2h8h A 2.2 BS01 H8H A 1 L273 V281 A293 K295 T338 Y340 M341 S342 G344 L393 D404 L189 V197 A209 K211 T254 Y256 M257 S258 G260 L309 D320 D386 R388 A390 N391 D404 F424 D302 R304 A306 N307 D320 F340 2.7.10.2 0000122,0001545,0001819,0002102,0002223,0002376,0002862,0004672,0004713,0004715,0005080,0005102,0005158,0005178,0005515,0005524,0005634,0005654,0005737,0005739,0005743,0005764,0005770,0005829,0005856,0005884,0005886,0005901,0005925,0006468,0007155,0007165,0007172,0007173,0007179,0007229,0007283,0007611,0008284,0009410,0009612,0010447,0010628,0010629,0010632,0010634,0010907,0010954,0014856,0014911,0016004,0016020,0016236,0016301,0016310,0016477,0018108,0019899,0019901,0019904,0020037,0022407,0030054,0030154,0030168,0030331,0030900,0031295,0031333,0031648,0031667,0032205,0032587,0032869,0033146,0033625,0034139,0034332,0034446,0034614,0035306,0035331,0035556,0036035,0036120,0038083,0038096,0038128,0038166,0042169,0042476,0042542,0043025,0043065,0043066,0043114,0043149,0043154,0043274,0044294,0044325,0044877,0045056,0045087,0045121,0045124,0045296,0045453,0045747,0045780,0045785,0045821,0046579,0046628,0046718,0046777,0046875,0048008,0048010,0048011,0048013,0048041,0048471,0048477,0050731,0050839,0050847,0050900,0051057,0051117,0051219,0051222,0051385,0051450,0051602,0051895,0051897,0051902,0060065,0060444,0060491,0060576,0070062,0070102,0070161,0070301,0070374,0070542,0070555,0070700,0071222,0071253,0071375,0071393,0071398,0071456,0071498,0071560,0071803,0071897,0071902,0086091,0090263,0097060,0097110,0098609,0098978,0099091,1900182,1902533,1902737,1903997,1904263,1904385,1904707,1990646,2000256,2000386,2000394,2000588,2000641,2000811,2001237,2001243,2001286 ic50=2.7nM -logKd/Ki=8.57, IC50=2.7nM IC50=2.7nM P12931 17064066 534 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 4qmx A 1.882 BS01 H8H A 1 I30 K32 A51 K53 M99 Y101 L102 I19 K21 A40 K42 M88 Y90 L91 D144 K146 A148 N149 D162 D171 T182 D133 K135 A137 N138 D151 D160 T171 2.7.11.1 0004672,0005524,0006468 ic50=11uM -logKd/Ki=4.96, IC50=11uM Q9Y6E0 27135311 401 GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQS 5vcx A 2.7 BS01 H8H A 1 L116 A137 K139 T187 C190 F240 D251 L42 A63 K65 T113 C116 F166 D177 D233 K235 N238 D251 D270 D159 K161 N164 D177 D196 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=5.55, Kd=2817nM IC50=418nM, Ki=40nM, Kd=2817nM Q99640 28792760 401 HQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 5vd3 A 1.8 BS01 H8H A 1 L116 A137 K139 L185 T187 C190 G191 P192 F240 L49 A70 K72 L118 T120 C123 G124 P125 F173 D233 K235 N238 D251 D270 D166 K168 N171 D184 D203 2.7.11.1 0004672,0005524,0006468 Kd=2817nM -logKd/Ki=5.55, Kd=2817nM IC50=418nM, Ki=40nM, Kd=2817nM Q99640 28792760 401 DLGTENLYFQQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 6zgc A 2.67 BS01 H8H A 1 V214 Y219 V222 A233 K235 L263 T283 Y285 H286 G289 L343 V10 Y15 V18 A29 K31 L59 T79 Y81 H82 G85 L139 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Q04771 33705358 501 ARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID 6zgc B 2.67 BS01 H8H B 1 V214 G215 V222 A233 K235 L263 T283 Y285 H286 E287 G289 L343 A353 V12 G13 V20 A31 K33 L61 T80 Y82 H83 E84 G86 L140 A150 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Q04771 33705358 501 TVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID 6zgc C 2.67 BS01 H8H C 1 V214 V222 A233 K235 L263 T283 Y285 H286 E287 G289 L343 A353 V14 V22 A33 K35 L63 T83 Y85 H86 E87 G89 L143 A153 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Q04771 33705358 501 QRTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 6zgc D 2.67 BS01 H8H D 1 V214 V222 A233 K235 L263 L281 T283 Y285 H286 M288 G289 L343 V12 V18 A29 K31 L59 L77 T79 Y81 H82 M84 G85 L139 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Q04771 33705358 501 TVARDITLLECVGKYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI