2rhq A 2.2 BS02 GAX A 1 S174 Q177 M181 Q214 E216 F254 F256 T257 G288 A289 A311 G313 S93 Q96 M100 Q133 E135 F173 F175 T176 G207 A208 A230 G232 Q158 H172 R200 Q214 T257 A311 Q77 H91 R119 Q133 T176 A230 6.1.1.20 0000049,0000166,0004812,0004826,0005524,0005737,0006432,0043039 Q4L5E3 18086534 352 LMEKLNQQLAEETIDVTLPSRQISIGSKHPLTRTVEEIEDLFLGLGYEIVDGYEVEQDYYNFEALNLPKSHPARDMQDSFYITDEILMRTHTSPVQARTMEKRNGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNIKMSDLKGTLELVAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSNEYSGFAFGMGPDRIAMLKYGIEDIRYFYTNDVRFLEQFKAVEDRGE 2rhs A 2.2 BS01 GAX A 1 S174 Q177 E216 F254 P255 F256 T257 G288 A289 A311 G313 S88 Q91 E130 F168 P169 F170 T171 G186 A187 A209 G211 Q158 H172 R200 Q214 T257 A311 Q72 H86 R114 Q128 T171 A209 6.1.1.20 0000049,0000166,0004812,0004826,0005524,0005737,0006432,0043039 Q4L5E3 18086534 1 NQQLAEETIDVTLPSRQISIGSKHPLTRTVEEIEDLFLGLGYEIVDGYEVEQDYYNFEALNLPKSHPARDMQDSFYITDEILMRTHTSPVQARTMEKRNGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNIKMSDLKGTLELVAKKLFGADREIRLRPSYFPFTEPSVEVDVSWIEILGAGMVHPNVLEMAGFDSNEYSGFAFGMGPDRIAMLKYGIEDIRYFYTNDVRFLEQFKAVEDRGE 2rhs C 2.2 BS02 GAX C 1 S174 Q177 M181 E216 F254 P255 F256 T257 G288 A289 A311 G313 S94 Q97 M101 E136 F174 P175 F176 T177 G208 A209 A231 G233 Q158 H172 R200 Q214 T257 A311 Q78 H92 R120 Q134 T177 A231 6.1.1.20 0000049,0000166,0004812,0004826,0005524,0005737,0006432,0043039 Q4L5E3 18086534 2 ELMEKLNQQLAEETIDVTLPSRQISIGSKHPLTRTVEEIEDLFLGLGYEIVDGYEVEQDYYNFEALNLPKSHPARDMQDSFYITDEILMRTHTSPVQARTMEKRNGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNIKMSDLKGTLELVAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSNEYSGFAFGMGPDRIAMLKYGIEDIRYFYTNDVRFLEQFKAVEDRGE 4p73 C 3.03 BS01 GAX C 1 L64 S92 Q95 M99 E131 F169 F171 G203 C204 A226 F227 G228 L56 S84 Q87 M91 E123 F161 F163 G183 C184 A206 F207 G208 H76 H90 R116 Q129 T172 A226 H68 H82 R108 Q121 T164 A206 6.1.1.20 0000049,0000166,0000287,0004812,0004826,0005524,0005737,0006412,0006432,0043039,0046872 -logKd/Ki=7.66, IC50=22nM Q9I0A3 24936059 301 AAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFEKQLEVRFRPSFFPFTEPSAEVDIQCQTGWLEVMGCGMVHPNVLRMSNIDPEKFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR 4p73 D 3.03 BS01 GAX D 1 L64 S92 Q95 M99 E131 F169 F171 G203 C204 A226 F227 G228 L57 S85 Q88 M92 E124 F162 F164 G187 C188 A210 F211 G212 H76 H90 R116 Q129 T172 A226 H69 H83 R109 Q122 T165 A210 6.1.1.20 0000049,0000166,0000287,0004812,0004826,0005524,0005737,0006412,0006432,0043039,0046872 Q9I0A3 24936059 301 LAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFEKQLEVRFRPSFFPFTEPSAEVDIQCVICQTGWLEVMGCGMVHPNVLRMSNIDPEKFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR