3c3d A 2.5 BS02 FO1 A 1 P45 W64 L86 K87 P45 W64 L86 K87 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Kd=1.38mM Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLEH 3c3d B 2.5 BS02 FO1 B 1 P45 W64 L86 K87 P45 W64 L86 K87 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Kd=1.38mM Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLEH 3c3d C 2.5 BS02 FO1 C 1 P45 W64 L86 K87 I152 P45 W64 L86 K87 I152 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Kd=1.38mM Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLEH 3c3d D 2.5 BS02 FO1 D 1 P45 W64 L86 K87 I152 P45 W64 L86 K87 I152 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Kd=1.38mM Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLEH 3c3e A 3.0 BS01 FO1 A 1 P45 W64 L86 K87 P45 W64 L86 K87 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLE 3c3e B 3.0 BS01 FO1 B 1 P45 D48 W64 L86 K87 D92 I152 P45 D48 W64 L86 K87 D92 I152 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLE 3c3e C 3.0 BS01 FO1 C 1 P45 W64 L86 K87 D92 P45 W64 L86 K87 D92 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLE 3c3e D 3.0 BS01 FO1 D 1 P45 D48 W64 L86 D92 P45 D48 W64 L86 D92 2.7.8.28 0000287,0016740,0016773,0043743,0052645 Q8PVT6 18252724 401 MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAFLE 3cvv A 2.1 BS04 FO1 A 1 R13 F44 I45 L46 D47 I50 M54 V56 R60 L64 D110 E112 Y114 S115 R118 K266 F267 R27 F58 I59 L60 D61 I64 M68 V70 R74 L78 D124 E126 Y128 S129 R132 K280 F281 Q299 W302 W330 H365 W384 W407 Q313 W316 W344 H379 W398 W421 ? 0000166,0003677,0003904,0005634,0005737,0032922,0043153,0071949 Q8SXK5 19570997 522 EKGASTSLYKKAGLMDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGRYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVR 3cvw A 3.2 BS04 FO1 A 1 K14 F44 I45 I50 M54 L64 D110 E112 R118 K266 K11 F41 I42 I47 M51 L61 D107 E109 R115 K263 Q299 W302 W330 N365 W384 W407 Q296 W299 W327 N362 W381 W404 ? 0000166,0003677,0003904,0005634,0005737,0032922,0043153,0071949 Q8SXK5 1422 QRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGRYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHNLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVR 4cdm A 2.7 BS02 FO1 A 1 S26 F55 C56 T58 M72 S118 K123 H272 F273 R411 S26 F55 C56 T58 M72 S118 K123 H264 F265 R403 E301 W305 A335 G375 E293 W297 A327 G367 4.1.99.3 0000166,0000719,0003677,0003904,0006281,0016829 Q8PYK9 24849603 1464 SHMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDEFLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAAHTFRPKLYALLPEFLEEFPELEPNSVTPEETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKVMESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFCYYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNASQMELLSTGKMHGYTRMYWAKKILEWSESPEKALEIAICLNDRYELDGRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYS 4cdn A 1.9 BS02 FO1 A 1 S26 R27 F55 C56 L57 T58 F61 M72 S118 K123 H272 F273 R411 S31 R32 F60 C61 L62 T63 F66 M77 S123 K128 H273 F274 R412 E301 W305 A335 G375 E302 W306 A336 G376 4.1.99.3 0000166,0000719,0003677,0003904,0006281,0016829 Q8PYK9 24849603 999 LVPRGSHMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDEFLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAAHTFRPKLYALLPEFLEEFPELEPNSVTPELGMVETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKVMESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFCYYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNASQMELLSTGKMHGYTRMYWAKKILEWSESPEKALEIAICLNDRYELDGRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYS 4cdn B 1.9 BS02 FO1 B 1 S26 R27 F55 C56 L57 T58 F61 M72 S118 K123 H272 F273 R411 S31 R32 F60 C61 L62 T63 F66 M77 S123 K128 H248 F249 R387 E301 W305 A335 G375 E277 W281 A311 G351 4.1.99.3 0000166,0000719,0003677,0003904,0006281,0016829 Q8PYK9 24849603 999 LVPRGSHMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDEFLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAAHTFRPKLYALLPEFLEEFPELEPNSVTPLKNKDPLFEPWHFEPGEKAAKKVMESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFCYYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNASQMELLSTGKMHGYTRMYWAKKILEWSESPEKALEIAICLNDRYELDGRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYS 6uw1 B 2.205 BS01 FO1 B 1 I54 P56 W75 F98 G99 D104 Q166 V170 I54 P56 W75 F98 G99 D104 Q166 V170 2.7.8.28 0000287,0016740,0043743 A0QTG2 32430409 401 MKITVLVGGVGGARFLLGVQNLLGLGSFADGPSKHELTAVVNIGDDAWMHGVRICPDLDTCMYTLGGGIDPDRGWGHRNETWNAKEELAAYGVQPDWFGLGDRDLATHLVRSQMLRAGYPLSQVTEALCKRWQPGARLLPASDERSETHVVITDPTDGERRAIHFQEWWVRYRAKVPTHSFAYVGADQATAGPGVVEAIGDADIVLLAPSNPVVSIGPILQIPGIRGALRSTSAPVIGYSPIIAADECLKVIGVESTSQAVGEFFGARAGTGLLDGWLVHEGDHAQIEGVKVKAVPLLMTDPEATAAMVRAGLDLAGVS 6uw5 B 2.2 BS02 FO1 B 1 D45 I54 P56 W75 F98 G99 F165 Q166 V170 R173 D45 I54 P56 W75 F98 G99 F165 Q166 V170 R173 2.7.8.28 0000287,0016740,0043743 A0QTG2 32430409 402 MKITVLVGGVGGARFLLGVQNLLGLGSFADGPSKHELTAVVNIGDDAWMHGVRICPDLDTCMYTLGGGIDPDRGWGHRNETWNAKEELAAYGVQPDWFGLGDRDLATHLVRSQMLRAGYPLSQVTEALCKRWQPGARLLPASDERSETHVVITDPTDGERRAIHFQEWWVRYRAKVPTHSFAYVGADQATAGPGVVEAIGDADIVLLAPSNPVVSIGPILQIPGIRGALRSTSAPVIGYSPIIAGKPLRGMADECLKVIGVESTSQAVGEFFGARAGTGLLDGWLVHEGDHAQIEGVKVKAVPLLMTDPEATAAMVRAGLDLAGVS