1mqi A 1.35 BS01 FWD A 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y59 L88 T89 R94 L136 G139 S140 T141 L190 E191 M194 ? 0015276,0016020 ic50=23.53nM -logKd/Ki=7.63, IC50=23.53nM Ki=4nM, EC50=460nM P19491 12872125 401 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 2al5 A 1.65 BS01 FWD A 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y59 L88 T89 R94 L136 G139 S140 T141 L190 E191 M194 ? 0015276,0016020 -logKd/Ki=8.40, Ki=4nM Ki=4nM, EC50=460nM P19491 16192394 901 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 2al5 B 1.65 BS02 FWD B 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y59 L88 T89 R94 L136 G139 S140 T141 L190 E191 M194 ? 0015276,0016020 Ki=4nM, EC50=460nM P19491 16192394 902 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 3rt6 B 2.836 BS01 FWD B 1 Y61 P89 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y58 P86 L87 T88 R93 L135 G138 S139 T140 L189 E190 M193 ? 0015276,0016020 -logKd/Ki=7.15, Ki=70nM Ki=18nM, EC50=20900nM P19492 21464198 401 RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 4u1y A 3.8999 BS01 FWD A 1 Y450 T480 R485 S654 T655 L704 E705 Y416 T446 R451 S567 T568 L617 E618 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25109876 2002 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEDEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKVFSFLDPLAYEIWMAIVFAYILVSVVLFLVSRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSALSLSNVAGVFYILVGGLGLAMLVALIEF 4u1y B 3.8999 BS01 FWD B 1 Y450 T480 R485 L650 G653 S654 T655 L704 E705 Y435 T465 R470 L578 G581 S582 T583 L632 E633 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25109876 2002 IQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEDDTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKFLDPLAYEIWMAIVFAYILVSVVLFLVSRFRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNVAGVFYILVGGLGLAMLVALIEFAY 4u1y C 3.8999 BS02 FWD C 1 Y450 L479 T480 G653 S654 T655 L704 E705 Y428 L457 T458 G574 S575 T576 L625 E626 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25109876 1001 QIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPFLDPLAYEIWMAIVFAYILVSVVLFLVSPRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 4u1y D 3.8999 BS02 FWD D 1 Y450 T480 R485 G653 S654 T655 L704 E705 M708 Y423 T453 R458 G572 S573 T574 L623 E624 M627 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25109876 2002 QIGGLFPRGADQEYSAFRVGMVQFTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSGVFSFLDPLAYEIWMAIVFAYILVSVVLFLVLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGASALSLSNVAGVFYILVGGLGLAMLVALIEFAYK 4u21 A 1.3908 BS01 FWD A 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y60 L89 T90 R95 L137 G140 S141 T142 L191 E192 M195 ? 0015276,0016020 Ki=4nM, EC50=460nM P19491 25109876 401 ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGS 4u21 B 1.3908 BS01 FWD B 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y59 L88 T89 R94 L136 G139 S140 T141 L190 E191 M194 ? 0015276,0016020 Ki=4nM, EC50=460nM P19491 25109876 401 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECG 4u22 A 1.4409 BS01 FWD A 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y60 L89 T90 R95 L137 G140 S141 T142 L191 E192 M195 ? 0015276,0016020 Ki=4nM, EC50=460nM P19491 25109876 401 ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGS 4u23 A 1.6734 BS01 FWD A 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y58 L87 T88 R93 L135 G138 S139 T140 L189 E190 M193 ? 0015276,0016020 Ki=4nM, EC50=460nM P19491 25109876 401 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECG 4u5c A 3.6883 BS01 FWD A 1 Y450 L479 T480 R485 G653 S654 T655 E705 M708 Y437 L466 T467 R472 G593 S594 T595 E645 M648 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25103405 902 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTESGDGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAYILVSVVLFLVSSPRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSALSLSNVAGVFYILVGGLGLAMLVALIEFAYK 4u5c B 3.6883 BS01 FWD B 1 Y450 L479 T480 R485 G653 S654 T655 E705 Y440 L469 T470 R475 G594 S595 T596 E646 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25103405 902 SIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTESGGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAYILVSVVLFLSPRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNVAGVFYILVGGLGLAMLVALIEFAYKR 4u5c C 3.6883 BS02 FWD C 1 Y450 L479 T480 R485 G653 S654 T655 L704 E705 Y440 L469 T470 R475 G595 S596 T597 L646 E647 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25103405 902 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAYILVSVVLFLVSPRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNVAGVFYILVGGLGLAMLVALIEFAY 4u5c D 3.6883 BS01 FWD D 1 Y450 P478 L479 T480 R485 G653 S654 T655 L704 E705 M708 Y439 P467 L468 T469 R474 G599 S600 T601 L650 E651 M654 ? 0000149,0001540,0001919,0004970,0004971,0005216,0005230,0005234,0005515,0005783,0005886,0006811,0007268,0008021,0008092,0008328,0009986,0010226,0014069,0015276,0015277,0016020,0019722,0019865,0019901,0021987,0022849,0030165,0030424,0030425,0030426,0030672,0031623,0032279,0032281,0032590,0032839,0032991,0034220,0035235,0035249,0035254,0035255,0036477,0038023,0042734,0042802,0043005,0043025,0043195,0043197,0043198,0043204,0044326,0044327,0044877,0045184,0045202,0045211,0048787,0050804,0050806,0051262,0051966,0060078,0060079,0060992,0097060,0097110,0098655,0098685,0098793,0098839,0098978,0099094,0099505,0099507,0099544,0106033,1904315,1905430,1990416 Ki=4nM, EC50=460nM P19491 25103405 902 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAYILVSVVLFLVSRADISPRSLSARIVAGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSALSLSNVAGVFYILVGGLGLAMLVALIEF 5jei A 1.229 BS01 FWD A 1 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 ? 0015276,0016020 Ki=4nM, EC50=460nM P19491 28211453 301 GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIACFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG