1moq A 1.57 BS01 GLP A 1 T302 S303 S347 Q348 S349 T352 V399 A602 K603 T60 S61 S105 Q106 S107 T110 V157 A360 K361 E481 K485 E488 H504 K603 E239 K243 E246 H262 K361 2.6.1.16 0004360,0097367,1901135,1901137 Ki=0.35mM -logKd/Ki=3.46, Ki=0.35mM P17169 9739095 609 GDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKLSRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTVE 2ri1 A 2.03 BS01 GLP A 1 S37 T38 H130 K194 S39 T40 H132 K196 D62 N128 H130 E135 D64 N130 H132 E137 3.5.99.6 0004342,0005737,0005975,0006040,0006043,0006044,0006046,0016787,0019262,0042802 Q8DV70 18436239 234 GSMKTIKVKNKTEGSKVAFRMLEEEITFGAKTLGLATGSTPLELYKEIRESHLDFSDMVSINLDEYVGLSADDKQSYAYFMKQNLFAAKPFKKSYLPNGLAADLAKETEYYDQILAQYPIDLQILGIGRNAHIGFNEPGTAFSSQTHLVDLTPSTIAANSRFFEKAEDVPKQAISMGLASIMSAKMILLMAFGEEKAEAVAAMVKGPVTEEIPASILQTHPKVILIVDEKAGAGI 2ri1 B 2.03 BS01 GLP B 1 G36 S37 T38 H130 K194 G38 S39 T40 H132 K196 D62 N128 H130 E135 D64 N130 H132 E137 3.5.99.6 0004342,0005737,0005975,0006040,0006043,0006044,0006046,0016787,0019262,0042802 Q8DV70 18436239 234 GSMKTIKVKNKTEGSKVAFRMLEEEITFGAKTLGLATGSTPLELYKEIRESHLDFSDMVSINLDEYVGLSADDKQSYAYFMKQNLFAAKPFKKSYLPNGLAADLAKETEYYDQILAQYPIDLQILGIGRNAHIGFNEPGTAFSSQTHLVDLTPSTIAANSRFFEKAEDVPKQAISMGLASIMSAKMILLMAFGEEKAEAVAAMVKGPVTEEIPASILQTHPKVILIVDEKAGAGI 2vf5 X 2.9 BS01 GLP X 1 C300 T302 S347 Q348 S349 T352 V399 A602 K603 C58 T60 S105 Q106 S107 T110 V157 A360 K361 Y248 H504 Y6 H262 2.6.1.16 0004360,0005515,0005737,0005829,0005975,0006002,0006047,0006048,0006487,0006541,0008483,0097367,1901135,1901137 P17169 18295797 609 GDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKLSRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTVE 2vhl A 2.05 BS01 GLP A 1 G146 A147 N226 A227 H258 D281 L314 G316 G144 A145 N224 A225 H256 D279 L312 G314 3.5.1.25 0005506,0006040,0006044,0006046,0008448,0016787,0016810,0019262,0042803,0046872,0047419 O34450 14557261 1395 ESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKEAD 2vhl B 2.05 BS01 GLP B 1 G146 A147 N226 A227 H258 D281 L314 G316 G145 A146 N225 A226 H257 D280 L313 G315 3.5.1.25 0005506,0006040,0006044,0006046,0008448,0016787,0016810,0019262,0042803,0046872,0047419 O34450 14557261 1395 AESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKEAD 3cxq A 2.3 BS01 GLP A 1 H111 Y151 E175 H110 Y150 E174 2.3.1.4 0000139,0004343,0005515,0005768,0005794,0005829,0006048,0010008,0016020,0016746,0016747,0042802 Q96EK6 18675810 185 KPDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCRRFL 4tkj A 0.87 BS01 GLP A 1 K58 N59 T73 T74 K59 N60 T74 T75 ? 0005515,0005615,0005634,0005737,0005829,0008092,0008285,0008289,0015909,0032365,0036041,0042632,0046320,0050873,0055091,0070062,0070538,0071073,0140214,2001245 P05413 25491543 204 MVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA 4u0v A 2.051 BS01 GLP A 1 S88 F89 T90 R133 R135 E145 S165 I166 Y167 R211 E222 Y228 S89 F90 T91 R134 R136 E146 S166 I167 Y168 R212 E223 Y229 ? 0003677,0003700,0006355,0045892 O34817 25564531 301 HMNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQFGISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGSRLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNESHFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNGTAFEHAKSVYRGDRYTFVHYMDRL 4u0v B 2.051 BS01 GLP B 1 S88 F89 T90 R133 R135 E145 S165 I166 Y167 R211 E222 S89 F90 T91 R134 R136 E146 S166 I167 Y168 R212 E223 ? 0003677,0003700,0006355,0045892 O34817 25564531 301 HMNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQFGISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGSRLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNESHFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNGTAFEHAKSVYRGDRYTFVHYMDR 4zsi A 1.652 BS01 GLP A 1 S97 Y98 T99 R142 R144 E154 S175 L176 Y177 R221 E232 V234 S11 Y12 T13 R56 R58 E68 S89 L90 Y91 R135 E146 V148 ? 0003677,0006355 Q9K492 27337024 301 MKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSQDRTGQPVEWVRSVYRGDRYKFVARLKRP 7ff6 A 0.83 BS02 GLP A 1 K58 N59 T73 T74 K59 N60 T74 T75 ? 0005515,0005615,0005634,0005737,0005829,0008092,0008285,0008289,0015909,0032365,0036041,0042632,0046320,0050873,0055091,0070062,0070538,0071073,0140214,2001245 P05413 204 MVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA 7ffx A 0.88 BS02 GLP A 1 K58 N59 T73 T74 K59 N60 T74 T75 ? 0005515,0005615,0005634,0005737,0005829,0008092,0008285,0008289,0015909,0032365,0036041,0042632,0046320,0050873,0055091,0070062,0070538,0071073,0140214,2001245 P05413 204 MVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA 7nut A 1.898 BS01 GLP A 1 A154 N235 A236 H272 D294 L328 S329 G330 A149 N230 A231 H267 D289 L323 S324 G325 3.5.1.25 0005515,0005634,0005829,0006040,0006044,0006046,0006048,0008448,0016787,0016810,0019262,0046872,0047419,0106279 Q9Y303 35229715 501 GAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADA 7nut A 1.898 BS03 GLP B 1 H242 R243 H237 R238 3.5.1.25 0005515,0005634,0005829,0006040,0006044,0006046,0006048,0008448,0016787,0016810,0019262,0046872,0047419,0106279 Q9Y303 35229715 501 GAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADA 7nut B 1.898 BS01 GLP A 1 H242 R243 H234 R235 3.5.1.25 0005515,0005634,0005829,0006040,0006044,0006046,0006048,0008448,0016787,0016810,0019262,0046872,0047419,0106279 Q9Y303 35229715 501 GARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADA 7nut B 1.898 BS02 GLP B 1 N235 A236 H272 D294 L328 S329 G330 N227 A228 H264 D286 L320 S321 G322 3.5.1.25 0005515,0005634,0005829,0006040,0006044,0006046,0006048,0008448,0016787,0016810,0019262,0046872,0047419,0106279 Q9Y303 35229715 501 GARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADA 7xbc A 0.92 BS02 GLP A 1 K58 N59 T73 T74 K59 N60 T74 T75 ? 0005515,0005615,0005634,0005737,0005829,0008092,0008285,0008289,0015909,0032365,0036041,0042632,0046320,0050873,0055091,0070062,0070538,0071073,0140214,2001245 P05413 203 MVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA