2ceq A 2.14 BS01 GIM A 1 Q18 H150 W151 E206 Y322 E387 W425 E432 W433 F441 Q18 H150 W151 E206 Y322 E387 W425 E432 W433 F441 R79 H150 E206 V209 N320 Y322 E387 R79 H150 E206 V209 N320 Y322 E387 3.2.1.23 0004553,0004565,0005975,0008422,0016798 Ki=53nM -logKd/Ki=7.28, Ki=53nM P22498 17002288 1492 MYSFPNSFRFGWSQAGFQSEMGTPGSEDPNTDWYKWVHDPENMAAGLVSGDLPENGPGYWGNYKTFHDNAQKMGLKIARLNVEWSRIFPNPLPRPQNFDESKQDVTEVEINENELKRLDEYANKDALNHYREIFKDLKSRGLYFILNMYHWPLPLWLHDPIRVRRGDFTGPSGWLSTRTVYEFARFSAYIAWKFDDLVDEYSTMNEPNVVGGLGYVGVKSGFPPGYLSFELSRRAMYNIIQAHARAYDGIKSVSKKPVGIIYANSSFQPLTDKDMEAVEMAENDNRWWFFDAIIRGEITRGNEKIVRDDLKGRLDWIGVNYYTRTVVKRTEKGYVSLGGYGHGCERNSVSLAGLPTSDFGWEFFPEGLYDVLTKYWNRYHLYMYVTENGIADDADYQRPYYLVSHVYQVHRAINSGADVRGYLHWSLADNYEWASGFSMRFGLLKVDYNTKRLYWRPSALVYREIATNGAITDEIEHLNSVPPVKPLRH 2ceq B 2.14 BS01 GIM B 1 Q18 H150 E206 Y322 E387 W425 E432 F441 Q18 H150 E206 Y322 E387 W425 E432 F441 R79 H150 E206 V209 N320 Y322 E387 R79 H150 E206 V209 N320 Y322 E387 3.2.1.23 0004553,0004565,0005975,0008422,0016798 Ki=53nM P22498 17002288 1493 MYSFPNSFRFGWSQAGFQSEMGTPGSEDPNTDWYKWVHDPENMAAGLVSGDLPENGPGYWGNYKTFHDNAQKMGLKIARLNVEWSRIFPNPLPRPQNFDESKQDVTEVEINENELKRLDEYANKDALNHYREIFKDLKSRGLYFILNMYHWPLPLWLHDPIRVRRGDFTGPSGWLSTRTVYEFARFSAYIAWKFDDLVDEYSTMNEPNVVGGLGYVGVKSGFPPGYLSFELSRRAMYNIIQAHARAYDGIKSVSKKPVGIIYANSSFQPLTDKDMEAVEMAENDNRWWFFDAIIRGEITRGNEKIVRDDLKGRLDWIGVNYYTRTVVKRTEKGYVSLGGYGHGCERNSVSLAGLPTSDFGWEFFPEGLYDVLTKYWNRYHLYMYVTENGIADDADYQRPYYLVSHVYQVHRAINSGADVRGYLHWSLADNYEWASGFSMRFGLLKVDYNTKRLYWRPSALVYREIATNGAITDEIEHLNSVPPVKPLRH 2ces A 2.15 BS01 GIM A 1 Q20 H121 N165 E166 Y295 E351 W398 E405 W406 F414 Q18 H119 N163 E164 Y293 E346 W393 E400 W401 F409 R77 H121 E166 V169 N293 Y295 E351 R75 H119 E164 V167 N291 Y293 E346 3.2.1.21 0004553,0005975,0008422,0016798,0030245,0102483 Kd=56nM -logKd/Ki=7.25, Kd=56nM Q08638 17002288 1447 VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLE 2ces B 2.15 BS01 GIM B 1 Q20 H121 N165 E166 Y295 E351 W398 E405 W406 F414 Q18 H119 N163 E164 Y293 E347 W394 E401 W402 F410 R77 H121 E166 V169 N293 Y295 E351 R75 H119 E164 V167 N291 Y293 E347 3.2.1.21 0004553,0005975,0008422,0016798,0030245,0102483 Kd=56nM Q08638 17002288 1446 VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGL 3d4z A 1.39 BS02 GIM A 1 H90 D92 W95 D204 D341 W415 H471 D472 Y727 R876 H61 D63 W66 D175 D312 W386 H442 D443 Y698 R847 H90 D92 D204 D341 H471 H61 D63 D175 D312 H442 3.2.1.114 0000139,0003824,0004559,0004572,0005783,0005794,0005795,0005975,0006013,0006486,0006491,0015923,0016020,0016063,0016798,0030246,0035010,0046872 Ki=13uM -logKd/Ki=4.89, Ki=13uM Q24451 18759458 1048 QCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKLHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHSS 4re3 A 2.55 BS01 GIM A 1 Q32 H133 E179 Y318 W361 E389 W436 E443 F452 Q37 H138 E184 Y323 W366 E394 W441 E448 F457 R89 H133 E179 C182 N316 Y318 E389 R94 H138 E184 C187 N321 Y323 E394 3.2.1.25 0004553,0004565,0005975,0008422,0033907 -logKd/Ki=8.57, Ki=2.7nM A2YPH1 507 AAPFTYWLNPEIYDAGGLSRRAFPEGFVFGTAASAYQVEGMAKQGGRGPSIWDAFIEKPGTIPNNATADVTVDEYHRYKEDVNIMKNMGFDAYRFSISWSRIFPNGTGMVNQEGVDYYNRLIDYMVKKGIKPYANLYHYDLPLALHEQYLGWLSPNIVEAFADYADFCFQTFGDRVKDWFTFNEPRCVAALGYDNGFHAPGRCSGCDAGGNSTTEPYLAAHHLILSHAAAVKRYREKYQLYQKGRIGILLDFVWYEPFSDSNADRAAAQRARDFHLGWFLDPIIHGRYPYSMLEIVKDRMPTFSDEESRMVKDSIDYVGINHYTSFYMKDPGPWNLTPTSYQDDWHVGFAYERNGVPIGAQANSYWLYIVPWGINKAVTYVKETYGNPTMILSENGMDQPGNVSITQGVHDTVRIRYYRNYITELKKAIDDGAKVIGYFAWSLLDNFEWRLGYTSRFGIVYVDYKTLKRYPKDSAFWFKNMLS 5bx4 A 1.65 BS01 GIM A 1 E441 Y445 D452 H507 Y523 T591 E777 R786 E409 Y413 D420 H475 Y491 T559 E745 R754 3.2.1.45 0004348,0004553,0005975,0006680,0008422,0016020,0016798,0046872 Ki=0.34uM F6BL85 27115290 901 DKISHKIDIPDSAWTIGIGEKFKNAGHPNVKYPMIDDSYVQGAPLGGFGAGTIGRTYNGGFSRWHLEIGKNKYTTVYANQFSVFQKVEGNKDGVAQVLYAGEPENGYLSSWKWDYPKESGMYYALYPNSWYTYTNKDLPVQLAVKQFSPIIPYNYKETSYPVAVFKWTAYNPTNKNVDVSIMFTWQNMIGFFGKQVNVNSGNFNKIIKDKSKDSEIVAAVMGNISNDNEEWNGEYSIGVKKVPGVDISYKAKFVTTGDGSDLWHEFSKNGILDNKDDETPTKQDGIGSAIAVNFKLQPGQTIEVPFALSWDLPIMKFGGGDKWYKMYTKYFGKNGKNSFAILKEALNNYQKWEKMIDDWQKPILSNKSKPDWYKTALFNELYYLADGGTAWENGKVGEKRTNNMFGLLECFDYNYYETLDVRFYGSFPLVMLWPDIEKQVMRQFADTINVQDSSEFKVGSNGAMAVKKVQGMIPHDLGSSYALPWIKINAYDWQNPNIWKDLNSKYVLLVYRDYVLTGKTDKEFLKYTWKSVKTALDKLKEMDKDNDGIPDNEGIPDQTYDTWSMKGTSAYCGSLWLAALKAAQEIGKVLKDNEAYIKYNEWYKIAQQNFEKELWNGEYYNFDTESDHKDSIMADQLAGQWYADILRLGDILPKDHVQKALKKIYEFNVMKFENGKMGAVNGMRPDGIVDESDIQAQEVWTGVTYALASFMKYRGMTEEAYNTAYGVYKMTYDKSGKGYWFRTPEAWTKDGNYRASMYMRPLSIWSMEV 6eug A 1.61 BS01 GIM A 1 E87 R88 Y113 D191 G260 W261 E83 R84 Y109 D187 G256 W257 3.2.1.73 0004553,0005975 Q8A1H8 30349080 401 GIASGKVWRDTDGNVINAHGGGILFHEGKYYWFGEHRPASGFVTEKGINCYSSTDLYNWKSEGIALAVSEEEGHDIEKGCIMERPKVIYNAKTGKFVMWLHLELKGQGYGPARAAVAVSDSPAGPYRFIRSGRVNPGAYPLNMTRKERKMKWNPEEYKEWWTPKWYEAIAKGMFVKRDLKDGQMSRDMTLFVDDDGKAYHIYSSEDNLTLQIAELADDYLSHTGKYIRIFPGGHNEAPAIFKKEGTYWMITSGCTGWDPNKARLLTADSMLGEWKQLPNPCVGEDADKTFGGQSTYILPLPEKGQFFFMADMWRPKSLADSRYIWLPVQFDDKGVPFIKWMDRWNFD 7bzm A 2.3 BS01 GIM A 1 Q29 H130 E176 Y315 W358 E386 W433 E440 F449 Q24 H125 E171 Y310 W353 E381 W428 E435 F444 R86 H130 E176 I179 N313 Y315 E386 R81 H125 E171 I174 N308 Y310 E381 3.2.1.21 0004553,0004565,0004567,0005576,0005975,0008422,0016798,0033907,0042803,0042973,0047668,0047701,0050224,0080079,0080083,0102483 Q75I93 32549280 501 WLGGLSRAAFPKRFVFGTVTSAYQVEGMAASGGRGPSIWDAFAHTPGNVAGNQNGDVATDQYHRYKEDVNLMKSLNFDAYRFSISWSRIFPDGEGRVNQEGVAYYNNLINYLLQKGITPYVNLYHYDLPLALEKKYGGWLNAKMADLFTEYADFCFKTFGNRVKHWFTFNEPRIVALLGYDQGTNPPKRCTKCAAGGNSATEPYIVAHNFLLSHAAAVARYRTKYQAAQQGKVGIVLDFNWYEALSNSTEDQAAAQRARDFHIGWYLDPLINGHYPQIMQDLVKDRLPKFTPEQARLVKGSADYIGINQYTASYMKGQQLMQQTPTSYSADWQVTYVFAKNGKPIGPQANSNWLYIVPWGMYGCVNYIKQKYGNPTVVITENGMDQPANLSRDQYLRDTTRVHFYRSYLTQLKKAIDEGANVAGYFAWSLLDNFEWLSGYTSKFGIVYVDFNTLERHPKASAYWFRDMLKH 7bzm B 2.3 BS02 GIM B 1 Q29 H130 E176 Y315 E386 W433 E440 F449 Q24 H125 E171 Y310 E381 W428 E435 F444 R86 H130 E176 I179 N313 Y315 E386 R81 H125 E171 I174 N308 Y310 E381 3.2.1.21 0004553,0004565,0004567,0005576,0005975,0008422,0016798,0033907,0042803,0042973,0047668,0047701,0050224,0080079,0080083,0102483 Q75I93 32549280 501 WLGGLSRAAFPKRFVFGTVTSAYQVEGMAASGGRGPSIWDAFAHTPGNVAGNQNGDVATDQYHRYKEDVNLMKSLNFDAYRFSISWSRIFPDGEGRVNQEGVAYYNNLINYLLQKGITPYVNLYHYDLPLALEKKYGGWLNAKMADLFTEYADFCFKTFGNRVKHWFTFNEPRIVALLGYDQGTNPPKRCTKCAAGGNSATEPYIVAHNFLLSHAAAVARYRTKYQAAQQGKVGIVLDFNWYEALSNSTEDQAAAQRARDFHIGWYLDPLINGHYPQIMQDLVKDRLPKFTPEQARLVKGSADYIGINQYTASYMKGQQLMQQTPTSYSADWQVTYVFAKNGKPIGPQANSNWLYIVPWGMYGCVNYIKQKYGNPTVVITENGMDQPANLSRDQYLRDTTRVHFYRSYLTQLKKAIDEGANVAGYFAWSLLDNFEWLSGYTSKFGIVYVDFNTLERHPKASAYWFRDMLKH