1h8l A 2.6 BS01 GEM A 1 H74 E77 R135 N144 R145 H181 N188 D192 G246 Y250 V252 E272 H71 E74 R132 N141 R142 H178 N185 D189 G243 Y247 V249 E269 3.4.17.22 0004180,0004181,0005615,0006508,0006518,0008237,0008270,0016020,0016485,0046872 -logKd/Ki=7.47, Ki=34nM P83852 11278909 801 QAVQPVDFRHHHFSDMEIFLRRYANEYPSITRLYSVGKSVELRELYVMEISDNPGIHEAGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVQSTRIHIMPSMNPDGYEKSQEGDRGGTVGRNNSNNYDLNRNFPDQFFQVTDPPQPETLAVMSWLKTYPFVLSANLHGGSLVVNYPFDDDEQGIAIYSKSPDDAVFQQLALSYSKENKKMYQGSPCKDLYPTEYFPHGITNGAQWYNVPGGMQDWNYLNTNCFEVTIELGCVKYPKAEELPKYWEQNRRSLLQFIKQVHRGIWGFVLDATDGRGILNATISVADINHPVTTYKDGDYWRLLVQGTYKVTASARGYDPVTKTVEVDSKGGVQVNFTLSRT 3d67 A 3.4 BS02 GEM A 1 H159 E162 R217 N234 R235 H288 S299 Y341 D348 E363 H159 E162 R217 N234 R235 H288 S299 Y341 D348 E363 H159 E162 R217 H288 E363 H159 E162 R217 H288 E363 3.4.17.20 0003331,0004180,0004181,0005576,0005615,0006508,0007596,0008237,0008270,0009410,0010757,0030163,0042730,0046872,0051918,0070062,0071333,0097421,2000346 -logKd/Ki=4.96, Ki=11uM Q96IY4 18559974 660 AQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQTAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKTSKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV 3d67 B 3.4 BS02 GEM B 1 H159 E162 R217 N234 R235 H288 S299 Y341 D348 E363 H159 E162 R217 N234 R235 H288 S299 Y341 D348 E363 H159 E162 R217 H288 E363 H159 E162 R217 H288 E363 3.4.17.20 0003331,0004180,0004181,0005576,0005615,0006508,0007596,0008237,0008270,0009410,0010757,0030163,0042730,0046872,0051918,0070062,0071333,0097421,2000346 Q96IY4 18559974 660 AQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQTAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKTSKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV 3d67 C 3.4 BS02 GEM C 1 H159 E162 R217 R235 H288 S299 Y341 D348 E363 H159 E162 R217 R235 H288 S299 Y341 D348 E363 H159 E162 R217 H288 E363 H159 E162 R217 H288 E363 3.4.17.20 0003331,0004180,0004181,0005576,0005615,0006508,0007596,0008237,0008270,0009410,0010757,0030163,0042730,0046872,0051918,0070062,0071333,0097421,2000346 Q96IY4 18559974 660 AQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQTAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKTSKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV 3mn8 A 2.7 BS02 GEM A 1 H101 E104 R165 N174 R175 H217 D228 G279 W282 Y283 L285 E305 H73 E76 R137 N146 R147 H181 D192 G243 W246 Y247 L249 E269 3.4.17.22 0004181,0006508,0008270 -logKd/Ki=6.17, Ki=0.67uM P42787 20600119 601 KEDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLEAQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPV 3mn8 B 2.7 BS02 GEM B 1 H101 R165 N174 R175 H217 D228 G279 W282 Y283 L285 E305 H74 R138 N147 R148 H183 D194 G245 W248 Y249 L251 E271 3.4.17.22 0004181,0006508,0008270 P42787 20600119 601 IKEDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQSQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPVE 3mn8 C 2.7 BS02 GEM C 1 H101 E104 R165 N174 R175 H217 D228 G279 Y283 L285 E305 H72 E75 R136 N145 R146 H183 D194 G245 Y249 L251 E271 3.4.17.22 0004181,0006508,0008270 P42787 20600119 601 EDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQLRAQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPV 3mn8 D 2.7 BS02 GEM D 1 H101 E104 R165 N174 R175 H217 D228 G279 W282 Y283 L285 E305 H75 E78 R139 N148 R149 H182 D193 G244 W247 Y248 L250 E270 3.4.17.22 0004181,0006508,0008270 P42787 20600119 601 TIKEDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLAQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPVE 3v7z A 1.61 BS04 GEM A 1 H69 E72 R129 N146 R147 H204 A251 Y255 T257 E277 H69 E72 R129 N146 R147 H204 A251 Y255 T257 E277 H69 E72 R129 H204 E277 H69 E72 R129 H204 E277 3.4.17.18 0004181,0006508,0008270 P29068 25619204 405 DFPSYDSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKISDNVGTDENEPEVLYTALHHAREHLTVEMALYTLDLFTQNYNLDSRITNLVNNREIYIVFNINPDGGEYDISSGSYKSWRKNRQPNSGSSYVGTDLNRNYGYKWGCCGGSSGSPSSETYRGRSAFSAPETAAMRDFINSRVVGGKQQIKTLITFHTYSELILYPYGYTYTDVPSDMTQDDFNVFKTMANTMAQTNGYTPQQASDLYITDGDMTDWAYGQHKIFAFTFEMYPTSYNPGFYPPDEVIGRETSRNKEAVLYVAEKADCPYSVIGKSC 4a39 A 1.6 BS02 GEM A 1 H167 R218 N227 R228 H260 Y306 L318 T333 E335 H167 R218 N227 R228 H260 Y306 L318 T333 E335 ? 0004181,0006508,0008270,0046872 Q9I012 22645247 1377 MQIRADFDSGNIQVIDASDPRRIRLAIRPDLASQHFQWFHFKVEGMAPATEHCFTLVNAGQSAYSHAWSGYQAVASYDGERWFRVPSQYDADGLHFQLEPEESEVRFAYFEPYSRERHARLVERALGIEGVERLAVGTSVQGRDIELLRVRRHPDSHLKLWVIAQQHPGEHMAEWFMEGLIERLQRPDDTEMQRLLEKADLYLVPNMNPDGAFHGNLRTNAAGQDLNRAWLEPSAERSPEVWFVQQEMKRHGVDLFLDIHGDEEIPHVFAAGCEGNPGYTPRLERLEQRFREELMARGEFQIRHGYPRSAPGQANLALACNFVGQTYDCLAFTIEMPFKDHDDNPEPGTGWSGARSKRLGQDVLSTLAVLVDELR