3e88 A 2.5 BS02 G96 A 1 G159 G164 K165 V166 A179 K181 L183 E200 F227 M229 M282 T292 D293 F294 F439 G14 G19 K20 V21 A34 K36 L38 E55 F82 M84 M137 T147 D148 F149 F294 D275 K277 N280 D293 T313 D130 K132 N135 D148 T168 2.7.11.1 0004672,0004674,0005524,0006468 Ki=2nM Ki=2nM, IC50=10nM P31751 19179070 1 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITQRTHFPQFDYSASIR 3e88 B 2.5 BS02 G96 B 1 G159 G164 K165 V166 A179 K181 E200 L204 F227 M229 M282 T292 D293 F294 F439 G14 G19 K20 V21 A34 K36 E55 L59 F82 M84 M137 T147 D148 F149 F294 D275 K277 N280 D293 T313 D130 K132 N135 D148 T168 2.7.11.1 0004672,0004674,0005524,0006468 Ki=2nM Ki=2nM, IC50=10nM P31751 19179070 1 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITQRTHFPQFDYSASIR 3e8c A 2.2 BS02 G96 A 1 L49 G52 F54 G55 R56 E91 L95 M120 E121 Y122 L173 T183 D184 F327 L43 G46 F48 G49 R50 E85 L89 M114 E115 Y116 L167 T177 D178 F321 D166 K168 E170 N171 D184 T201 D160 K162 E164 N165 D178 T195 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 19179070 351 KKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3e8c B 2.2 BS02 G96 B 1 L49 G50 G52 F54 G55 R56 V57 K72 E91 L95 M120 E121 Y122 L173 T183 D184 F327 L46 G47 G49 F51 G52 R53 V54 K69 E88 L92 M117 E118 Y119 L170 T180 D181 F324 D166 K168 E170 N171 D184 T201 D163 K165 E167 N168 D181 T198 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 19179070 351 AAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3e8c C 2.2 BS02 G96 C 1 L49 G52 F54 G55 R56 V57 L74 E91 L95 M120 E121 Y122 L173 T183 D184 F327 L43 G46 F48 G49 R50 V51 L68 E85 L89 M114 E115 Y116 L167 T177 D178 F321 D166 K168 E170 N171 D184 T201 D160 K162 E164 N165 D178 T195 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 19179070 351 KKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3e8c D 2.2 BS02 G96 D 1 L49 G50 G52 F54 G55 R56 V57 K72 L74 E91 L95 M120 Y122 L173 T183 D184 F327 L46 G47 G49 F51 G52 R53 V54 K69 L71 E88 L92 M117 Y119 L170 T180 D181 F324 D166 K168 E170 N171 D184 T201 D163 K165 E167 N168 D181 T198 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 19179070 351 AAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3e8c E 2.2 BS02 G96 E 1 L49 G52 F54 G55 R56 V57 L74 E91 L95 M120 Y122 L173 T183 D184 F327 L37 G40 F42 G43 R44 V45 L62 E79 L83 M108 Y110 L161 T171 D172 F315 D166 K168 E170 N171 D184 T201 D154 K156 E158 N159 D172 T189 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 19179070 351 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 3e8c F 2.2 BS02 G96 F 1 L49 G52 F54 G55 R56 V57 K72 L74 E91 L95 M120 E121 Y122 L173 T183 D184 F327 L43 G46 F48 G49 R50 V51 K66 L68 E85 L89 M114 E115 Y116 L167 T177 D178 F321 D166 K168 E170 N171 D184 T201 D160 K162 E164 N165 D178 T195 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 19179070 351 KKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF