1a0f A 2.1 BS01 GTS A 1 A9 C10 L32 K35 Q51 V52 E65 H106 A9 C10 L32 K35 Q51 V52 E65 H106 2.5.1.18 0004364,0005737,0016740,0042542,0042803 P0A9D2 9680481 203 MKLFYKPGACSLASHITLRESGKDFTLVSVDLMKKRLENGDDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKDEHWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK 1a0f B 2.1 BS01 GTS B 1 A9 C10 L32 K35 Q51 V52 E65 H106 A9 C10 L32 K35 Q51 V52 E65 H106 2.5.1.18 0004364,0005737,0016740,0042542,0042803 P0A9D2 9680481 203 MKLFYKPGACSLASHITLRESGKDFTLVSVDLMKKRLENGDDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKDEHWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK 1ev4 A 2.2 BS01 GTS A 1 Y9 R15 K45 Q54 V55 Q67 T68 Y220 Y8 R14 K44 Q53 V54 Q66 T67 Y219 Y9 R15 R20 Y8 R14 R19 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 230 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPMDAKQIEEARKIYKF 1ev4 C 2.2 BS01 GTS C 1 Y9 R15 D53 Q54 V55 Q67 T68 Y8 R14 D52 Q53 V54 Q66 T67 Y9 R15 R20 Y8 R14 R19 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 240 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPM 1ev4 D 2.2 BS01 GTS C 1 D101 R131 D100 R130 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 240 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPMDAKQIEEARKIYKF 1ev4 D 2.2 BS02 GTS D 1 R15 K45 Q54 V55 Q67 T68 R14 K44 Q53 V54 Q66 T67 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 250 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPMDAKQIEEARKIYKF 1ev9 A 2.2 BS01 GTS A 1 R15 K45 D53 Q54 V55 Q67 T68 R14 K44 D52 Q53 V54 Q66 T67 Y9 R15 R20 Y8 R14 R19 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 230 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPMDAKQIEEARKIF 1ev9 C 2.2 BS01 GTS C 1 Y9 F10 D53 Q54 V55 Q67 T68 Y8 F9 D52 Q53 V54 Q66 T67 Y9 R15 R20 Y8 R14 R19 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 240 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPM 1ev9 D 2.2 BS01 GTS D 1 F10 R15 K45 Q54 V55 Q67 T68 F9 R14 K44 Q53 V54 Q66 T67 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005737,0005829,0006629,0006693,0006749,0006805,0009410,0016740,0016853,0030855,0031667,0035731,0042178,0042803,0043295,0043651,0098869,1901687 P00502 11119643 250 SGKPVLHYFNARGRMECIRFLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNKLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPMDAKQIEEAR 1glp A 1.9 BS01 GTS A 1 Y7 F8 W38 K44 Q51 L52 Q64 S65 Y7 F8 W38 K44 Q51 L52 Q64 S65 Y7 R13 R18 Y7 R13 R18 2.5.1.18 0000302,0002674,0004364,0005634,0005737,0005739,0005829,0006629,0006693,0006749,0006805,0008432,0009636,0014003,0016740,0019207,0031100,0031667,0032355,0032691,0032720,0032869,0032872,0032873,0032930,0032991,0033591,0035726,0043066,0043124,0043200,0045471,0048147,0051122,0051771,0070372,0070373,0070664,0071222,0071364,0071385,0071460,0071638,1901687,2000429,2001237 P19157 8145243 210 PPYTIVYFPVRGRCEAMRMLLADQGQSWKEEVVTIDTWMQGLLKPTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKNQREAAQMDMVNDGVEDLRGKYVTLIYTNYENGKNDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFADYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPEHVNRPINGNGKQ 1glp B 1.9 BS01 GTS B 1 Y7 F8 R13 W38 K44 Q51 L52 Q64 S65 Y7 F8 R13 W38 K44 Q51 L52 Q64 S65 Y7 R13 R18 Y7 R13 R18 2.5.1.18 0000302,0002674,0004364,0005634,0005737,0005739,0005829,0006629,0006693,0006749,0006805,0008432,0009636,0014003,0016740,0019207,0031100,0031667,0032355,0032691,0032720,0032869,0032872,0032873,0032930,0032991,0033591,0035726,0043066,0043124,0043200,0045471,0048147,0051122,0051771,0070372,0070373,0070664,0071222,0071364,0071385,0071460,0071638,1901687,2000429,2001237 P19157 8145243 210 PPYTIVYFPVRGRCEAMRMLLADQGQSWKEEVVTIDTWMQGLLKPTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKNQREAAQMDMVNDGVEDLRGKYVTLIYTNYENGKNDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFADYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPEHVNRPINGNGKQ 1m99 A 2.3 BS01 GTS A 1 Y7 W8 L13 W41 K45 N54 L55 Q67 S68 Y7 W8 L13 W41 K45 N54 L55 Q67 S68 Y7 L13 Y7 L13 2.5.1.18 0004364,0006749,0016740 P08515 12596270 220 MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHP 1n2a A 1.9 BS01 GTS A 1 A9 C10 K35 Q51 V52 E65 G66 H106 A9 C10 K35 Q51 V52 E65 G66 H106 2.5.1.18 0004364,0005737,0016740,0042542,0042803 P0A9D2 14635120 301 MKLFYKPGACSLASHITLRESGKDFTLVSVDLMKKRLENGDDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKDEHWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK 1n2a A 1.9 BS02 GTS B 1 N99 E104 N99 E104 2.5.1.18 0004364,0005737,0016740,0042542,0042803 P0A9D2 14635120 401 MKLFYKPGACSLASHITLRESGKDFTLVSVDLMKKRLENGDDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKDEHWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK 1n2a B 1.9 BS01 GTS B 1 A9 C10 Q51 V52 E65 H106 A9 C10 Q40 V41 E54 H95 2.5.1.18 0004364,0005737,0016740,0042542,0042803 P0A9D2 14635120 401 MKLFYKPGACSLASHITLRESGKDFTLVSVDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK 1r5a A 2.5 BS02 GTS A 1 S11 P13 I35 Q40 H52 C53 I54 E66 S67 S10 P12 I34 Q39 H51 C52 I53 E65 S66 S11 S10 2.5.1.18 0004364,0006749,0016740,0046872 Q9GQG7 15717864 1004 TTVLYYLPASPPCRSVLLLAKMIGVELDLKVLNIMEGEQLKPDFVELNPQHCIPTMDDHGLVLWESRVILSYLVSAYGKDENLYPKDFRSRAIVDQRLHFDLGTLYQRVVDYYFPTIHLGAHLDQTKKAKLAEALGWFEAMLKQYQWSAANHFTIADIALCVTVSQIEAFQFDLHPYPRVRAWLLKCKDELEGHGYKEINETGAETLAGLFRSK 1v2a A 2.15 BS01 GTS A 1 S9 P11 V33 H49 T50 I51 E63 S64 S9 P11 V33 H49 T50 I51 E63 S64 S9 S9 2.5.1.18 0003824,0004364,0006749,0016740 Q9BHB0 15717864 1001 MDYYYSLISPPCQSAILLAKKLGITLNLKKTNVHDPVERDALTKLNPQHTIPTLVDNGHVVWESYAIVLYLVETYAKDDTLYPKDPKVRSVVNQRLFFDIGTLYKRIIDVIHLVMKKEQPSDEQMEKLKGALDLLEQFVTERAYAAADHLTVADICLLGTVTALNWLKHDLEPFPHIRAWLERVRAEMPDYEEFSKQVADDTLAYVAS 1v2a B 2.15 BS01 GTS B 1 S9 V33 H49 T50 I51 E63 S64 S9 V33 H49 T50 I51 E63 S64 S9 S9 2.5.1.18 0003824,0004364,0006749,0016740 Q9BHB0 15717864 2001 MDYYYSLISPPCQSAILLAKKLGITLNLKKTNVHDPVERDALTKLNPQHTIPTLVDNGHVVWESYAIVLYLVETYAKDDTLYPKDPKVRSVVNQRLFFDIGTLYKRIIDVIHLVMKKEQPSDEQMEKLKGALDLLEQFVTERAYAAADHLTVADICLLGTVTALNWLKHDLEPFPHIRAWLERVRAEMPDYEEFSKQVADDTLAYVASR 1v2a C 2.15 BS01 GTS C 1 S9 V33 H49 T50 I51 E63 S64 S9 V33 H49 T50 I51 E63 S64 S9 S9 2.5.1.18 0003824,0004364,0006749,0016740 Q9BHB0 15717864 3001 MDYYYSLISPPCQSAILLAKKLGITLNLKKTNVHDPVERDALTKLNPQHTIPTLVDNGHVVWESYAIVLYLVETYAKDDTLYPKDPKVRSVVNQRLFFDIGTLYKRIIDVIHLVMKKEQPSDEQMEKLKGALDLLEQFVTERAYAAADHLTVADICLLGTVTALNWLKHDLEPFPHIRAWLERVRAEMPDYEEFSKQVADDTLAYVAS 1v2a D 2.15 BS01 GTS D 1 S9 P11 H49 T50 I51 E63 S64 S9 P11 H49 T50 I51 E63 S64 S9 S9 2.5.1.18 0003824,0004364,0006749,0016740 Q9BHB0 15717864 4001 MDYYYSLISPPCQSAILLAKKLGITLNLKKTNVHDPVERDALTKLNPQHTIPTLVDNGHVVWESYAIVLYLVETYAKDDTLYPKDPKVRSVVNQRLFFDIGTLYKRIIDVIHLVMKKEQPSDEQMEKLKGALDLLEQFVTERAYAAADHLTVADICLLGTVTALNWLKHDLEPFPHIRAWLERVRAEMPDYEEFSKQVADDTLAYVAS 2gsr A 2.11 BS01 GTS A 1 Y7 F8 R13 W38 K42 Q49 L50 Q62 S63 Y7 F8 R13 W38 K42 Q49 L50 Q62 S63 Y7 R13 R18 Y7 R13 R18 2.5.1.18 0004364,0005634,0005737,0005739,0005829,0006629,0006693,0016740,0051122,1901687 Ki=4uM P80031 7932743 208 PPYTITYFPVRGRCEAMRMLLADQDQSWKEEVVTMETWPPLKPSCLFRQLPKFQDGDLTLYQSNAILRHLGRSFGLYGKDQKEAALVDMVNDGVEDLRCKYATLIYTNYEAGKEKYVKELPEHLKPFETLLSQNQGGQAFVVGSQISFADYNLLDLLRIHQVLNPSCLDAFPLLSAYVARLSARPKIKAFLASPEHVNRPINGNGKQ 2gsr B 2.11 BS01 GTS B 1 Y7 F8 R13 W38 K42 Q49 L50 Q62 S63 Y7 F8 R13 W38 K42 Q49 L50 Q62 S63 Y7 R13 R18 Y7 R13 R18 2.5.1.18 0004364,0005634,0005737,0005739,0005829,0006629,0006693,0016740,0051122,1901687 Ki=4uM P80031 7932743 208 PPYTITYFPVRGRCEAMRMLLADQDQSWKEEVVTMETWPPLKPSCLFRQLPKFQDGDLTLYQSNAILRHLGRSFGLYGKDQKEAALVDMVNDGVEDLRCKYATLIYTNYEAGKEKYVKELPEHLKPFETLLSQNQGGQAFVVGSQISFADYNLLDLLRIHQVLNPSCLDAFPLLSAYVARLSARPKIKAFLASPEHVNRPINGNGKQ 3erg A 2.2 BS01 GTS A 1 P28 Y29 P30 H58 T71 V72 E85 C86 H133 P10 Y11 P12 H40 T53 V54 E67 C68 H115 G27 G9 2.5.1.18 0004364,0005737,0005739,0006749,0016740,0043295 Q12390 19851333 234 MIIYDTPAGPYPARVRIALAEKNMLSSVQFVRINLWKGEHKKPEFLAKNYSGTVPVLELDDGTLIAECTAITEYIDALDGTPTLTGKTPLEKGVIHMMNKRAELELLDPVSVYFHHATPGLGPEVELYQNKEWGLRQRDKALHGMHYFDTVLRERPYVAGDSFSMADITVIAGLIFAAIVKLQVPEECEALRAWYKRMQQRPSVKKLL 3erg B 2.2 BS01 GTS B 1 P28 Y29 P30 H58 T71 V72 E85 C86 H133 P10 Y11 P12 H40 T53 V54 E67 C68 H115 G27 G9 2.5.1.18 0004364,0005737,0005739,0006749,0016740,0043295 Q12390 19851333 234 MIIYDTPAGPYPARVRIALAEKNMLSSVQFVRINLWKGEHKKPEFLAKNYSGTVPVLELDDGTLIAECTAITEYIDALDGTPTLTGKTPLEKGVIHMMNKRAELELLDPVSVYFHHATPGLGPEVELYQNKEWGLRQRDKALHGMHYFDTVLRERPYVAGDSFSMADITVIAGLIFAAIVKLQVPEECEALRAWYKRMQQRPSVKKLL 3hkk A 2.9 BS01 GTS A 1 R51 N55 E58 Y59 Y97 R104 L108 R51 N55 E58 Y59 Y97 R104 L108 2.5.1.-,4.4.1.20 0004364,0004464,0004602,0005515,0005634,0005635,0005640,0005783,0005789,0006629,0006691,0008047,0008289,0016020,0016740,0016829,0019370,0031965,0042759,0042802,0043231,0098869 Q16873 203 HKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRT 3vur A 1.365 BS01 GTS A 1 Y7 F8 W38 K42 Q49 M50 Q62 S63 Y7 F8 W38 K42 Q49 M50 Q62 S63 Y7 L13 R18 Y7 L13 R18 2.5.1.18 0004364,0006749,0016740 Q5CCJ4 302 PNVKFYYFPVKALGESQRLLLAYGGQEFEDNRISSENWPEFKPKTPFGQMPVLEIDGKQYAQSTAICRYLGRKYGLAGANDEEAFEIDQNVEFLNDIRASAASVHYEKDEAVKAKKKAELEETKYPFFFEKLNEILTKNNGHIALGKLTWGDFVYAGMYDYLKAMLQKPDLEQKYPAFRKPIEAVLAIPKVKAYVDAAPRTEL 4jed A 1.1 BS01 GTS A 1 S14 Y16 P38 W39 E52 K53 L54 E67 S68 S11 Y13 P35 W36 E49 K50 L51 E64 S65 ? 0004364,0006559,0006749,0016034,0016740 B1M0X3 302 TRYRLISATPSPYARKVRIALAEKGLPFELVTEVPWDSATTVPRHNPLEKLPVLLLPAGGSVYESSYILQWLELKHPDPPLLPPDPDGVLAARRYEVLCDGICDAVVLTFFERQRDEAGRSAPWLARQRRKIEGGLAEIARLLGDRDWTVGDRFTLGDIAAGTVTGYLSVRFPELDWRARHPNLARLSDRLEARPSFADSVPYAQTITDRVV 6f01 B 2.5 BS01 GTS B 1 S12 H39 T52 V53 E65 S66 S11 H38 T51 V52 E64 S65 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIMFASVMGFPSDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 A 2.2 BS01 GTS A 1 S12 L34 H39 T52 V53 E65 S66 S11 L33 H38 T51 V52 E64 S65 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIMFDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 B 2.2 BS01 GTS B 1 A11 S12 H39 T52 V53 E65 S66 F171 A10 S11 H38 T51 V52 E64 S65 F161 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIMDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSFPA 6f05 C 2.2 BS01 GTS C 1 S12 L34 H39 T52 V53 E65 S66 F171 S11 L33 H38 T51 V52 E64 S65 F160 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 D 2.2 BS01 GTS D 1 A11 S12 L34 H39 T52 V53 E65 S66 A10 S11 L33 H38 T51 V52 E64 S65 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 E 2.2 BS01 GTS E 1 S12 H39 K40 T52 V53 E65 S66 F171 S11 H38 K39 T51 V52 E64 S65 F159 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 F 2.2 BS01 GTS F 1 A11 S12 H39 T52 V53 E65 S66 F171 A10 S11 H38 T51 V52 E64 S65 F161 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHISDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 G 2.2 BS01 GTS G 1 S12 H39 T52 V53 E65 S66 F171 S10 H37 T50 V51 E63 S64 F157 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 LKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYS 6f05 H 2.2 BS01 GTS H 1 S12 L34 H39 T52 V53 E65 S66 F171 S11 L33 H38 T51 V52 E64 S65 F159 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIMFLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 I 2.2 BS01 GTS I 1 S12 H39 T52 V53 E65 S66 S11 H38 T51 V52 E64 S65 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM -logKd/Ki=4.47, Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTLHIMFASDEKLIKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYSF 6f05 J 2.2 BS01 GTS J 1 S12 H39 K40 T52 V53 E65 S66 S11 H38 K39 T51 V52 E64 S65 2.5.1.18 0000325,0004364,0004601,0004602,0005507,0005737,0005777,0005829,0005886,0006952,0009407,0009506,0009507,0009570,0009579,0009636,0010043,0016740,0043295,0046686,0048046,0098869,1901149 Ki=34uM O80852 29732642 301 VLKVYGPHFASPKRALVTLIEKGVAFETIPVDLMKGEHKQPAYLALQPFGTVPAVVDGDYKIFESRAVMRYVAEKYRSQGPDLLGKTVEDRGQVEQWLDVEATTYHPPLLNLTKESEEKLAGVLDVYEAHLSKSKYLAGDFVSLADLAHLPFTDYLVGPIGKAYMIKDRKHVSAWWDDISSRPAWKETVAKYS 6ssw A 3.0 BS01 GTS A 1 R51 N55 E58 Y93 Y97 R104 F108 R48 N52 E55 Y90 Y94 R101 F105 1.11.1.-,2.5.1.18,4.4.1.20 0004364,0004464,0004602,0005515,0005635,0005783,0005789,0005886,0006629,0006691,0006750,0008047,0016020,0016491,0016740,0016829,0019370,0032496,0042802,0043231,0043295,0046466,0050729,0098869 Q99735 33741927 201 NSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNI 6ssw A 3.0 BS02 GTS C 1 A23 V26 R30 Q53 A20 V23 R27 Q50 1.11.1.-,2.5.1.18,4.4.1.20 0004364,0004464,0004602,0005515,0005635,0005783,0005789,0005886,0006629,0006691,0006750,0008047,0016020,0016491,0016740,0016829,0019370,0032496,0042802,0043231,0043295,0046466,0050729,0098869 Q99735 33741927 201 NSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNI 6ssw B 3.0 BS01 GTS A 1 V26 R30 F50 Q53 V24 R28 F48 Q51 1.11.1.-,2.5.1.18,4.4.1.20 0004364,0004464,0004602,0005515,0005635,0005783,0005789,0005886,0006629,0006691,0006750,0008047,0016020,0016491,0016740,0016829,0019370,0032496,0042802,0043231,0043295,0046466,0050729,0098869 Q99735 33741927 201 GNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKK 6ssw B 3.0 BS02 GTS B 1 R51 N55 E58 Y93 Y97 R104 F108 R49 N53 E56 Y91 Y95 R102 F106 1.11.1.-,2.5.1.18,4.4.1.20 0004364,0004464,0004602,0005515,0005635,0005783,0005789,0005886,0006629,0006691,0006750,0008047,0016020,0016491,0016740,0016829,0019370,0032496,0042802,0043231,0043295,0046466,0050729,0098869 Q99735 33741927 201 GNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKK 6ssw C 3.0 BS01 GTS B 1 A23 V26 R30 F50 Q53 A20 V23 R27 F47 Q50 1.11.1.-,2.5.1.18,4.4.1.20 0004364,0004464,0004602,0005515,0005635,0005783,0005789,0005886,0006629,0006691,0006750,0008047,0016020,0016491,0016740,0016829,0019370,0032496,0042802,0043231,0043295,0046466,0050729,0098869 Q99735 33741927 201 NSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDE 6ssw C 3.0 BS02 GTS C 1 R51 N55 E58 F59 Y93 Y97 R104 F108 R48 N52 E55 F56 Y90 Y94 R101 F105 1.11.1.-,2.5.1.18,4.4.1.20 0004364,0004464,0004602,0005515,0005635,0005783,0005789,0005886,0006629,0006691,0006750,0008047,0016020,0016491,0016740,0016829,0019370,0032496,0042802,0043231,0043295,0046466,0050729,0098869 Q99735 33741927 201 NSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDE