1dwv A 2.35 BS04 HAR A 1 Q257 P344 Y367 E371 D376 Q181 P268 Y291 E295 D300 C194 R197 W366 E371 C118 R121 W290 E295 1.14.13.39 0004517,0006809,0020037 P29477 10769116 909 QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQ 1dwv B 2.35 BS04 HAR B 1 Q257 P344 G365 Y367 E371 D376 Q181 P268 G289 Y291 E295 D300 C194 R197 W366 E371 C118 R121 W290 E295 1.14.13.39 0004517,0006809,0020037 P29477 10769116 909 QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQ 1dww A 2.35 BS04 HAR A 1 Q257 P344 G365 W366 Y367 E371 D376 Q181 P268 G289 W290 Y291 E295 D300 C194 R197 W366 E371 C118 R121 W290 E295 1.14.13.39 0004517,0006809,0020037 P29477 10769116 909 QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQ 1dww B 2.35 BS04 HAR B 1 Q257 P344 G365 W366 Y367 E371 D376 Q181 P268 G289 W290 Y291 E295 D300 C194 R197 W366 E371 C118 R121 W290 E295 1.14.13.39 0004517,0006809,0020037 P29477 10769116 909 QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQ 1dwx A 2.6 BS03 HAR A 1 P344 G365 W366 Y367 E371 D376 P262 G283 W284 Y285 E289 D294 C194 R197 W366 E371 C112 R115 W284 E289 1.14.13.39 0004517,0006809,0020037 P29477 10769116 906 QYVRIKNWGSGEILHDTLHHKATSDSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQ 1dwx B 2.6 BS03 HAR B 1 P344 G365 W366 Y367 E371 D376 P259 G280 W281 Y282 E286 D291 C194 R197 W366 E371 C109 R112 W281 E286 1.14.13.39 0004517,0006809,0020037 P29477 10769116 906 QYVRIKNWGSGEILHDTLHHKATCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQ 1hqf A 2.9 BS03 HAR A 1 D124 H126 D128 H141 E186 D232 D234 E277 D119 H121 D123 H136 E181 D227 D229 E272 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 -logKd/Ki=5.00, Ki=10uM P07824 11258880 906 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf B 2.9 BS03 HAR B 1 D124 H126 D128 H141 E186 D232 D234 E277 D119 H121 D123 H136 E181 D227 D229 E272 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 907 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf C 2.9 BS03 HAR C 1 D124 H126 D128 H141 E186 D232 D234 E277 D119 H121 D123 H136 E181 D227 D229 E272 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 908 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1lzx A 2.0 BS04 HAR A 1 Q478 V567 G586 Y588 E592 D597 Q169 V258 G277 Y279 E283 D288 C415 R418 W587 E592 C106 R109 W278 E283 1.14.13.39 0004517,0006809,0020037 P29476 12437343 770 RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVW 1lzx B 2.0 BS05 HAR B 1 Q478 G586 W587 Y588 E592 D597 Q171 G279 W280 Y281 E285 D290 C415 R418 W587 E592 C108 R111 W280 E285 1.14.13.39 0004517,0006809,0020037 P29476 12437343 1770 RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWK 1m7z A 2.14 BS02 HAR A 1 Q125 I214 G233 W234 Y235 E239 N244 Q129 I216 G235 W236 Y237 E241 N246 C62 R65 W234 E239 C66 R69 W236 E241 1.14.14.47 0004517,0005575,0006809,0016491,0020037,0046872 O34453 12220171 909 GSHMEILWNEAKAFIAECYQELGKEEEVKDRLDSIKSEIDRTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEDVRDALFHHIETATNNGKIRPSITIFPPEEKGEKQVEIWNHQLIRYAGYEGERIGDPASRSLTAACEQLGWRGERTDFDLLPLIFRMRGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGISTNYNTDLWKDQALVELNKAVLYSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE 2fbz X 2.1 BS03 HAR X 1 Q125 I214 G233 W234 Y235 E239 N244 Q129 I216 G235 W236 Y237 E241 N246 1.14.14.47 0004517,0005575,0006809,0016491,0020037,0046872 O34453 16489746 909 GSHMEILWNEAKAFIAECYQELGKEEEVKDRLDSIKSEIDRTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEDVRDALFHHIETATNNGKIRPSITIFPPEEKGEKQVEIWNHQLIRYAGYEGERIGDPASRSLTAACEQLGWRGERTDFDLLPLIFRMRGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGISTNYNTDLWKDQALVELNKAVLYSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE 2fc2 A 2.2 BS02 HAR A 1 G233 W234 Y235 E239 N244 G236 W237 Y238 E242 N247 C62 R65 W234 E239 C65 R68 W237 E242 1.14.14.47 0004517,0005575,0006809,0016491,0020037,0046872 O34453 16489746 909 SHMEILWNEAKAFIAECYQELGKEEEVKDRLDSIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEDVRDALFHHIETATNNGKIRPSITIFPPEEKGEKQVEIWNHQLIRYAGYEAAGERIGDPASCSLTAACEQLGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGISTNYNTDLWKDQALVELNKAVLYSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE 2fc2 B 2.2 BS01 HAR A 2 Q125 I214 G233 W234 Y235 E239 N244 Q128 I217 G236 W237 Y238 E242 N247 C62 R65 W234 E239 C65 R68 W237 E242 1.14.14.47 0004517,0005575,0006809,0016491,0020037,0046872 O34453 16489746 910 SHMEILWNEAKAFIAECYQELGKEEEVKDRLDSIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEDVRDALFHHIETATNNGKIRPSITIFPPEEKGEKQVEIWNHQLIRYAGYEAAGERIGDPASCSLTAACEQLGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGISTNYNTDLWKDQALVELNKAVLYSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE 3hsn A 1.91 BS03 HAR A 1 Q478 P565 V567 G586 W587 Y588 E592 D597 Q171 P258 V260 G279 W280 Y281 E285 D290 C415 R418 W587 E592 C108 R111 W280 E285 1.14.13.39 0004517,0006809 P29476 19791770 770 RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKG 3hsn B 1.91 BS05 HAR B 1 Q478 P565 V567 G586 W587 Y588 E592 D597 Q173 P260 V262 G281 W282 Y283 E287 D292 C415 R418 W587 E592 C110 R113 W282 E287 1.14.13.39 0004517,0006809 P29476 19791770 1770 PRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKG 3hso A 2.02 BS03 HAR A 1 Q478 P565 V567 G586 W587 Y588 E592 D597 Q171 P258 V260 G279 W280 Y281 E285 D290 C415 R418 W587 E592 C108 R111 W280 E285 1.14.13.39 0004517,0006809 P29476 19791770 770 RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKG 3hso B 2.02 BS03 HAR B 1 Q478 P565 V567 G586 W587 Y588 E592 D597 Q173 P260 V262 G281 W282 Y283 E287 D292 C415 R418 W587 E592 C110 R113 W282 E287 1.14.13.39 0004517,0006809 P29476 19791770 1770 CPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKG 3hsp A 2.2 BS03 HAR A 1 Q478 P565 V567 G586 W587 Y588 E592 D597 Q172 P259 V261 G280 W281 Y282 E286 D291 C415 R418 W587 E592 C109 R112 W281 E286 1.14.13.39 0004517,0006809 P29476 19791770 770 RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKG 3hsp B 2.2 BS04 HAR B 1 Q478 P565 V567 G586 W587 Y588 E592 D597 Q173 P260 V262 G281 W282 Y283 E287 D292 C415 R418 W587 E592 C110 R113 W282 E287 1.14.13.39 0004517,0006809 P29476 19791770 1770 PRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKG 3lp7 A 2.04 BS03 HAR A 1 D124 H126 D128 N130 S137 H141 D183 T246 D119 H121 D123 N125 S132 H136 D178 T241 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 Kd=3600nM -logKd/Ki=5.44, Kd=3.6uM P05089 20153713 906 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3lp7 B 2.04 BS03 HAR B 1 H126 D128 N130 H141 G142 D183 E186 T246 H121 D123 N125 H136 G137 D178 E181 T241 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 Kd=3600nM P05089 20153713 908 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3nos A 2.4 BS02 HAR A 1 Q247 Y357 E361 N366 Q167 Y277 E281 N286 C184 R187 W356 E361 C104 R107 W276 E281 1.14.13.39 0004517,0006809 P29474 10074942 512 KFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW 3nos B 2.4 BS03 HAR B 1 Q247 Y357 E361 N366 Q167 Y277 E281 N286 C184 R187 W356 E361 C104 R107 W276 E281 1.14.13.39 0004517,0006809 P29474 10074942 1012 KFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW 4q3t A 2.142 BS03 HAR A 1 D154 H156 D158 N160 H171 D213 D262 E307 D129 H131 D133 N135 H146 D188 D237 E282 H131 D154 H156 D158 H171 D262 D264 E307 H106 D129 H131 D133 H146 D237 D239 E282 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.33uM -logKd/Ki=6.48, Kd=0.33uM Q6WVP6 25007099 405 PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3t B 2.142 BS03 HAR B 1 D154 H156 D158 N160 H171 G172 D213 D262 E307 D127 H129 D131 N133 H144 G145 D186 D235 E280 H131 D154 H156 D158 H171 D262 D264 E307 H104 D127 H129 D131 H144 D235 D237 E280 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.33uM Q6WVP6 25007099 405 PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQT 4q3t C 2.142 BS03 HAR C 1 H131 H156 D158 N160 S167 H171 G172 D213 T276 E307 H103 H128 D130 N132 S139 H143 G144 D185 T248 E279 H131 D154 H156 D158 H171 D262 D264 E307 H103 D126 H128 D130 H143 D234 D236 E279 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.33uM Q6WVP6 25007099 405 PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQT 4q3t D 2.142 BS01 HAR D 1 D154 H156 D158 N160 S167 H171 D124 H126 D128 N130 S137 H141 H131 D154 H156 D158 H171 D262 D264 E307 H101 D124 H126 D128 H141 D232 D234 E277 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.33uM Q6WVP6 25007099 401 LLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAH 5nse A 1.9 BS03 HAR A 1 Q249 P336 G357 Y359 E363 N368 Q183 P270 G291 Y293 E297 N302 C186 R189 W358 E363 C120 R123 W292 E297 1.14.13.39 0004517,0006809 P29473 770 GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPW 5nse B 1.9 BS03 HAR B 1 Q249 P336 V338 W358 Y359 E363 N368 Q181 P268 V270 W290 Y291 E295 N300 C186 R189 W358 E363 C118 R121 W290 E295 1.14.13.39 0004517,0006809 P29473 771 KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPW 5vka A 1.169 BS03 HAR A 1 E84 T86 R171 H189 D191 Y192 F314 R316 C317 E82 T84 R169 H187 D189 Y190 F312 R314 C315 1.13.12.19,1.14.20.7 0009693,0016706,0046872,0051213,0102276 P32021 28780854 403 NLQTFELPTEVTGCAADISLGRALIQAWQKDGIFQIKTDSEQDRKTQEAMAASKQFCKEPLTFKSSCVSDLTYSGYVASGEEVTAGKPDFPEIFTVCKDLSVGDQRVKAGWPCHGPVPWPNNTYQKSMKTFMEELGLAGERLLKLTALGFELPINTFTDLTRDGWHHMRVLRFPPQTSTLSRGIGAHTDYGLLVIAAQDDVGGLYIRPPVEGEKRNRNWLPGESSAGMFEHDEPWTFVTPTPGVWTVFPGDILQFMTGGQLLSTPHKVKLNTRERFACAYFHEPNFEASAYPLFEPSANERIHYGEHFTNMFMRCYPDRITTQRINKENRLAHLEDLKKYSDTRATGS 5zee A 1.74 BS01 HAR A 1 D124 H126 D128 N130 S137 H141 G142 D225 D124 H126 D128 N130 S137 H141 G142 D225 3.5.3.1 0000050,0004053,0005737,0005829,0006525,0016787,0019547,0030145,0042802,0046872 -logKd/Ki=2.80, IC50=1.57mM C4LSS0 31199070 301 MQFEKVTYIAVPQKYGQKKVGVEEGPKFLEKLGFMNVLEQVAKSVNKKTITEPKTPQELGVTNARNLNEVESVNIELRDTIAKEYDVNNLLINIGGDHSIGLGTIAGVVKAMKPNARVGVVWFDAHPDMNTPENSPSGNIHGMPLACAVGLGPQRLTSIMPHYITPKDIMYVGIRSIDVGEQFEIQDKHIDHFTAEDVKRVGMKEVIEAINKKFVDYDVIHLSFDIDGIDPEFILGTGTPVPKGISLEDSLYFMSEMGKMKKLHSVDIVEYNPKIEEEITGKNVLKCISSLFGIK 5zee B 1.74 BS01 HAR B 1 D124 H126 D128 N130 S137 H141 D178 D225 E270 D126 H128 D130 N132 S139 H143 D180 D227 E272 3.5.3.1 0000050,0004053,0005737,0005829,0006525,0016787,0019547,0030145,0042802,0046872 C4LSS0 31199070 301 QSMQFEKVTYIAVPQKYGQKKVGVEEGPKFLEKLGFMNVLEQVAKSVNKKTITEPKTPQELGVTNARNLNEVESVNIELRDTIAKEYDVNNLLINIGGDHSIGLGTIAGVVKAMKPNARVGVVWFDAHPDMNTPENSPSGNIHGMPLACAVGLGPQRLTSIMPHYITPKDIMYVGIRSIDVGEQFEIQDKHIDHFTAEDVKRVGMKEVIEAINKKFVDYDVIHLSFDIDGIDPEFILGTGTPVPKGISLEDSLYFMSEMGKMKKLHSVDIVEYNPKIEEEITGKNVLKCISSLFGIK