6h4r A 2.14 BS03 FQB A 1 Y132 Y177 F185 H188 E190 K206 W208 H276 Y127 Y164 F172 H175 E177 K193 W195 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 Ki=0.004nM -logKd/Ki=7.03, IC50=0.093uM Ki=4.0nM, IC50=93nM O75164 31158747 403 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4r B 2.14 BS03 FQB B 1 Y132 Y175 Y177 F185 H188 E190 K206 W208 K241 H276 Y126 Y162 Y164 F172 H175 E177 K193 W195 K228 H263 G170 Y177 H188 E190 H276 S288 G157 Y164 H175 E177 H263 S275 1.14.11.66,1.14.11.69 Ki=0.004nM Ki=4.0nM, IC50=93nM O75164 31158747 403 TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEF 6h4r C 2.14 BS03 FQB C 1 Y132 D135 Y177 F185 H188 E190 K206 W208 H276 Y123 D126 Y166 F174 H177 E179 K195 W197 H265 G170 Y177 H188 E190 H276 S288 G159 Y166 H177 E179 H265 S277 1.14.11.66,1.14.11.69 Ki=0.004nM Ki=4.0nM, IC50=93nM O75164 31158747 403 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 6h4r D 2.14 BS03 FQB D 1 Y132 D135 Y177 F185 H188 E190 K206 W208 H276 Y123 D126 Y159 F167 H170 E172 K188 W190 H258 G170 Y177 H188 E190 H276 S288 G152 Y159 H170 E172 H258 S270 1.14.11.66,1.14.11.69 Ki=0.004nM Ki=4.0nM, IC50=93nM O75164 31158747 403 PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL