2ht7 A 2.6 BS01 G39 A 1 R152 W178 I222 R224 E276 R292 R371 Y406 R70 W97 I141 R143 E195 R211 R288 Y322 D151 E277 R292 R371 Y406 D69 E196 R211 R288 Y322 3.2.1.18 0004308,0005975,0016020,0033644,0055036 IC50=8.9nM Q07599 16915235 800 TYMNNTEAICDAKGFAPFSKDNGIRIGSRGHIFVIREPFVSCSPIECRTFFLTQGSLLNDKHSNGTVKDRSPFRTLMSVEVGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDSKAVAVIHYGGVPTDVVNSWAGDILRTQESSCTCIQGDCYWVMTDGPANRQAQYRIYKANQGRIIGQTDISFNGGHIEECSCYPNDGKVECVCRDGWTGTNRPVLVISPDLSYRVGYLCAGIPSDTPRGEDTQFTGSCTSPMGNQGYGVKGFGFRQGTDVWMGRTISRTSRSGFEILRIKNGWTQTSKEQIRKQVVVDNLNWSGYSGSFTLPVELSGKDCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDYEVADWSWHDGAILPFDI 2ht8 A 2.4 BS01 G39 A 1 R118 E119 D151 R152 R224 E276 R292 Y347 R371 Y406 R36 E37 D69 R70 R143 E195 R211 Y264 R288 Y322 D151 E277 R292 R371 Y406 D69 E196 R211 R288 Y322 3.2.1.18 0004308,0005975,0016020,0033644,0055036 IC50=8.9nM Q07599 16915235 800 TYMNNTEAICDAKGFAPFSKDNGIRIGSRGHIFVIREPFVSCSPIECRTFFLTQGSLLNDKHSNGTVKDRSPFRTLMSVEVGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDSKAVAVIHYGGVPTDVVNSWAGDILRTQESSCTCIQGDCYWVMTDGPANRQAQYRIYKANQGRIIGQTDISFNGGHIEECSCYPNDGKVECVCRDGWTGTNRPVLVISPDLSYRVGYLCAGIPSDTPRGEDTQFTGSCTSPMGNQGYGVKGFGFRQGTDVWMGRTISRTSRSGFEILRIKNGWTQTSKEQIRKQVVVDNLNWSGYSGSFTLPVELSGKDCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDYEVADWSWHDGAILPFDI 2hu0 B 2.95 BS01 G39 B 1 R152 R224 E276 R292 N294 R371 Y406 R70 R143 E195 R211 N213 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 800 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 A 2.5 BS01 G39 A 1 E119 D151 W178 R292 N294 Y347 R371 Y406 E37 D69 W97 R211 N213 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 800 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 B 2.5 BS01 G39 B 1 E119 D151 W178 E276 R292 N294 Y347 R371 Y406 E37 D69 W97 E195 R211 N213 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 801 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 C 2.5 BS01 G39 C 1 E119 D151 R152 W178 R224 E276 R292 N294 Y347 R371 Y406 E37 D69 R70 W97 R143 E195 R211 N213 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 802 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 D 2.5 BS01 G39 D 1 E119 D151 W178 R224 E276 R292 R371 Y406 E37 D69 W97 R143 E195 R211 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 803 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 E 2.5 BS01 G39 E 1 E119 D151 R224 E276 R292 Y347 R371 Y406 E37 D69 R143 E195 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 804 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 F 2.5 BS01 G39 F 1 E119 D151 E276 R292 N294 Y347 R371 Y406 E37 D69 E195 R211 N213 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 805 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 G 2.5 BS01 G39 G 1 E119 D151 R152 W178 R224 E276 R292 Y347 R371 Y406 E37 D69 R70 W97 R143 E195 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 806 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2hu4 H 2.5 BS01 G39 H 1 E119 D151 R224 E276 R292 Y347 R371 Y406 E37 D69 R143 E195 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 16915235 807 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 2qwh A 1.8 BS01 G39 A 1 R118 E119 D151 R152 W178 I222 E276 R371 Y406 R37 E38 D70 R71 W98 I142 E196 R290 Y324 D151 E277 K292 R371 Y406 D70 E197 K212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=13uM P03472 9655825 800 RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGERAEITCTCKDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL 2qwk A 1.8 BS01 G39 A 1 R118 E119 D151 R152 W178 E276 R292 R371 Y406 R37 E38 D70 R71 W98 E196 R212 R290 Y324 D151 E277 R292 R371 Y406 D70 E197 R212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=0.002uM P03472 9655825 800 RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL 2ya8 A 1.75 BS01 G39 A 1 R332 D357 I401 D402 F550 R648 R706 Y737 R26 D51 I95 D96 F244 R342 R400 Y431 S356 D357 E632 Y737 S50 D51 E326 Y431 3.2.1.18 0004308 Ki=1.77uM -logKd/Ki=5.75, Ki=1.77uM Ki=1.77e+3nM P62575 21514303 1777 ALTEKTDIFESGRNGNPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGDQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLDGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSK 2ya8 B 1.75 BS01 G39 B 1 R332 D357 I401 D402 F550 R648 R706 Y737 R26 D51 I95 D96 F244 R342 R400 Y431 S356 D357 E632 Y737 S50 D51 E326 Y431 3.2.1.18 0004308 Ki=1.77uM Ki=1.77e+3nM P62575 21514303 1777 ALTEKTDIFESGRNGNPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGDQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLDGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSK 3cl0 A 2.2 BS01 G39 A 1 R118 E119 D151 R152 W178 E276 R292 N294 Y347 R371 Y406 R36 E37 D69 R70 W97 E195 R211 N213 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=84.8nM -logKd/Ki=7.07, Ki=84.8nM Q6DPL2 18480754 800 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYYYEECSCYPNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 A 2.538 BS01 G39 A 1 E119 D151 W178 S246 R292 Y347 R371 Y406 E37 D69 W97 S165 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 -logKd/Ki=7.59, Ki=25.9nM Q6DPL2 18480754 800 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 B 2.538 BS01 G39 B 1 R118 E119 D151 W178 S246 R292 Y347 R371 Y406 R36 E37 D69 W97 S165 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 801 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 C 2.538 BS01 G39 C 1 R118 E119 D151 W178 S246 E276 R292 R371 Y406 R36 E37 D69 W97 S165 E195 R211 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 802 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 D 2.538 BS01 G39 D 1 R118 E119 D151 W178 R224 E276 R292 Y347 R371 Y406 R36 E37 D69 W97 R143 E195 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 803 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 E 2.538 BS01 G39 E 1 R118 E119 D151 W178 S246 E276 R292 Y347 R371 Y406 R36 E37 D69 W97 S165 E195 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 805 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 F 2.538 BS01 G39 F 1 E119 D151 W178 S246 E276 R292 Y347 R371 Y406 E37 D69 W97 S165 E195 R211 Y262 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 806 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 G 2.538 BS01 G39 G 1 R118 E119 D151 W178 R224 E276 R292 R371 Y406 R36 E37 D69 W97 R143 E195 R211 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 807 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3cl2 H 2.538 BS01 G39 H 1 R118 E119 D151 W178 R224 S246 E276 R292 R371 Y406 R36 E37 D69 W97 R143 S165 E195 R211 R286 Y320 D151 E277 R292 R371 Y406 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q6DPL2 18480754 808 VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI 3k3a A 2.59 BS02 G39 A 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 -logKd/Ki=7.08, Ki=84.0nM Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a B 2.59 BS02 G39 B 1 R116 E117 D149 R150 R223 A245 E275 R292 R374 Y409 R39 E40 D72 R73 R146 A168 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a C 2.59 BS02 G39 C 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a D 2.59 BS02 G39 D 1 R116 E117 D149 R150 R223 A245 E275 R292 N294 R374 Y409 R39 E40 D72 R73 R146 A168 E198 R215 N217 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a E 2.59 BS02 G39 E 1 R116 E117 D149 R150 R223 E275 R292 N294 R374 Y409 R39 E40 D72 R73 R146 E198 R215 N217 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a F 2.59 BS02 G39 F 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a G 2.59 BS02 G39 G 1 R116 E117 D149 R150 W177 I221 R223 E275 R292 N294 R374 Y409 R39 E40 D72 R73 W100 I144 R146 E198 R215 N217 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a H 2.59 BS02 G39 H 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a I 2.59 BS02 G39 I 1 R116 E117 D149 R150 R223 E275 R292 N294 R374 Y409 R39 E40 D72 R73 R146 E198 R215 N217 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a J 2.59 BS02 G39 J 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a K 2.59 BS02 G39 K 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a L 2.59 BS02 G39 L 1 R116 E117 D149 R150 I221 R223 E275 R292 R374 Y409 R39 E40 D72 R73 I144 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a M 2.59 BS02 G39 M 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a N 2.59 BS02 G39 N 1 R116 E117 D149 R150 I221 R223 E275 R292 R374 Y409 R39 E40 D72 R73 I144 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a O 2.59 BS02 G39 O 1 R116 E117 D149 R150 R223 E275 R292 R374 Y409 R39 E40 D72 R73 R146 E198 R215 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3k3a P 2.59 BS02 G39 P 1 R116 E117 D149 R150 R223 A245 E275 R292 N294 R374 Y409 R39 E40 D72 R73 R146 A168 E198 R215 N217 R297 Y332 D149 E276 R292 R374 Y409 D72 E199 R215 R297 Y332 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q3S340 20695427 1 PEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPENNALLKIKYGEAYTDTYHSYANNILRTQESACNCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 3ti6 A 1.69 BS03 G39 A 1 R118 E119 D151 R152 W178 R224 E276 R292 N294 R371 Y406 R37 E38 D70 R71 W98 R144 E196 R212 N214 R287 Y321 D151 E277 R292 R371 Y406 D70 E197 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=0.54nM -logKd/Ki=9.27, IC50=0.54nM C3W5S3 22028647 801 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 3ti6 B 1.69 BS03 G39 B 1 R118 E119 D151 R152 R224 E276 R292 N294 R371 Y406 R37 E38 D70 R71 R144 E196 R212 N214 R287 Y321 D151 E277 R292 R371 Y406 D70 E197 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=0.54nM C3W5S3 22028647 801 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 4b7j A 2.417 BS02 G39 A 1 D151 R225 E277 R293 R368 Y402 D69 R143 E195 R211 R286 Y320 D151 E278 R293 R368 Y402 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046761,0046872,0052794,0052795,0052796,0055036 Ki=11.1nM -logKd/Ki=7.95, Ki=11.1nM F8UU09 23028314 1470 VKLAGNSSLCPVSGWAIYSKDNSIRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNRLRTQESECACVNGSCFTVMTDGPSDGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNDFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 4b7r A 1.9 BS03 G39 A 1 R118 E119 D151 R152 R225 R293 R368 Y402 R36 E37 D69 R70 R143 R211 R286 Y320 D151 E278 R293 R368 Y402 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=0.23nM -logKd/Ki=9.64, Ki=0.23nM C7FH46 23028314 801 VKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 4b7r B 1.9 BS03 G39 B 1 R118 E119 D151 R152 R225 E277 R293 N295 R368 Y402 R36 E37 D69 R70 R143 E195 R211 N213 R286 Y320 D151 E278 R293 R368 Y402 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=0.23nM C7FH46 23028314 801 VKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 4b7r C 1.9 BS03 G39 C 1 R118 E119 D151 R152 R225 E277 R293 N295 R368 Y402 R36 E37 D69 R70 R143 E195 R211 N213 R286 Y320 D151 E278 R293 R368 Y402 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=0.23nM C7FH46 23028314 801 VKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 4b7r D 1.9 BS03 G39 D 1 R118 E119 D151 R152 R225 E277 R293 R368 Y402 R36 E37 D69 R70 R143 E195 R211 R286 Y320 D151 E278 R293 R368 Y402 D69 E196 R211 R286 Y320 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=0.23nM C7FH46 23028314 801 VKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 4cpm A 2.75 BS02 G39 A 1 R115 E116 D148 R149 W176 R222 A244 E274 R291 N293 R373 Y408 R40 E41 D73 R74 W101 R147 A169 E199 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 C0LT34 24795482 700 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNNALLKVKYGEAYTDTYHSYANKILRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPNDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpm B 2.75 BS02 G39 B 1 R115 E116 D148 R149 W176 R222 E274 R291 R373 Y408 R40 E41 D73 R74 W101 R147 E199 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 C0LT34 24795482 700 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNNALLKVKYGEAYTDTYHSYANKILRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPNDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpy A 1.8 BS02 G39 A 1 R115 E116 D148 R149 A244 E274 R291 N293 R373 Y408 R40 E41 D73 R74 A169 E199 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=491.35nM -logKd/Ki=6.31, Ki=491.35nM U5XBU0 24795482 1470 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpy B 1.8 BS02 G39 B 1 R115 E116 D148 R149 W176 E274 R291 N293 R373 Y408 R40 E41 D73 R74 W101 E199 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=491.35nM U5XBU0 24795482 1470 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4gzp A 2.3 BS02 G39 A 1 R118 E119 D151 R152 E276 R292 R371 Y406 R37 E38 D70 R71 E195 R211 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046761,0046872,0052794,0052795,0052796,0055036 Ki=14.3nM -logKd/Ki=7.84, Ki=14.3nM K7N5N3 23015718 512 AEYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNVHSNNTVRDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDSSSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVIEGWSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKEETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMPI 4gzt A 2.19 BS02 G39 A 1 R118 E119 R152 R224 E276 R292 R371 Y406 R37 E38 R71 R143 E195 R211 R290 Y325 G151 E277 R292 R371 Y406 G70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046761,0046872,0052794,0052795,0052796,0055036 Ki=17nM -logKd/Ki=7.77, Ki=17.0nM K7N5N3 23015718 501 AEYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNVHSNNTVRGRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDSSSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVIEGWSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKEETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMPI 4gzt B 2.19 BS02 G39 B 1 E119 R152 E276 E277 R292 N294 R371 Y406 E38 R71 E195 E196 R211 N213 R290 Y325 G151 E277 R292 R371 Y406 G70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046761,0046872,0052794,0052795,0052796,0055036 Ki=17nM K7N5N3 23015718 501 AEYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNVHSNNTVRGRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDSSSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVIEGWSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKEETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMPI 4gzt C 2.19 BS02 G39 C 1 R118 E119 R224 R292 N294 R371 Y406 R37 E38 R143 R211 N213 R290 Y325 G151 E277 R292 R371 Y406 G70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046761,0046872,0052794,0052795,0052796,0055036 Ki=17nM K7N5N3 23015718 501 AEYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNVHSNNTVRGRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDSSSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVIEGWSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKEETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMPI 4gzt D 2.19 BS03 G39 D 1 R118 E119 R152 R224 R292 N294 R371 Y406 R37 E38 R71 R143 R211 N213 R290 Y325 G151 E277 R292 R371 Y406 G70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046761,0046872,0052794,0052795,0052796,0055036 Ki=17nM K7N5N3 23015718 501 AEYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNVHSNNTVRGRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDSSSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVIEGWSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKEETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMPI 4hzx A 2.2 BS02 G39 A 1 R118 E119 D151 R152 W178 R224 E276 R292 N294 R371 Y406 R37 E38 D70 R71 W98 R144 E197 R212 N214 R289 Y324 D151 E277 R292 R371 Y406 D70 E198 R212 R289 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 ic50=0.5nM -logKd/Ki=9.30, IC50=0.5nM A9YN63 23824808 508 FRPFKSPLPLCPFRGFFPFHKDNAIRLGENKDVIVTREPYVSCDNDNCWSFALAQGALLGTKHSNGTIKDRTPYRSLIRFPIGTAPVLGNYKEICIAWSSSSCFDGKEWMHVCMTGNDNDASAQIIYGGRMTDSIKSWRKDILRTQESECQCIDGTCVVAVTDGPAANSADYRVYWIREGKIIKYENVPKTKIQHLEECSCYVDIDVYCICRDNWKGSNRPWMRINNETILETGYVCSKFHSDTPRPADPSTMSCDSPSNVNGGPGVKGFGFKAGDDVWLGRTVSTSGRSGFEIIKVTEGWINSPNHVKSITQTLVSNNDWSGYSGSFIVKAKDCFQPCFYVELIRGRPNKNDDVSWTSNSIVTFCGLDNEPGSGNWPDGSNIGFMPK 4hzz A 1.601 BS02 G39 A 1 R118 E119 D151 R152 R224 R292 R371 Y406 R36 E37 D69 R70 R143 R211 R288 Y323 D151 E277 R292 R371 Y406 D69 E197 R211 R288 Y323 3.2.1.18 0004308,0005975,0016020,0033644,0055036 ic50=8.31nM -logKd/Ki=8.08, IC50=8.31nM A9YN63 23824808 509 RPFKSPLPLCPFRGFFPFHKDNAIRLGENKDVIVTREPYVSCDNDNCWSFALAQGALLGTKHSNGTIKDRTPYRSLIRFPIGTAPVLGNYKEICIAWSSSSCFDGKEWMHVCMTGNDNDASAQIIYGGRMTDSIKSWRKDILRTQESECQCIDGTCVVAVTDGPAANSADYRVYWIREGKIIKYENVPKTKIQYLEECSCYVDIDVYCICRDNWKGSNRPWMRINNETILETGYVCSKFHSDTPRPADPSTMSCDSPSNVNGGPGVKGFGFKAGDDVWLGRTVSTSGRSGFEIIKVTEGWINSPNHVKSITQTLVSNNDWSGYSGSFIVKAKDCFQPCFYVELIRGRPNKNDDVSWTSNSIVTFCGLDNEPGSGNWPDGSNIGFMPK 4k1i A 1.8 BS02 G39 A 1 E119 D151 R152 R224 R292 N294 R371 Y406 E38 D70 R71 R143 R211 N213 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q194T1 23531861 507 VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHIEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKESRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI 4k1i B 1.8 BS04 G39 B 1 E119 D151 R152 R224 E276 R292 N294 R371 Y406 E38 D70 R71 R143 E195 R211 N213 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q194T1 23531861 507 VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHIEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKESRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI 4k1j A 2.2 BS04 G39 A 1 R118 E119 D151 W178 R224 E276 R292 N294 R371 Y406 R37 E38 D70 W97 R143 E195 R211 N213 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q194T1 23531861 508 VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHIEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKESRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI 4k1j B 2.2 BS02 G39 B 1 R118 E119 D151 W178 R224 E276 R292 N294 R371 Y406 R37 E38 D70 W97 R143 E195 R211 N213 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q194T1 23531861 508 VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHIEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKESRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI 4k1k A 1.6 BS02 G39 A 1 R118 E119 R152 R224 E276 R292 N294 R371 Y406 R37 E38 R71 R143 E195 R211 N213 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q194T1 23531861 509 VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHIEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKESRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI 4k1k B 1.6 BS04 G39 B 1 R118 E119 R152 R224 E276 R292 N294 R371 Y406 R37 E38 R71 R143 E195 R211 N213 R290 Y325 D151 E277 R292 R371 Y406 D70 E196 R211 R290 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Q194T1 23531861 510 VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHIEECSCYPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRNPNNERGTQGVKGWAFDNGNDLWMGRTISKESRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI 4mwq A 2.0 BS02 G39 A 1 R119 E120 D152 R153 W180 I224 R226 R294 N296 R372 Y406 R37 E38 D70 R71 W98 I142 R144 R212 N214 R290 Y324 D152 E279 R294 R372 Y406 D70 E197 R212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=0.79nM -logKd/Ki=9.10, IC50=0.79nM A0A024E3Q2 24165891 513 RNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSCYGERTGITCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPNDPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPNALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL 4mww A 1.9 BS02 G39 A 1 R119 E120 D152 R153 W180 I224 R372 Y406 R37 E38 D70 R71 W98 I142 R290 Y324 D152 E279 K294 R372 Y406 D70 E197 K212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 -logKd/Ki=3.67, IC50=214770nM A0A067Y7N7 24165891 513 RNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSCYGERTGITCTCKDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPNDPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPNALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL 4qn7 A 2.302 BS02 G39 A 1 R36 D69 I141 R143 R211 N213 R290 Y324 R36 D69 I141 R143 R211 N213 R290 Y324 D69 E196 R211 R290 Y324 D69 E196 R211 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 ic50=0.84nM -logKd/Ki=9.08, IC50=0.84nM Q20R18 24899180 508 NYLMLNKSLCKVEGWVVVAKDNAIRFGESEQIIVTREPYVSCDPLGCKMYALHQGTTIRNKHSNGTIHDRTAFRGLISTPLGSPPIVSNSDFLCVGWSSTSCHDGIGRMTICVQGNNDNATATVYYDRRLTTTIKTWAGNILRTQESECVCHNGTCVVIMTDGSASSQAYTKVLYFHKGLVIKEEALKGSARHIEECSCYGHNSKVTCVCRDNWQGANRPVIEIDMNAMEHTSQYLCTGVLTDTSRPSDKSIGDCNNPITGSPGAPGVKGFGFLDSGNTWLGRTISPRSRSGFEMLKIPNAGTDPNSRITERQEIVDNNNWSGYSGSFIDYWDESSECYNPCFYVELIRGRPEEAKYVWWTSNSLVALCGSPVPVGSGSFPDGAQIQYFS 4qn7 B 2.302 BS02 G39 B 1 R36 D69 R70 I141 R143 R211 N213 R290 Y324 R36 D69 R70 I141 R143 R211 N213 R290 Y324 D69 E196 R211 R290 Y324 D69 E196 R211 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 ic50=0.84nM Q20R18 24899180 508 NYLMLNKSLCKVEGWVVVAKDNAIRFGESEQIIVTREPYVSCDPLGCKMYALHQGTTIRNKHSNGTIHDRTAFRGLISTPLGSPPIVSNSDFLCVGWSSTSCHDGIGRMTICVQGNNDNATATVYYDRRLTTTIKTWAGNILRTQESECVCHNGTCVVIMTDGSASSQAYTKVLYFHKGLVIKEEALKGSARHIEECSCYGHNSKVTCVCRDNWQGANRPVIEIDMNAMEHTSQYLCTGVLTDTSRPSDKSIGDCNNPITGSPGAPGVKGFGFLDSGNTWLGRTISPRSRSGFEMLKIPNAGTDPNSRITERQEIVDNNNWSGYSGSFIDYWDESSECYNPCFYVELIRGRPEEAKYVWWTSNSLVALCGSPVPVGSGSFPDGAQIQYFS 4wa4 A 1.95 BS01 G39 A 1 R116 E117 R150 E275 R291 Y344 R368 Y402 R36 E37 R66 E191 R207 Y260 R284 Y318 E276 R291 R368 Y402 E192 R207 R284 Y318 3.2.1.18 0004308,0005975,0016020,0033644,0055036 ic50=0.66nM I6NW33 25540377 501 QFMQNTEALCDVKGFAPFSKDNGIRIGSRGHVFVIREPFVSCSPTECRTFFLTQGSLLNDKHSNGRSPYRTLMSVEIGQSPNVYQARFEAVAWSATACHDGKKWMTIGVTGPDAKAVAVVHYGGIPTDVINSWAGDILRTQESSCTCILGECYWVMTDGPANRQAQYRAFKAKQGKIIGQVEISFNGGHIEECSCYPNDGKVECVCRDNWTGTNRPVLVISPDLSYRVGYLCAGLSSDTPRGEDSQFTGSCTSPVGNQGYGVKGFGFRQGNDVWMGRTISRTSRSGFEILKVRNGWVQTSKEQIKRQVVVDNLNRSGYSGSFTLPVELTKRDCLVPCFWVEMIRGKPAEKTIWTSSSSIVMCGVDHEVADWSWHDGAILPFDID 4x49 A 2.01 BS01 G39 A 1 R257 D282 D339 S364 R575 R637 Y677 W698 R23 D48 D105 S130 R341 R403 Y443 W464 0004308 ic50=0.0296mM -logKd/Ki=4.53, IC50=29.6uM 26154892 801 GAMADIGSNIFYAGDATKSNYFRIPSLLALDSGTVIAAADARYGGTHDAKSKINTAFAKSTDGGKTWGQPTLPLKFDDYVAKNIDWPRDSVGKNVQIQGSASYIDPVLLEDKETHRVFLFADMMPAGIGSSNASVGSGFKEVDGKKYLKLHWKDDAAGTYDYSVRENGTIYNDTTNSATEYSVDGEYNLYKNGNAMLCKQYDYNFEGTKLLETQTDTDVNMNVFYKDADFKVFPTTYLAMKYSDDEGETWSDLQIVSTFKPEESKFLVLGPGVGKQIANGEHAGRLIVPLYSKSSAELGFMYSDDHGNNWTYVEADQNTGGATAEAQIVEMPDGSLKTYLRTGSGYIAQVMSTDGGETWSERVPLTEIATTGYGTQLSVINYSQPVDGKPAILLSAPNATNGRKNGKIWIGLISETGNSGKDKYSVDWKYCYSVDTPQMGYSYSCLTELPDGEIGLLYEKYDSWSRNELHLKNILKYERFNIDELKVQP 4yw5 A 2.3 BS01 G39 A 1 R290 D315 D372 F396 R600 R662 Y695 W716 R208 D233 D290 F314 R518 R580 Y613 W634 D315 E584 Y695 D233 E502 Y613 3.2.1.18 0004308,0005737,0005975,0006689,0009313,0016020,0016798,0043231,0052794,0052795,0052796 A0A0H2UQE4 26370075 801 ETPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFENNKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKNL 4yw5 B 2.3 BS01 G39 B 1 R290 D315 D372 S582 R600 R662 Y695 W716 R208 D233 D290 S500 R518 R580 Y613 W634 D315 E584 Y695 D233 E502 Y613 3.2.1.18 0004308,0005737,0005975,0006689,0009313,0016020,0016798,0043231,0052794,0052795,0052796 A0A0H2UQE4 26370075 801 ETPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFENNKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKNL 4yz3 A 2.38 BS01 G39 A 1 R290 D315 D372 Y553 R600 R662 Y695 W716 R207 D232 D289 Y467 R514 R576 Y609 W630 D315 E584 Y695 D232 E498 Y609 3.2.1.18 0004308,0005737,0005975,0006689,0009313,0016020,0016798,0043231,0052794,0052795,0052796 A0A0H2UQE4 1001 TPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKN 4yz3 B 2.38 BS01 G39 B 1 R290 D315 D372 Y553 R600 R662 Y695 W716 R208 D233 D290 Y469 R516 R578 Y611 W632 D315 E584 Y695 D233 E500 Y611 3.2.1.18 0004308,0005737,0005975,0006689,0009313,0016020,0016798,0043231,0052794,0052795,0052796 A0A0H2UQE4 1001 NTPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFEKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKN 5l15 A 2.4 BS02 G39 A 1 R119 E120 D152 R226 R294 R372 Y406 R37 E38 D70 R144 R212 R290 Y324 D152 E279 R294 R372 Y406 D70 E197 R212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 -logKd/Ki=9.57, IC50=0.27nM R4NFR6 28934455 512 RNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSCYGERTGITCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPNDPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPNALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL 5nwe A 2.0 BS03 G39 A 1 E119 D151 R152 I223 E277 R293 R368 Y402 E38 D70 R71 I142 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=13200nM -logKd/Ki=4.88, Kd=13200nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 5nwe B 2.0 BS03 G39 B 1 R118 E119 D151 R152 E278 R293 R368 Y402 R37 E38 D70 R71 E197 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=13200nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 5nwe C 2.0 BS03 G39 C 1 E119 D151 R152 W179 R225 E277 R293 R368 Y402 E38 D70 R71 W98 R144 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=13200nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 5nwe D 2.0 BS03 G39 D 1 R118 E119 D151 R152 S247 R293 R368 Y402 R37 E38 D70 R71 S166 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=13200nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK 5nz4 A 1.36 BS03 G39 A 1 E119 D151 R152 R225 E277 R293 R368 Y402 E38 D70 R71 R144 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=520nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNVLRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nz4 B 1.36 BS03 G39 B 1 R118 E119 D151 R152 R225 E277 R293 N295 R368 Y402 R37 E38 D70 R71 R144 E196 R212 N214 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=520nM -logKd/Ki=6.28, Kd=520nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNVLRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nze A 1.69 BS03 G39 A 1 R118 E119 D151 R152 R225 E277 R293 R368 Y402 R37 E38 D70 R71 R144 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=410nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nze B 1.69 BS03 G39 B 1 R118 E119 D151 R152 R225 E277 R293 R368 Y402 R37 E38 D70 R71 R144 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Kd=410nM -logKd/Ki=6.39, Kd=410nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzf A 1.75 BS03 G39 A 1 E119 D151 R152 W179 E277 R293 R368 Y402 E38 D70 R71 W98 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=94000nM -logKd/Ki=4.03, Ki=94000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNVLRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzf B 1.75 BS03 G39 B 1 R118 E119 D151 R152 W179 E277 E278 R293 R368 Y402 R37 E38 D70 R71 W98 E196 E197 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=94000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNVLRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzf C 1.75 BS03 G39 C 1 R118 E119 D151 R152 E277 R293 R368 Y402 R37 E38 D70 R71 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=94000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNVLRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzf D 1.75 BS03 G39 D 1 R118 E119 D151 R152 W179 E277 R293 R368 Y402 R37 E38 D70 R71 W98 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=94000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNVLRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzn A 1.73 BS03 G39 A 1 R118 E119 D151 R152 W179 E277 R293 R368 Y402 R37 E38 D70 R71 W98 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=220000nM -logKd/Ki=3.66, Ki=220000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzn B 1.73 BS03 G39 B 1 R118 E119 D151 R152 W179 I223 N247 E277 R293 N295 R368 Y402 R37 E38 D70 R71 W98 I142 N166 E196 R212 N214 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=220000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzn C 1.73 BS03 G39 C 1 R118 E119 D151 R152 W179 E277 R293 R368 Y402 R37 E38 D70 R71 W98 E196 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=220000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 5nzn D 1.73 BS03 G39 D 1 R118 E119 D151 R152 W179 I223 N247 R293 R368 Y402 R37 E38 D70 R71 W98 I142 N166 R212 R287 Y321 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 Ki=220000nM C3W6G3 29933553 503 SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID 6eks A 1.87 BS04 G39 A 1 R250 D276 Q343 E645 R661 D663 R738 Y766 R197 D223 Q290 E592 R608 D610 R685 Y713 3.2.1.18 0004308,0005576,0005737,0006689,0009313,0016020,0016798,0033691,0043231,0052794,0052795,0052796 ic50=144uM -logKd/Ki=3.84, IC50=144uM P0C6E9 29149072 908 ALFDYNATGDTFDSPAKQGWMQDNTNNGSGVLTNAMPAWLVQGIGGRAQWTYSLSTNQHAQASSFGWRMTTEMKVLSGGMITNYYANGTQRVLPIISLDSSGNLVVEFEGQTGRTVLATGTAATEYHKFELVFLPGSNPSASFYFDGKLIRDNIQPTASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGDVIFRGPDRIPSIVASSVTPGVVTAFAEKRVGGGDPGALSNTNDIITRTSRDGGITWDTELNLTEQINVSDEFDFSDPRPIYDPSSNTVLVSYARWPTDAAQNGDRIKPWMPNGIFYSVYDVASGNWQAPIDVTDQVKERSFQIAGWGGSELYRRNTSLNSQQDWQSNAKIRIVDGAANQIQVADGSRKYVVTLSIDESGGLVANLNGVSAPIILQSEHAKVHSFHDYELQYSALNHTTTLFVDGQQITTWAGEVSQENNIQFGNADAQIDGRLHVQKIVLTQQGHNLVEFDAFYLAQQTPEVEKDLEKLGWTKIKTGNTMSLYGNASVNPGPGHGITLTRQQNISGSQNGRLIYPAIVLDRFFLNVMSIYSDDGGSNWQTGSTLPIPFRWKSSSILETLEPSEADMVELQNGDLLLTARLDFNQIVNGVNYSPRQQFLSKDGGITWSLLEANNANVFSNISTGTVDASITRFEQSDGSHFLLFTNPQGNPAGTNGRQNLGLWFSFDEGVTWKGPIQLVNGASAYSDIYQLDSENAIVIVETDNSNMRILRMPITLLKQKL 6heb A 1.75 BS02 G39 A 1 R119 E120 D152 R153 W180 R226 R294 R372 Y406 R37 E38 D70 R71 W98 R144 R212 R290 Y324 D152 E279 R294 R372 Y406 D70 E197 R212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 P03472 522 RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL 6hg5 A 1.6 BS05 G39 A 1 R118 E119 D151 R152 R225 E277 R293 N295 R372 Y406 R37 E38 D70 R71 R144 E196 R212 N214 R291 Y325 D151 E278 R293 R372 Y406 D70 E197 R212 R291 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q6XV27 511 RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSCYGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE 6hg5 B 1.6 BS05 G39 B 1 R118 E119 D151 R152 R225 E277 R293 N295 R372 Y406 R37 E38 D70 R71 R144 E196 R212 N214 R291 Y325 D151 E278 R293 R372 Y406 D70 E197 R212 R291 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q6XV27 510 RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSCYGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE 6hg5 C 1.6 BS05 G39 C 1 R118 E119 D151 R152 R225 E277 R293 N295 R372 Y406 R37 E38 D70 R71 R144 E196 R212 N214 R291 Y325 D151 E278 R293 R372 Y406 D70 E197 R212 R291 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q6XV27 510 RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSCYGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE 6hg5 D 1.6 BS05 G39 D 1 R118 E119 D151 R152 R225 E277 R293 N295 R372 Y406 R37 E38 D70 R71 R144 E196 R212 N214 R291 Y325 D151 E278 R293 R372 Y406 D70 E197 R212 R291 Y325 3.2.1.18 0004308,0005975,0016020,0033644,0055036 Q6XV27 510 RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSCYGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE 7cm1 A 2.14 BS02 G39 A 1 D148 R149 R222 E275 E276 R292 R369 Y403 D69 R70 R143 E196 E197 R213 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 A0A2P1GNT2 33135677 602 PKYRMSRPTCRGQKWTVMSNVWTSRWVATGTNARNIRPPTAIFLKKGLRAVSLAHNTAGPNPLSGTGSDRSEFRDLITWSPSGYPGDESTETICKAWSFFACFDGKEDLIGCISGPDNNAVLTIMYGGKPTDLYNSYALDILRTMESQCVCNNGTCSAMITDGPDIGPSKARMLFIKEGKIEKVVIVDGPGSSMVEECSCINEDSNEFGCLCRDNTANSRRPFLKCFWDSRTCKADYTCSQTLLDCPRPNDSIQTCGTSFGSLAGGLKGAYIPLGKGRICATRTVDKIQRKGMELMCTNGNILLEQDAMKKIGDLVTPTAQTGYSSATTIPRATEECDTICVATELVFSGAKGTNADLVIHCLLGEARETESVVTAVVDRTTYSSLL 7cm1 B 2.14 BS02 G39 B 1 D148 R222 E275 E276 R292 R369 Y403 D69 R143 E196 E197 R213 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 A0A2P1GNT2 33135677 602 PKYRMSRPTCRGQKWTVMSNVWTSRWVATGTNARNIRPPTAIFLKKGLRAVSLAHNTAGPNPLSGTGSDRSEFRDLITWSPSGYPGDESTETICKAWSFFACFDGKEDLIGCISGPDNNAVLTIMYGGKPTDLYNSYALDILRTMESQCVCNNGTCSAMITDGPDIGPSKARMLFIKEGKIEKVVIVDGPGSSMVEECSCINEDSNEFGCLCRDNTANSRRPFLKCFWDSRTCKADYTCSQTLLDCPRPNDSIQTCGTSFGSLAGGLKGAYIPLGKGRICATRTVDKIQRKGMELMCTNGNILLEQDAMKKIGDLVTPTAQTGYSSATTIPRATEECDTICVATELVFSGAKGTNADLVIHCLLGEARETESVVTAVVDRTTYSSLL 7fgd A 2.1 BS01 G39 A 1 D148 R149 R292 N294 R369 Y403 D69 R70 R213 N215 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 A0A2P1GNT2 36191180 501 PKYRMSRPTCRGQKWTVMSNVWTSRWVATGTNARNIRPPTAIFLKKGLRAVSLAHNTAGPNPLSGTGSDRSEFRDLITWSPSGYPGDESTETICKAWSFFACFDGKEDLIGCISGPDNNAVLTIMYGGKPTDLYNSYALDILRTMESQCVCNNGTCSAMITDGPDIGPSKARMLFIKEGKIEKVVIVDGPGSSMVEECSCINEDSNEFGCLCRDNTANSRRPFLKCFWDSRTCKADYTCSQTLLDCPRPNDSIQTCGTSFGSLAGGLKGAYIPLGKGRICATRTVDKIQRKGMELMCTNGNILLEQDAMKKIGDLVTPTAQTGYSSATTIPRATEECDTICVATELVFSGAKGTNADLVIHCLLGEARETESVVTAVVDRTTYSSLL 7fgd B 2.1 BS01 G39 B 1 D148 R149 R222 E275 R292 R369 Y403 D69 R70 R143 E196 R213 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0055036 A0A2P1GNT2 36191180 501 PKYRMSRPTCRGQKWTVMSNVWTSRWVATGTNARNIRPPTAIFLKKGLRAVSLAHNTAGPNPLSGTGSDRSEFRDLITWSPSGYPGDESTETICKAWSFFACFDGKEDLIGCISGPDNNAVLTIMYGGKPTDLYNSYALDILRTMESQCVCNNGTCSAMITDGPDIGPSKARMLFIKEGKIEKVVIVDGPGSSMVEECSCINEDSNEFGCLCRDNTANSRRPFLKCFWDSRTCKADYTCSQTLLDCPRPNDSIQTCGTSFGSLAGGLKGAYIPLGKGRICATRTVDKIQRKGMELMCTNGNILLEQDAMKKIGDLVTPTAQTGYSSATTIPRATEECDTICVATELVFSGAKGTNADLVIHCLLGEARETESVVTAVVDRTTYSSLL 7qy9 A 1.92 BS01 G39 A 1 R212 D237 D280 W308 T406 R423 R487 Y518 R179 D204 D247 W275 T373 R390 R454 Y485 ? 0004308,0005737,0006689,0009313,0016020,0043231 G8UIQ1 35916484 601 DSVYVQNPQIPILVDRTDNVLFRIRIPDATKGDVLNRLTIRFGNEDKLSEVKAVRLFYAGTEAATKGRSRFAPVTYVSSHNIRNTRSANPSYSIRQDEVTTVANTLTLKTRQPMVKGINYFWVSVEMDRNTSLLSKLTSTVTEVVINDKPAVIAGEQAAVRRMGIGVRHAGDDGSASFRIPGLVTTNKGTLLGVYDVRYNNSVDLQEHIDVGLSRSTDKGQTWEPMRIAMSFGETDGLPSGQNGVGDPSILVDERTNTVWVVAAWTHGMGNARAWTNSMPGMTPDETAQLMMVKSTDDGRTWSESTNITSQVKDPSWCFLLQGPGRGITMRDGTLVFPIQFIDSLRVPHAGIMYSKDRGETWHIHQPARTNTTEAQVAEVEPGVLMLNMRDNRGGSRAVSITRDLGKSWTEHSSNRSALPESICMASLISVKAKDNIIGKDLLLFSNPNTTEGRHHITIKASLDGGVTWLPAHQVLLDEEDGWGYSCLSMIDRETVGIFYESSVAHMTFQAVKIKDLIR 7qy9 B 1.92 BS01 G39 B 1 R212 D237 D280 W308 R423 R487 Y518 R179 D204 D247 W275 R390 R454 Y485 ? 0004308,0005737,0006689,0009313,0016020,0043231 G8UIQ1 35916484 601 DSVYVQNPQIPILVDRTDNVLFRIRIPDATKGDVLNRLTIRFGNEDKLSEVKAVRLFYAGTEAATKGRSRFAPVTYVSSHNIRNTRSANPSYSIRQDEVTTVANTLTLKTRQPMVKGINYFWVSVEMDRNTSLLSKLTSTVTEVVINDKPAVIAGEQAAVRRMGIGVRHAGDDGSASFRIPGLVTTNKGTLLGVYDVRYNNSVDLQEHIDVGLSRSTDKGQTWEPMRIAMSFGETDGLPSGQNGVGDPSILVDERTNTVWVVAAWTHGMGNARAWTNSMPGMTPDETAQLMMVKSTDDGRTWSESTNITSQVKDPSWCFLLQGPGRGITMRDGTLVFPIQFIDSLRVPHAGIMYSKDRGETWHIHQPARTNTTEAQVAEVEPGVLMLNMRDNRGGSRAVSITRDLGKSWTEHSSNRSALPESICMASLISVKAKDNIIGKDLLLFSNPNTTEGRHHITIKASLDGGVTWLPAHQVLLDEEDGWGYSCLSMIDRETVGIFYESSVAHMTFQAVKIKDLIR 7xvu A 1.6 BS01 G39 A 1 R121 E122 D154 R155 R228 E280 E281 R297 R380 Y414 R38 E39 D71 R72 R145 E197 E198 R214 R297 Y331 3.2.1.18 0004308,0005975,0016020,0033644,0055036 A0A2P1GNP4 36191180 501 EWRFPKSTCPGRSLQKMLQLNPHRHATAGSQAATIPNREPFISCSQDECRLFTLDHDVSTPGAYDGITWEDRSKRRRLVSFPLGSELTLDNMKVHLSGWSGTACHDGKEWTYATVNGPDNSAVMRLKYGDQIRGSFPSYANNILRTQESECVCIDGKCYIIVIDGPAGGTATPKVLVTREGEVTSEIIVTGRNKMGEECSCLATNRTWIECLCRDNAFSAKRPIIRIDTVAGTARGYLMCSDTYLDTPRPADGSITGSCETDGTSGGGGVKGAFALSRTTEATTERFYVRTVSSSARSGAVFYKTTDDPTESNNPLTLIGTAVGGAIPMWYSFSFEIPGKVCDQTCIGLEMGLTMGHQLWTSNSVAVYCVIGDNLDWDSTTDVVPADIV 7xvu B 1.6 BS01 G39 B 1 R121 E122 D154 R155 R228 E280 R297 N299 R380 Y414 R38 E39 D71 R72 R145 E197 R214 N216 R297 Y331 3.2.1.18 0004308,0005975,0016020,0033644,0055036 A0A2P1GNP4 36191180 501 EWRFPKSTCPGRSLQKMLQLNPHRHATAGSQAATIPNREPFISCSQDECRLFTLDHDVSTPGAYDGITWEDRSKRRRLVSFPLGSELTLDNMKVHLSGWSGTACHDGKEWTYATVNGPDNSAVMRLKYGDQIRGSFPSYANNILRTQESECVCIDGKCYIIVIDGPAGGTATPKVLVTREGEVTSEIIVTGRNKMGEECSCLATNRTWIECLCRDNAFSAKRPIIRIDTVAGTARGYLMCSDTYLDTPRPADGSITGSCETDGTSGGGGVKGAFALSRTTEATTERFYVRTVSSSARSGAVFYKTTDDPTESNNPLTLIGTAVGGAIPMWYSFSFEIPGKVCDQTCIGLEMGLTMGHQLWTSNSVAVYCVIGDNLDWDSTTDVVPADIV