGFGGGMIYLPPIATAPKWWPDRRALATGFAVVGLGLGSFLMGPLATYIIGWRYVFWYCGVAMGIMALIAGAFLEPRDWTYEEAKGDTKFWLLYLAYFCGSFAGLMVIGHLAGFGRDAGLTAMAAAGAVSSLAFSNAATRILSGWFVDKIGIRVYFAALFALQTAAMIAIFQLGGSVVGLSIVAIVIGWNYGAMFTLFPATCLQFYGPTAQGSNYGLLFTACGLAGFAGPWVGGWLKDTTGTYYLPFLCAAALCALGTAIVFMTKP 7nra AAA 1.91 BS01 HCI AAA 1 F10 Y72 R146 V168 E188 V189 L213 F215 Q251 F9 Y71 R145 V167 E187 V188 L212 F214 Q250 ? 0042597,0055085 A3K0X1 34375507 401 EVTLTLHQFLPAQANVPKDVLDVWADNVEEASDGRIEIERYPSMQLGGTPPELMDQAIDGIADIVWTVVGYTPGRYPSTEVFELPFMVSDARAASYAYWKMFEEHMKDGEFADVKILGTWVHGPGMFHTNKPVAVPSDLEGMKIRGGSRLVNDLLTRVGAEPIGMPVPAISEALSKGVIDGTTIPWEVTSALKVPELVGNHTEFDGPALYNLTFVLAMNKDAYESLPEDLQEVIDSQSGLAFSIFAGGTQADADGPARQIAVDRGNNIVTVSQEDAKAWDALVNPIYETWVAEMNDKGIDGQALIDEAKSLMEEYDPSMDTYGKAAA 7nra BBB 1.91 BS01 HCI BBB 1 F10 L11 W67 Y72 R146 P186 E188 V189 L213 F215 Q251 F10 L11 W67 Y72 R146 P186 E188 V189 L213 F215 Q251 ? 0042597,0055085 A3K0X1 34375507 401 QEVTLTLHQFLPAQANVPKDVLDVWADNVEEASDGRIEIERYPSMQLGGTPPELMDQAIDGIADIVWTVVGYTPGRYPSTEVFELPFMVSDARAASYAYWKMFEEHMKDGEFADVKILGTWVHGPGMFHTNKPVAVPSDLEGMKIRGGSRLVNDLLTRVGAEPIGMPVPAISEALSKGVIDGTTIPWEVTSALKVPELVGNHTEFDGPALYNLTFVLAMNKDAYESLPEDLQEVIDSQSGLAFSIFAGGTQADADGPARQIAVDRGNNIVTVSQEDAKAWDALVNPIYETWVAEMNDKGIDGQALIDEAKSLMEEYDPSMDTYGKAAA 7ntr A 2.23 BS01 HCI A 1 F49 T260 G332 T333 A334 F28 T236 G308 T309 A310 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 36261130 401 VGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREERDWTIVLS 7ntr A 2.23 BS03 HCI B 1 Y90 V175 Y69 V154 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 36261130 401 VGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREERDWTIVLS 7ntr B 2.23 BS01 HCI B 1 F49 Y193 T260 G332 T333 A334 F28 Y172 T235 G307 T308 A309 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 36261130 401 VGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREERDWTIVLS 7xro B 2.8 BS01 HCI B 1 T98 S100 T130 R148 I200 G201 L202 S203 L204 T14 S16 T46 R64 I116 G117 L118 S119 L120 ? 0006355 Q9RQ20 302 VARGESGVLRVGFTASAAFNSVVPGAIRTFKRAYPDVRLQLEEGNTTQLADELNEGSLDVAFLRPGFTGNERFQLRLLSEEPMVIVLAETHPAAACKQIALSILKDEFFLLFPREIGLSLYDAVIKACGKAGFEPKIGQLVPQISSVINLVSAEMGVSMVPDSMRQVNVKGVVYRPVADQMPVAKLALAYRRGDTSPTLRNFILKVT