3bny A 1.89 BS01 FPF A 1 Y67 F153 N219 W308 Y55 F141 N207 W285 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W285 4.2.3.9 0016829,0045483,0046872 Q9UR08 18385128 400 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYLCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV 3bny B 1.89 BS01 FPF B 1 F87 D90 F153 L184 N219 W308 R314 F75 D78 F141 L172 N207 W287 R293 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W287 4.2.3.9 0016829,0045483,0046872 Q9UR08 18385128 401 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYTILCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV 3bny C 1.89 BS01 FPF C 1 Y67 F87 F153 L184 N219 W308 R314 Y315 Y55 F75 F141 L172 N207 W284 R290 Y291 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W284 4.2.3.9 0016829,0045483,0046872 Q9UR08 18385128 402 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYTLCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGTPGLAAYVEGLEYQMSGNELWSQTTLRYSV 3bny D 1.89 BS02 FPF D 1 Y67 L86 F87 F153 K181 L184 N219 R314 Y315 Y55 L74 F75 F141 K169 L172 N207 R294 Y295 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W288 4.2.3.9 0016829,0045483,0046872 Q9UR08 18385128 403 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYTSKLCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV 3g4f A 2.651 BS01 FPF A 1 D307 R448 D451 E455 Y527 Y535 V536 D279 R420 D423 E427 Y493 Y496 V497 R270 W279 I300 D307 D311 T407 C408 G409 R448 D451 E455 Y527 R242 W251 I272 D279 D283 T379 C380 G381 R420 D423 E427 Y493 4.2.3.13 0000287,0010333,0016102,0016114,0016829,0046872,0047461 -logKd/Ki=4.52, IC50=30uM Q39761 19489610 801 ADFQPSIWGDLFLNCPDDAETEKRHQQLKEEVRKMIVAPMANSTQKLAFIDSVQRLGVSYHFTKEIEDELENIYHNNNDAENDLYTTSIRFRLLREHGYNVSCDVFNKFKDEQGNFKSSVTSDVRGLLELYQASYLRVHGEDILDEAISFTTHHLSLAVASLDHPLSEEVSHALKQSIRRGLPRVEARHYLSVYQDESHNKALLEFAKIDFNMLQFLHRKELSEICRWWKDLDFQRKLPYARDRVVEGYFWISGVYFEPQYSLGRKMLTKVIAMASIVDDTYDSYATYEELIPYTNAIERWDIKCIDEIPEYMKPSYKALLDVYEEMVQLVAEHGRQYRVEYAKNAMIRLAQSYLVEAKWTLQNYKPSFEEFKANALPTCGYAMLAITSFVGMGDIVTPETFKWAASDPKIIQASTIICRFMDDVAEHKFDCSAIECYMEEYGVTAQEAYDVFNKHVESAWKDLNQEFLKPTEMPTEVLNRSLNLARVMDVLYREYVGKAAKGGITSLLIEPIAL 3g4f B 2.651 BS01 FPF B 1 D307 D451 E455 Y527 Y535 V536 D279 D423 E427 Y493 Y496 V497 R270 W279 I300 D307 D311 T407 C408 G409 R448 D451 E455 Y527 R242 W251 I272 D279 D283 T379 C380 G381 R420 D423 E427 Y493 4.2.3.13 0000287,0010333,0016102,0016114,0016829,0046872,0047461 Q39761 19489610 802 ADFQPSIWGDLFLNCPDDAETEKRHQQLKEEVRKMIVAPMANSTQKLAFIDSVQRLGVSYHFTKEIEDELENIYHNNNDAENDLYTTSIRFRLLREHGYNVSCDVFNKFKDEQGNFKSSVTSDVRGLLELYQASYLRVHGEDILDEAISFTTHHLSLAVASLDHPLSEEVSHALKQSIRRGLPRVEARHYLSVYQDESHNKALLEFAKIDFNMLQFLHRKELSEICRWWKDLDFQRKLPYARDRVVEGYFWISGVYFEPQYSLGRKMLTKVIAMASIVDDTYDSYATYEELIPYTNAIERWDIKCIDEIPEYMKPSYKALLDVYEEMVQLVAEHGRQYRVEYAKNAMIRLAQSYLVEAKWTLQNYKPSFEEFKANALPTCGYAMLAITSFVGMGDIVTPETFKWAASDPKIIQASTIICRFMDDVAEHKFDCSAIECYMEEYGVTAQEAYDVFNKHVESAWKDLNQEFLKPTEMPTEVLNRSLNLARVMDVLYREYVGKAAKGGITSLLIEPIAL 3lz9 A 2.28 BS01 FPF A 1 R264 W273 D301 D305 T402 T403 R250 W259 D287 D291 T388 T389 R264 W273 I294 D301 D305 T401 T402 T403 R441 D444 T448 E452 Y520 R250 W259 I280 D287 D291 T387 T388 T389 R427 D430 T434 E438 Y506 4.2.3.61 0000287,0005737,0006720,0010333,0016102,0016114,0016829,0016838,0046872,0051762,0102698 Q40577 20175559 700 RPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQTRNMLLATGMKLADTLNLIDTIERLGISYHFEKEIDDILDQIYNQNSNCNDLCTSALQFRLLRQHGFNISPEIFSKFQDENGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAFSTIHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFISSIYDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWKDLDFVTTLPYARDRVVECYFWTLGVYFEPQYSQARVMLVKTISMISIVDDTFDAYGTVKELEAYTDAIQRWDINEIDRLPDYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMKEIVRNYNVESTWFIEGYTPPVSEYLSNALATTTYYLLATTSYLGMKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVEKSRGQIATGIECCMRDYGISTKEAMAKFQNMAETAWKDINEGLLRPTPVSTEFLTPILNLARIIEVTYIHNEKVLKPHIINLLVDSIKI 3m01 A 2.6 BS01 FPF A 1 R264 W273 D301 D444 Y520 R251 W260 D288 D431 Y507 R264 W273 I294 D301 D305 T401 T402 T403 R441 D444 T448 E452 Y520 R251 W260 I281 D288 D292 T388 T389 T390 R428 D431 T435 E439 Y507 4.2.3.61 0000287,0005737,0006720,0010333,0016102,0016114,0016829,0016838,0046872,0051762,0102698 Q40577 20175559 549 VRPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQTRNMLLATGMKLADTLNLIDTIERLGISYHFEKEIDDILDQIYNQNSNCNDLCTSALQFRLLRQHGFNISPEIFSKFQDENGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAFSTIHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFISSIYDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWKDLDFVTTLPYARDRVVECYFWALGVYFEPQYSQARVMLVKTISMISIVDDTFDAYGTVKELEAYTDAIQRWDINEIDRLPDYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMKEVVRNYNVESTWFIEGYTPPVSEYLSNALATTTYYYLATTSYLGMKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVEKSRGQIATGIECCMRDYGISTKEAMAKFQNMAETAWKDINEGLLRPTPVSTEFLTPILNLARIVEVTYIHTHPEKVLKPHIINLLVDSIKI 7xqz A 2.0 BS01 FPF A 1 R132 K133 Q163 W165 F248 F293 A303 W393 G499 P500 R501 Y505 R102 K103 Q133 W135 F218 F263 A273 W363 G469 P470 R471 Y475 ? 0003824,0005811,0008610,0016104,0016866,0046872 A0A2P2GK84 36416740 601 ATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAYLRTTLRTAPPDPFQCAVARAVLGDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPWEAYDTRPQQSWLHMEMKALKVLAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLKHVAGRLRPDGGMPFIDGMTVFTTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVADTCYVLEFLRRAAPDRHRTAVAEAEGYLLALRNPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWSRNATNAVFRAVLALTGVAAHGEERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPLDRALAYLVERQHPDGGYRSRPDQAGPRPLLYDVPALADVFVLLALAHAT