1a4r B 2.5 BS01 GNH B 1 A213 G215 K216 T217 C218 F228 Q316 D318 L319 S358 A359 L360 A13 G15 K16 T17 C18 F28 Q116 D118 L119 S158 A159 L160 3.6.5.2 0000139,0000322,0002040,0003015,0003161,0003253,0003924,0003925,0005515,0005525,0005737,0005789,0005813,0005819,0005829,0005856,0005886,0005911,0005925,0006897,0006911,0007015,0007030,0007088,0007097,0007163,0007229,0007264,0007399,0008104,0009653,0010591,0010592,0016020,0016787,0017119,0019901,0021762,0030036,0030141,0030154,0030175,0030225,0030307,0030335,0030425,0030496,0030742,0031252,0031256,0031274,0031333,0031435,0031996,0032427,0032467,0032488,0032956,0032991,0034191,0034329,0034332,0035050,0035088,0036336,0036464,0038189,0042802,0042995,0043005,0043025,0043197,0043410,0043525,0044788,0045177,0045198,0045335,0045740,0046330,0046847,0048549,0048664,0051130,0051233,0051489,0051491,0051492,0051496,0051647,0051649,0051683,0051835,0051897,0051988,0060047,0060071,0060501,0060661,0060997,0061630,0070062,0071346,0071944,0072384,0072686,0086101,0090135,0090316,0098685,0098794,0098978,0099159,0099175,1900026 Kd=0.22uM -logKd/Ki=6.66, Kd=0.22uM P60953 10211824 400 MQTIKCVVVGDVAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVL 1hon A 2.3 BS01 GNH A 1 G15 G17 T42 T300 K331 D333 S414 G416 G15 G17 T42 T300 K331 D333 S414 G416 D13 K16 G40 H41 Q224 D13 K16 G40 H41 Q224 6.3.4.4 0000166,0000287,0004019,0005515,0005525,0005737,0005829,0006164,0006974,0015949,0016020,0016874,0044208,0046040,0046086,0046872,0097216 P0A7D4 8663109 432 GNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA 1hoo A 2.3 BS01 GNH A 1 G15 G17 G40 T300 K331 D333 S414 G416 P417 G15 G17 G40 T300 K331 D333 S414 G416 P417 D13 K16 G40 H41 Q224 D13 K16 G40 H41 Q224 6.3.4.4 0000166,0000287,0004019,0005515,0005525,0005737,0005829,0006164,0006974,0015949,0016020,0016874,0044208,0046040,0046086,0046872,0097216 P0A7D4 8663109 432A GNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA 2efe A 2.08 BS01 GNH B 1 N180 D185 N164 D169 ? 0005085,0016192 Q9LT31 20833725 1200 MRKPSAGDFVKSIKSFIVSFSNNAPDPEKDCAMVQEFFSKMEAAFRAHPLWSGCSEEELDSAGDGLEKYVMTKLFTRVFASNTEEVIADEKLFQKMSLVQQFISPENLDIQPTFQNESSWLLAQKELQKINMYKAPRDKLVCILNCCKVINNLLLNASIASNENAPGADEFLPVLIYVTIKANPPQLHSNLLYIQRYRRESKLVGEAAYFFTNILSAESFISNIDAKSISLDEAEFEKNMESARAR 2efe B 2.08 BS01 GNH B 1 G20 G22 K23 S24 S25 F35 N123 K124 D126 S153 A154 G13 G15 K16 S17 S18 F28 N116 K117 D119 S146 A147 ? 0003924,0005515,0005525,0005737,0005768,0005769,0005783,0005886,0006886,0007033,0015031,0031901,0032585,0036094,0043229,0045324,0140313 Q9SN68 20833725 1200 SINAKLVLLGDVGAGKSSLVLRFVKDQFVEFQESTIGAAFFSQTLAVNDATVKFEIWDTAGQERYHSLAPMYYRGAAAAIIVFDVTNQASFERAKKWVQELQAQGNPNMVMALAGNKSDLLDARKVTAEDAQTYAQENGLFFMETSAKTATNVKEIFYEIARRLP 2efe C 2.08 BS01 GNH D 1 N180 D185 N164 D169 ? 0005085,0016192 Q9LT31 20833725 2200 MRKPSAGDFVKSIKSFIVSFSNNAPDPEKDCAMVQEFFSKMEAAFRAHPLWSGCSEEELDSAGDGLEKYVMTKLFTRVFASNTEEVIADEKLFQKMSLVQQFISPENLDIQPTFQNESSWLLAQKELQKINMYKAPRDKLVCILNCCKVINNLLLNASIASNENAPGADEFLPVLIYVTIKANPPQLHSNLLYIQRYRRESKLVGEAAYFFTNILSAESFISNIDAKSISLDEAEFEKNMESARAR 2efe D 2.08 BS01 GNH D 1 G20 G22 K23 S24 S25 F35 N123 K124 D126 L127 S153 A154 K155 G13 G15 K16 S17 S18 F28 N116 K117 D119 L120 S146 A147 K148 ? 0003924,0005515,0005525,0005737,0005768,0005769,0005783,0005886,0006886,0007033,0015031,0031901,0032585,0036094,0043229,0045324,0140313 Q9SN68 20833725 2200 SINAKLVLLGDVGAGKSSLVLRFVKDQFVEFQESTIGAAFFSQTLAVNDATVKFEIWDTAGQERYHSLAPMYYRGAAAAIIVFDVTNQASFERAKKWVQELQAQGNPNMVMALAGNKSDLLDARKVTAEDAQTYAQENGLFFMETSAKTATNVKEIFYEIARRLP 3b1y A 2.5 BS01 GNH A 1 N11 G13 K14 T15 S16 N113 M114 D116 S142 A143 L144 N11 G13 K14 T15 S16 N113 M114 D116 S138 A139 L140 ? 0005525 Q5M586 22101824 300 MTEIALIGNPNSGKTSLFNLITGHNQRVGNWPGVAVERKSGLVKKNKDLEIQDLPGIYSMSPYSPEEKVARDYLLSQRADSILNVVDATNLERNLYLTTQLIETGIPVTIALNMIDVLDKINVDKLSYHLGVPVVATSALKQTGVDQVVKKAAHTTTSTVGDLAFPIYDDRLEAAISQILEVLGNSVPQRSARFYAIKLFEQDSLVEAELDLSQFQRKEIEDIIRITEEIFTEDAESIVINERYAFIERVCQMAE 3w6n A 2.0 BS01 GNH A 1 S35 G37 K38 S39 S40 R53 G54 K216 D218 L219 V245 N246 R247 S248 Q249 S37 G39 K40 S41 S42 R55 G56 K204 D206 L207 V233 N234 R235 S236 Q237 3.6.5.5 0003924,0005525 O00429 801 GPMEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSRRKEAADMLKALQGASQIIAEIRETHLW 3w6n B 2.0 BS01 GNH B 1 S35 G37 K38 S39 S40 R53 G54 K216 D218 L219 V245 N246 R247 S248 Q249 S37 G39 K40 S41 S42 R55 G56 K210 D212 L213 V239 N240 R241 S242 Q243 3.6.5.5 0003924,0005525 O00429 801 GPMEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNRRKEAADMLKALQGASQIIAEIRETHLW 4r98 A 2.22 BS01 GNH A 1 N13 G15 K16 T17 T18 N120 M121 D123 I124 V149 T151 N12 G14 K15 T16 T17 N112 M113 D115 I116 V141 T143 ? 0005525,0006826,0015093,0016020 P33650 25517170 300 KKLTIGLIGNPNSGKTTLFNQLTGSRQRVGNWAERKEGQFSTTDHQVTLVDLPGTYSLTTQTSLDEQIACHYILSGDADLLINVVDASNLERNLYLTLQLLELGIPCIVALNMLDIAEKQNIRIEIDALSARLGCPVIPLVATDTKNVQFVLKLAIDRYKANENVELVHYAQPLLNEADSLAKVMPSDIPLKQRRWLGLQMLEGDIYSRAYAGEASQHLDAALARLRNEMDDPALHIADARYQCIAAICDVVSNTL 4r98 B 2.22 BS01 GNH A 1 N13 G15 M121 N12 G14 M118 ? 0005525,0006826,0015093,0016020 P33650 25517170 300 KKLTIGLIGNPNSGKTTLFNQLTGSRQRVGNWAGVTVERKEGQFSTTDHQVTLVDLPGTYSLTTISTSLDEQIACHYILSGDADLLINVVDASNLERNLYLTLQLLELGIPCIVALNMLDIAEKQNIRIEIDALSARLGCPVIPLVATDTKNVQFVLKLAIDRYKANENVELVHYAQPLLNEADSLAKVMPSDIPLKQRRWLGLQMLEGDIYSRAYAGEASQHLDAALARLRNEMDDPALHIADARYQCIAAICDVVSNTL 6jq8 A 1.546 BS01 GNH A 1 L7 A8 G9 G10 S53 E80 P83 G85 A89 N106 D108 L7 A8 G9 G10 S53 E80 P83 G85 A89 N106 D108 ? 0005525,0005737,0009058,0016740,0016779 Q8GJ95 31906195 301 MYDVVILAGGLGTRLKSVSGDIPKPMVDISGKPFLYRLMEYLEDQGVQRIILSLSYKADYIIDSVIKDNPVNSKVDFIIENEPLGTGGAIKNACKYIEASKFIVINGDTYCELDYKKFIESSLDSDLQISGVEVDDVCRYGSLDIDHDFHVNSIVEKGRQGTGIINSGTYILSKKIIEDYPHDKFSFELDFLPKFTGVFKAFVTKAYFIDIGIPEDYYKACEKFK